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                  Page - 1 of 1                  Record - 1 of 9   [TOP]
Compound ID3412
Compound Structure
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Plant SourceGlycyrrhiza inflata     Common Name:Chinese Licorice
Source FamilyFabaceae
OriginIndia
Plant Part UsedRoot
ExtractMethanol
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneBACTEC Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml< 20 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedLicochalcone A
PubChem ID   5318998
Ethnomedicinal Information
PubMed ID [Source Literature]12058317
Extract PreparationSoxhlet extraction, concentrated in vacuo to dryness
Chemical Classification [Active Compound]Aromatic, Alkene, Chalcone, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight338.152
Molecular FormulaC21H22O4
SMILESOc1c(C(C)(C)C=C)cc(c(OC)c1)/C=C/C(=O)c1ccc(O)cc1
XLogP4.443
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count6
No. of Rings2
No. of N0
No. of O4
No. of S0
Reference(s)1) Friis-Møller A, Chen M, Fuursted K, Christensen SB, Kharazmi A.In vitro antimycobacterial and antilegionella activity of licochalcone A from Chinese licorice roots.Planta Med. 2002 May;68(5):416-9

CuratorGppreetha, vikramjitmandal

                  Record - 2 of 9   [TOP]
Compound ID3941
Compound Structure
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Plant SourceButea monosperma (LAM.) TAUB.     Common Name:Flame of the Forest
Source FamilyFabaceae
OriginTropical Southern Asia, Pakistan, India, Bangladesh
Plant Part UsedFlower
ExtractEtOAc and MeOH
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Kanamycin Sulphate (2.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.004 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedButein
PubChem ID   5281222
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19336944
Extract PreparationThe dried flowers (15.0 kg) were milled and soaked successively with n - hexane, EtOAc and MeOH. The hexane, EtOAc and MeOH extracts were evaporated under reduced pressure to give the crude hexane extract (brownish syrup, 32.8 g), the EtOAc extract (dark brownish sticky solid, 102.7 g) and the MeOH extract (dark brownish sticky solid, 527.6 g)
Chemical Classification [Active Compound]Aromatic, Alkene. Chalcone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight272.068
Molecular FormulaC15H12O5
SMILESOc1c(C(=O)/C=C/c2cc(O)c(O)cc2)ccc(O)c1
XLogP2.019
PSA97.990
H-bond Donor4
H-bond Acceptor5
No. of Rotatable Bond Count3
No. of Rings2
No. of N0
No. of O5
No. of S0
Reference(s)1) Chokchaisiri R, Suaisom C, Sriphota S, Chindaduang A, Chuprajob T, Suksamrarn A.Bioactive flavonoids of the flowers of Butea monosperma.Chem Pharm Bull (Tokyo). 2009 Apr;57(4):428-32

CuratorVikramjitmandal, Keyamukherjee, najiya-beegum, swatigandhi

                  Record - 3 of 9   [TOP]
Compound ID3943
Compound Structure
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Plant SourceButea monosperma (LAM.) TAUB.     Common Name:Flame of the Forest
Source FamilyFabaceae
OriginTropical Southern Asia, Pakistan, India, Bangladesh
Plant Part UsedFlower
ExtractEtOAc and MeOH
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Kanamycin Sulphate (2.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.004 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedMonospermoside
PubChem ID   42607524
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19336944
Extract PreparationThe dried flowers (15.0 kg) were milled and soaked successively with n - hexane, EtOAc and MeOH. The hexane, EtOAc and MeOH extracts were evaporated under reduced pressure to give the crude hexane extract (brownish syrup, 32.8 g), the EtOAc extract (dark brownish sticky solid, 102.7 g) and the MeOH extract (dark brownish sticky solid, 527.6 g)
Chemical Classification [Active Compound]Aromatic, Alkene, Chalcone, Phenol, Sugar
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight434.121
Molecular FormulaC21H22O10
SMILESO1[C@@H]([C@@H](O)[C@H](O)[C@@H](O)[C@@H]1Oc1cc(ccc1O)/C=C/C(=O)c1c(O)cc(O)cc1)CO
XLogP0.482
PSA177.140
H-bond Donor7
H-bond Acceptor10
No. of Rotatable Bond Count6
No. of Rings3
No. of N0
No. of O10
No. of S0
Reference(s)1) Chokchaisiri R, Suaisom C, Sriphota S, Chindaduang A, Chuprajob T, Suksamrarn A.Bioactive flavonoids of the flowers of Butea monosperma.Chem Pharm Bull (Tokyo). 2009 Apr;57(4):428-32

