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                  Page - 1 of 8                  Record - 1 of 187   [TOP]
Compound ID1084
Compound Structure
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Plant SourceAilanthus altissima (Mill.) Swingle syn. Altissima glandulsa Desf.     Common Name:Tree of Heaven, Ailanto (English), Aralu (Sanskrit)
Source FamilySimaroubaceae
OriginIndia, China
Plant Part UsedMother tinture
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)Rifampin (0.031 µg/ml)
Inhibition [%]19 %
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedShinjulactone K
PubChem ID   460541
Ethnomedicinal InformationUsed for treating mental illness, nausea and headache, treating cardiac palpitation, asthma and epilepsy
PubMed ID [Source Literature]17276637
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Terpene, Triterpene, Quassinoid, Lactone, O-Acetyl, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight408.215
Molecular FormulaC22H32O7
SMILESO1[C@H]2[C@@]3([C@@H]([C@@]4([C@@H](C2)[C@@H](C[C@H](O)C4=O)C)C)[C@H](O)[C@H](OC(=O)C)[C@@H]([C@@H]3CC1=O)C)C
XLogP1.595
PSA110.130
H-bond Donor2
H-bond Acceptor7
No. of Rotatable Bond Count2
No. of Rings4
No. of N0
No. of O7
No. of S0
Reference(s)1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34

2) Rahman S, Fukamiya N, Okano M, Tagahara K, Lee KH.Anti-tuberculosis activity of quassinoids.Chem Pharm Bull (Tokyo). 1997 Sep;45(9):1527-9

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                  Record - 2 of 187   [TOP]
Compound ID1243
Compound Structure
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Plant SourceBauhinia saccocalyx     Common Name:
Source FamilyFabaceae
OriginThailand
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml6.25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedBauhinoxepins A
PubChem ID   11723631
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Oxapin, Benzopyran, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]Against Vero, human epidermoid carcinoma in the mouth (KB) and human breast cancer cells (BC)
Molecular Weight322.121
Molecular FormulaC20H18O4
SMILESO1C(C=Cc2c1c(c(O)c1Oc3c(C=Cc21)c(O)ccc3)C)(C)C
XLogP3.407
PSA58.920
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count0
No. of Rings4
No. of N0
No. of O4
No. of S0
Reference(s)1) Prasat Kittakoop, Sombat Nopichai, Nuntawan Thongon, Panarat Charoenchai, Yodhathai Thebtaranonth.Bauhinoxepins A and B: New Antimycobacterial Dibenzo[b,f]oxepins from Bauhinia saccocalyx.Helvetica Chimica Acta, Volume 87, Issue 1, pages 175–179, January 2004

