BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 6 [TOP]

Compound ID	1923
Compound Structure
Plant Source	Inula racemosa Hook. f. syn. Inula helenium L. Common Name:Elecampane (English), Pushkaramula, Pushkara, Paushkara, Padmapatra, Kaashmira, Kushtha - bheda (Sanskrit)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Root
Extract	Hexane, dichloromethane
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Radiorespirometric Bioassay
Positive Control Used (conc.)	Rifampin (0.25 – 0.125 µg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, lung disorders, cough, expectorant, random screening, bronchitis
PubMed ID [Source Literature]	10364842
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Cantrell CL, Abate L, Fronczek FR, Franzblau SG, Quijano L, Fischer NH.Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa.Planta Med. 1999 May;65(4):351-5 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 2 of 6 [TOP]

Compound ID	1993
Compound Structure
Plant Source	Lantana trifolia L. Common Name:Shrub Verbena
Source Family	Verbenaceae
Origin	America, Kenya
Plant Part Used	Leaf
Extract	Hexane, dichloromethane
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Heart problems, gonorrhea, tuberculosis, coughs
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) LEITAO, Suzana G. et al. Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test. Rev. bras. farmacogn. [online]. 2006, vol.16, n.1, pp. 6-11
Curator

Record - 3 of 6 [TOP]

Compound ID	2066
Compound Structure
Plant Source	Lippia lacunosa Common Name:
Source Family	Verbenaceae
Origin	USA
Plant Part Used	Leaf
Extract	Hexane, dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294 H37Rv)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) LEITAO, Suzana G. et al. Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test. Rev. bras. farmacogn. [online]. 2006, vol.16, n.1, pp. 6-11
Curator

Record - 4 of 6 [TOP]

Compound ID	2078
Compound Structure
Plant Source	Lippia rotundifolia Common Name:
Source Family	Verbenaceae
Origin	USA
Plant Part Used	Leaf
Extract	Hexane, dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294 H37Rv)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) LEITAO, Suzana G. et al. Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test. Rev. bras. farmacogn. [online]. 2006, vol.16, n.1, pp. 6-11
Curator

Record - 5 of 6 [TOP]

Compound ID

3090

Compound Structure

Plant Source

Prismatomeris fragrans E.T. Geddes Common Name:Khao - San

Source Family

Rubiaceae

Origin

Northeastern, Eastern and Southeastern parts of Thailand and in the Northwest of Laos

Plant Part Used

Root, stem

Extract

Hexane, dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin Sulphate (2.5 µg/ml), Isoniazid (0.05 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Nordamnacanthal

PubChem ID

160712

Ethnomedicinal Information

Antimalarial, antifungal

PubMed ID [Source Literature]

15885942

Extract Preparation

Air dried roots and stems ground and extracted with solvents hexane and dichloromethane

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Quinone, Phenol, Aldehyde

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Against human epidermoid carcinoma in the mouth (KB), human breast cancer cells (BC), human lung cancer cells (NCI - H187)

Molecular Weight

268.037

Molecular Formula

C₁₅H₈O₅

SMILES

Oc1c2c(C(=O)c3c(C2=O)cccc3)cc(O)c1C=O

XLogP

2.235

PSA

91.670

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Kanokmedhakul K, Kanokmedhakul S, Phatchana R.Biological activity of Anthraquinones and Triterpenoids from Prismatomeris fragrans.J Ethnopharmacol. 2005 Sep 14;100(3):284-8

Curator

KeyaMukherjee

Record - 6 of 6 [TOP]