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                  Page - 1 of 3                  Record - 1 of 70   [TOP]
Compound ID1440
Compound Structure
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Plant SourceChromolaena odorata     Common Name:Siam Weed, Christmas Bush, Common Floss Flower
Source FamilyAsteraceae (Compositae)
OriginNeotropics, Worldwide
Plant Part UsedFlower
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Kanamycin sulphate (2.50 µg/ml), Isoniazid (0.06 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedIsosakuranetin
PubChem ID   160481
Ethnomedicinal InformationTreat skin wounds
PubMed ID [Source Literature]15202555, 10811796
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight286.084
Molecular FormulaC16H14O5
SMILESO1[C@@H](CC(=O)c2c1cc(O)cc2O)c1ccc(OC)cc1
XLogP1.416
PSA75.990
H-bond Donor2
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Suksamrarn, A., Chotipong, A., Suavansri, T., Boongird, S., Timsuksai, P., Vimuttipong, S., et al. (2004). Antimycobacterial activity and cytotoxicity of flavonoids from the flowers of Chromolaena odorata. Arch Pharm Res 27, 507u511

2) Schmidt GJ, Schilling EE.Phylogeny and biogeography of Eupatorium (Asteraceae: Eupatorieae) based on nuclear ITS sequence data.Am J Bot. 2000 May;87(5):716-26

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                  Record - 2 of 70   [TOP]
Compound ID1441
Compound Structure
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Plant SourceChromolaena odorata     Common Name:Siam Weed, Christmas Bush, Common Floss Flower
Source FamilyAsteraceae (Compositae)
OriginNeotropics, Worldwide
Plant Part UsedFlower
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Kanamycin sulphate (2.50 µg/ml), Isoniazid (0.06 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified4` - Hydroxy - 5, 6, 7 - Trimethoxyflavanone
PubChem ID   244387
Ethnomedicinal InformationTreats skin wounds
PubMed ID [Source Literature]15202555, 10811796
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight330.110
Molecular FormulaC18H18O6
SMILESO1C(CC(=O)c2c1cc(OC)c(OC)c2OC)c1ccc(O)cc1
XLogP1.491
PSA74.220
H-bond Donor1
H-bond Acceptor6
No. of Rotatable Bond Count4
No. of Rings3
No. of N0
No. of O6
No. of S0
Reference(s)1) Suksamrarn, A., Chotipong, A., Suavansri, T., Boongird, S., Timsuksai, P., Vimuttipong, S., et al. (2004). Antimycobacterial activity and cytotoxicity of flavonoids from the flowers of Chromolaena odorata. Arch Pharm Res 27, 507u511

2) Schmidt GJ, Schilling EE.Phylogeny and biogeography of Eupatorium (Asteraceae: Eupatorieae) based on nuclear ITS sequence data.Am J Bot. 2000 May;87(5):716-26

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                  Record - 3 of 70   [TOP]
Compound ID1442
Compound Structure
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Plant SourceChromolaena odorata     Common Name:Siam Weed, Christmas Bush, Common Floss Flower
Source FamilyAsteraceae (Compositae)
OriginNeotropics, Worldwide
Plant Part UsedFlower
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Kanamycin sulphate (2.50 µg/ml), Isoniazid (0.06 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedAcacetin
PubChem ID   5280442
Ethnomedicinal InformationTreats skin wounds
PubMed ID [Source Literature]15202555, 10811796
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight284.068
Molecular FormulaC16H12O5
SMILESO1c2c(c(=O)cc1c1ccc(OC)cc1)c(O)cc(O)c2
XLogP1.645
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Suksamrarn, A., Chotipong, A., Suavansri, T., Boongird, S., Timsuksai, P., Vimuttipong, S., et al. (2004). Antimycobacterial activity and cytotoxicity of flavonoids from the flowers of Chromolaena odorata. Arch Pharm Res 27, 507u511

2) Schmidt GJ, Schilling EE.Phylogeny and biogeography of Eupatorium (Asteraceae: Eupatorieae) based on nuclear ITS sequence data.Am J Bot. 2000 May;87(5):716-26

