BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 3 [TOP]

Compound ID

2274

Compound Structure

Plant Source

Oplopanax horridus Smith Miq. Common Name:Devil's Club

Source Family

Araliaceae

Origin

USA

Plant Part Used

Inner bark

Extract

Methanol, dichloromethane

Target Bacteria

Mycobacterium tuberculosis, Mycobacterium avium

Assay / Test Done

Disk Diffusion Assay

Positive Control Used (conc.)

Isoniazid (100 µg/disk)

Inhibition [%]

100 %

Activity [MIC] µg/ml

100 µg/disk

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Falcarindiol

PubChem ID

6436239

Ethnomedicinal Information

Diabetes, rheumatism, tuberculosis, colds, headaches and lung ailments

PubMed ID [Source Literature]

9392889

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Alkyne, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

260.178

Molecular Formula

C₁₇H₂₄O₂

SMILES

O[C@@H](/C=CCCCCCCC)C#CC#C[C@@H](O)C=C

XLogP

4.573

PSA

40.460

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Kobaisy M, Abramowski Z, Lermer L, Saxena G, Hancock RE, Towers GH, Doxsee D, Stokes RW.Antimycobacterial polyynes of Devils Club (Oplopanax horridus), a North American native medicinal plant.J Nat Prod. 1997 Nov;60(11):1210-3

2) Turner, N. J., L. C. Thompson, M. T. Thompson and A. Z. York. 1990. Thompson Ethnobotany: Knowledge and usage of plants by the Thompson Indians of British Columbia. Victoria: Royal British Columbia Museum, Memoir No. 3

Curator

Record - 2 of 3 [TOP]

Compound ID

2275

Compound Structure

Plant Source

Oplopanax horridus Smith Miq. Common Name:Devil's Club

Source Family

Araliaceae

Origin

USA

Plant Part Used

Inner bark

Extract

Methanol, dichloromethane

Target Bacteria

Mycobacterium tuberculosis, Mycobacterium avium

Assay / Test Done

Disk Diffusion Assay

Positive Control Used (conc.)

Inhibition [%]

100 %

Activity [MIC] µg/ml

20 µg/disk

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Falcarinol

PubChem ID

5469789

Ethnomedicinal Information

Diabetes, rheumatism, tuberculosis, colds, headaches and lung ailments

PubMed ID [Source Literature]

9392889

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Alkyne, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

244.183

Molecular Formula

C₁₇H₂₄O

SMILES

O[C@H](C#CC#CC/C=CCCCCCCC)C=C

XLogP

6.197

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Kobaisy M, Abramowski Z, Lermer L, Saxena G, Hancock RE, Towers GH, Doxsee D, Stokes RW.Antimycobacterial polyynes of Devils Club (Oplopanax horridus), a North American native medicinal plant.J Nat Prod. 1997 Nov;60(11):1210-3

2) Turner, N. J., L. C. Thompson, M. T. Thompson and A. Z. York. 1990. Thompson Ethnobotany: Knowledge and Usage of Plants by the Thompson Indians of British Columbia. Victoria, British Columbia, Royal British Columbia Museum

Curator

Record - 3 of 3 [TOP]

Compound ID

2276

Compound Structure

Plant Source

Oplopanax horridus Smith Miq. Common Name:Devil's Club

Source Family

Araliaceae

Origin

USA

Plant Part Used

Inner bark

Extract

Methanol, dichloromethane

Target Bacteria

Mycobacterium tuberculosis, Mycobacterium avium

Assay / Test Done

Disk Diffusion Assay

Positive Control Used (conc.)

Isoniazid

Inhibition [%]

Activity [MIC] µg/ml

10 µg/disk

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Oplopandiol

PubChem ID

6474833

Ethnomedicinal Information

Diabetes, rheumatism, tuberculosis, colds, headaches and lung ailments

PubMed ID [Source Literature]

9392889

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Alkyne, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

262.193

Molecular Formula

C₁₇H₂₆O₂

SMILES

O[C@@H](/C=CCCCCCCC)C#CC#C[C@@H](O)CC

XLogP

4.977

PSA

40.460

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Kobaisy M, Abramowski Z, Lermer L, Saxena G, Hancock RE, Towers GH, Doxsee D, Stokes RW.Antimycobacterial polyynes of Devils Club (Oplopanax horridus), a North American native medicinal plant.J Nat Prod. 1997 Nov;60(11):1210-3

2) Turner, N. J., L. C. Thompson, M. T. Thompson and A. Z. York. 1990. Thompson Ethnobotany: Knowledge and Usage of Plants by the Thompson Indians of British Columbia. Victoria, British Columbia, Royal British Columbia Museum

Curator

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