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                  Page - 1 of 1                  Record - 1 of 4   [TOP]
Compound ID1084
Compound Structure
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Plant SourceAilanthus altissima (Mill.) Swingle syn. Altissima glandulsa Desf.     Common Name:Tree of Heaven, Ailanto (English), Aralu (Sanskrit)
Source FamilySimaroubaceae
OriginIndia, China
Plant Part UsedMother tinture
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)Rifampin (0.031 µg/ml)
Inhibition [%]19 %
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedShinjulactone K
PubChem ID   460541
Ethnomedicinal InformationUsed for treating mental illness, nausea and headache, treating cardiac palpitation, asthma and epilepsy
PubMed ID [Source Literature]17276637
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Terpene, Triterpene, Quassinoid, Lactone, O-Acetyl, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight408.215
Molecular FormulaC22H32O7
SMILESO1[C@H]2[C@@]3([C@@H]([C@@]4([C@@H](C2)[C@@H](C[C@H](O)C4=O)C)C)[C@H](O)[C@H](OC(=O)C)[C@@H]([C@@H]3CC1=O)C)C
XLogP1.595
PSA110.130
H-bond Donor2
H-bond Acceptor7
No. of Rotatable Bond Count2
No. of Rings4
No. of N0
No. of O7
No. of S0
Reference(s)1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34

2) Rahman S, Fukamiya N, Okano M, Tagahara K, Lee KH.Anti-tuberculosis activity of quassinoids.Chem Pharm Bull (Tokyo). 1997 Sep;45(9):1527-9

Curator

                  Record - 2 of 4   [TOP]
Compound ID1085
Compound Structure
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Plant SourceAilanthus altissima (Mill.) Swingle syn. Altissima glandulsa Desf.     Common Name:Tree of Heaven, Ailanto (English), Aralu (Sanskrit)
Source FamilySimaroubaceae
OriginIndia, China
Plant Part UsedMother tinture
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)Rifampin (0.031 µg/ml)
Inhibition [%]17 %
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedAilanthone
PubChem ID   72965
Ethnomedicinal InformationUsed for treating mental illness, nausea and headache, treating cardiac palpitation, asthma and epilepsy
PubMed ID [Source Literature]17276637
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Pentacyclic, Terpene, Triterpene, Quassinoid, Furanoid, Lactone, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight376.152
Molecular FormulaC20H24O7
SMILESO1[C@]2(O)[C@H]3[C@]4([C@H](OC(=O)C[C@H]4C(=C)[C@H]2O)C[C@@H]2[C@@]3([C@H](O)C(=O)C=C2C)C)C1
XLogP-0.429
PSA113.290
H-bond Donor3
H-bond Acceptor7
No. of Rotatable Bond Count0
No. of Rings5
No. of N0
No. of O7
No. of S0
Reference(s)1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34

2) Rahman S, Fukamiya N, Okano M, Tagahara K, Lee KH.Anti-tuberculosis activity of quassinoids.Chem Pharm Bull (Tokyo). 1997 Sep;45(9):1527-9

Curator

                  Record - 3 of 4   [TOP]
Compound ID1086
Compound Structure
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Plant SourceAilanthus altissima (Mill.) Swingle syn. Altissima glandulsa Desf.     Common Name:Tree of Heaven, Ailanto (English), Aralu (Sanskrit)
Source FamilySimaroubaceae
OriginIndia, China
Plant Part UsedMother tinture
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)Rifampin (0.031 µg/ml)
Inhibition [%]15 %
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedShinjudilactone
PubChem ID   460534
Ethnomedicinal InformationUsed for treating mental illness, nausea and headache, treating cardiac palpitation, asthma and epilepsy
PubMed ID [Source Literature]17276637
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Pentacyclic, Terpene, Triterpene, Quassinoid, Lactone
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight376.152
Molecular FormulaC20H24O7
SMILESO1[C@H]2[C@]34[C@@H]([C@@]5([C@@H](C2)C(=CC(=O)[C@H]5O)C)C)[C@](O)(C([C@@H]3CC1=O)C)C(=O)OC4
XLogP0.413
PSA110.130
H-bond Donor2
H-bond Acceptor7
No. of Rotatable Bond Count0
No. of Rings5
No. of N0
No. of O7
No. of S0
Reference(s)1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34

2) Rahman S, Fukamiya N, Okano M, Tagahara K, Lee KH.Anti-tuberculosis activity of quassinoids.Chem Pharm Bull (Tokyo). 1997 Sep;45(9):1527-9

Curator

                  Record - 4 of 4   [TOP]
Compound ID1297
Compound Structure
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Plant SourceBrucea javanica (L.) Merrill syn. Rhus javanica L.     Common Name:Java Brucea
Source FamilySimaroubaceae
OriginIndia, China
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)Rifampin
Inhibition [%]7 %
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedBruceoside D
PubChem ID   460525
Ethnomedicinal InformationTreatment of amoebic dysentery and malaria, stomach complaints
PubMed ID [Source Literature]9332005
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Pentacyclic, Terpene, Triterpene, Quassinoid, Sugar
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight668.232
Molecular FormulaC31H40O16
SMILESO1C2([C@H]3[C@]4([C@@H]([C@@]5([C@@H](C[C@H]4OC(=O)[C@@H]3OC(=O)C=C(C)C)[C@@H](C(=O)C(=C5)O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C)C)[C@@H](O)[C@@H]2O)C1)C(=O)O
XLogP-0.909
PSA256.040
H-bond Donor7
H-bond Acceptor16
No. of Rotatable Bond Count7
No. of Rings6
No. of N0
No. of O16
No. of S0
Reference(s)1) Rahman S, Fukamiya N, Okano M, Tagahara K, Lee KH.Anti-tuberculosis activity of quassinoids.Chem Pharm Bull (Tokyo). 1997 Sep;45(9):1527-9

2) http://www.hear.org/pier/commonnames/details/brucea_javanica.htm

Curator


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