BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 18 [TOP]

Compound ID	2852
Compound Structure	N/A
Plant Source	Cananga odorata Common Name:Ylang - Ylang Cananga Tree, Macassar - Oil Plant, Perfume Tree
Source Family	Annonaceae
Origin	Colombia
Plant Part Used	Flower
Extract	Flower extract (1.2 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Macrodilution Method, following the protocol described by Abate et al. (1998)
Positive Control Used (conc.)	Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	300 ± 217 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Mixture of Essential oils (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19753839
Extract Preparation	Microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60
Curator	Reshmi

Record - 2 of 18 [TOP]

Compound ID	2853
Compound Structure	N/A
Plant Source	Hyptis mutabilis Common Name:Tropical Bushmint
Source Family	Lamiaceae
Origin	Colombia
Plant Part Used	Leaf, stem
Extract	Leaf and stem (0.3 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Macrodilution Method, following the protocol described by Abate et al. (1998)
Positive Control Used (conc.)	Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	125 ± 0.01 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Mixture of Essential oils (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19753839
Extract Preparation	Microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60
Curator	Reshmi, KeyaMukherjee

Record - 3 of 18 [TOP]

Compound ID	2854
Compound Structure	N/A
Plant Source	Lippia alba Common Name:Bushy Matgrass
Source Family	Verbenaceae
Origin	Colombia
Plant Part Used	Leaf, stem
Extract	Leaf and stem (2.5 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Macrodilution Method, following the protocol described by Abate et al. (1998)
Positive Control Used (conc.)	Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	200 ± 72 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Mixture of Essential oils (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19753839
Extract Preparation	Microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60
Curator	Reshmi

Record - 4 of 18 [TOP]

Compound ID	2855
Compound Structure	N/A
Plant Source	Lippia alba Common Name:Bushy Matgrass
Source Family	Verbenaceae
Origin	Colombia
Plant Part Used	Leaf, stem
Extract	Leaf and stem extract (1.6 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Macrodilution Method, following the protocol described by Abate et al. (1998)
Positive Control Used (conc.)	Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	130 ± 95 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Mixture of Essential oils (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19753839
Extract Preparation	Microwave - assisted hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60
Curator	Reshmi

Record - 5 of 18 [TOP]

Compound ID	2856
Compound Structure	N/A
Plant Source	Lippia origanoides Common Name:Wild Marjoram
Source Family	Verbenaceae
Origin	Colombia
Plant Part Used	Leaf, stem
Extract	Leaf and stem (3.1 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	125 ± 0.01 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Mixture of Essential oils (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19753839
Extract Preparation	Microwave - Assisted Hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60
Curator	Keya Mukherjee, reshmi

Record - 6 of 18 [TOP]

Compound ID	2857
Compound Structure	N/A
Plant Source	Lippia origanoides Common Name:Wild Marjoram
Source Family	Verbenaceae
Origin	Colombia
Plant Part Used	Leaf, stem
Extract	Leaf and stem (3.1 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	125 ± 0.01 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Mixture of Essential oils (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19753839
Extract Preparation	Microwave - Assisted Hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60
Curator	Keya Mukherjee, reshmi

Record - 7 of 18 [TOP]

Compound ID	2858
Compound Structure	N/A
Plant Source	Lippia origanoides Common Name:Wild Marjoram
Source Family	Verbenaceae
Origin	Colombia
Plant Part Used	Leaf, stem
Extract	Leaf and stem (1.5 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Macrodilution Method, following the protocol described by Abate et al. (1998)
Positive Control Used (conc.)	Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	400 ± 220 µg.ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Mixture of Essential oils (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19753839
Extract Preparation	Microwave - Assisted Hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60
Curator	Reshmi

Record - 8 of 18 [TOP]

Compound ID	2859
Compound Structure	N/A
Plant Source	Piper auritum Common Name:Mexican Pepper Leaves
Source Family	Piperaceae
Origin	Colombia
Plant Part Used	Leaf
Extract	Leaf (2.3 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Macrodilution Method, following the protocol described by Abate et al. (1998)
Positive Control Used (conc.)	Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	400 ± 220 µg.ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Mixture of Essential oils (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19753839
Extract Preparation	Microwave - Assisted Hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60
Curator	Reshmi

Record - 9 of 18 [TOP]

Compound ID	2860
Compound Structure	N/A
Plant Source	Piper bogotense Common Name:NR
Source Family	Piperaceae
Origin	Colombia
Plant Part Used	Leaf
Extract	Leaf (0.2 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Macrodilution Method, following the protocol described by Abate et al. (1998)
Positive Control Used (conc.)	Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	130 ± 95 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Mixture of Essential oils (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19753839
Extract Preparation	Microwave - Assisted Hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60
Curator	Reshmi

Record - 10 of 18 [TOP]

Compound ID	2861
Compound Structure	N/A
Plant Source	Swinglea glutinosa Common Name:Tabog, Glutinous Swinglea
Source Family	Rutaceae
Origin	Colombia
Plant Part Used	Fruit peel
Extract	Fruit peel (0.7 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Macrodilution Method, following the protocol described by Abate et al. (1998)
Positive Control Used (conc.)	Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	100 ± 36 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Mixture of Essential oils (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19753839
Extract Preparation	Microwave - Assisted Hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60
Curator	Vikramjitmandal, reshmi

Record - 11 of 18 [TOP]

Compound ID	3470
Compound Structure	N/A
Plant Source	Ipomoea muricatum Don syn. Calonyction muricatum Don Common Name:
Source Family	Convolvulaceae
Origin	India
Plant Part Used	Seed
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	Alkaloidal fractions (Mixture)
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]
Extract Preparation
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Guevara, Beatrice Q, Solevilla, Rosalinda C, Ochoa, Yolanda B, Santiago, Asuncion T, Chua, Jose A.Preliminary phytochemical, microbiological and pharmacological studies of Calonyction muricatum Linn (Convolvulaceae).1978, Acta Manilana, Vol.(Issue) 17(27), Pages 20-39
Curator