CuratorVikramjitmandal, Keyamukherjee, najiya-beegum, swatigandhi

                  Record - 4 of 9   [TOP]
Compound ID3946
Compound Structure
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Plant SourceButea monosperma (LAM.) TAUB.     Common Name:Flame of the Forest
Source FamilyFabaceae
OriginTropical Southern Asia, Pakistan, India, Bangladesh
Plant Part UsedFlower
ExtractEtOAc and MeOH
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Kanamycin Sulphate (2.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.004 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedDihydromonospermoside
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19336944
Extract PreparationThe dried flowers (15.0 kg) were milled and soaked successively with n - hexane, EtOAc and MeOH. The hexane, EtOAc and MeOH extracts were evaporated under reduced pressure to give the crude hexane extract (brownish syrup, 32.8 g), the EtOAc extract (dark brownish sticky solid, 102.7 g) and the MeOH extract (dark brownish sticky solid, 527.6 g)
Chemical Classification [Active Compound]Aromatic, Chalcone, Ketone, Ether, Phenol, Sugar
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight436.137
Molecular FormulaC21H24O10
SMILES[C@@H]1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)Oc1c(ccc(c1)CCC(=O)c1ccc(cc1O)O)O
XLogP0.230
PSA177.140
H-bond Donor7
H-bond Acceptor10
No. of Rotatable Bond Count7
No. of Rings3
No. of N0
No. of O10
No. of S0
Reference(s)1) Chokchaisiri R, Suaisom C, Sriphota S, Chindaduang A, Chuprajob T, Suksamrarn A.Bioactive flavonoids of the flowers of Butea monosperma.Chem Pharm Bull (Tokyo). 2009 Apr;57(4):428-32

CuratorVikramjitmandal, Keyamukherjee, najiya-beegum, swatigandhi

                  Record - 5 of 9   [TOP]
Compound ID3947
Compound Structure
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Plant SourceButea monosperma (LAM.) TAUB.     Common Name:Flame of the Forest
Source FamilyFabaceae
OriginTropical Southern Asia, Pakistan, India, Bangladesh
Plant Part UsedFlower
ExtractEtOAc and MeOH
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Kanamycin Sulphate (2.5 µg/ml), Isoniazid (0.06 µg/ml), Rifampin (0.004 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedIsoliquiritigenin
PubChem ID   638278
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19336944
Extract PreparationThe dried flowers (15.0 kg) were milled and soaked successively with n - hexane, EtOAc and MeOH. The hexane, EtOAc and MeOH extracts were evaporated under reduced pressure to give the crude hexane extract (brownish syrup, 32.8 g), the EtOAc extract (dark brownish sticky solid, 102.7 g) and the MeOH extract (dark brownish sticky solid, 527.6 g)
Chemical Classification [Active Compound]Aromatic, Alkene, Chalcone, Phenol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight256.074
Molecular FormulaC15H12O4
SMILESOc1c(C(=O)/C=C/c2ccc(O)cc2)ccc(O)c1
XLogP2.764
PSA77.760
H-bond Donor3
H-bond Acceptor4
No. of Rotatable Bond Count3
No. of Rings2
No. of N0
No. of O4
No. of S0
Reference(s)1) Chokchaisiri R, Suaisom C, Sriphota S, Chindaduang A, Chuprajob T, Suksamrarn A.Bioactive flavonoids of the flowers of Butea monosperma.Chem Pharm Bull (Tokyo). 2009 Apr;57(4):428-32

CuratorVikramjitmandal, Keyamukherjee, najiya-beegum, swatigandhi

                  Record - 6 of 9   [TOP]
Compound ID4061
Compound Structure
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Plant SourceFatoua pilosa     Common Name:
Source FamilyMoraceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml18 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedIsobavachalcone
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Chalcone, Ketone, Prenylated, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight324.136
Molecular FormulaC20H20O4
SMILESO=C(/C=C/c1ccc(O)cc1)c1c(c(CC=C(C)C)c(cc1)O)O
XLogP4.234
PSA77.760
H-bond Donor3
H-bond Acceptor4
No. of Rotatable Bond Count5
No. of Rings2
No. of N0
No. of O4
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

                  Record - 7 of 9   [TOP]
Compound ID4062
Compound Structure
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Plant SourceFatoua pilosa     Common Name:
Source FamilyMoraceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml30 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedEJMC158
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Alkene, Chalcone, Benzopyran, Prenylated, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight406.178
Molecular FormulaC25H26O5
SMILESO=C(/C=C/c1cc2C=CC(C)(C)Oc2c(O)c1)c1c(c(CC=C(C)C)c(cc1)O)O
XLogP4.460
PSA86.990
H-bond Donor3
H-bond Acceptor5
No. of Rotatable Bond Count5
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

                  Record - 8 of 9   [TOP]
Compound ID4063
Compound Structure
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Plant SourceHelichrysum melanacme     Common Name:
Source FamilyAsteraceae (Compositae)
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml0.05 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedEJMC159
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Chalcone, Ketone, Prenylated, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight324.136
Molecular FormulaC20H20O4
SMILESOc1c(CC=C(C)C)c(O)cc(O)c1C(=O)/C=C/c1ccccc1
XLogP5.718
PSA77.760
H-bond Donor3
H-bond Acceptor4
No. of Rotatable Bond Count5
No. of Rings2
No. of N0
No. of O4
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

                  Record - 9 of 9   [TOP]
Compound ID4064
Compound Structure
DOWNLOAD:
Plant SourceHelichrysum melanacme     Common Name:
Source FamilyAsteraceae (Compositae)
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml0.05 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedEJMC160
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Chalcone, Benzopyran, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight340.131
Molecular FormulaC20H20O5
SMILESOc1c2c(OC(C)(C)C(O)C2)cc(O)c1C(=O)/C=C/c1ccccc1
XLogP4.809
PSA86.990
H-bond Donor3
H-bond Acceptor5
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator


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