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                  Page - 1 of 2                  Record - 1 of 26   [TOP]
Compound ID3361
Compound Structure
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Plant SourceAmyris elemifera     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 100 µg/ml, 7H11 agar: 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedHeraclenol
PubChem ID   328236
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Tricyclic, Coumarin, Benzofuranoid, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight304.095
Molecular FormulaC16H16O6
SMILESO(CC(O)C(O)(C)C)c1c2occc2cc2c1oc(=O)cc2
XLogP1.710
PSA79.900
H-bond Donor2
H-bond Acceptor5
No. of Rotatable Bond Count4
No. of Rings3
No. of N0
No. of O6
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 2 of 26   [TOP]
Compound ID3362
Compound Structure
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Plant SourceAmyris elemifera     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium avium 733
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 100 µg/ml, 7H11 agar: 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedHeraclenol
PubChem ID   328236
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Tricyclic, Coumarin, Benzofuranoid, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight304.095
Molecular FormulaC16H16O6
SMILESO(CC(O)C(O)(C)C)c1c2occc2cc2c1oc(=O)cc2
XLogP1.710
PSA79.900
H-bond Donor2
H-bond Acceptor5
No. of Rotatable Bond Count4
No. of Rings3
No. of N0
No. of O6
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 3 of 26   [TOP]
Compound ID3363
Compound Structure
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Plant SourceAmyris elemifera     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium kansasii (Clinical isolate 94 - 069)
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedHeraclenol
PubChem ID   328236
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Tricyclic, Coumarin, Benzofuranoid, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight304.095
Molecular FormulaC16H16O6
SMILESO(CC(O)C(O)(C)C)c1c2occc2cc2c1oc(=O)cc2
XLogP1.710
PSA79.900
H-bond Donor2
H-bond Acceptor5
No. of Rotatable Bond Count4
No. of Rings3
No. of N0
No. of O6
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 4 of 26   [TOP]
Compound ID3364
Compound Structure
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Plant SourceAmyris elemifera     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 25 µg/ml, 7H11 agar: 25 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedTexalin
PubChem ID   473253
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine, Oxazole, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight266.069
Molecular FormulaC15H10N2O3
SMILESO1c2c(OC1)ccc(c2)c1oc(nc1)c1cccnc1
XLogP2.463
PSA57.380
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings4
No. of N2
No. of O3
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 5 of 26   [TOP]
Compound ID3365
Compound Structure
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Plant SourceAmyris elemifera     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium avium 733
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 25 µg/ml, 7H11 agar: 50 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedTexalin
PubChem ID   473253
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine, Oxazole, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight266.069
Molecular FormulaC15H10N2O3
SMILESO1c2c(OC1)ccc(c2)c1oc(nc1)c1cccnc1
XLogP2.463
PSA57.380
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings4
No. of N2
No. of O3
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 6 of 26   [TOP]
Compound ID3366
Compound Structure
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Plant SourceAmyris elemifera     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium kansasii (Clinical isolate 94 - 069)
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 25 µg/ml, 7H11 agar: 50 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedTexalin
PubChem ID   473253
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine, Oxazole, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight266.069
Molecular FormulaC15H10N2O3
SMILESO1c2c(OC1)ccc(c2)c1oc(nc1)c1cccnc1
XLogP2.463
PSA57.380
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings4
No. of N2
No. of O3
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 7 of 26   [TOP]
Compound ID3367
Compound Structure
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Plant SourceCanella winterana     Common Name:NR
Source FamilyCanellaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 100 µg/ml, 7H11 agar: 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCanellal
PubChem ID   325604
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Sesquiterpene, Aldehyde, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight248.141
Molecular FormulaC15H20O3
SMILESOC1(C2(C(C(=C)C(CC2)C)CC=C1C=O)C)C=O
XLogP2.567
PSA54.370
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 8 of 26   [TOP]
Compound ID3368
Compound Structure
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Plant SourceCanella winterana     Common Name:NR
Source FamilyCanellaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium avium 733
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCanellal
PubChem ID   325604
