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                  Page - 1 of 1                  Record - 1 of 6   [TOP]
Compound ID3091
Compound Structure
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Plant SourcePrismatomeris fragrans E.T. Geddes     Common Name:Khao - San
Source FamilyRubiaceae
OriginNortheastern, Eastern and Southeastern parts of Thailand and in the Northwest of Laos
Plant Part UsedRoot, stem
ExtractHexane, dichloromethane
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Kanamycin Sulphate (2.5 µg/ml), Isoniazid (0.05 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedDamnacanthal
PubChem ID   2948
Ethnomedicinal InformationAntimalarial, antifungal
PubMed ID [Source Literature]15885942
Extract PreparationAir dried roots and stems ground and extracted with solvents hexane and dichloromethane
Chemical Classification [Active Compound]Aromatic, Tricyclic, Alkaloid, Anthraquinone, Aldehyde
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]Against human epidermoid carcinoma in the mouth (KB), human breast cancer cells (BC), human lung cancer cells (NCI - H187)
Molecular Weight282.053
Molecular FormulaC16H10O5
SMILESO(c1c2c(C(=O)c3c(C2=O)cccc3)cc(O)c1C=O)C
XLogP2.325
PSA80.670
H-bond Donor1
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Kanokmedhakul K, Kanokmedhakul S, Phatchana R.Biological activity of Anthraquinones and Triterpenoids from Prismatomeris fragrans.J Ethnopharmacol. 2005 Sep 14;100(3):284-8

CuratorKeyaMukherjee

                  Record - 2 of 6   [TOP]
Compound ID3092
Compound Structure
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Plant SourcePrismatomeris fragrans E.T. Geddes     Common Name:Khao - San
Source FamilyRubiaceae
OriginNortheastern, Eastern and Southeastern parts of Thailand and in the Northwest of Laos
Plant Part UsedRoot, stem
ExtractNR
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Kanamycin Sulphate (2.5 µg/ml), Isoniazid (0.05 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedRubiadin
PubChem ID   124062
Ethnomedicinal InformationAntimalarial, antifungal
PubMed ID [Source Literature]15885942
Extract PreparationAir dried roots and stems ground and extracted with solvents hexane and dichloromethane
Chemical Classification [Active Compound]Aromatic, Tricyclic, Anthraquinone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]Against human epidermoid carcinoma in the mouth (KB), human breast cancer cells (BC), human lung cancer cells (NCI - H187)
Molecular Weight254.058
Molecular FormulaC15H10O4
SMILESOc1c2c(C(=O)c3c(C2=O)cccc3)cc(O)c1C
XLogP1.838
PSA74.600
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count0
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) Kanokmedhakul K, Kanokmedhakul S, Phatchana R.Biological activity of Anthraquinones and Triterpenoids from Prismatomeris fragrans.J Ethnopharmacol. 2005 Sep 14;100(3):284-8

CuratorKeyaMukherjee, vsheeba

                  Record - 3 of 6   [TOP]
Compound ID3093
Compound Structure
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Plant SourcePrismatomeris fragrans E.T. Geddes     Common Name:Khao - San
Source FamilyRubiaceae
OriginNortheastern, Eastern and Southeastern parts of Thailand and in the Northwest of Laos
Plant Part UsedRoot, stem
ExtractNR
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Kanamycin Sulphate (2.5 µg/ml), Isoniazid (0.05 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified1 - Hydroxy - 2 - Hydroxymethyl - 3 - Methoxyanthraquinone
PubChem ID   10085264
Ethnomedicinal InformationNR
PubMed ID [Source Literature]15885942
Extract PreparationAir dried roots and stems ground and extracted with solvents hexane and dichloromethane
Chemical Classification [Active Compound]Aromatic, Tricyclic, Anthraquinone, Alcohol, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]Against human epidermoid carcinoma in the mouth (KB), human breast cancer cells (BC), human lung cancer cells (NCI - H187)
Molecular Weight284.068
Molecular FormulaC16H12O5
SMILESO(c1c(c(O)c2c(C(=O)c3c(C2=O)cccc3)c1)CO)C
XLogP1.654
PSA83.830
H-bond Donor2
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Kanokmedhakul K, Kanokmedhakul S, Phatchana R.Biological activity of Anthraquinones and Triterpenoids from Prismatomeris fragrans.J Ethnopharmacol. 2005 Sep 14;100(3):284-8

CuratorKeyaMukherjee, vsheeba

                  Record - 4 of 6   [TOP]
Compound ID3667
Compound Structure
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Plant SourceEngelhardia roxburghiana Hay     Common Name:
Source FamilyJuglandaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneAgar - Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/mlNR
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified3-Methoxycarbonyl-1,5-dihydroxyanthraquinone
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]15729627
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Tricyclic, Anthraquinone, Ester, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight298.048
Molecular FormulaC16H10O6
SMILESC1ccc(c2c1C(=O)c1c(C2=O)cc(cc1O)C(=O)OC)O
XLogP0.862
PSA100.900
H-bond Donor2
H-bond Acceptor6
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O6
No. of S0
Reference(s)1) Lin WY, Peng CF, Tsai IL, Chen JJ, Cheng MJ, Chen IS.Antitubercular constituents from the roots of Engelhardia roxburghiana.Planta Med. 2005 Feb;71(2):171-5

CuratorVsheeba, vikramjitmandal

                  Record - 5 of 6   [TOP]
Compound ID4083
Compound Structure
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Plant SourceRumex nepalensis     Common Name:
Source FamilyPolygonaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml1.8 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedEJMC182
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Tricyclic, Anthraquinone, Phenol, O-Acetyl, Sugar
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight458.121
Molecular FormulaC23H22O10
SMILESO[C@H]1[C@H](O)[C@@H](COC(=O)C)O[C@@H](Oc2cccc3C(=O)c4c(c(O)cc(C)c4)C(=O)c23)[C@@H]1O
XLogP0.830
PSA159.820
H-bond Donor4
H-bond Acceptor10
No. of Rotatable Bond Count5
No. of Rings4
No. of N0
No. of O10
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

                  Record - 6 of 6   [TOP]
Compound ID4084
Compound Structure
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Plant SourceRumex hastatus     Common Name:
Source FamilyPolygonaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml1.8 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedEJMC182
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Tricyclic, Anthraquinone, Phenol, O-Acetyl, Sugar
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight458.121
Molecular FormulaC23H22O10
SMILESO[C@H]1[C@H](O)[C@@H](COC(=O)C)O[C@@H](Oc2cccc3C(=O)c4c(c(O)cc(C)c4)C(=O)c23)[C@@H]1O
XLogP0.830
PSA159.820
H-bond Donor4
H-bond Acceptor10
No. of Rotatable Bond Count5
No. of Rings4
No. of N0
No. of O10
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator


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