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                  Record - 4 of 70   [TOP]
Compound ID1443
Compound Structure
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Plant SourceChromolaena odorata     Common Name:Siam Weed, Christmas Bush, Common Floss Flower
Source FamilyAsteraceae (Compositae)
OriginNeotropics, Worldwide
Plant Part UsedFlower
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Kanamycin sulphate (2.50 µg/ml), Isoniazid (0.06 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedLuteolin
PubChem ID   5280445
Ethnomedicinal InformationTreats skin wounds
PubMed ID [Source Literature]15202555, 10811796
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight286.048
Molecular FormulaC15H10O6
SMILESO1c2c(c(=O)cc1c1cc(O)c(O)cc1)c(O)cc(O)c2
XLogP0.592
PSA97.990
H-bond Donor4
H-bond Acceptor5
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O6
No. of S0
Reference(s)1) Suksamrarn, A., Chotipong, A., Suavansri, T., Boongird, S., Timsuksai, P., Vimuttipong, S., et al. (2004). Antimycobacterial activity and cytotoxicity of flavonoids from the flowers of Chromolaena odorata. Arch Pharm Res 27, 507u511

2) Schmidt GJ, Schilling EE.Phylogeny and biogeography of Eupatorium (Asteraceae: Eupatorieae) based on nuclear ITS sequence data.Am J Bot. 2000 May;87(5):716-26

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                  Record - 5 of 70   [TOP]
Compound ID1656
Compound Structure
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Plant SourceErythrina variegata L. var. orientalis (L.) Merr.syn. Erythrina indica Lam.     Common Name:Indian Coral Tree (English), Paaribhadra, Paaribhadraka, Paarijaataka, Mandaara (Sanskrit)
Source FamilyPapilionaceae
OriginIndia
Plant Part UsedRoot bark
ExtractPhenol
Target BacteriaMycobacterium smegmatis (ATCC 607)
Assay / Test DoneAgar Dilution - Streak Assay
Positive Control Used (conc.)Streptomycin (1.7 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 450 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5,4'-Di-O-Methylalpinumisoflavone
PubChem ID   10384155
Ethnomedicinal InformationCough, microbial infections
PubMed ID [Source Literature]10820816
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Flavonoid, Benzopyran, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight364.131
Molecular FormulaC22H20O5
SMILESO1C(C=Cc2c1cc1occ(c(=O)c1c2OC)c1ccc(OC)cc1)(C)C
XLogP3.663
PSA44.760
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count3
No. of Rings4
No. of N0
No. of O5
No. of S0
Reference(s)1) Waffo AK, Azebaze GA, Nkengfack AE, Fomum ZT, Meyer M, Bodo B, van Heerden FR.Indicanines B and C, two isoflavonoid derivatives from the root bark of Erythrina indica.Phytochemistry. 2000 Apr;53(8):981-5

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                  Record - 6 of 70   [TOP]
Compound ID1657
Compound Structure
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Plant SourceErythrina indica     Common Name:
Source FamilyLeguminosae
OriginIbadan, Nigeria
Plant Part UsedRoot bark
ExtractPhenol
Target BacteriaMycobacterium smegmatis (ATCC 607)
Assay / Test DoneAgar Dilution - Streak Assay
Positive Control Used (conc.)Streptomycin (1.7 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 400 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCajanin
PubChem ID   5281706
Ethnomedicinal InformationTrachoma, Elephantiasis, Microbial infections
PubMed ID [Source Literature]10820816
Extract PreparationDried and ground root bark of Erythrina indica was successively extracted with a mixture of dichloro-methane-MeOH (1:1) and methanol. The dichloro-methane-MeOH (1:1) extract was concentrated to dryness
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight300.063
Molecular FormulaC16H12O6
SMILESO1c2c(c(=O)c(c3c(O)cc(O)cc3)c1)c(O)cc(OC)c2
XLogP0.781
PSA86.990
H-bond Donor3
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O6
No. of S0
Reference(s)1) Waffo AK, Azebaze GA, Nkengfack AE, Fomum ZT, Meyer M, Bodo B, van Heerden FR.Indicanines B and C, two isoflavonoid derivatives from the root bark of Erythrina indica.Phytochemistry. 2000 Apr;53(8):981-5

