BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 3 Record - 1 of 70 [TOP]

Compound ID	1049
Compound Structure	N/A
Plant Source	Acorus calamus L. var. americanus (Raf.) Common Name:Sweetflag
Source Family	Araceae
Origin	North America
Plant Part Used	Root
Extract
Target Bacteria
Assay / Test Done	Microplate Resazurin Assay (MRA)
Positive Control Used (conc.)	Rifampin (2 and 0.4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Adjuvant, analgesic, antihelmintic, antihemorrhagic, anti-inflammatory, antipyretic, antirheumatic, cold, cough, dermatological, emetic, gastrointestinal, gynaecological, child birth, hallucinogen, panacea, tonic, pediatric, pulmonary, stimulant, venereal infection
PubMed ID [Source Literature]	20657619
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Duncan Webster, Timothy D.G. Lee, Jill MoWebster D, Lee TD, Moore J, Manning T, Kunimoto D, LeBlanc D, Johnson JA, Gray CA.Antimycobacterial screening of traditional medicinal plants using the microplate resazurin assay.Can J Microbiol. 2010 Jun;56(6):487-94
Curator

Record - 2 of 70 [TOP]

Compound ID	1278
Compound Structure
Plant Source	Borago officinalis Linn. Common Name:Borage
Source Family	Boraginaceae
Origin	Europe, North Africa, North America
Plant Part Used	Herb
Extract	Methanol (19.44 %)
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used in pulmonary diseases, consumption and to treat fever
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 3 of 70 [TOP]

Compound ID	1279
Compound Structure
Plant Source	Borago officinalis Linn. Common Name:Borage
Source Family	Boraginaceae
Origin	Europe, North Africa, North America
Plant Part Used	Herb
Extract	Methanol (19.44 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used in pulmonary diseases, consumption and to treat fever
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 4 of 70 [TOP]

Compound ID	1332
Compound Structure
Plant Source	Caesalpinia pulcherrima Common Name:Poinciana, Peacock Flower, Red Bird of Paradise
Source Family	Fabaceae
Origin	Native to Central America, grown widely in South and Southeast Asia
Plant Part Used	Root
Extract
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	6.25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Fever, sores, cough, breathing difficulty and chest pain
PubMed ID [Source Literature]	14531033
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Promsawan N, Kittakoop P, Boonphong S, Nongkunsarn P.Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima.Planta Med. 2003 Aug;69(8):776-7 2) "Taxon: Caesalpinia pulcherrima (L.) Sw.". Germplasm Resources Information Network. United States Department of Agriculture. 2004-03-26 3) S. Allen Counter (2006-07-24). "Amazon mystery: A medicine man understood the secrets of this plant long before we did. How?". The Boston Globe.
Curator

Record - 5 of 70 [TOP]

Compound ID	1333
Compound Structure
Plant Source	Caesalpinia pulcherrima Common Name:Poinciana, Peacock Flower, Red Bird of Paradise
Source Family	Fabaceae
Origin	Native to Central America, grown widely in South and Southeast Asia
Plant Part Used	Root
Extract
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	14531033
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Promsawan N, Kittakoop P, Boonphong S, Nongkunsarn P.Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima.Planta Med. 2003 Aug;69(8):776-7
Curator

Record - 6 of 70 [TOP]

Compound ID	1785
Compound Structure
Plant Source	Galipea officinalis Common Name:Angustura Vera
Source Family	Rutaceae
Origin	South America
Plant Part Used	Bark
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:320 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used to treat diarrhoea and fevers
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91
Curator

Record - 7 of 70 [TOP]

Compound ID

1786

Compound Structure

Plant Source

Galipea officinalis Common Name:Angustura Vera

Source Family

Rutaceae

Origin

South America

Plant Part Used

Bark

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Isoniazid (0.12 µg/ml), Rifampin (0.001 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cusparine

PubChem ID

442893

Ethnomedicinal Information

Used to treat diarrhoea and fevers

PubMed ID [Source Literature]

10232071

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Alkaloid, Quinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

307.121

Molecular Formula

C₁₉H₁₇NO₃

SMILES

O1c2cc(CCc3nc4c(c(OC)c3)cccc4)ccc2OC1

XLogP

4.688

PSA

40.580

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Houghton PJ, Woldemariam TZ, Watanabe Y, Yates M.Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis.Planta Med. 1999 Apr;65(3):250-4

