BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 27 [TOP]

Compound ID	1012
Compound Structure
Plant Source	Acacia nilotica (L.) Willd. ex Del. subsp. kraussiana (Benth.) Brenan Common Name:Indian Gum Arabic Tree
Source Family	Fabaceae
Origin	Africa
Plant Part Used	Leaf
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	780 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Dry coughs, respiratory ailments including tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251
Curator

Record - 2 of 27 [TOP]

Compound ID	1014
Compound Structure
Plant Source	Acacia nilotica (L.) Willd. ex Del. subsp. kraussiana (Benth.) Brenan Common Name:Indian Gum Arabic Tree
Source Family	Fabaceae
Origin	Africa
Plant Part Used	Bark
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	780 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Dry coughs, respiratory ailments including tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251
Curator

Record - 3 of 27 [TOP]

Compound ID	1017
Compound Structure
Plant Source	Acacia sieberiana DC. var. woodii (Burtt Davy) Keay & Brenan Common Name:Paperbark Thorn
Source Family	Fabaceae
Origin	Africa
Plant Part Used	Leaf
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	3120 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Fever, infectious diseases, inflammation and pain in the back
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251
Curator

Record - 4 of 27 [TOP]

Compound ID	1020
Compound Structure
Plant Source	Acacia sieberiana DC. var. woodii (Burtt Davy) Keay & Brenan Common Name:Paperbark Thorn
Source Family	Fabaceae
Origin	Africa
Plant Part Used	Root
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	3120 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Fever, infectious diseases, inflammation and pain in the back
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251
Curator

Record - 5 of 27 [TOP]

Compound ID	1381
Compound Structure
Plant Source	Carpobrotus mellei Common Name:
Source Family	Aizoaceae
Origin	Africa
Plant Part Used	Leaf juice
Extract	Ethyl acetate
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Disc Diffusion and Bioautography
Positive Control Used (conc.)	Ciprofloxacin (40 µg/Disc)
Inhibition [%]
Activity [MIC] µg/ml	15000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, infections
PubMed ID [Source Literature]	12834010
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Springfield EP, Amabeoku G, Weitz F, Mabusela W, Johnson Q. An assessment of two Carpobrotus species extracts as potential antimicrobial agents. Phytomedicine. 2003;10(5):434-9
Curator

Record - 6 of 27 [TOP]

Compound ID	1515
Compound Structure
Plant Source	Combretum kraussii Hochst. Common Name:Forest bushwillow
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Leaf
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1560 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Various stomach complaints, fever, wounds and inflammation
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://www.plantzAfrica.com/plantcd/combretkraus.htm
Curator

Record - 7 of 27 [TOP]

Compound ID	1517
Compound Structure
Plant Source	Combretum kraussii Hochst. Common Name:Forest Bushwillow
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Bark
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1560 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Various stomach complaints, fever, wounds and inflammation
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://www.plantzAfrica.com/plantcd/combretkraus.htm
Curator

Record - 8 of 27 [TOP]

Compound ID	1519
Compound Structure
Plant Source	Combretum kraussii Hochst. Common Name:Forest Bushwillow
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Root
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	780 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Various stomach complaints, fever, wounds and inflammation
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://www.plantzAfrica.com/plantcd/combretkraus.htm
Curator

Record - 9 of 27 [TOP]

Compound ID	1733
Compound Structure
Plant Source	Faidherbia albida (Del.) A. Chev. Common Name:Ana Tree
Source Family	Fabaceae
Origin	Africa
Plant Part Used	Leaf
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	6250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stomach disorders, colds, ophthalmia and infections
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://www.plantzAfrica.com/plantefg/faidalb.htm
Curator

Record - 10 of 27 [TOP]

Compound ID	1756
Compound Structure
Plant Source	Ficus sur Forssk. Common Name:Fig, Bush Fig, Fig of Heaven
Source Family	Moraceae
Origin	Africa
Plant Part Used	Leaf
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	195 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, influenza and colic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://plants.jstor.org/upwta/4_318
Curator

Record - 11 of 27 [TOP]

Compound ID	1759
Compound Structure
Plant Source	Ficus sur Forssk. Common Name:Fig, Bush Fig, Fig of Heaven
Source Family	Moraceae
Origin	Africa
Plant Part Used	Root
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	780 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, influenza and colic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://plants.jstor.org/upwta/4_318
Curator

Record - 12 of 27 [TOP]

Compound ID	1790
Compound Structure
Plant Source	Galium aparine L. Common Name:Goosegrass, Clivers, Cleavers, Catch Weed (English), Choleretic, Stomachic (Sanskrit)
Source Family	Rubiaceae
Origin	India
Plant Part Used	Whole plant
Extract	Ethyl acetate
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Agar - Well Diffusion Assay
Positive Control Used (conc.)	Streptomycin sulphate (1 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	20000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	5 mm, 20 mm (control)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Aperient, diuretic, refrigerant, antiscorbutic and fruits used as a substitute for coffee
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) James D. Mcchesney, Robert P. Adams.Co-evaluation of plant extracts as petrochemical substitutes and for biologically active compounds.Economic Botany. 12/1984, 39(1):74-86
Curator

