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                  Page - 1 of 1                  Record - 1 of 5   [TOP]
Compound ID2385
Compound Structure
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Plant SourcePiper sarmentosum Roxb.     Common Name:Cha Plu
Source FamilyPiperaceae
OriginProbably Southeast Asia, Malaysia
Plant Part UsedFresh root
ExtractEthanol
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID   17758236
Ethnomedicinal InformationCough, anti - tuberculosis and anti - plasmodial activities
PubMed ID [Source Literature]16462055
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Pentacyclic, Alkaloid, Thiophene, Benzopyran, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight485.202
Molecular FormulaC30H31NO3S
SMILESS1c(/C=C/2Oc3c(c4c2c2c(NC(C=C2C)(C)C)cc4)c(OC)c(O)cc3)c(/C(=C/CC)/C)cc1
XLogP7.049
PSA78.960
H-bond Donor2
H-bond Acceptor5
No. of Rotatable Bond Count4
No. of Rings5
No. of N1
No. of O3
No. of S1
Reference(s)1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

                  Record - 2 of 5   [TOP]
Compound ID3936
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium fortuitum
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml> 128 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Thiophene
PubChem ID   45272211
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationNR
Chemical Classification [Active Compound]Aromatic, Thiophene, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight161.963
Molecular FormulaC5H6S3
SMILESS1c(SSC)ccc1
XLogP2.741
PSA78.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings1
No. of N0
No. of O0
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 3 of 5   [TOP]
Compound ID3937
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium smegmatis
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml64 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Thiophene
PubChem ID   45272211
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationNR
Chemical Classification [Active Compound]Aromatic, Thiophene, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight161.963
Molecular FormulaC5H6S3
SMILESS1c(SSC)ccc1
XLogP2.741
PSA78.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings1
No. of N0
No. of O0
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 4 of 5   [TOP]
Compound ID3938
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium smegmatis (mc2 2700)
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/mlNot tested
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Thiophene
PubChem ID   45272211
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationNR
Chemical Classification [Active Compound]Aromatic, Thiophene, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight161.963
Molecular FormulaC5H6S3
SMILESS1c(SSC)ccc1
XLogP2.741
PSA78.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings1
No. of N0
No. of O0
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 5 of 5   [TOP]
Compound ID3939
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium phlei
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml> 128 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Thiophene
PubChem ID   45272211
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationNR
Chemical Classification [Active Compound]Aromatic, Thiophene, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight161.963
Molecular FormulaC5H6S3
SMILESS1c(SSC)ccc1
XLogP2.741
PSA78.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings1
No. of N0
No. of O0
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal


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