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                  Record - 3 of 187   [TOP]
Compound ID1258
Compound Structure
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Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedDihydrocheleritrine
PubChem ID   485077
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight349.131
Molecular FormulaC21H19NO4
SMILESO1c2cc3c4N(Cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C
XLogP3.232
PSA40.160
H-bond Donor0
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 4 of 187   [TOP]
Compound ID1259
Compound Structure
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Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrocheleritrine
PubChem ID   189060
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight379.142
Molecular FormulaC22H21NO5
SMILESO(C1N(c2c(c3c1c(OC)c(OC)cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.216
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count3
No. of Rings5
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 5 of 187   [TOP]
Compound ID1260
Compound Structure
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Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6, 12 - Dimethoxydihydrocheleritrine
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight409.153
Molecular FormulaC23H23NO6
SMILESC1cc(c(c2c1c1c(N(C2OC)C)c2c(c(c1)OC)cc1OCOc1c2)OC)OC
XLogP2.561
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count4
No. of Rings5
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 6 of 187   [TOP]
Compound ID1261
Compound Structure
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Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrosanguinarine
PubChem ID   14847270
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight363.111
Molecular FormulaC21H17NO5
SMILESO(C1N(c2c(c3c1c1OCOc1cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.143
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings6
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 7 of 187   [TOP]
Compound ID1262
Compound Structure
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Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.06 µg/ml), Ethambutol (2 µg/ml), Rifampin (0.06 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrochelirubine
PubChem ID   15932479
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight393.121
Molecular FormulaC22H19NO6
SMILESO(C1N(c2c(c3c1c1OCOc1cc3OC)ccc1c2cc2OCOc2c1)C)C
XLogP2.699
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count2
No. of Rings6
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 8 of 187   [TOP]
Compound ID1263
Compound Structure
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Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedDihydrocheleritrine
PubChem ID   485077
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight349.131
Molecular FormulaC21H19NO4
SMILESO1c2cc3c4N(Cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C
XLogP3.232
PSA40.160
H-bond Donor0
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 9 of 187   [TOP]
Compound ID1264
Compound Structure
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Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrocheleritrine
PubChem ID   189060
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight379.142
Molecular FormulaC22H21NO5
SMILESO(C1N(c2c(c3c1c(OC)c(OC)cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.216
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count3
No. of Rings5
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 10 of 187   [TOP]
Compound ID1265
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6, 12 - Dimethoxydihydrocheleritrine
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight409.153
Molecular FormulaC23H23NO6
SMILESC1cc(c(c2c1c1c(N(C2OC)C)c2c(c(c1)OC)cc1OCOc1c2)OC)OC
XLogP2.561
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count4
No. of Rings5
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 11 of 187   [TOP]
Compound ID1266
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrosanguinarine
PubChem ID   14847270
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight363.111
Molecular FormulaC21H17NO5
SMILESO(C1N(c2c(c3c1c1OCOc1cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.143
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings6
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 12 of 187   [TOP]
Compound ID1267
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (345)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (3.125 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrochelirubine
PubChem ID   15932479
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight393.121
Molecular FormulaC22H19NO6
SMILESO(C1N(c2c(c3c1c1OCOc1cc3OC)ccc1c2cc2OCOc2c1)C)C
XLogP2.699
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count2
No. of Rings6
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 13 of 187   [TOP]
Compound ID1268
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedDihydrocheleritrine
PubChem ID   485077
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight349.131
Molecular FormulaC21H19NO4
SMILESO1c2cc3c4N(Cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C
XLogP3.232
PSA40.160
H-bond Donor0
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 14 of 187   [TOP]
Compound ID1269
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrocheleritrine
PubChem ID   189060
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight379.142
Molecular FormulaC22H21NO5
SMILESO(C1N(c2c(c3c1c(OC)c(OC)cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.216
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count3
No. of Rings5
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

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                  Record - 15 of 187   [TOP]
Compound ID1270
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6, 12 - Dimethoxydihydrocheleritrine
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight409.153
Molecular FormulaC23H23NO6
SMILESC1cc(c(c2c1c1c(N(C2OC)C)c2c(c(c1)OC)cc1OCOc1c2)OC)OC
XLogP2.561
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count4
No. of Rings5
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 16 of 187   [TOP]
Compound ID1271
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrosanguinarine
PubChem ID   14847270
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight363.111
Molecular FormulaC21H17NO5
SMILESO(C1N(c2c(c3c1c1OCOc1cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.143
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings6
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 17 of 187   [TOP]
Compound ID1272
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M12)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (12.50 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrochelirubine
PubChem ID   15932479
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight393.121
Molecular FormulaC22H19NO6
SMILESO(C1N(c2c(c3c1c1OCOc1cc3OC)ccc1c2cc2OCOc2c1)C)C
XLogP2.699
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count2
No. of Rings6
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 18 of 187   [TOP]
Compound ID1273
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedDihydrocheleritrine
PubChem ID   485077
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight349.131
Molecular FormulaC21H19NO4
SMILESO1c2cc3c4N(Cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C
XLogP3.232
PSA40.160
H-bond Donor0
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings5
No. of N1
No. of O4
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 19 of 187   [TOP]
Compound ID1274
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrocheleritrine
PubChem ID   189060
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight379.142
Molecular FormulaC22H21NO5
SMILESO(C1N(c2c(c3c1c(OC)c(OC)cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.216
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count3
No. of Rings5
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 20 of 187   [TOP]
Compound ID1275
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6, 12 - Dimethoxydihydrocheleritrine
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight409.153
Molecular FormulaC23H23NO6
SMILESC1cc(c(c2c1c1c(N(C2OC)C)c2c(c(c1)OC)cc1OCOc1c2)OC)OC
XLogP2.561
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count4
No. of Rings5
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 21 of 187   [TOP]
Compound ID1276
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrosanguinarine
PubChem ID   14847270
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight363.111
Molecular FormulaC21H17NO5
SMILESO(C1N(c2c(c3c1c1OCOc1cc3)ccc1c2cc2OCOc2c1)C)C
XLogP3.143
PSA49.390
H-bond Donor0
H-bond Acceptor6
No. of Rotatable Bond Count1
No. of Rings6
No. of N1
No. of O5
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 22 of 187   [TOP]
Compound ID1277
Compound Structure
DOWNLOAD:
Plant SourceBocconia arborea     Common Name:Bocconia
Source FamilyPapaveraceae
OriginMexico
Plant Part UsedAerial
Extract
Target BacteriaMycobacterium tuberculosis (M20)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Streptomycin (25 µg/ml), Isoniazid (< 50 µg/ml), Ethambutol (12.50 µg/ml), Rifampin (< 50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methoxydihydrochelirubine
PubChem ID   15932479
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Benzophenanthridine, Quinoline, Ether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight393.121
Molecular FormulaC22H19NO6
SMILESO(C1N(c2c(c3c1c1OCOc1cc3OC)ccc1c2cc2OCOc2c1)C)C
XLogP2.699
PSA58.620
H-bond Donor0
H-bond Acceptor7
No. of Rotatable Bond Count2
No. of Rings6
No. of N1
No. of O6
No. of S0
Reference(s)1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75