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                  Record - 7 of 70   [TOP]
Compound ID1724
Compound Structure
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Plant SourceEysenhardtia platycarpa     Common Name:
Source FamilyFabaceae
OriginMexico
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5, 7 - Dihydroxy - 8 - Prenyl - Flavanone
PubChem ID   3144815
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol, Prenylated
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight324.136
Molecular FormulaC20H20O4
SMILESO1C(CC(=O)c2c1c(CC=C(C)C)c(O)cc2O)c1ccccc1
XLogP3.963
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

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                  Record - 8 of 70   [TOP]
Compound ID1725
Compound Structure
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Plant SourceEysenhardtia platycarpa     Common Name:
Source FamilyFabaceae
OriginMexico
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5, 7 - Dihydroxy - 6 - Methyl - 8 - Prenyl - Flavanone
PubChem ID   14188388
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol, Prenylated
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight338.152
Molecular FormulaC21H22O4
SMILESO1C(CC(=O)c2c1c(c(O)c(c2O)C)CC=C(C)C)c1ccccc1
XLogP4.075
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

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                  Record - 9 of 70   [TOP]
Compound ID1726
Compound Structure
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Plant SourceEysenhardtia platycarpa     Common Name:
Source FamilyFabaceae
OriginMexico
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5, 7 - Dihydroxy - 8 - Prenyl - Flavanone
PubChem ID   3144815
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol, Prenylated
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight324.136
Molecular FormulaC20H20O4
SMILESO1C(CC(=O)c2c1c(CC=C(C)C)c(O)cc2O)c1ccccc1
XLogP3.963
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

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                  Record - 10 of 70   [TOP]
Compound ID1727
Compound Structure
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Plant SourceEysenhardtia platycarpa     Common Name:
Source FamilyFabaceae
OriginMexico
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5, 7 - Dihydroxy - 6 - Methyl - 8 - Prenyl - Flavanone
PubChem ID   14188388
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol, Prenylated
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight338.152
Molecular FormulaC21H22O4
SMILESO1C(CC(=O)c2c1c(c(O)c(c2O)C)CC=C(C)C)c1ccccc1
XLogP4.075
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

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                  Record - 11 of 70   [TOP]
Compound ID1728
Compound Structure
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Plant SourceEysenhardtia platycarpa     Common Name:
Source FamilyFabaceae
OriginMexico
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5, 7 - Dihydroxy - 8 - Prenyl - Flavanone
PubChem ID   3144815
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol, Prenylated
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight324.136
Molecular FormulaC20H20O4
SMILESO1C(CC(=O)c2c1c(CC=C(C)C)c(O)cc2O)c1ccccc1
XLogP3.963
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

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                  Record - 12 of 70   [TOP]
Compound ID1729
Compound Structure
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Plant SourceEysenhardtia platycarpa     Common Name:
Source FamilyFabaceae
OriginMexico
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5, 7 - Dihydroxy - 6 - Methyl - 8 - Prenyl - Flavanone
PubChem ID   14188388
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol, Prenylated
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight338.152
Molecular FormulaC21H22O4
SMILESO1C(CC(=O)c2c1c(c(O)c(c2O)C)CC=C(C)C)c1ccccc1
XLogP4.075
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

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                  Record - 13 of 70   [TOP]
Compound ID1730
Compound Structure
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Plant SourceEysenhardtia platycarpa     Common Name:
Source FamilyFabaceae
OriginMexico
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5, 7 - Dihydroxy - 8 - Prenyl - Flavanone
PubChem ID   3144815
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol, Prenylated
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight324.136
Molecular FormulaC20H20O4
SMILESO1C(CC(=O)c2c1c(CC=C(C)C)c(O)cc2O)c1ccccc1
XLogP3.963
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

