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                  Page - 1 of 1                  Record - 1 of 16   [TOP]
Compound ID1789
Compound Structure
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Plant SourceGalipea officinalis     Common Name:Angustura Vera
Source FamilyRutaceae
OriginSouth America
Plant Part UsedBark
ExtractEthanol
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)Isoniazid (0.12 µg/ml), Rifampin (0.001 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedN - Methyl - 2 - Quinolone
PubChem ID   11820
Ethnomedicinal InformationUsed to treat diarrhoea and fevers
PubMed ID [Source Literature]10232071
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Quinolone, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight159.068
Molecular FormulaC10H9NO
SMILESO=c1n(c2c(cc1)cccc2)C
XLogP2.261
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Houghton PJ, Woldemariam TZ, Watanabe Y, Yates M.Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis.Planta Med. 1999 Apr;65(3):250-4

Curator

                  Record - 2 of 16   [TOP]
Compound ID3678
Compound Structure
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Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium fortuitum (ATCC 6841)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (16 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml32 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - Tetradecyl - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkaloid, Quinolone, Ketone
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight313.241
Molecular FormulaC21H31NO
SMILESC1cccc2c1n(c(cc2=O)CCCCCCCCCCC)C
XLogP7.530
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count10
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 3 of 16   [TOP]
Compound ID3679
Compound Structure
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Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium fortuitum (ATCC 6841)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (16 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - [(6E) - Undec - 6 - En - 1 - Yl] - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Alkyl, Alkene, Alkaloid, Quinolone
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight311.225
Molecular FormulaC21H29NO
SMILESCCCC/C=C/CCCCCc1cc(=O)c2c(cccc2)n1C
XLogP7.014
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count9
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 4 of 16   [TOP]
Compound ID3680
Compound Structure
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Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium fortuitum (ATCC 6841)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (16 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - [(8E) - Tridec - 8 - En - 1 - Yl] - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Quinolone, Alkene, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight339.256
Molecular FormulaC23H33NO
SMILESCCCC/C=C/CCCCCCCc1cc(=O)c2c(cccc2)n1C
XLogP8.152
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count11
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 5 of 16   [TOP]
Compound ID3681
Compound Structure
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Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium fortuitum (ATCC 6841)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (16 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - [(4E, 7E) - Trideca - 4, 7 - Dien - 1 - Yl] - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Quinolone, Alkene, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight337.241
Molecular FormulaC23H31NO
SMILESCCCCC/C=C/C/C=C/CCCc1cc(=O)c2c(cccc2)n1C
XLogP7.825
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count10
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 6 of 16   [TOP]
Compound ID3682
Compound Structure
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Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium fortuitum (ATCC 6841)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (16 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - [(6E, 9E) - Pentadeca - 6, 9 - Dien - 1 - Yl] - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Alkyl, Alkene, Alkaloid, Quinolone
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight365.272
Molecular FormulaC25H35NO
SMILESCCCCC/C=C/C/C=C/CCCCCc1cc(=O)c2c(cccc2)n1C
XLogP8.963
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count12
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 7 of 16   [TOP]
Compound ID3683
Compound Structure
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Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium smegmatis (ATCC 19429)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (1 µg/ml), Isoniazid (4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - Tetradecyl - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkaloid, Quinolone, Ketone
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight313.241
Molecular FormulaC21H31NO
SMILESC1cccc2c1n(c(cc2=O)CCCCCCCCCCC)C
XLogP7.530
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count10
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 8 of 16   [TOP]
Compound ID3684
Compound Structure
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Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium smegmatis (ATCC 19429)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (1 µg/ml), Isoniazid (4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - [(6E) - Undec - 6 - En - 1 - Yl] - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Alkyl, Alkene, Alkaloid, Quinolone
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight311.225
Molecular FormulaC21H29NO
SMILESCCCC/C=C/CCCCCc1cc(=O)c2c(cccc2)n1C
