BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 7 [TOP]

Compound ID

3959

Compound Structure

Plant Source

Swinglea glutinosa Common Name:Tabog, Glutinous Swinglea

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

α - Terpineol

PubChem ID

17100

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Terpene, Monoterpene, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

154.136

Molecular Formula

C₁₀H₁₈O

SMILES

OC(C1CCC(=CC1)C)(C)C

XLogP

2.369

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

Record - 2 of 7 [TOP]

Compound ID

2658

Compound Structure

Plant Source

Swinglea glutinosa Common Name:

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

β - Pinene

PubChem ID

14896

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Monoterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

136.125

Molecular Formula

C₁₀H₁₆

SMILES

C1(C2CC1C(=C)CC2)(C)C

XLogP

4.222

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

Record - 3 of 7 [TOP]

Compound ID

2659

Compound Structure

Plant Source

Swinglea glutinosa Common Name:

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

α - Pinene (12 %)

PubChem ID

6654

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Monoterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

136.125

Molecular Formula

C₁₀H₁₆

SMILES

C1(C2CC1C(=CC2)C)(C)C

XLogP

4.177

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

Record - 4 of 7 [TOP]

Compound ID

2660

Compound Structure

Plant Source

Swinglea glutinosa Common Name:

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sabinene

PubChem ID

18818

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Monoterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

136.125

Molecular Formula

C₁₀H₁₆

SMILES

C12(C(C1)C(=C)CC2)C(C)C

XLogP

4.222

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

Record - 5 of 7 [TOP]

Compound ID

2661

Compound Structure

Plant Source

Swinglea glutinosa Common Name:

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Bicyclosesquiphellandrene

PubChem ID

521496

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Sesquiterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

204.188

Molecular Formula

C₁₅H₂₄

SMILES

C12C(CCC(C1=CC(=C)CC2)C(C)C)C

XLogP

6.239

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

Record - 6 of 7 [TOP]

Compound ID

2662

Compound Structure

Plant Source

Swinglea glutinosa Common Name:

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Limonene (4.4 %)

PubChem ID

22311

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Terpene, Monoterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

136.125

Molecular Formula

C₁₀H₁₆

SMILES

C1(CCC(=CC1)C)C(=C)C

XLogP

3.729

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

Record - 7 of 7 [TOP]

Compound ID

2663

Compound Structure

Plant Source

Swinglea glutinosa Common Name:

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1, 8 - Cineol

PubChem ID

2758

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Monoterpene, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

154.136

Molecular Formula

C₁₀H₁₈O

SMILES

O1C2(CCC(C1(C)C)CC2)C

XLogP

2.595

PSA

9.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

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