Record - 13 of 27 [TOP]

Compound ID	2123
Compound Structure
Plant Source	Mallotus philippensis (Linn.) Muell Arg. Common Name:Kamala Tree (English), Kampillaka, Kampilla, Karkash, Raktaanga, Rechan (Sanskrit)
Source Family	Euphorbiaceae
Origin	India
Plant Part Used	Leaf
Extract	Ethyl acetate
Target Bacteria	Mycobacterium smegmatis (MTCC 6)
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Rifampin (5.0 µg/Disc)
Inhibition [%]
Activity [MIC] µg/ml	125 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, bronchitis, random screening, antihelmentic
PubMed ID [Source Literature]	21114505
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Shukla C, Bisht GR, Saikia D, Kumar S, Thakur RL.Detection of anti-tuberculosis activity in some folklore plants by radiometric BACTEC assay.Lett Appl Microbiol. 2011 Jan;52(1):33-40
Curator

Record - 14 of 27 [TOP]

Compound ID	2124
Compound Structure
Plant Source	Mallotus philippensis (Linn.) Muell Arg. Common Name:Kamala Tree (English), Kampillaka, Kampilla, Karkash, Raktaanga, Rechan (Sanskrit)
Source Family	Euphorbiaceae
Origin	India
Plant Part Used	Leaf
Extract	Ethyl acetate
Target Bacteria	Mycobacterium smegmatis (MTCC 994)
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Rifampin (5.0 µg/Disc)
Inhibition [%]
Activity [MIC] µg/ml	250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, bronchitis, random screening, antihelmentic
PubMed ID [Source Literature]	21114505
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gupta VK, Shukla C, Bisht GR, Saikia D, Kumar S, Thakur RL.Detection of anti-tuberculosis activity in some folklore plants by radiometric BACTEC assay.Lett Appl Microbiol. 2011 Jan;52(1):33-40
Curator

Record - 15 of 27 [TOP]

Compound ID	2158
Compound Structure
Plant Source	Melilotus alba Desr. Common Name:White Sweet Clover (English)
Source Family	Fabaceae
Origin	India
Plant Part Used	Whole plant
Extract	Ethyl acetate
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Agar - Well Diffusion Assay
Positive Control Used (conc.)	Streptomycin sulphate (1 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	0.02 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	2 mm, 20 mm (control)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Occasionally used as a substitute for Melilotus officinalis Lam. which is used for demulcent, aphrodisiac, leucoderma and styptic purpose
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) James D. Mcchesney, Robert P. Adams.Co-evaluation of plant extracts as petrochemical substitutes and for biologically active compounds.Economic Botany. 12/1984, 39(1):74-86 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 16 of 27 [TOP]

Compound ID	2442
Compound Structure
Plant Source	Prunus africana (Hook. f.) Kalkman Common Name:Red Stinkwood
Source Family	Rosaceae
Origin	Africa
Plant Part Used	Leaf
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	780 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Chest pain, diarrhoea, fever, allergies, stomach ache, prostrate gland disease and kidney disease
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) Pujol, J., 1990. NaturAfrica–the Herbalist Handbook. Jean Pujol Natural Healer's Foundation, Durban 3) http://www.iucnredlist.org/apps/redlist/details/33631/0
Curator

Record - 17 of 27 [TOP]

Compound ID	2444
Compound Structure
Plant Source	Prunus africana (Hook. f.) Kalkman Common Name:Red Stinkwood
Source Family	Rosaceae
Origin	Africa
Plant Part Used	Bark
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1560 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Chest pain, diarrhoea, fever, allergies, stomach ache, prostrate gland disease and kidney disease
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) Pujol, J., 1990. NaturAfrica–the Herbalist Handbook. Jean Pujol Natural Healer's Foundation, Durban 3) http://www.iucnredlist.org/apps/redlist/details/33631/0
Curator

Record - 18 of 27 [TOP]

Compound ID	2526
Compound Structure
Plant Source	Salix mucronata Thunb. Common Name:Flute Willow, Safsaf Willow
Source Family	Salicaceae
Origin	Africa
Plant Part Used	Root
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	6250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Rheumatism, fever, rheumatic fever, wound dressing, pain relief and anti - infective
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) Iwu, M.M., 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, Florida, USA 3) http://www.zimbabweflora.co.zw/speciesdata/species.php?species_id=120010
Curator

Record - 19 of 27 [TOP]

Compound ID	2710
Compound Structure
Plant Source	Terminalia sericea Burchel ex Dc. Common Name:Yellow Wood, Silver Terminalia Tree
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Bark
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	3120 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stomach disorders, wounds, diarrhoea and swollen painful eyes
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://www.worldagroforestry.org/treedb2/AFTPDFS/Terminalia_sericea.pdf
Curator

