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                  Page - 1 of 1                  Record - 1 of 8   [TOP]
Compound ID2383
Compound Structure
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Plant SourcePiper sarmentosum Roxb.     Common Name:Cha Plu
Source FamilyPiperaceae
OriginProbably Southeast Asia, Malaysia
Plant Part UsedFruit
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/mlNR
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedSesamin
PubChem ID   72307
Ethnomedicinal InformationCough, anti - tuberculosis and anti - plasmodial activities
PubMed ID [Source Literature]15234750
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Polycyclic, Lignan, Furanoid, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight354.110
Molecular FormulaC20H18O6
SMILESO1[C@@H]([C@@H]2[C@@H]([C@H](OC2)c2cc3OCOc3cc2)C1)c1cc2OCOc2cc1
XLogP2.576
PSA55.380
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count2
No. of Rings6
No. of N0
No. of O6
No. of S0
Reference(s)1) Rukachaisirikul T, Siriwattanakit P, Sukcharoenphol K, Wongvein C, Ruttanaweang P, Wongwattanavuch P, Suksamrarn A.Chemical constituents and bioactivity of Piper sarmentosum.J Ethnopharmacol. 2004 Aug;93(2-3):173-6

Curator

                  Record - 2 of 8   [TOP]
Compound ID3726
Compound Structure
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Plant SourcePiper sarmentosum     Common Name:Cha Plu
Source FamilyPiperaceae
OriginThailand
Plant Part UsedFresh root
ExtractEthanol (95 %)
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedHorsfieldin
PubChem IDNR
Ethnomedicinal InformationAntimycobacterial and antiplasmodial activity, antifungal
PubMed ID [Source Literature]16462055
Extract PreparationThe fresh roots of Piper sarmentosum (481 g) were ground and extracted with 95 % EtOH at room temperature. After filtration and evaporation, the ethanolic extract was obtained as a brown viscous oil (19.4 g). The oil was partitioned between water (200 ml) and EtOAc (3 x 200 ml) and the water layer was further partitioned with n - BuOH (3 x 200 ml). Evaporation of the EtOAc-, n-BuOH- and water - soluble fractions gave a dark brown oil (6.3 g), a brown oil (1.8 g) and a light brown oil (10.5 g), respectively. The EtOAc - soluble fraction (6.3 g) was separated by flash column chromatography using silica gel
Chemical Classification [Active Compound]Aromatic, Pentacyclic, Lignan, Furanoid, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight356.126
Molecular FormulaC20H20O6
SMILESO1CC2C(C1c1cc(c(cc1)OC)O)CO[C@H]2c1ccc2OCOc2c1
XLogP2.130
PSA66.380
H-bond Donor1
H-bond Acceptor6
No. of Rotatable Bond Count3
No. of Rings5
No. of N0
No. of O6
No. of S0
Reference(s)1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

CuratorKeyaMukherjee, rachanake

                  Record - 3 of 8   [TOP]
Compound ID4065
Compound Structure
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Plant SourceBeilschmiedia tsangii     Common Name:
Source FamilyLauraceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis 90-221387
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml30 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedEpoxybeilschmin A
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Lignan, Furanoid, Epoxy, Ether
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight430.163
Molecular FormulaC23H26O8
SMILESC[C@H]1[C@@]2(C)[C@](c3cc(OC)c4OCOc4c3)(O2)O[C@@H]1c1cc(OC)c(OC)c(OC)c1
XLogP2.537
PSA77.140
H-bond Donor0
H-bond Acceptor8
No. of Rotatable Bond Count6
No. of Rings5
No. of N0
No. of O8
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

                  Record - 4 of 8   [TOP]
Compound ID4066
Compound Structure
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Plant SourceBeilschmiedia tsangii     Common Name:
Source FamilyLauraceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis 90-221388
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml40 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedEpoxybeilschmin B
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Lignan, Furanoid, Epoxy, Ether
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight446.194
Molecular FormulaC24H30O8
SMILESC[C@H]1[C@@]2(C)[C@](c3cc(OC)c(OC)c(OC)c3)(O2)O[C@@H]1c1cc(OC)c(OC)c(OC)c1
XLogP2.610
PSA77.140
H-bond Donor0
H-bond Acceptor8
No. of Rotatable Bond Count8
No. of Rings4
No. of N0
No. of O8
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

                  Record - 5 of 8   [TOP]
Compound ID4067
Compound Structure
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Plant SourceBeilschmiedia tsangii     Common Name:
Source FamilyLauraceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis 90-221389
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedBeilschmin D
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Lignan, Furanoid, Epoxy, Ether
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight414.131
Molecular FormulaC22H22O8
SMILESC[C@H]1[C@@]2(C)[C@](c3cc(OC)c4OCOc4c3)(O2)O[C@@H]1c1cc2OCOc2c(OC)c1
XLogP2.464
PSA77.140
H-bond Donor0
H-bond Acceptor8
No. of Rotatable Bond Count4
No. of Rings6
No. of N0
No. of O8
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

                  Record - 6 of 8   [TOP]
Compound ID4068
Compound Structure
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Plant SourceBeilschmiedia tsangii     Common Name:
Source FamilyLauraceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis 90-221390
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml2.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedBeilschmin A
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Lignan, Furanoid, Ether
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight416.184
Molecular FormulaC23H28O7
SMILESC[C@H]1[C@H](C)[C@H](c2cc(OC)c3OCOc3c2)O[C@@H]1c1cc(OC)c(OC)c(OC)c1
XLogP3.007
PSA64.610
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count6
No. of Rings4
No. of N0
No. of O7
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

                  Record - 7 of 8   [TOP]
Compound ID4069
Compound Structure
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Plant SourceBeilschmiedia tsangii     Common Name:
Source FamilyLauraceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis 90-221391
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml7.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedBeilschmin B
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Tricyclic, Lignan, Furanoid, Ether
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight432.215
Molecular FormulaC24H32O7
SMILESC[C@H]1[C@H](C)[C@H](c2cc(OC)c(OC)c(OC)c2)O[C@@H]1c1cc(OC)c(OC)c(OC)c1
XLogP3.080
PSA64.610
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count8
No. of Rings3
No. of N0
No. of O7
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator

                  Record - 8 of 8   [TOP]
Compound ID4070
Compound Structure
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Plant SourceLitsea hypophaea     Common Name:
Source FamilyLauraceae
Origin
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)Ethambutol (6.25 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml1.6 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedFeruloyltyramine
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Lignan, Amide, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight343.142
Molecular FormulaC19H21NO5
SMILESOc1c(OC)cc(/C=C/C(=O)NCCc2ccc(O)c(OC)c2)cc1
XLogP2.247
PSA88.020
H-bond Donor3
H-bond Acceptor6
No. of Rotatable Bond Count8
No. of Rings2
No. of N1
No. of O5
No. of S0
Reference(s)1) In silico Comparison of Antimycobacterial Natural Products with Known Antituberculosis Drugs. Marlene Espinoza-Moraga, Nicholas M. Njuguna, Grace Mugumbate, Julio Caballero, and Kelly Chibale. Journal of Chemical Information and Modeling 2013 53 (3), 649-660

2) García, A., Bocanegra-García, V., Palma-Nicolás, J. P., Rivera, G. Vennerstrom, J. L. Recent Advances in Antitubercular Natural Products. Eur. J. Med. Chem. 2012, 49, 1-23

Curator


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