BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 5 [TOP]

Compound ID

3090

Compound Structure

Plant Source

Prismatomeris fragrans E.T. Geddes Common Name:Khao - San

Source Family

Rubiaceae

Origin

Northeastern, Eastern and Southeastern parts of Thailand and in the Northwest of Laos

Plant Part Used

Root, stem

Extract

Hexane, dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin Sulphate (2.5 µg/ml), Isoniazid (0.05 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Nordamnacanthal

PubChem ID

160712

Ethnomedicinal Information

Antimalarial, antifungal

PubMed ID [Source Literature]

15885942

Extract Preparation

Air dried roots and stems ground and extracted with solvents hexane and dichloromethane

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Quinone, Phenol, Aldehyde

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Against human epidermoid carcinoma in the mouth (KB), human breast cancer cells (BC), human lung cancer cells (NCI - H187)

Molecular Weight

268.037

Molecular Formula

C₁₅H₈O₅

SMILES

Oc1c2c(C(=O)c3c(C2=O)cccc3)cc(O)c1C=O

XLogP

2.235

PSA

91.670

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Kanokmedhakul K, Kanokmedhakul S, Phatchana R.Biological activity of Anthraquinones and Triterpenoids from Prismatomeris fragrans.J Ethnopharmacol. 2005 Sep 14;100(3):284-8

Curator

KeyaMukherjee

Record - 2 of 5 [TOP]

Compound ID

3091

Compound Structure

Plant Source

Prismatomeris fragrans E.T. Geddes Common Name:Khao - San

Source Family

Rubiaceae

Origin

Northeastern, Eastern and Southeastern parts of Thailand and in the Northwest of Laos

Plant Part Used

Root, stem

Extract

Hexane, dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin Sulphate (2.5 µg/ml), Isoniazid (0.05 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Damnacanthal

PubChem ID

2948

Ethnomedicinal Information

Antimalarial, antifungal

PubMed ID [Source Literature]

15885942

Extract Preparation

Air dried roots and stems ground and extracted with solvents hexane and dichloromethane

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Alkaloid, Anthraquinone, Aldehyde

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Against human epidermoid carcinoma in the mouth (KB), human breast cancer cells (BC), human lung cancer cells (NCI - H187)

Molecular Weight

282.053

Molecular Formula

C₁₆H₁₀O₅

SMILES

O(c1c2c(C(=O)c3c(C2=O)cccc3)cc(O)c1C=O)C

XLogP

2.325

PSA

80.670

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Kanokmedhakul K, Kanokmedhakul S, Phatchana R.Biological activity of Anthraquinones and Triterpenoids from Prismatomeris fragrans.J Ethnopharmacol. 2005 Sep 14;100(3):284-8

Curator

KeyaMukherjee

Record - 3 of 5 [TOP]

Compound ID

3092

Compound Structure

Plant Source

Prismatomeris fragrans E.T. Geddes Common Name:Khao - San

Source Family

Rubiaceae

Origin

Northeastern, Eastern and Southeastern parts of Thailand and in the Northwest of Laos

Plant Part Used

Root, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin Sulphate (2.5 µg/ml), Isoniazid (0.05 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Rubiadin

PubChem ID

124062

Ethnomedicinal Information

Antimalarial, antifungal

PubMed ID [Source Literature]

15885942

Extract Preparation

Air dried roots and stems ground and extracted with solvents hexane and dichloromethane

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Anthraquinone, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Against human epidermoid carcinoma in the mouth (KB), human breast cancer cells (BC), human lung cancer cells (NCI - H187)

Molecular Weight

254.058

Molecular Formula

C₁₅H₁₀O₄

SMILES

Oc1c2c(C(=O)c3c(C2=O)cccc3)cc(O)c1C

XLogP

1.838

PSA

74.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Kanokmedhakul K, Kanokmedhakul S, Phatchana R.Biological activity of Anthraquinones and Triterpenoids from Prismatomeris fragrans.J Ethnopharmacol. 2005 Sep 14;100(3):284-8

Curator

KeyaMukherjee, vsheeba

Record - 4 of 5 [TOP]

Compound ID

3093

Compound Structure

Plant Source

Prismatomeris fragrans E.T. Geddes Common Name:Khao - San

Source Family

Rubiaceae

Origin

Northeastern, Eastern and Southeastern parts of Thailand and in the Northwest of Laos

Plant Part Used

Root, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin Sulphate (2.5 µg/ml), Isoniazid (0.05 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - Hydroxy - 2 - Hydroxymethyl - 3 - Methoxyanthraquinone

PubChem ID

10085264

Ethnomedicinal Information

PubMed ID [Source Literature]

15885942

Extract Preparation

Air dried roots and stems ground and extracted with solvents hexane and dichloromethane

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Anthraquinone, Alcohol, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Against human epidermoid carcinoma in the mouth (KB), human breast cancer cells (BC), human lung cancer cells (NCI - H187)

Molecular Weight

284.068

Molecular Formula

C₁₆H₁₂O₅

SMILES

O(c1c(c(O)c2c(C(=O)c3c(C2=O)cccc3)c1)CO)C

XLogP

1.654

PSA

83.830

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Kanokmedhakul K, Kanokmedhakul S, Phatchana R.Biological activity of Anthraquinones and Triterpenoids from Prismatomeris fragrans.J Ethnopharmacol. 2005 Sep 14;100(3):284-8

Curator

KeyaMukherjee, vsheeba

Record - 5 of 5 [TOP]

Compound ID

3094

Compound Structure

Plant Source

Prismatomeris fragrans E.T. Geddes Common Name:Khao - San

Source Family

Rubiaceae

Origin

Northeastern, Eastern and Southeastern parts of Thailand and in the Northwest of Laos

Plant Part Used

Root, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin Sulphate (2.5 µg/ml), Isoniazid (0.07 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

3 - β - Acetylolean - 12 - En - 28 - Olic Acid

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

15885942

Extract Preparation

Air dried roots and stems ground and extracted with solvents hexane and dichloromethane

Chemical Classification [Active Compound]

Aromatic, Pentacyclic, Terpene, Triterpene, O-Acetyl, Acid

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Against human epidermoid carcinoma in the mouth (KB), human breast cancer cells (BC), human lung cancer cells (NCI - H187)

Molecular Weight

498.371

Molecular Formula

C₃₂H₅₀O₄

SMILES

C1C[C@@H](C(C2[C@]1(C1[C@@](CC2)(C2(C(=CC1)C1[C@@](CC2)(CCC(C1)(C)C)C(=O)O)C)C)C)(C)C)OC(=O)C

XLogP

9.792

PSA

63.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Kanokmedhakul K, Kanokmedhakul S, Phatchana R.Biological activity of Anthraquinones and Triterpenoids from Prismatomeris fragrans.J Ethnopharmacol. 2005 Sep 14;100(3):284-8

Curator

KeyaMukherjee, vsheeba

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