XLogP7.014
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count9
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 9 of 16   [TOP]
Compound ID3685
Compound Structure
DOWNLOAD:
Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium smegmatis (ATCC 19429)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (1 µg/ml), Isoniazid (4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - [(8E) - Tridec - 8 - En - 1 - Yl] - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Quinolone, Alkene, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight339.256
Molecular FormulaC23H33NO
SMILESCCCC/C=C/CCCCCCCc1cc(=O)c2c(cccc2)n1C
XLogP8.152
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count11
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 10 of 16   [TOP]
Compound ID3686
Compound Structure
DOWNLOAD:
Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium smegmatis (ATCC 19429)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (1 µg/ml), Isoniazid (4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - [(4E, 7E) - Trideca - 4, 7 - Dien - 1 - Yl] - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Quinolone, Alkene, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight337.241
Molecular FormulaC23H31NO
SMILESCCCCC/C=C/C/C=C/CCCc1cc(=O)c2c(cccc2)n1C
XLogP7.825
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count10
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 11 of 16   [TOP]
Compound ID3687
Compound Structure
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Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium smegmatis (ATCC 19429)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (1 µg/ml), Isoniazid (4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - [(6E, 9E) - Pentadeca - 6, 9 - Dien - 1 - Yl] - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Alkyl, Alkene, Alkaloid, Quinolone
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight365.272
Molecular FormulaC25H35NO
SMILESCCCCC/C=C/C/C=C/CCCCCc1cc(=O)c2c(cccc2)n1C
XLogP8.963
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count12
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 12 of 16   [TOP]
Compound ID3688
Compound Structure
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Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium phlei (ATCC 19249)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - Tetradecyl - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Bicyclic, Alkaloid, Quinolone, Ketone
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight313.241
Molecular FormulaC21H31NO
SMILESC1cccc2c1n(c(cc2=O)CCCCCCCCCCC)C
XLogP7.530
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count10
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 13 of 16   [TOP]
Compound ID3689
Compound Structure
DOWNLOAD:
Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium phlei (ATCC 19249)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - [(6E) - Undec - 6 - En - 1 - Yl] - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Alkyl, Alkene, Alkaloid, Quinolone
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight311.225
Molecular FormulaC21H29NO
SMILESCCCC/C=C/CCCCCc1cc(=O)c2c(cccc2)n1C
XLogP7.014
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count9
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 14 of 16   [TOP]
Compound ID3690
Compound Structure
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Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium phlei (ATCC 19249)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - [(8E) - Tridec - 8 - En - 1 - Yl] - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Quinolone, Alkene, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight339.256
Molecular FormulaC23H33NO
SMILESCCCC/C=C/CCCCCCCc1cc(=O)c2c(cccc2)n1C
XLogP8.152
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count11
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 15 of 16   [TOP]
Compound ID3691
Compound Structure
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Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium phlei (ATCC 19249)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - [(4E, 7E) - Trideca - 4, 7 - Dien - 1 - Yl] - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Quinolone, Alkene, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight337.241
Molecular FormulaC23H31NO
SMILESCCCCC/C=C/C/C=C/CCCc1cc(=O)c2c(cccc2)n1C
XLogP7.825
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count10
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal

                  Record - 16 of 16   [TOP]
Compound ID3692
Compound Structure
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Plant SourceEvodia rutaecarpa (Juss.) Benth.     Common Name:
Source FamilyRutaceae
Origin
Plant Part UsedUnripe Fruit
ExtractN - hexane
Target BacteriaMycobacterium phlei (ATCC 19249)
Assay / Test Done
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1 - Methyl - 4 - Methylidene - 2 - [(6E, 9E) - Pentadeca - 6, 9 - Dien - 1 - Yl] - 1, 4 - Dihydroquinoline
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]16051468
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Alkyl, Alkene, Alkaloid, Quinolone
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight365.272
Molecular FormulaC25H35NO
SMILESCCCCC/C=C/C/C=C/CCCCCc1cc(=O)c2c(cccc2)n1C
XLogP8.963
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count12
No. of Rings2
No. of N1
No. of O1
No. of S0
Reference(s)1) Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E.Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds.Int J Antimicrob Agents. 2005 Sep;26(3):262-4

CuratorVsheeba, vikramjitmandal


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