Curator

Record - 8 of 70 [TOP]

Compound ID

1787

Compound Structure

Plant Source

Galipea officinalis Common Name:Angustura Vera

Source Family

Rutaceae

Origin

South America

Plant Part Used

Bark

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Isoniazid (0.12 µg/ml), Rifampin (0.001 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Galipine

PubChem ID

68235

Ethnomedicinal Information

Used to treat diarrhoea and fevers

PubMed ID [Source Literature]

10232071

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Quinoline, Alkaloid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

323.152

Molecular Formula

C₂₀H₂₁NO₃

SMILES

O(c1c2c(nc(CCc3cc(OC)c(OC)cc3)c1)cccc2)C

XLogP

4.761

PSA

40.580

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Houghton PJ, Woldemariam TZ, Watanabe Y, Yates M.Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis.Planta Med. 1999 Apr;65(3):250-4

Curator

Record - 9 of 70 [TOP]

Compound ID

1788

Compound Structure

Plant Source

Galipea officinalis Common Name:Angustura Vera

Source Family

Rutaceae

Origin

South America

Plant Part Used

Bark

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Isoniazid (0.12 µg/ml), Rifampin (0.001 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

4 - Methoxy - 2 - N - Pentylquinoleine

PubChem ID

3009247

Ethnomedicinal Information

Used to treat diarrhoea and fevers

PubMed ID [Source Literature]

10232071

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Alkyl, Alkaloid, Quinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

229.147

Molecular Formula

C₁₅H₁₉NO

SMILES

O(c1cc(nc2c1cccc2)CCCCC)C

XLogP

5.146

PSA

22.120

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Houghton PJ, Woldemariam TZ, Watanabe Y, Yates M.Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis.Planta Med. 1999 Apr;65(3):250-4

Curator

Record - 10 of 70 [TOP]

Compound ID

1789

Compound Structure

Plant Source

Galipea officinalis Common Name:Angustura Vera

Source Family

Rutaceae

Origin

South America

Plant Part Used

Bark

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Isoniazid (0.12 µg/ml), Rifampin (0.001 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

N - Methyl - 2 - Quinolone

PubChem ID

11820

Ethnomedicinal Information

Used to treat diarrhoea and fevers

PubMed ID [Source Literature]

10232071

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Quinolone, Alkaloid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

159.068

Molecular Formula

C₁₀H₉NO

SMILES

O=c1n(c2c(cc1)cccc2)C

XLogP

2.261

PSA

17.070

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Houghton PJ, Woldemariam TZ, Watanabe Y, Yates M.Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis.Planta Med. 1999 Apr;65(3):250-4

Curator

Record - 11 of 70 [TOP]

Compound ID

1876

Compound Structure

Plant Source

Hydrastis canadensis Common Name:Goldenseal

Source Family

Ranunculaceae

Origin

North America

Plant Part Used

Root

Extract

Ethanol

Target Bacteria

Mycobacterium smegmatis (ATCC 607)

Assay / Test Done

Positive Control Used (conc.)

Streptomycin sulfate (1.56 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Berberine

PubChem ID

2353

Ethnomedicinal Information

Berberine has been demonstrated to reduce the infectivity of bacteria, fungi and protozoa in animals and humans by inhibiting the adherence of microorganisms to the host cells

PubMed ID [Source Literature]

9784149, 4906191

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

336.124

Molecular Formula

C₂₀H₁₈NO₄

SMILES

O1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1

XLogP

2.896

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gentry EJ, Jampani HB, Keshavarz-Shokri A, Morton MD, Velde DV, Telikepalli H, Mitscher LA, Shawar R, Humble D, Baker W.Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2.J Nat Prod. 1998 Oct;61(10):1187-93

2) Amin AH, Subbaiah TV, Abbasi KM.Berberine sulfate: antimicrobial activity, bioassay, and mode of action.Can J Microbiol. 1969 Sep;15(9):1067-76

Curator

Record - 12 of 70 [TOP]

Compound ID

1877

Compound Structure

Plant Source

Hydrastis canadensis Common Name:Goldenseal

Source Family

Ranunculaceae

Origin

North America

Plant Part Used

Root

Extract

Ethanol

Target Bacteria

Mycobacterium bovis (BCG - Bacillus Calmette Guerin)

