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                  Page - 1 of 1                  Record - 1 of 4   [TOP]
Compound ID1657
Compound Structure
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Plant SourceErythrina indica     Common Name:
Source FamilyLeguminosae
OriginIbadan, Nigeria
Plant Part UsedRoot bark
ExtractPhenol
Target BacteriaMycobacterium smegmatis (ATCC 607)
Assay / Test DoneAgar Dilution - Streak Assay
Positive Control Used (conc.)Streptomycin (1.7 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml> 400 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCajanin
PubChem ID   5281706
Ethnomedicinal InformationTrachoma, Elephantiasis, Microbial infections
PubMed ID [Source Literature]10820816
Extract PreparationDried and ground root bark of Erythrina indica was successively extracted with a mixture of dichloro-methane-MeOH (1:1) and methanol. The dichloro-methane-MeOH (1:1) extract was concentrated to dryness
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight300.063
Molecular FormulaC16H12O6
SMILESO1c2c(c(=O)c(c3c(O)cc(O)cc3)c1)c(O)cc(OC)c2
XLogP0.781
PSA86.990
H-bond Donor3
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings3
No. of N0
No. of O6
No. of S0
Reference(s)1) Waffo AK, Azebaze GA, Nkengfack AE, Fomum ZT, Meyer M, Bodo B, van Heerden FR.Indicanines B and C, two isoflavonoid derivatives from the root bark of Erythrina indica.Phytochemistry. 2000 Apr;53(8):981-5

Curator

                  Record - 2 of 4   [TOP]
Compound ID3113
Compound Structure
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Plant SourceErythrina indica     Common Name:Indian Coral Tree (English), Paaribhadra, Paaribhadraka, Paarijaataka, Mandaara (Sanskrit)
Source FamilyLeguminosae
OriginIbadan, Nigeria
Plant Part UsedRoot bark
ExtractPhenol
Target BacteriaMycobacterium smegmatis (ATCC 607)
Assay / Test DoneAgar Dilution - Streak Assay
Positive Control Used (conc.)Streptomycin (1.7 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml18.5 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedIndicanine B
PubChem IDNR
Ethnomedicinal InformationTrachoma, Elephantiasis, Microbial infections
PubMed ID [Source Literature]10820816
Extract PreparationDichloromethane - methanol (1:1)
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Flavonoid, Coumarin, Benzopyran, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight366.110
Molecular FormulaC21H18O6
SMILESO1C(C=Cc2c1cc1c(c2OC)c(c(c(=O)o1)c1ccc(cc1)O)O)(C)C
XLogP4.028
PSA75.990
H-bond Donor2
H-bond Acceptor5
No. of Rotatable Bond Count2
No. of Rings4
No. of N0
No. of O6
No. of S0
Reference(s)1) Waffo AK, Azebaze GA, Nkengfack A E, Fomum ZT, Meyer M, Bodo B, Heerden FR. Indicanines B and C, two isoflavonoids derivatives from the root bark of Erythrina indica. Phytochemistry. 2003;53:981–985. 2000.

CuratorKeyaMukherjee, vsheeba

                  Record - 3 of 4   [TOP]
Compound ID3114
Compound Structure
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Plant SourceErythrina indica     Common Name:NR
Source FamilyFabaceae
OriginIbadan, Nigeria
Plant Part UsedRoot bark
ExtractPhenol
Target BacteriaMycobacterium smegmatis (ATCC 607)
Assay / Test DoneAgar Dilution - Streak Assay
Positive Control Used (conc.)Streptomycin (1.7 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml> 150 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedIndicanine C
PubChem ID   10736576
Ethnomedicinal InformationTrachoma, Elephantiasis, Microbial infections
PubMed ID [Source Literature]10820816
Extract PreparationDichloromethane - methanol (1:1)
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Flavonoid, Benzopyran, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight350.115
Molecular FormulaC21H18O5
SMILESO1C(C=Cc2c1cc1occ(c(=O)c1c2OC)c1ccc(O)cc1)(C)C
XLogP3.144
PSA55.760
H-bond Donor1
H-bond Acceptor4
No. of Rotatable Bond Count2
No. of Rings4
No. of N0
No. of O5
No. of S0
Reference(s)1) Waffo AK, Azebaze GA, Nkengfack A E, Fomum ZT, Meyer M, Bodo B, Heerden FR. Indicanines B and C, two isoflavonoids derivatives from the root bark of Erythrina indica. Phytochemistry. 2003;53:981–985. 2000.

CuratorKeyaMukherjee, vsheeba

                  Record - 4 of 4   [TOP]
Compound ID3115
Compound Structure
DOWNLOAD:
Plant SourceErythrina indica     Common Name:NR
Source FamilyFabaceae
OriginIbadan, Nigeria
Plant Part UsedRoot bark
ExtractNR
Target BacteriaMycobacterium smegmatis (ATCC 607)
Assay / Test DoneAgar Dilution - Streak Assay
Positive Control Used (conc.)Streptomycin (1.7 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml> 450 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedDimethyl Alpinumisoflavone
PubChem ID   10384155
Ethnomedicinal InformationTrachoma, Elephantiasis, Microbial infections
PubMed ID [Source Literature]10820816
Extract PreparationDichloromethane - methanol (1:1)
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Flavonoid, Benzopyran, Ether
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight364.131
Molecular FormulaC22H20O5
SMILESO1C(C=Cc2c1cc1occ(c(=O)c1c2OC)c1ccc(OC)cc1)(C)C
XLogP3.663
PSA44.760
H-bond Donor0
H-bond Acceptor4
No. of Rotatable Bond Count3
No. of Rings4
No. of N0
No. of O5
No. of S0
Reference(s)1) Waffo AK, Azebaze GA, Nkengfack A E, Fomum ZT, Meyer M, Bodo B, Heerden FR. Indicanines B and C, two isoflavonoids derivatives from the root bark of Erythrina indica. Phytochemistry. 2003;53:981–985. 2000.

CuratorKeyaMukherjee, vsheeba


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