BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 9 [TOP]

Compound ID	1763
Compound Structure
Plant Source	Foeniculum vulgare Mill. Common Name:Fennel
Source Family	Apiaceae (Umbelliferae)
Origin	India, Pakistan, Mediterranean region, Mexico, Africa
Plant Part Used	Seed
Extract	Methanol (13.26 %)
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diseases of the chest, cough, fever, respiratory diseases, digestion, over - weight, boosting metabolism as well as for stomach cramps
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) http://www.ageless.co.za/fennel.htm
Curator

Record - 2 of 9 [TOP]

Compound ID	1764
Compound Structure
Plant Source	Foeniculum vulgare Mill. Common Name:Fennel
Source Family	Apiaceae (Umbelliferae)
Origin	India, Pakistan, Mediterranean region, Mexico,Africa
Plant Part Used	Seed
Extract	Methanol (13.26 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diseases of the chest, cough, fever, respiratory diseases,digestion, over - weight, boosting metabolism as well as for stomach cramps
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) http://www.ageless.co.za/fennel.htm
Curator

Record - 3 of 9 [TOP]

Compound ID	1765
Compound Structure
Plant Source	Foeniculum vulgare Mill. Common Name:Fennel
Source Family	Apiaceae (Umbelliferae)
Origin	India, Pakistan, Mediterranean region,Mexico,Africa
Plant Part Used	Aerial
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis H37Rv (Sensitive)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diseases of the chest, cough, fever, respiratory diseases,digestion, over - weight, boosting metabolism as well as for stomach cramps
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75 2) http://www.ageless.co.za/fennel.htm
Curator

Record - 4 of 9 [TOP]

Compound ID	1766
Compound Structure
Plant Source	Foeniculum vulgare Mill. Common Name:Fennel
Source Family	Apiaceae (Umbelliferae)
Origin	India, Pakistan, Mediterranean region, Mexico, Africa
Plant Part Used	Aerial
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis H37Rv (Rifampin resistant), Mycobacterium tuberculosis (Isoniazid resistant), Mycobacterium tuberculosis (Streptomycin resistant), Mycobacterium tuberculosis (Ethambutol resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diseases of the chest, cough, fever, respiratory diseases,digestion, over - weight, boosting metabolism as well as for stomach cramps
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75 2) http://www.ageless.co.za/fennel.htm
Curator

Record - 5 of 9 [TOP]

Compound ID	1767
Compound Structure
Plant Source	Foeniculum vulgare Mill. Common Name:Fennel
Source Family	Apiaceae (Umbelliferae)
Origin	India, Pakistan, Mediterranean region, Mexico, Africa
Plant Part Used	Aerial
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis H37Rv (Sensitive)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diseases of the chest, cough, fever, respiratory diseases,digestion, over - weight, boosting metabolism as well as for stomach cramps
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75 2) http://www.ageless.co.za/fennel.htm
Curator

Record - 6 of 9 [TOP]

Compound ID	1768
Compound Structure
Plant Source	Foeniculum vulgare Mill. Common Name:Fennel
Source Family	Apiaceae (Umbelliferae)
Origin	India, Pakistan, Mediterranean region, Mexico, Africa
Plant Part Used	Aerial
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis H37Rv (Rifampin resistant), Mycobacterium tuberculosis (Isoniazid resistant), Mycobacterium tuberculosis (Streptomycin resistant), Mycobacterium tuberculosis (Ethambutol resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diseases of the chest, cough, fever, respiratory diseases, digestion, over - weight, boosting metabolism as well as for stomach cramps
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75 2) http://www.ageless.co.za/fennel.htm
Curator

Record - 7 of 9 [TOP]

Compound ID	1769
Compound Structure
Plant Source	Foeniculum vulgare Mill. Common Name:Fennel
Source Family	Apiaceae (Umbelliferae)
Origin	India, Pakistan, Mediterranean region, Mexico,Africa
Plant Part Used	Aerial
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (Sensitive)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diseases of the chest, cough, fever, respiratory diseases, digestion, over - weight, boosting metabolism as well as for stomach cramps
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75 2) http://www.ageless.co.za/fennel.htm
Curator

Record - 8 of 9 [TOP]

Compound ID	1770
Compound Structure
Plant Source	Foeniculum vulgare Mill. Common Name:Fennel
Source Family	Apiaceae (Umbelliferae)
Origin	India, Pakistan, Mediterranean region, Mexico, Africa
Plant Part Used	Aerial
Extract	Water
Target Bacteria	Mycobacterium tuberculosis H37Rv (Sensitive)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diseases of the chest, cough, fever, respiratory diseases, digestion, over - weight, boosting metabolism as well as for stomach cramps
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75 2) http://www.ageless.co.za/fennel.htm
Curator

Record - 9 of 9 [TOP]

Compound ID	1771
Compound Structure
Plant Source	Foeniculum vulgare Mill. Common Name:Fennel
Source Family	Apiaceae (Umbelliferae)
Origin	India, Pakistan, Mediterranean region, Mexico, Africa
Plant Part Used	Fruit
Extract	Essential oil
Target Bacteria
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diseases of the chest, cough, fever, respiratory diseases, digestion, over - weight, boosting metabolism as well as for stomach cramps
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Bruneton, J. 1995. Pharmacognosy, phytochemistry, medicinal plants. Intercept Ltd., Andover, Hampshire, England 2) Grieve, M. 1967. A modern herbal. Hafner Publishing Co., New York, Dictionary of Natural Products (2003). CD-ROM. London: Chapman & Hall/CRC, http://plants.usda.gov/java/profile?symbol=FOVU 3) http://www.ageless.co.za/fennel.htm
Curator

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