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                  Page - 1 of 1                  Record - 1 of 4   [TOP]
Compound ID2054
Compound Structure
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Plant SourceLippia alba (Miller) N. E.Brown     Common Name:
Source FamilyVerbenaceae
OriginColombia, Puerto Rico, India
Plant Part UsedLeaf, stem
ExtractEssential oil (1.6 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml130 ± 95 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified6 - Methyl - 5 - hepten - 2 - one (2.1 %)
PubChem ID   9862
Ethnomedicinal InformationDigestive troubles in general, nausea, bronchitis, sore throat, flu, cough, cold, hypertension, skin diseases, wounds, stomach ache, nervous complaints, folklore medicine of Puerto Rico
PubMed ID [Source Literature]19753839
Extract PreparationN/A
Chemical Classification [Active Compound]Aliphatic, Alkene, Ketone
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight126.104
Molecular FormulaC8H14O
SMILESO=C(CCC=C(C)C)C
XLogP1.796
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count3
No. of Rings0
No. of N0
No. of O1
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

2) Thierry Hennebelle, Sevser Sahpaz, Henry Joseph, François Bailleul.Ethnopharmacology of Lippia alba.Journal of Ethnopharmacology, Volume 116, Issue 2, 5 March 2008, Pages 211-222

Curator

                  Record - 2 of 4   [TOP]
Compound ID2055
Compound Structure
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Plant SourceLippia alba (Miller) N. E.Brown     Common Name:
Source FamilyVerbenaceae
OriginColombia, Puerto Rico, India
Plant Part UsedLeaf, stem
ExtractEssential oil (1.6 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml130 ± 95 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCis - Verbenol (1.9 %)
PubChem ID   87839
Ethnomedicinal InformationDigestive troubles in general, nausea, bronchitis, sore throat, flu, cough, cold, hypertension, skin diseases, wounds, stomach ache, nervous complaints, folklore medicine of Puerto Rico
PubMed ID [Source Literature]19753839
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Monoterpene, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight152.120
Molecular FormulaC10H16O
SMILESO[C@@H]1[C@@H]2C([C@@H](C2)C(=C1)C)(C)C
XLogP2.147
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings1
No. of N0
No. of O1
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

2) Thierry Hennebelle, Sevser Sahpaz, Henry Joseph, François Bailleul.Ethnopharmacology of Lippia alba.Journal of Ethnopharmacology, Volume 116, Issue 2, 5 March 2008, Pages 211-222

Curator

                  Record - 3 of 4   [TOP]
Compound ID2056
Compound Structure
DOWNLOAD:
Plant SourceLippia alba (Miller) N. E.Brown     Common Name:
Source FamilyVerbenaceae
OriginColombia, Puerto Rico, India
Plant Part UsedLeaf, stem
ExtractEssential oil (1.6 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml130 ± 95 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedTrans - Verbenol (1.5 %)
PubChem ID   89664
Ethnomedicinal InformationDigestive troubles in general, nausea, bronchitis, sore throat, flu, cough, cold, hypertension, skin diseases, wounds, stomach ache, nervous complaints, folklore medicine of Puerto Rico
PubMed ID [Source Literature]19753839
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Monoterpene, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight152.120
Molecular FormulaC10H16O
SMILESO[C@@H]1[C@H]2C([C@H](C2)C(=C1)C)(C)C
XLogP2.147
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count0
No. of Rings1
No. of N0
No. of O1
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

2) Thierry Hennebelle, Sevser Sahpaz, Henry Joseph, François Bailleul.Ethnopharmacology of Lippia alba.Journal of Ethnopharmacology, Volume 116, Issue 2, 5 March 2008, Pages 211-222

Curator

                  Record - 4 of 4   [TOP]
Compound ID2057
Compound Structure
DOWNLOAD:
Plant SourceLippia alba (Miller) N. E.Brown     Common Name:
Source FamilyVerbenaceae
OriginColombia, Puerto Rico, India
Plant Part UsedLeaf, stem
ExtractEssential oil (1.6 %)
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMacrodilution method in glass tubes
Positive Control Used (conc.)Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml130 ± 95 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identifiedα - Humulene (1.4 %)
PubChem ID   5281520
Ethnomedicinal InformationDigestive troubles in general, nausea, bronchitis, sore throat, flu, cough, cold, hypertension, skin diseases, wounds, stomach ache, nervous complaints, folklore medicine of Puerto Rico
PubMed ID [Source Literature]19753839
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Terpene, Sesquiterpene
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight204.188
Molecular FormulaC15H24
SMILESC1(C/C=C(/CC/C=C(/C/C=C/1)C)C)(C)C
XLogP5.940
PSA0.000
H-bond Donor0
H-bond Acceptor0
No. of Rotatable Bond Count0
No. of Rings1
No. of N0
No. of O0
No. of S0
Reference(s)1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

2) Thierry Hennebelle, Sevser Sahpaz, Henry Joseph, François Bailleul.Ethnopharmacology of Lippia alba.Journal of Ethnopharmacology, Volume 116, Issue 2, 5 March 2008, Pages 211-222

Curator


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