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                  Page - 1 of 1                  Record - 1 of 5   [TOP]
Compound ID2202
Compound Structure
Plant SourceMorinda citrifolia L.     Common Name:Indian Mulberry (English), Ashyuka, Akshi, Atchy (Sanskrit)
Source FamilyRubiaceae
OriginMalaysia, India
Plant Part UsedLeaf
ExtractEthanol, hexane
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneBroth dilution assay using BACTEC system
Positive Control Used (conc.)Rifampin (0.125 µg/ml)
Inhibition [%]89 and 95 %
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationAsthma, joint pains, immune problems, pain relief, cellular regeneration, tuberculosis, respiratory disorders
PubMed ID [Source Literature]12410555
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Saludes JP, Garson MJ, Franzblau SG, Aguinaldo AM.Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae).Phytother Res. 2002 Nov;16(7):683-5

2) http://www.motherherbs.com/morinda-citrifolia.html

Curator

                  Record - 2 of 5   [TOP]
Compound ID2205
Compound Structure
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Plant SourceMorinda citrifolia L.     Common Name:Indian Mulberry (English), Ashyuka, Akshi, Atchy (Sanskrit)
Source FamilyRubiaceae
OriginIndo - Pacific region
Plant Part UsedLeaf
ExtractEthanol, Hexane
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)Rifampin (0.125 µg/ml)
Inhibition [%]Crude ethanol extract - 89 % and hexane fraction - 95 %
Activity [MIC] µg/ml< 2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedStigmasta - 4 - 22 - Dien - 3 - One
PubChem ID   6479802
Ethnomedicinal InformationAsthma, joint pains, immune problems, pain relief, cellular regeneration, tuberculosis, respiratory disorders
PubMed ID [Source Literature]12410555
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Steroid, Ketone
Media / Broth Used [Antimicrobial Assay/Test]Bactec 12B broth
Cytotoxicity Assay [AID]N/A
Molecular Weight424.371
Molecular FormulaC30H48O
SMILESO=C1CC[C@@]2(C3C([C@]4([C@@]([C@H](CC4)C(C)/C=C/[C@H](C(C)C)CC)(CC3)C)C)CCC2=C1)C
XLogP11.670
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count5
No. of Rings4
No. of N0
No. of O1
No. of S0
Reference(s)1) Saludes JP, Garson MJ, Franzblau SG, Aguinaldo AM.Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae).Phytother Res. 2002 Nov;16(7):683-5

2) http://www.motherherbs.com/morinda-citrifolia.html

Curator

                  Record - 3 of 5   [TOP]
Compound ID2206
Compound Structure
DOWNLOAD:
Plant SourceMorinda citrifolia L.     Common Name:Indian Mulberry (English), Ashyuka, Akshi, Atchy (Sanskrit)
Source FamilyRubiaceae
OriginIndo - Pacific region
Plant Part UsedLeaf
ExtractEthanol, Hexane
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)Rifampin (0.125 µg/ml)
Inhibition [%]Crude ethanol extract - 89 % and hexane fraction - 95 %
Activity [MIC] µg/ml128 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identifiedβ - sitosterol
PubChem ID   222284
Ethnomedicinal InformationAsthma, joint pains, immune problems, pain relief, cellular regeneration, tuberculosis, respiratory disorders
PubMed ID [Source Literature]12410555
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Steroid, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight414.386
Molecular FormulaC29H50O
SMILESO[C@@H]1CC2=CC[C@H]3[C@H]4[C@@]([C@H](CC4)[C@@H](CC[C@H](C(C)C)CC)C)(CC[C@@H]3[C@]2(CC1)C)C
XLogP11.595
PSA20.230
H-bond Donor1
H-bond Acceptor1
No. of Rotatable Bond Count6
No. of Rings4
No. of N0
No. of O1
No. of S0
Reference(s)1) Saludes JP, Garson MJ, Franzblau SG, Aguinaldo AM.Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae).Phytother Res. 2002 Nov;16(7):683-5

2) http://www.motherherbs.com/morinda-citrifolia.html

Curator

                  Record - 4 of 5   [TOP]
Compound ID2795
Compound Structure
Plant SourceVitex cymosa     Common Name:
Source FamilyVerbenaceae
OriginUSA
Plant Part UsedFruit
ExtractEthanol, hexane
Target BacteriaMycobacterium tuberculosis (ATCC 27294 H37Rv)
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Rifampin
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) LEITAO, Suzana G. et al. Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test. Rev. bras. farmacogn. [online]. 2006, vol.16, n.1, pp. 6-11

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                  Record - 5 of 5   [TOP]
Compound ID3418
Compound Structure
DOWNLOAD:
Plant SourceMorinda citrifolia     Common Name:Noni
Source FamilyRubiaceae
OriginIndo - Pacific region
Plant Part UsedLeaf
ExtractEthanol, Hexane
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRadiorespirometric Bioassay
Positive Control Used (conc.)Rifampin (0.125 µg/ml)
Inhibition [%]Crude ethanol extract - 89 % and hexane fraction - 95 %
Activity [MIC] µg/ml< 2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedStigmasta - 4 - En - 3 - One
PubChem ID   579897
Ethnomedicinal InformationNR
PubMed ID [Source Literature]12410555
Extract PreparationDried leaves were extracted with ethanol to give a green, syrupy extract which was further partitioned into hexane DCM , EtOAc and n - BuOH fractions
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Steroid, Ketone
Media / Broth Used [Antimicrobial Assay/Test]Bactec 12B broth
Cytotoxicity Assay [AID]NR
Molecular Weight412.371
Molecular FormulaC29H48O
SMILESO=C1CCC2(C3C(C4C(C(CC4)C(CCC(C(C)C)CC)C)(CC3)C)CCC2=C1)C
XLogP11.588
PSA17.070
H-bond Donor0
H-bond Acceptor1
No. of Rotatable Bond Count6
No. of Rings4
No. of N0
No. of O1
No. of S0
Reference(s)1) Saludes JP, Garson MJ, Franzblau SG, Aguinaldo AM.Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae).Phytother Res. 2002 Nov;16(7):683-5

CuratorReshmi


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