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Berberine

PubChem ID

2353

Ethnomedicinal Information

Berberine has been demonstrated to reduce the infectivity of bacteria, fungi and protozoa in animals and humans by inhibiting the adherence of microorganisms to the host cells

PubMed ID [Source Literature]

9784149, 4906191

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

336.124

Molecular Formula

C₂₀H₁₈NO₄

SMILES

O1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1

XLogP

2.896

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 13 of 70 [TOP]

Compound ID

1878

Compound Structure

Plant Source

Hydrastis canadensis Common Name:Goldenseal

Source Family

Ranunculaceae

Origin

North America

Plant Part Used

Root

Extract

Ethanol

Target Bacteria

Mycobacterium avium complex

Assay / Test Done

Positive Control Used (conc.)

Streptomycin sulfate (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Berberine

PubChem ID

2353

Ethnomedicinal Information

Berberine has been demonstrated to reduce the infectivity of bacteria, fungi and protozoa in animals and humans by inhibiting the adherence of microorganisms to the host cells

PubMed ID [Source Literature]

9784149, 4906191

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

336.124

Molecular Formula

C₂₀H₁₈NO₄

SMILES

O1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1

XLogP

2.896

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 14 of 70 [TOP]

Compound ID

1931

Compound Structure

Plant Source

Ipomoea leptophylla Common Name:Bush Morning Glory, Manroot

Source Family

Convolvulaceae

Origin

North America

Plant Part Used

Leaf

Extract

Soluble extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

BACTEC 460 radiometric system

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

NR (inactive)

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Operculinic acid

PubChem ID

44584575

Ethnomedicinal Information

Treatment for stomach troubles, tuberculosis

PubMed ID [Source Literature]

14640518

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Fatty acid, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

1018.520

Molecular Formula

C₄₆H₈₂O₂₄

SMILES

O([C@@H]1O[C@H]([C@H](O[C@@H]2O[C@H]([C@H](O)[C@@H](O)[C@H]2O)C)[C@@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO)C)[C@@H]1[C@@H](O)[C@@H](O)[C@@H](O[C@H]1C)O[C@@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]1O[C@H](CCCCCCCCCC(=O)O)CCCCC)C

XLogP

1.041

PSA

372.360

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Barnes CC, Smalley MK, Manfredi KP, Kindscher K, Loring H, Sheeley DM.Characterization of an anti-tuberculosis resin glycoside from the prairie medicinal plant Ipomoea leptophylla.J Nat Prod. 2003 Nov;66(11):1457-62

Curator

Record - 15 of 70 [TOP]

Compound ID

1932

Compound Structure

Plant Source

Ipomoea leptophylla Common Name:Bush Morning Glory, Manroot

Source Family

Convolvulaceae

Origin

North America

Plant Part Used

Leaf

Extract

Soluble extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

BACTEC 460 radiometric system

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Trans - Cinnamic Acid

PubChem ID

444539

Ethnomedicinal Information

Treatment for stomach troubles, tuberculosis

PubMed ID [Source Literature]

14640518

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkene, Acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

148.052

Molecular Formula

C₉H₈O₂

SMILES

OC(=O)/C=C/c1ccccc1

XLogP

3.904

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 16 of 70 [TOP]

Compound ID

1933

Compound Structure

Plant Source

Ipomoea leptophylla Common Name:Bush Morning Glory, Manroot

Source Family

Convolvulaceae

Origin

North America

Plant Part Used

Leaf

Extract

Soluble extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

BACTEC 460 radiometric system

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Propanoic acid

PubChem ID

1032

Ethnomedicinal Information

Treatment for stomach troubles, tuberculosis

PubMed ID [Source Literature]

14640518

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

74.037

Molecular Formula

C₃H₆O₂

SMILES

OC(=O)CC

XLogP

0.173

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 17 of 70 [TOP]

Compound ID

1934

Compound Structure

Plant Source

Ipomoea leptophylla Common Name:Bush Morning Glory, Manroot

Source Family

Convolvulaceae

Origin

North America

Plant Part Used

Leaf

Extract

Soluble extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

BACTEC 460 radiometric system

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Lauric acid

PubChem ID

3893

Ethnomedicinal Information

Treatment for stomach troubles, tuberculosis

PubMed ID [Source Literature]

14640518

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Fatty acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