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                  Record - 14 of 70   [TOP]
Compound ID1731
Compound Structure
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Plant SourceEysenhardtia platycarpa     Common Name:
Source FamilyFabaceae
OriginMexico
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5, 7 - Dihydroxy - 6 - Methyl - 8 - Prenyl - Flavanone
PubChem ID   14188388
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol, Prenylated
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight338.152
Molecular FormulaC21H22O4
SMILESO1C(CC(=O)c2c1c(c(O)c(c2O)C)CC=C(C)C)c1ccccc1
XLogP4.075
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

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                  Record - 15 of 70   [TOP]
Compound ID1747
Compound Structure
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Plant SourceFicus nervosa Synonym : Ficus angustifolia Roxb     Common Name:Wild Banyan Tree (English)
Source FamilyMoraceae
OriginIndia
Plant Part UsedRoot
ExtractMethanol
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMiddlebrook 7 H10 agar method
Positive Control Used (conc.)Ethambutol (6.25 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml110 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCarpachromene
PubChem ID   10449654
Ethnomedicinal InformationUsed in treatment of cough and asthma
PubMed ID [Source Literature]20658670
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Flavonoid, Benzopyran, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight336.100
Molecular FormulaC20H16O5
SMILESO1C(C=Cc2c1cc1oc(cc(=O)c1c2O)c1ccc(O)cc1)(C)C
XLogP2.526
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count1
No. of Rings4
No. of N0
No. of O5
No. of S0
Reference(s)1) Chen LW, Cheng MJ, Peng CF, Chen IS. Secondary Metabolites and Antimycobacterial Activities from the Roots of Ficus nervosa, Chemistry & Biodiversity Volume 7, Issue 7, pages 1814–1821, July 2010

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                  Record - 16 of 70   [TOP]
Compound ID1748
Compound Structure
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Plant SourceFicus nervosa Synonym : Ficus angustifolia Roxb     Common Name:Wild Banyan Tree (English)
Source FamilyMoraceae
OriginIndia
Plant Part UsedRoot
ExtractMethanol
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMiddlebrook 7 H10 agar method
Positive Control Used (conc.)Ethambutol (6.25 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml35 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedGenistein
PubChem ID   5280961
Ethnomedicinal InformationUsed in treatment of cough and asthma
PubMed ID [Source Literature]20658670
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Flavonoid, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight270.053
Molecular FormulaC15H10O5
SMILESO1c2c(c(=O)c(c3ccc(O)cc3)c1)c(O)cc(O)c2
XLogP1.225
PSA77.760
H-bond Donor3
H-bond Acceptor4
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Chen LW, Cheng MJ, Peng CF, Chen IS. Secondary Metabolites and Antimycobacterial Activities from the Roots of Ficus nervosa, Chemistry & Biodiversity Volume 7, Issue 7, pages 1814–1821, July 2010

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                  Record - 17 of 70   [TOP]
Compound ID1749
Compound Structure
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Plant SourceFicus nervosa     Common Name:Wild Banyan Tree (English)
Source FamilyMoraceae
OriginIndia
Plant Part UsedRoot
ExtractMethanol
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMiddlebrook 7 H10 agar method
Positive Control Used (conc.)Ethambutol (6.25 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml110 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCajanin
PubChem ID   5281706
Ethnomedicinal InformationUsed in treatment of cough and asthma
PubMed ID [Source Literature]20658670
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight300.063
Molecular FormulaC16H12O6
SMILESO1c2c(c(=O)c(c3c(O)cc(O)cc3)c1)c(O)cc(OC)c2
XLogP0.781
PSA86.990
H-bond Donor3
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O6
No. of S0
Reference(s)1) Chen LW, Cheng MJ, Peng CF, Chen IS. Secondary Metabolites and Antimycobacterial Activities from the Roots of Ficus nervosa, Chemistry & Biodiversity Volume 7, Issue 7, pages 1814–1821, July 2010