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Sesquiterpene, Aldehyde, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight248.141
Molecular FormulaC15H20O3
SMILESOC1(C2(C(C(=C)C(CC2)C)CC=C1C=O)C)C=O
XLogP2.567
PSA54.370
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 9 of 26   [TOP]
Compound ID3369
Compound Structure
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Plant SourceCanella winterana     Common Name:NR
Source FamilyCanellaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium kansasii (Clinical isolate 94 - 069)
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 100 µg/ml, 7H11 agar: 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCanellal
PubChem ID   325604
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Sesquiterpene, Aldehyde, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight248.141
Molecular FormulaC15H20O3
SMILESOC1(C2(C(C(=C)C(CC2)C)CC=C1C=O)C)C=O
XLogP2.567
PSA54.370
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings2
No. of N0
No. of O3
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 10 of 26   [TOP]
Compound ID3373
Compound Structure
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Plant SourcePhysalis angulata L.     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedFresh leaf
Extract25 % NH4OH, 2 % HCl
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)0.1 ml of aliquot from each of the 10 - fold dilutions
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedPilocarpin
PubChem IDNR
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Alkaloid, Lactone, Imidazole
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight208.121
Molecular FormulaC11H16N2O2
SMILESO1C(=O)C(C(C1)Cc1n(cnc1)C)CC
XLogP1.307
PSA44.120
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 11 of 26   [TOP]
Compound ID3374
Compound Structure
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Plant SourcePhysalis angulata L.     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedFresh leaf
Extract25 % NH4OH, 2 % HCl
Target BacteriaMycobacterium avium 733
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)0.1 ml of aliquot from each of the 10 - fold dilutions
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedPilocarpin
PubChem IDNR
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Alkaloid, Lactone, Imidazole
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight208.121
Molecular FormulaC11H16N2O2
SMILESO1C(=O)C(C(C1)Cc1n(cnc1)C)CC
XLogP1.307
PSA44.120
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 12 of 26   [TOP]
Compound ID3376
Compound Structure
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Plant SourceRauwolfia biauriculata     Common Name:NR
Source FamilyApocynaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/ml Bactec: 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedLochnerin
PubChem ID   6436184
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Indole, Alkaloid, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight324.184
Molecular FormulaC20H24N2O2
SMILESOC[C@H]1[C@H]2N3[C@@H](C[C@H]1/C(=CC)/C3)c1[nH]c3c(c1C2)cc(OC)cc3
XLogP1.784
PSA48.490
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings3
No. of N2
No. of O2
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 13 of 26   [TOP]
Compound ID3377
Compound Structure
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Plant SourceRauwolfia biauriculata     Common Name:NR
Source FamilyApocynaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium avium 733
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedLochnerin
PubChem ID   6436184
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Indole, Alkaloid, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight324.184
Molecular FormulaC20H24N2O2
SMILESOC[C@H]1[C@H]2N3[C@@H](C[C@H]1/C(=CC)/C3)c1[nH]c3c(c1C2)cc(OC)cc3
XLogP1.784
PSA48.490
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings3
No. of N2
No. of O2
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 14 of 26   [TOP]
Compound ID3378
Compound Structure
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Plant SourceRauwolfia biauriculata     Common Name:NR
Source FamilyApocynaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium kansasii (Clinical isolate 94 - 069)
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedLochnerin
PubChem ID   6436184
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Indole, Alkaloid, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight324.184
Molecular FormulaC20H24N2O2
SMILESOC[C@H]1[C@H]2N3[C@@H](C[C@H]1/C(=CC)/C3)c1[nH]c3c(c1C2)cc(OC)cc3
XLogP1.784
PSA48.490
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings3
No. of N2
No. of O2
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 15 of 26   [TOP]
Compound ID3379
Compound Structure
DOWNLOAD:
Plant SourceTabernaemontana citrifolia     Common Name:NR
Source FamilyApocynaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium avium 733
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedIbogaine
PubChem ID   197060
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Pentacyclic, Alkaloid, Indole, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight310.205
Molecular FormulaC20H26N2O
SMILESO(c1cc2c3c([nH]c2cc1)[C@H]1[C@H]2N(C[C@@H](C1)C[C@@H]2CC)CC3)C
XLogP3.580
PSA28.260
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings3
No. of N2
No. of O1
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorVikramjitmandal, rachanake