2) http://zipcodezoo.com/Plants/B/Bocconia_arborea/

Curator

                  Record - 23 of 187   [TOP]
Compound ID1280
Compound Structure
DOWNLOAD:
Plant SourceBorrichia frutescens L.     Common Name:Sea Daisy
Source FamilyAsteraceae (Compositae)
OriginSoutheastern USA
Plant Part UsedFlower, leaf, stem
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)Fusidic acid (4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified(24R)-24,25-epoxycycloartan-3-one
PubChem ID   469544
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]8988597
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Terpene, Triterpene, Cycloartane, Ketone, Epoxy
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]Against vero cells
Molecular Weight440.365
Molecular FormulaC30H48O2
SMILESO=C1C([C@H]2[C@@]3([C@@]4(C3)[C@H]([C@]3([C@](CC4)([C@H](CC3)[C@@H](CC[C@H]3OC3(C)C)C)C)C)CC2)CC1)(C)C
XLogP9.983
PSA29.600
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count4
No. of Rings6
No. of N0
No. of O2
No. of S0
Reference(s)1) Cantrell CL, Lu T, Fronczek FR, Fischer NH, Adams LB, Franzblau SG.Antimycobacterial cycloartanes from Borrichia frutescens.J Nat Prod. 1996 Dec;59(12):1131-6

Curator

                  Record - 24 of 187   [TOP]
Compound ID1281
Compound Structure
DOWNLOAD:
Plant SourceBorrichia frutescens L.     Common Name:Sea Daisy
Source FamilyAsteraceae (Compositae)
OriginUSA
Plant Part UsedFlower, leaf, stem
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)Fusidic acid (4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified(3β, 24R) - 24, 25 - Epoxycycloartan - 3 - Ol
PubChem ID   469545
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]8988597
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Terpene, Triterpene, Cycloartane, Epoxy, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]Against Vero cells
Molecular Weight442.381
Molecular FormulaC30H50O2
SMILESO[C@H]1C([C@H]2[C@@]3([C@@]4(C3)[C@H]([C@]3([C@](CC4)([C@H](CC3)[C@@H](CC[C@H]3OC3(C)C)C)C)C)CC2)CC1)(C)C
XLogP10.590
PSA32.760
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count4
No. of Rings6
No. of N0
No. of O2
No. of S0
Reference(s)1) Cantrell CL, Lu T, Fronczek FR, Fischer NH, Adams LB, Franzblau SG.Antimycobacterial cycloartanes from Borrichia frutescens.J Nat Prod. 1996 Dec;59(12):1131-6

Curator

                  Record - 25 of 187   [TOP]
Compound ID1282
Compound Structure
DOWNLOAD:
Plant SourceBorrichia frutescens L.     Common Name:Sea Daisy
Source FamilyAsteraceae (Compositae)
OriginUSA
Plant Part UsedFlower, leaf, stem
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)Fusidic acid (4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml64 - 128 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified(23R)-3-Oxolanosta-8,24-dien-23-Ol
PubChem ID   469546
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]8988597
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Steroid, Ketone, Prenylated
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]Against Vero cells
Molecular Weight440.365
Molecular FormulaC30H48O2
SMILESO=C1C([C@H]2[C@@](C3=C([C@]4([C@@]([C@H](CC4)[C@@H](C[C@@H](O)C=C(C)C)C)(CC3)C)C)CC2)(CC1)C)(C)C
XLogP7.784
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count4
No. of Rings4
No. of N0
No. of O2
No. of S0
Reference(s)1) Cantrell CL, Lu T, Fronczek FR, Fischer NH, Adams LB, Franzblau SG.Antimycobacterial cycloartanes from Borrichia frutescens.J Nat Prod. 1996 Dec;59(12):1131-6

Curator


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