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                  Record - 18 of 70   [TOP]
Compound ID1752
Compound Structure
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Plant SourceFicus nervosa Synonym : Ficus angustifolia Roxb     Common Name:Wild Banyan Tree (English)
Source FamilyMoraceae
OriginIndia
Plant Part UsedRoot
ExtractMethanol
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMiddlebrook 7 H10 agar method
Positive Control Used (conc.)Ethambutol (6.25 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml30 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedPrunetin
PubChem ID   5281804
Ethnomedicinal InformationUsed in treatment of cough and asthma
PubMed ID [Source Literature]20658670
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight284.068
Molecular FormulaC16H12O5
SMILESO1c2c(c(=O)c(c3ccc(O)cc3)c1)c(O)cc(OC)c2
XLogP1.744
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Chen LW, Cheng MJ, Peng CF, Chen IS. Secondary Metabolites and Antimycobacterial Activities from the Roots of Ficus nervosa, Chemistry & Biodiversity Volume 7, Issue 7, pages 1814–1821, July 2010

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                  Record - 19 of 70   [TOP]
Compound ID1753
Compound Structure
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Plant SourceFicus nervosa Synonym : Ficus angustifolia Roxb     Common Name:Wild Banyan Tree (English)
Source FamilyMoraceae
OriginIndia
Plant Part UsedRoot
ExtractMethanol
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMiddlebrook 7 H10 agar method
Positive Control Used (conc.)Ethambutol (6.25 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml70 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedApigenin
PubChem ID   5280443
Ethnomedicinal InformationUsed in treatment of cough and asthma
PubMed ID [Source Literature]20658670
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight270.053
Molecular FormulaC15H10O5
SMILESO1c2c(c(=O)cc1c1ccc(O)cc1)c(O)cc(O)c2
XLogP1.126
PSA77.760
H-bond Donor3
H-bond Acceptor4
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Chen LW, Cheng MJ, Peng CF, Chen IS. Secondary Metabolites and Antimycobacterial Activities from the Roots of Ficus nervosa, Chemistry & Biodiversity Volume 7, Issue 7, pages 1814–1821, July 2010

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                  Record - 20 of 70   [TOP]
Compound ID1754
Compound Structure
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Plant SourceFicus nervosa Synonym : Ficus angustifolia Roxb     Common Name:Wild Banyan Tree (English)
Source FamilyMoraceae
OriginIndia
Plant Part UsedRoot
ExtractMethanol
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMiddlebrook 7 H10 agar method
Positive Control Used (conc.)Ethambutol (6.25 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml<= 2.8 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified(2S) - Naringenin
PubChem ID   25244584
Ethnomedicinal InformationUsed in treatment of cough and asthma
PubMed ID [Source Literature]20658670
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight271.061
Molecular FormulaC15H11O5
SMILESO1[C@@H](CC(=O)c2c1cc(O)cc2[O-])c1ccc(O)cc1
XLogP0.897
PSA89.820
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Chen LW, Cheng MJ, Peng CF, Chen IS. Secondary Metabolites and Antimycobacterial Activities from the Roots of Ficus nervosa, Chemistry & Biodiversity Volume 7, Issue 7, pages 1814–1821, July 2010

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                  Record - 21 of 70   [TOP]
Compound ID1783
Compound Structure
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Plant SourceGalenia africana L.     Common Name:Yellow Bush
Source FamilyAizoaceae
OriginAfrica
Plant Part UsedLeaf
ExtractHexane:Ethyl acetate
Target BacteriaMycobacterium smegmatis
Assay / Test DoneRapid Radiometric Method using BACTEC - 460 System
Positive Control Used (conc.)Ciprofloxacin (0.156 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml31.2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5, 7, 2` - Trihydroxyflavone
PubChem ID   5322064
Ethnomedicinal InformationChest pains, tuberculosis, asthma
PubMed ID [Source Literature]18412151
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight270.053
Molecular FormulaC15H10O5
SMILESO1c2c(c(=O)cc1c1c(O)cccc1)c(O)cc(O)c2
XLogP1.337
PSA77.760
H-bond Donor3
H-bond Acceptor4
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Mativandlela SP, Meyer JJ, Hussein AA, Houghton PJ, Hamilton CJ, Lall N.Activity against Mycobacterium smegmatis and M. tuberculosis by extract of South African medicinal plants.Phytother Res. 2008 Jun;22(6):841-5