Record - 20 of 27 [TOP]

Compound ID	2712
Compound Structure
Plant Source	Terminalia sericea Burchel ex Dc. Common Name:Yellow Wood, Silver Terminalia Tree
Source Family	Combretaceae
Origin	Africa
Plant Part Used	Root
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1560 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stomach disorders, wounds, diarrhoea and swollen painful eyes
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://www.worldagroforestry.org/treedb2/AFTPDFS/Terminalia_sericea.pdf
Curator

Record - 21 of 27 [TOP]

Compound ID	2738
Compound Structure
Plant Source	Trichilia dregeana Harv. & Sond. Common Name:Forest Mahogany, Forest Natal Mahogany, Cape Mahogany, Thunder Tree, Christmas Bells, Red Ash
Source Family	Meliaceae
Origin	Africa
Plant Part Used	Leaf
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	6250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Gonorrhea, fever, diarrhoea, pain in the back and as a purgative
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Eldeen, I.M.S., Van Staden, J., 2007. Antimycobacterial activity of some trees used in South African traditional medicine. South African Journal of Botany 73, 248–25 2) http://database.prota.org/PROTAhtml/Trichilia%20dregeana_En.htm
Curator

Record - 22 of 27 [TOP]

Compound ID	2752
Compound Structure
Plant Source	Tridax procumbens L. Common Name:Mexican Daisy (English), Jayanti (Sanskrit)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Aerial
Extract	Ethyl acetate
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	10000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchial catarrh, leprosy
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 23 of 27 [TOP]

Compound ID	2810
Compound Structure	N/A
Plant Source	Xanthium strumarium L. Common Name:Cocklebur, Burweed (English), Shankheshwara, Arishta, Aartagala (Sanskrit)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Whole plant
Extract	Ethyl acetate
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Agar - Well Diffusion Assay
Positive Control Used (conc.)	Streptomycin sulphate (1 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml	20000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	4 mm, 20 mm (control)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Cancer, wounds, headache, malaria, ulcers, rheumatism, random screening
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) James D. Mcchesney, Robert P. Adams.Co-evaluation of plant extracts as petrochemical substitutes and for biologically active compounds.Economic Botany. 12/1984, 39(1):74-86 2) Sudhanshu Kumar Jain.Dictionary of Indian Folk Medicine and Ethnobotany:A Reference Manual of Man-Plant Relationships, Ethnic Groups & Ethnobotanists in India.Deep Publications, 1991 - 311 pages
Curator

Record - 24 of 27 [TOP]

Compound ID

3755

Compound Structure

Plant Source

Calliandra californica Benth. Common Name:NR

Source Family

Fabaceae

Origin

Plant Part Used

Root

Extract

Ethyl acetate

Target Bacteria

Mycobacterium tuberculosis H37Rv (CIBIN / UMF15 : 099)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Escobarine A

PubChem ID

11983334

Ethnomedicinal Information

PubMed ID [Source Literature]

16755469

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Diterpene, Epoxy, Aldehyde, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Against 5 human tumor cell lines

Molecular Weight

330.183

Molecular Formula

C₂₀H₂₆O₄

SMILES

O1[C@@]2([C@H]3[C@@H]([C@@]4([C@H](C(CCC4)(C)C)C[C@@H]3O)C)CC(=O)[C@]12C#C)C=O

XLogP

3.288

PSA

66.900

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Encarnación-Dimayuga R, Agúndez-Espinoza J, García A, Delgado G, Molina-Salinas GM, Said-Fernández S.Two new cassane-type diterpenes from Calliandra californica with antituberculosis and cytotoxic activities.Planta Med. 2006 Jun;72(8):757-61. Epub 2006 Jun 1

Curator

Reshmi, vikramjitmandal

Record - 25 of 27 [TOP]

Compound ID	3782
Compound Structure	NR
Plant Source	Evodia elleryana (Melicope elleryana) Common Name:Sehit
Source Family	Rutaceae
Origin	Kurti region of Manus Island, Papua New Guinea
Plant Part Used	Bark
Extract	Ethyl acetate
Target Bacteria	Mycobacterium tuberculosis H37Ra (ATCC 25177)
Assay / Test Done	MTT assay
Positive Control Used (conc.)	Rifampin (5 µg/ml), Isoniazid (50 µg/ml)
Inhibition [%]	>= 70 % (50 µg/ml)
Activity [MIC] µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Cough, fever, whooping cough, occasionally used to control fertility in women
PubMed ID [Source Literature]	17350179
Extract Preparation	Soxhlet extracts (hexane, ethyl acetate and methanol in sequence) of bark, stem and leaves
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]	Against Human T cells
Reference(s)	1) Barrows LR, Powan E, Pond CD, Matainaho T.Anti-TB activity of Evodia elleryana bark extract.Fitoterapia. 2007 Apr;78(3):250-2. Epub 2007 Feb 3
Curator	Vikramjitmandal, rachanake

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