                  Record - 16 of 26   [TOP]
Compound ID3380
Compound Structure
DOWNLOAD:
Plant SourceTabernaemontana citrifolia     Common Name:NR
Source FamilyApocynaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium kansasii (Clinical isolate 94 - 069)
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 100 µg/ml, 7H11 agar: 100 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedVoacangine
PubChem ID   73255
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Indole, Alkaloid, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight368.210
Molecular FormulaC22H28N2O3
SMILESO(C(=O)[C@]12[C@H]3N(C[C@H](C1)C[C@@H]3CC)CCc1c2[nH]c2c1cc(OC)cc2)C
XLogP3.286
PSA54.560
H-bond Donor1
H-bond Acceptor5
No. of Rotatable Bond Count4
No. of Rings3
No. of N2
No. of O3
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorVikramjitmandal, rachanake

                  Record - 17 of 26   [TOP]
Compound ID3381
Compound Structure
DOWNLOAD:
Plant SourceTabernaemontana citrifolia     Common Name:NR
Source FamilyApocynaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 50 µg/ml, 7H11 agar: 50 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedVoacangine
PubChem ID   73255
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Indole, Alkaloid, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight368.210
Molecular FormulaC22H28N2O3
SMILESO(C(=O)[C@]12[C@H]3N(C[C@H](C1)C[C@@H]3CC)CCc1c2[nH]c2c1cc(OC)cc2)C
XLogP3.286
PSA54.560
H-bond Donor1
H-bond Acceptor5
No. of Rotatable Bond Count4
No. of Rings3
No. of N2
No. of O3
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorVikramjitmandal, rachanake

                  Record - 18 of 26   [TOP]
Compound ID3382
Compound Structure
DOWNLOAD:
Plant SourceTabernaemontana citrifolia     Common Name:NR
Source FamilyApocynaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium avium 733
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 50 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedVoacangine
PubChem ID   73255
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Indole, Alkaloid, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight368.210
Molecular FormulaC22H28N2O3
SMILESO(C(=O)[C@]12[C@H]3N(C[C@H](C1)C[C@@H]3CC)CCc1c2[nH]c2c1cc(OC)cc2)C
XLogP3.286
PSA54.560
H-bond Donor1
H-bond Acceptor5
No. of Rotatable Bond Count4
No. of Rings3
No. of N2
No. of O3
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorVikramjitmandal, rachanake

                  Record - 19 of 26   [TOP]
Compound ID3383
Compound Structure
DOWNLOAD:
Plant SourceTabernaemontana citrifolia     Common Name:NR
Source FamilyApocynaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium kansasii (Clinical isolate 94 - 069)
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 50 µg/ml, 7H11 agar: 50 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedIbogaine
PubChem ID   197060
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Pentacyclic, Alkaloid, Indole, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight310.205
Molecular FormulaC20H26N2O
SMILESO(c1cc2c3c([nH]c2cc1)[C@H]1[C@H]2N(C[C@@H](C1)C[C@@H]2CC)CC3)C
XLogP3.580
PSA28.260
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings3
No. of N2
No. of O1
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorVikramjitmandal, rachanake

                  Record - 20 of 26   [TOP]
Compound ID3385
Compound Structure
DOWNLOAD:
Plant SourceTriphasia trifolia     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractChloroform
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 100 µg/ml, 7H11 agar: 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedIsomeranzin
PubChem ID   473252
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Bicyclic, Coumarin, Ketone, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight260.105
Molecular FormulaC15H16O4
SMILESO1c2c(CC(=O)C(C)C)c(OC)ccc2ccc1=O
XLogP2.615
PSA43.370
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings2
No. of N0
No. of O4
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 21 of 26   [TOP]
Compound ID3386
Compound Structure
DOWNLOAD:
Plant SourceTriphasia trifolia     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractChloroform
Target BacteriaMycobacterium avium 733
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedIsomeranzin
PubChem ID   473252
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Bicyclic, Coumarin, Ketone, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight260.105
Molecular FormulaC15H16O4
SMILESO1c2c(CC(=O)C(C)C)c(OC)ccc2ccc1=O
XLogP2.615
PSA43.370
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings2
No. of N0
No. of O4
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 22 of 26   [TOP]
Compound ID3387
Compound Structure
DOWNLOAD:
Plant SourceTriphasia trifolia     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractChloroform
Target BacteriaMycobacterium kansasii (Clinical isolate 94 - 069)
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedIsomeranzin
PubChem ID   473252
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Bicyclic, Coumarin, Ketone, Ether
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight260.105
Molecular FormulaC15H16O4
SMILESO1c2c(CC(=O)C(C)C)c(OC)ccc2ccc1=O
XLogP2.615
PSA43.370
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings2
No. of N0
No. of O4
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 23 of 26   [TOP]
Compound ID3529
Compound StructureNR
Plant SourceCanella winterana     Common Name:NR
Source FamilyCanellaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCanella oil (Mixture)
PubChem IDNR
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by Chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with Chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Mixture
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 24 of 26   [TOP]
Compound ID3530
Compound StructureNR
Plant SourceCanella winterana     Common Name:NR
Source FamilyCanellaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium avium 733
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCanella oil (Mixture)
PubChem IDNR
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by Chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with Chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Mixture
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 25 of 26   [TOP]
Compound ID3531
Compound StructureNR
Plant SourceCanella winterana     Common Name:NR
Source FamilyCanellaceae
OriginGuadeloupe
Plant Part UsedNR
ExtractNR
Target BacteriaMycobacterium kansasii (Clinical isolate 94 - 069)
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCanella oil (Mixture)
PubChem IDNR
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by Chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with Chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Mixture
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachana-ke


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