|  Home  |Search   |  Browse  |Similarity   |Data Visualization  |Submission  |Contact Us  |  













                  Page - 1 of 1                  Record - 1 of 4   [TOP]
Compound ID2646
Compound Structure
DOWNLOAD:
Plant SourceStrobilanthes cusia     Common Name:
Source FamilyAcanthaceae
OriginChina, Taiwan
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneBACTEC Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml1 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedTryptanthrin
PubChem ID   73549
Ethnomedicinal InformationHas folkloric reputation for the topical treatment of athletes foot
PubMed ID [Source Literature]9828037
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Quinazolinone, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight248.059
Molecular FormulaC15H8N2O2
SMILESO=C1c2n(c3c1cccc3)c(=O)c1c(n2)cccc1
XLogP3.519
PSA46.500
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O2
No. of S0
Reference(s)1) Mitscher LA, Baker W.Tuberculosis: a search for novel therapy starting with natural products.Med Res Rev. 1998 Nov;18(6):363-74

2) L. A. Mitscher and W. R. Baker.A search for novel chemotherapy against tuberculosis amongst natural products.Pure Appl. Chem., 1998, Vol. 70, No. 2, pp. 365-371

Curator

                  Record - 2 of 4   [TOP]
Compound ID2647
Compound Structure
DOWNLOAD:
Plant SourceStrobilanthes cusia     Common Name:
Source FamilyAcanthaceae
OriginChina, Taiwan
Plant Part Used
Extract
Target BacteriaMycobacterium smegmatis
Assay / Test DoneAgar - Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedTryptanthrin
PubChem ID   73549
Ethnomedicinal InformationHas folkloric reputation for the topical treatment of athletes foot
PubMed ID [Source Literature]9828037
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Quinazolinone, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight248.059
Molecular FormulaC15H8N2O2
SMILESO=C1c2n(c3c1cccc3)c(=O)c1c(n2)cccc1
XLogP3.519
PSA46.500
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O2
No. of S0
Reference(s)1) Mitscher LA, Baker W.Tuberculosis: a search for novel therapy starting with natural products.Med Res Rev. 1998 Nov;18(6):363-74

2) L. A. Mitscher and W. R. Baker.A search for novel chemotherapy against tuberculosis amongst natural products.Pure Appl. Chem., 1998, Vol. 70, No. 2, pp. 365-371

Curator

                  Record - 3 of 4   [TOP]
Compound ID2648
Compound Structure
DOWNLOAD:
Plant SourceStrobilanthes cusia     Common Name:
Source FamilyAcanthaceae
OriginChina, Taiwan
Plant Part Used
Extract
Target BacteriaMycobacterium avium complex
Assay / Test DoneBACTEC Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedTryptanthrin
PubChem ID   73549
Ethnomedicinal InformationHas folkloric reputation for the topical treatment of athletes foot
PubMed ID [Source Literature]9828037
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Quinazolinone, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight248.059
Molecular FormulaC15H8N2O2
SMILESO=C1c2n(c3c1cccc3)c(=O)c1c(n2)cccc1
XLogP3.519
PSA46.500
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O2
No. of S0
Reference(s)1) Mitscher LA, Baker W.Tuberculosis: a search for novel therapy starting with natural products.Med Res Rev. 1998 Nov;18(6):363-74

2) L. A. Mitscher and W. R. Baker.A search for novel chemotherapy against tuberculosis amongst natural products.Pure Appl. Chem., 1998, Vol. 70, No. 2, pp. 365-371

Curator

                  Record - 4 of 4   [TOP]
Compound ID3699
Compound Structure
Plant SourceStachys sylvatica     Common Name:NR
Source FamilyLamiaceae
OriginBrazil
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlNR
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTraditional use against tuberculosis
PubMed ID [Source Literature]16302058
Extract PreparationWater
Chemical Classification [Active Compound]Aromatic, Quinazolinone, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Reference(s)1) Basso LA, da Silva LH, Fett-Neto AG, de Azevedo WF Jr, Moreira Ide S, Palma MS, Calixto JB, Astolfi Filho S, dos Santos RR, Soares MB, Santos DS.The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases--a review.Mem Inst Oswaldo Cruz. 2005 Oct;100(6):475-506. Epub 2005 Nov 8

CuratorRachana, gppreetha


Developed by: CSIR- OSDD Unit, Delhi, India and Hosted by: Bioinformatics Centre,   Institute of Microbial Technology, Sec-39A, Chandigarh, India.
The website has been tested on the latest version of Google Chrome (34.0.1847.137 m) and Mozilla Firefox (29.0.1)