200.178

Molecular Formula

C₁₂H₂₄O₂

SMILES

OC(=O)CCCCCCCCCCC

XLogP

5.294

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 18 of 70 [TOP]

Compound ID	1993
Compound Structure
Plant Source	Lantana trifolia L. Common Name:Shrub Verbena
Source Family	Verbenaceae
Origin	America, Kenya
Plant Part Used	Leaf
Extract	Hexane, dichloromethane
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Heart problems, gonorrhea, tuberculosis, coughs
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) LEITAO, Suzana G. et al. Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test. Rev. bras. farmacogn. [online]. 2006, vol.16, n.1, pp. 6-11
Curator

Record - 19 of 70 [TOP]

Compound ID	1994
Compound Structure
Plant Source	Lantana trifolia L. Common Name:Shrub Verbena
Source Family	Verbenaceae
Origin	America, Kenya
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2, 1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Heart problems, gonorrhea, tuberculosis, coughs
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
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Record - 20 of 70 [TOP]

Compound ID	1995
Compound Structure
Plant Source	Lantana trifolia L. Common Name:Shrub Verbena
Source Family	Verbenaceae
Origin	America, Kenya
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium kansasii
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2, 1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Heart problems, gonorrhea, tuberculosis, coughs
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 21 of 70 [TOP]

Compound ID	1996
Compound Structure
Plant Source	Lantana trifolia L. Common Name:Shrub Verbena
Source Family	Verbenaceae
Origin	America, Kenya
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium fortuitum
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2, 1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Heart problems, gonorrhea, tuberculosis, coughs
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 22 of 70 [TOP]

Compound ID	1997
Compound Structure
Plant Source	Lantana trifolia L. Common Name:Shrub Verbena
Source Family	Verbenaceae
Origin	America, Kenya
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2,1 & 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Heart problems, gonorrhea, tuberculosis, coughs
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 23 of 70 [TOP]

Compound ID	2161
Compound Structure
Plant Source	Mentha piperita L emend Huds. Common Name:Peppermint, Brandy Mint (English), Vilaayati Pudinaa (Sanskrit)
Source Family	Labiatae
Origin	India, cultivated widely particularly in Europe and America
Plant Part Used	Leaf
Extract	Methanol (19.65 %)
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic, antiviral, inhaled for chest complaints, ingredient of some cough and cold remedies.
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 24 of 70 [TOP]

Compound ID	2162
Compound Structure
Plant Source	Mentha piperita L emend Huds. Common Name:Peppermint, Brandy Mint (English), Vilaayati Pudinaa (Sanskrit)
Source Family	Labiatae
Origin	India, cultivated widely particularly in Europe and America
Plant Part Used	Leaf
Extract	Methanol (19.65 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic, antiviral, inhaled for chest complaints, ingredient of some cough and cold remedies.
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 25 of 70 [TOP]

Compound ID

2298

Compound Structure

Plant Source

Pedilanthus tithymaloides Common Name:Devil's Backbone, Zigzag Plant, Jacob's Ladder

Source Family

Euphorbiaceae

Origin

Thailand, Tropical America

Plant Part Used

Milky juice or latex

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.1 µg/ml), Kanamycin (2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1α, 13β, 14α - trihydroxy - 3β, 7β - dibenzoyloxy - 9β, 15β - diacetoxyjatropha - 5, 11 E - diene

PubChem ID

23642402

Ethnomedicinal Information

Anti - inflammatory, antioxidant, anti - malaria

PubMed ID [Source Literature]

17844996

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Diterpene, Jatrophane, Benzoyl, Acetyl

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

678.304

Molecular Formula

C₃₈H₄₆O₁₁

SMILES

O([C@@]12[C@H]([C@@H](OC(=O)c3ccccc3)[C@H]([C@@H]1O)C)/C=C([C@H](OC(=O)c1ccccc1)C[C@H](OC(=O)C)C(/C=C/[C@](O)([C@H]2O)C)(C)C)/C)C(=O)C

XLogP

6.947

PSA

165.890

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Mongkolvisut W, Sutthivaiyakit S.Antimalarial and antituberculous poly-O-acylated jatrophane diterpenoids from Pedilanthus tithymaloides.J Nat Prod. 2007 Sep;70(9):1434-8

2) http://www.flowersofIndia.net/catalog/slides/Devil%27s%20Backbone.html

Curator

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