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                  Page - 1 of 1                  Record - 1 of 4   [TOP]
Compound ID3715
Compound Structure
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Plant SourceHarrisonia perforata     Common Name:
Source FamilySimaroubaceae
OriginHainan, Cambodia, Cochin, China, Burma and West Malaysia
Plant Part UsedBranch
ExtractEthanol (95 %)
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.04 - 0.09 µg/ml), Kanamycin sulphate (2.0 - 5.1 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedPeucenin - 7 - Methyl Ether
PubChem IDNR
Ethnomedicinal InformationAntimalarial activity, Tuberculosis
PubMed ID [Source Literature]16394547
Extract PreparationThe branches of Harrisonia perforata (5.1 kg) were extracted with 95 % EtOH at room temperature. The ethanolic extract was filtered and evaporated to a dark brown viscous oil (186.3 g). The extract was partitioned between water (500 ml) and EtOAc (3 x 500 ml) and the water layer was further extracted with n-BuOH (3 x 400 ml). After evaporation, the EtOAc-, n-BuOH- and water - soluble fractions gave a brown viscous oil (69.8 g), a dark brown viscous oil (25.7 g) and a light brown viscous oil (50.8 g), respectively. The ethyl acetate soluble fraction is separated by flash column chromatography using silica gel
Chemical Classification [Active Compound]Aromatic, Bicyclic, Chromone, Prenylated, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight274.121
Molecular FormulaC16H18O4
SMILESC1(c(c(cc2c1c(=O)cc(o2)C)OC)CC=C(C)C)O
XLogP1.989
PSA46.530
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count3
No. of Rings2
No. of N0
No. of O4
No. of S0
Reference(s)1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chromones from the branches of Harrisonia perforata.Chem Pharm Bull (Tokyo). 2006 Jan;54(1):44-7

CuratorVikramjitmandal, Reshmi

                  Record - 2 of 4   [TOP]
Compound ID3717
Compound Structure
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Plant SourceHarrisonia perforata     Common Name:
Source FamilySimaroubaceae
OriginHainan, Cambodia, Cochin, China, Burma and West Malaysia
Plant Part UsedBranch
ExtractEthanol (95 %)
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.04 - 0.09 µg/ml), Kanamycin sulphate (2.0 - 5.3 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedPerforamone A
PubChem ID   11572850
Ethnomedicinal InformationAntimalarial activity
PubMed ID [Source Literature]16394547
Extract PreparationThe branches of Harrisonia perforata (5.1 kg) were extracted with 95 % EtOH at room temperature. The ethanolic extract was filtered and evaporated to a dark brown viscous oil (186.3 g). The extract was partitioned between water (500 ml) and EtOAc (3 x 500 ml) and the water layer was further extracted with n-BuOH (3 x 400 ml). After evaporation, the EtOAc-, n-BuOH- and water - soluble fractions gave a brown viscous oil (69.8 g), a dark brown viscous oil (25.7 g) and a light brown viscous oil (50.8 g), respectively. The ethyl acetate soluble fraction is separated by flash column chromatography using silica gel
Chemical Classification [Active Compound]Aromatic, Bicyclic, Chromone, Epoxy, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight290.115
Molecular FormulaC16H18O5
SMILESO1C(C1Cc1c2oc(cc(=O)c2c(O)cc1OC)C)(C)C
XLogP1.056
PSA59.060
H-bond Donor1
H-bond Acceptor4
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chromones from the branches of Harrisonia perforata.Chem Pharm Bull (Tokyo). 2006 Jan;54(1):44-7

CuratorVikramjitmandal, Reshmi

                  Record - 3 of 4   [TOP]
Compound ID3718
Compound Structure
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Plant SourceHarrisonia perforata     Common Name:
Source FamilySimaroubaceae
OriginHainan, Cambodia, Cochin, China, Burma and West Malaysia
Plant Part UsedBranch
ExtractEthanol (95 %)
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.04 - 0.09 µg/ml), Kanamycin sulphate (2.0 - 5.4 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedPerforamone B
PubChem ID   11608981
Ethnomedicinal InformationAntimalarial activity
PubMed ID [Source Literature]16394547
Extract PreparationThe branches of Harrisonia perforata (5.1 kg) were extracted with 95 % EtOH at room temperature. The ethanolic extract was filtered and evaporated to a dark brown viscous oil (186.3 g). The extract was partitioned between water (500 ml) and EtOAc (3 x 500 ml) and the water layer was further extracted with n-BuOH (3 x 400 ml). After evaporation, the EtOAc-, n-BuOH- and water - soluble fractions gave a brown viscous oil (69.8 g), a dark brown viscous oil (25.7 g) and a light brown viscous oil (50.8 g), respectively. The ethyl acetate soluble fraction is separated by flash column chromatography using silica gel
Chemical Classification [Active Compound]Aromatic, Bicyclic, Chromone, Ether, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight290.115
Molecular FormulaC16H18O5
SMILESO1c2c(C(O)CC(=C)C)c(OC)cc(O)c2c(=O)cc1C
XLogP0.558
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count4
No. of Rings2
No. of N0
No. of O5
No. of S0
Reference(s)1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chromones from the branches of Harrisonia perforata.Chem Pharm Bull (Tokyo). 2006 Jan;54(1):44-7

CuratorVikramjitmandal, Reshmi

                  Record - 4 of 4   [TOP]
Compound ID3722
Compound Structure
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Plant SourceHarrisonia perforata     Common Name:
Source FamilySimaroubaceae
OriginHainan, Cambodia, Cochin, China, Burma and West Malaysia
Plant Part UsedBranch
ExtractEthanol (95 %)
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.8 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedGreveichromenol
PubChem IDNR
Ethnomedicinal InformationAntimalarial activity, Tuberculosis
PubMed ID [Source Literature]16394547
Extract PreparationThe branches of Harrisonia perforata (5.1 kg) were extracted with 95 % EtOH at room temperature. The ethanolic extract was filtered and evaporated to a dark brown viscous oil (186.3 g). The extract was partitioned between water (500 ml) and EtOAc (3 x 500 ml) and the water layer was further extracted with n-BuOH (3 x 400 ml). After evaporation, the EtOAc-, n-BuOH- and water - soluble fractions gave a brown viscous oil (69.8 g), a dark brown viscous oil (25.7 g) and a light brown viscous oil (50.8 g), respectively. The ethyl acetate soluble fraction is separated by flash column chromatography using silica gel
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Benzopyran, Phenol, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight274.084
Molecular FormulaC15H14O5
SMILESO1c(cc(=O)c2c1cc1c(c2O)C=CC(O1)(C)C)CO
XLogP0.339
PSA66.760
H-bond Donor2
H-bond Acceptor4
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chromones from the branches of Harrisonia perforata.Chem Pharm Bull (Tokyo). 2006 Jan;54(1):44-7

CuratorVikramjitmandal, Reshmi


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