Record - 12 of 18 [TOP]

Compound ID	3529
Compound Structure	NR
Plant Source	Canella winterana Common Name:NR
Source Family	Canellaceae
Origin	Guadeloupe
Plant Part Used	NR
Extract	NR
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	NR
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	Bactec: 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Canella oil (Mixture)
PubChem ID	NR
Ethnomedicinal Information	Antimycobacterial
PubMed ID [Source Literature]	9626931
Extract Preparation	The dried powdered material was moistened with 25 % NH₄OH, and extracted by Chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH₄OH, and extracted with Chloroform. The organic phase was washed with water, and dried over Na₂SO₄. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73
Curator	Wvarsha, rachanake

Record - 13 of 18 [TOP]

Compound ID	3530
Compound Structure	NR
Plant Source	Canella winterana Common Name:NR
Source Family	Canellaceae
Origin	Guadeloupe
Plant Part Used	NR
Extract	NR
Target Bacteria	Mycobacterium avium 733
Assay / Test Done	NR
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	Bactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Canella oil (Mixture)
PubChem ID	NR
Ethnomedicinal Information	Antimycobacterial
PubMed ID [Source Literature]	9626931
Extract Preparation	The dried powdered material was moistened with 25 % NH₄OH, and extracted by Chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH₄OH, and extracted with Chloroform. The organic phase was washed with water, and dried over Na₂SO₄. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73
Curator	Wvarsha, rachanake

Record - 14 of 18 [TOP]

Compound ID	3531
Compound Structure	NR
Plant Source	Canella winterana Common Name:NR
Source Family	Canellaceae
Origin	Guadeloupe
Plant Part Used	NR
Extract	NR
Target Bacteria	Mycobacterium kansasii (Clinical isolate 94 - 069)
Assay / Test Done	NR
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	Bactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Canella oil (Mixture)
PubChem ID	NR
Ethnomedicinal Information	Antimycobacterial
PubMed ID [Source Literature]	9626931
Extract Preparation	The dried powdered material was moistened with 25 % NH₄OH, and extracted by Chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH₄OH, and extracted with Chloroform. The organic phase was washed with water, and dried over Na₂SO₄. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73
Curator	Wvarsha, rachana-ke

Record - 15 of 18 [TOP]

Compound ID

3852

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (bovine isolate [NCTC 8578])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

26.2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cinnamon (Cassia) oil

PubChem ID

6850781

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Mixture, Alkene, Phenol, OIL

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

164.084

Molecular Formula

C₁₉H₂₂O₂

SMILES

O(c1cc(CC=C)ccc1O)C.c1(ccccc1)/C=C/C

XLogP

2.484

PSA

29.460

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Wong SY, Grant IR, Friedman M, Elliott CT, Situ C.Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis.Appl Environ Microbiol. 2008 Oct;74(19):5986-90. Epub 2008 Aug 1

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 16 of 18 [TOP]

Compound ID

3853

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (human isolate [ATCC 43015])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

26.2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cinnamon (Cassia) oil

PubChem ID

6850781

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Mixture, Alkene, Phenol, OIL

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

164.084

Molecular Formula

C₁₉H₂₂O₂

SMILES

O(c1cc(CC=C)ccc1O)C.c1(ccccc1)/C=C/C

XLogP

2.484

PSA

29.460

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 17 of 18 [TOP]

Compound ID

3854

Compound Structure

Plant Source

Apple, Tea, Cinnamon, Cassia and other plants (not reported specifically) Common Name:NR

Source Family

Origin

Plant Part Used

Extract

Target Bacteria

Mycobacterium avium subsp. paratuberculosis (raw - milk isolate [806R])

Assay / Test Done

Macro - broth susceptibility testing using Bactec 460 system

Positive Control Used (conc.)

Rifampin (< 0.6 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

26.2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cinnamon (Cassia) oil

PubChem ID

6850781

Ethnomedicinal Information

PubMed ID [Source Literature]

18676709

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Mixture, Alkene, Phenol, OIL

Media / Broth Used [Antimicrobial Assay/Test]

Middlebrook 7H9 broth

Cytotoxicity Assay [AID]

Molecular Weight

164.084

Molecular Formula

C₁₉H₂₂O₂

SMILES

O(c1cc(CC=C)ccc1O)C.c1(ccccc1)/C=C/C

XLogP

2.484

PSA

29.460

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, Farzana Shamsudeen

Record - 18 of 18 [TOP]

Compound ID	3952
Compound Structure	N/A
Plant Source	Knema gluaca Common Name:NR
Source Family	Myristicaceae
Origin	Evergreen forests in Thailand
Plant Part Used	Fruit, leaf, stem
Extract	NR
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.05 µg/ml) and Kanamycin sulphate (1.25 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	NR
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Acyclic diterpene, glaucaic acid and acyl phenols
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19471882
Extract Preparation	The dried and milled fruits (350 g), leaves (570 g) and stems (700 g) of Knema glauca were separately macerated with n - hexane (5 × 3 l), EtOAc (5 × 3 l) and MeOH (5 × 3 l), respectively
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	Resazurin microplate assay
Reference(s)	1) Rangkaew N, Suttisri R, Moriyasu M, Kawanishi K.A new acyclic diterpene acid and bioactive compounds from Knema glauca.Arch Pharm Res. 2009 May;32(5):685-92. Epub 2009 May 27
Curator	KeyaMukherjee, Swati Gandhi

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