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                  Record - 22 of 70   [TOP]
Compound ID1784
Compound Structure
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Plant SourceGalenia africana L.     Common Name:Yellow Bush
Source FamilyAizoaceae
OriginAfrica
Plant Part UsedLeaf
ExtractHexane:Ethyl acetate
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRapid Radiometric Method using BACTEC - 460 System
Positive Control Used (conc.)Isoniazid (0.2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5, 7, 2` - Trihydroxyflavone
PubChem ID   5322064
Ethnomedicinal InformationChest pains, tuberculosis, asthma
PubMed ID [Source Literature]18412151
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight270.053
Molecular FormulaC15H10O5
SMILESO1c2c(c(=O)cc1c1c(O)cccc1)c(O)cc(O)c2
XLogP1.337
PSA77.760
H-bond Donor3
H-bond Acceptor4
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Mativandlela SP, Meyer JJ, Hussein AA, Houghton PJ, Hamilton CJ, Lall N.Activity against Mycobacterium smegmatis and M. tuberculosis by extract of South African medicinal plants.Phytother Res. 2008 Jun;22(6):841-5

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                  Record - 23 of 70   [TOP]
Compound ID1818
Compound Structure
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Plant SourceGlycyrrhiza glabra L.     Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source FamilyFabaceae
OriginIndia, Africa
Plant Part UsedRoot
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedLico - Isoflavone
PubChem ID   392443
Ethnomedicinal InformationExpectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]17276637
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Flavonoid, Benzopyran, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight354.110
Molecular FormulaC20H18O6
SMILESO1C(C=Cc2c(O)c(C3COc4c(C3=O)c(O)cc(O)c4)ccc12)(C)C
XLogP1.167
PSA96.220
H-bond Donor3
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings4
No. of N0
No. of O6
No. of S0
Reference(s)1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34

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                  Record - 24 of 70   [TOP]
Compound ID1819
Compound Structure
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Plant SourceGlycyrrhiza glabra L.     Common Name:Licorice, Liquorice (English), Yashtimadhu (Sanskrit)
Source FamilyFabaceae
OriginIndia, Africa
Plant Part UsedRoot
Extract
Target BacteriaMycobacterium smegmatis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedLico - Isoflavone
PubChem ID   392443
Ethnomedicinal InformationExpectorant, consumption, bronchitis, chest complaint, cough
PubMed ID [Source Literature]17276637
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Flavonoid, Benzopyran, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight354.110
Molecular FormulaC20H18O6
SMILESO1C(C=Cc2c(O)c(C3COc4c(C3=O)c(O)cc(O)c4)ccc12)(C)C
XLogP1.167
PSA96.220
H-bond Donor3
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings4
No. of N0
No. of O6
No. of S0
Reference(s)1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34

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                  Record - 25 of 70   [TOP]
Compound ID1838
Compound Structure
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Plant SourceHaplopappus sonoriensis     Common Name:
Source FamilyAsteraceae (Compositae)
OriginUSA
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]33 %
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5 - Hydroxy - 3, 7, 4` - Trimethoxyflavone
PubChem ID   5468749
Ethnomedicinal InformationTo treat coughs
PubMed ID [Source Literature]12727485
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]Against human colorectal cancer cells, HCT-116 (ATCC CCL-247)
Molecular Weight328.095
Molecular FormulaC18H16O6
SMILESO1c2c(c(=O)c(OC)c1c1ccc(OC)cc1)c(O)cc(OC)c2
XLogP2.540
PSA64.990
H-bond Donor1
H-bond Acceptor5
No. of Rotatable Bond Count4
No. of Rings3
No. of N0
No. of O6
No. of S0
Reference(s)1) Murillo JI, Encarnación-Dimayuga R, Malmstrøm J, Christophersen C, Franzblau SG. Antimycobacterial flavones from Haplopappus sonorensis.Fitoterapia Volume 74, Issue 3, April 2003, Pages 226-230

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