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                  Page - 1 of 1                  Record - 1 of 8   [TOP]
Compound ID2836
Compound Structure
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Plant SourceZingiber officinale Rosc.     Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)
Source FamilyZingiberaceae
OriginIndia, Malaysia
Plant Part UsedRhizome
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Gingerol
PubChem ID   3473
Ethnomedicinal InformationLeprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Butenolide, Lactone, Alkene
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight294.183
Molecular FormulaC17H26O4
SMILESOC(CCCCC)CC(=O)CCc1cc(OC)c(O)cc1
XLogP2.887
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count10
No. of Rings1
No. of N0
No. of O4
No. of S0
Reference(s)1) R.D. Hiserodt,S.G. Franzblau and R.T. Rosen.Isolation of 6-, 8-, and 10-Gingerol from Ginger Rhizome by HPLC and Preliminary Evaluation of Inhibition of Mycobacterium avium and Mycobacterium tuberculosis.J. Agric. Food Chem., 1998, 46 (7), pp 2504–2508

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

3) Jain, S.K., Tarafder, C.R., 1970. Medicinal plant lore of the Santals. A revival of P.O. Boddings, work. Economic Botany 24, 241–278.

Curator

                  Record - 2 of 8   [TOP]
Compound ID3983
Compound Structure
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Plant SourceZingiber officinale Rosc.     Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)
Source FamilyZingiberaceae
OriginIndia, Malaysia
Plant Part UsedRhizome
ExtractDichloromethane
Target BacteriaMycobacterium avium
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Gingerol
PubChem ID   3473
Ethnomedicinal InformationLeprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Alicyclic, Butenolide, Lactone, Alkene
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight294.183
Molecular FormulaC17H26O4
SMILESOC(CCCCC)CC(=O)CCc1cc(OC)c(O)cc1
XLogP2.887
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count10
No. of Rings1
No. of N0
No. of O4
No. of S0
Reference(s)1) R.D. Hiserodt,S.G. Franzblau and R.T. Rosen.Isolation of 6-, 8-, and 10-Gingerol from Ginger Rhizome by HPLC and Preliminary Evaluation of Inhibition of Mycobacterium avium and Mycobacterium tuberculosis.J. Agric. Food Chem., 1998, 46 (7), pp 2504–2508

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

3) Jain, S.K., Tarafder, C.R., 1970. Medicinal plant lore of the Santals. A revival of P.O. Boddings, work. Economic Botany 24, 241–278.

Curator

                  Record - 3 of 8   [TOP]
Compound ID3670
Compound Structure
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Plant SourceMicromelum hirsutum     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedStem bark
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneFluorometric Alamar Blue Microassay (FMABA)
Positive Control Used (conc.)Rifampin (0.040 ± 0.017 µg/ml)
Inhibition [%]> 90 %
Activity [MIC] µg/ml1.5 ± 0.4 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified(-) - Z - 9 - Octadecene - 4 - Olide [Micromolide]
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]15770548
Extract PreparationThe dried, milled stem bark of Micromelum hirsutum was extracted with CH2Cl2 to yield 45.5 g extract, of which 32.1 g were chromatographed by vacuum liquid chromatography over a silica gel column
Chemical Classification [Active Compound]Alicyclic, Butenolide, Lactone, Alkene
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]Against Vero cells (ATCCCCL- 81) in the CellTiter 96 aqueous nonradioactive cell proliferation assay
Molecular Weight280.240
Molecular FormulaC18H32O2
SMILESO1C(=O)CCC1CCCC/C=CCCCCCCCC
XLogP7.349
PSA26.300
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count12
No. of Rings1
No. of N0
No. of O2
No. of S0
Reference(s)1) Ma C, Case RJ, Wang Y, Zhang HJ, Tan GT, Van Hung N, Cuong NM, Franzblau SG, Soejarto DD, Fong HH, Pauli GF.Anti-tuberculosis constituents from the stem bark of Micromelum hirsutum.Planta Med. 2005 Mar;71(3):261-7

CuratorVikramjitmandal

                  Record - 4 of 8   [TOP]
Compound ID3984
Compound Structure
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Plant SourceCinnamomum kotoense     Common Name:
Source FamilyLauraceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml2.8 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedLincomolide B
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Alicyclic, Butenolides, Fattyacid, Lactone, Ether, Alcohol, Alkene, Alkyne,
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight278.188
Molecular FormulaC17H26O3
SMILESC[C@@H]1OC(=O)/C(=C/CCCCCCCCCC#C)/[C@@H]1O
XLogP5.004
PSA46.530
H-bond Donor2
H-bond Acceptor3
No. of Rotatable Bond Count9
No. of Rings1
No. of N0
No. of O3
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) Rogoza, L. N.; Salakhutdinov, N. F.; Tolstikov, G. A. Anti-tubercular Activity of Natural Products: Recent Developments. In Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry; Tiwari, V. K. Ed.; Research Signpost: India, 2011; pp 103-120

Curator

                  Record - 5 of 8   [TOP]
Compound ID4097
Compound Structure
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Plant SourceLitsea hypophaea     Common Name:
Source FamilyLauraceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedLitseakolide L
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Alicyclic, Butenolides, Fattyacid, Lactone, Ether, Alcohol, Alkene
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight340.261
Molecular FormulaC20H36O4
SMILESO=C1O[C@](C)(OC)[C@H](O)/C/1=C/CCCCCCCCCCCCC
XLogP7.218
PSA55.760
H-bond Donor1
H-bond Acceptor4
No. of Rotatable Bond Count13
No. of Rings1
No. of N0
No. of O4
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

                  Record - 6 of 8   [TOP]
Compound ID4111
Compound Structure
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Plant SourcePolyalthia debilis     Common Name:
Source FamilyAnnonaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedDebilisone B
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Alicyclic, Butenolides, Fattyacid, Lactone, Alcohol, Alkyne
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight404.293
Molecular FormulaC25H40O4
SMILESCCCCC[C@H](O)C#CC#CCCCCCCCCCC[C@H]1C[C@@H](CO)OC1=O
XLogP7.566
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count15
No. of Rings1
No. of N0
No. of O4
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

                  Record - 7 of 8   [TOP]
Compound ID4112
Compound Structure
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Plant SourcePolyalthia debilis     Common Name:
Source FamilyAnnonaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedDebilisone C
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Alicyclic, Butenolides, Fattyacid, Lactone, Alcohol, Alkyne, Alkene,
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight386.282
Molecular FormulaC25H38O3
SMILESCCCC/C=C/C#CC#CCCCCCCCCCC[C@H]1C[C@@H](CO)OC1=O
XLogP8.849
PSA46.530
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count14
No. of Rings1
No. of N0
No. of O3
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

                  Record - 8 of 8   [TOP]
Compound ID4113
Compound Structure
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Plant SourcePolyalthia debilis     Common Name:
Source FamilyAnnonaceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedDebilisone E
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Alicyclic, Butenolide, Fattyacid, Lactone, Alkyne, Alkene, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight384.266
Molecular FormulaC25H36O3
SMILESC=CCC/C=C/C#CC#CCCCCCCCCCC[C@H]1C[C@@H](CO)OC1=O
XLogP8.483
PSA46.530
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count14
No. of Rings1
No. of N0
No. of O3
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator


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