BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 38 [TOP]

Compound ID	1003
Compound Structure
Plant Source	Abrus precatorius L. Common Name:Indian Wild Liquorice, Jequirity, Crab's Eye (English), Gunja, Gunjaka (Sanskrit)
Source Family	Fabaceae
Origin	India, Puerto Rico, Nigeria
Plant Part Used
Extract	Hexane (21.33 %)
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculous glands, asthma, pain in chest, cough, bronchitis, folklore medicine of Puerto Rico
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Ibrahim, K., Oyewale, A.O., Amupitan, J.O., and Okogun, J.I., 2009, Antimycobacterial activity of some medicinal plants in Niger State, Nigeria. Afri. J. Infect. Dis., 3(2), 44-48 2) Indian Medicinal Plants: An Illustrated Dictionary By C.P. Khare
Curator

Record - 2 of 38 [TOP]

Compound ID	1004
Compound Structure
Plant Source	Abrus precatorius L. Common Name:Indian wild liquorice, Jequirity, Crab's Eye (English), Gunja, Gunjaka (Sanskrit)
Source Family	Fabaceae
Origin	India, Puerto Rico, Nigeria
Plant Part Used	Stem
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Middlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)	Rifampin (1 µg/ml)
Inhibition [%]	42 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculous glands, asthma, pain in chest, cough, bronchitis, folklore medicine of Puerto Rico
PubMed ID [Source Literature]	11746852
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun, M.D., Ramos, Z., Vazques, J., Oquendo, I., Proctor, G.R., Gerena, L., Franzblau, S.G., 2001. Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities. Phytotherapy Research 15, 638–642 2) Indian Medicinal Plants: An Illustrated Dictionary By C.P. Khare
Curator

Record - 3 of 38 [TOP]

Compound ID

1005

Compound Structure

Plant Source

Abrus precatorius L. Common Name:Indian wild liquorice, Jequirity, Crab's Eye (English), Gunja, Gunjaka (Sanskrit)

Source Family

Fabaceae

Origin

India, Puerto Rico, Nigeria

Plant Part Used

Aerial

Extract

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Abruquinone B

PubChem ID

44257521

Ethnomedicinal Information

Tuberculous glands, asthma, pain in chest, cough, bronchitis, folklore medicine of Puerto Rico

PubMed ID [Source Literature]

15114511

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Benzopyran, Quinone, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

390.131

Molecular Formula

C₂₀H₂₂O₈

SMILES

O1CC(Cc2c1c(OC)c(OC)c(OC)c2)C1=CC(=O)C(=C(OC)C1=O)OC

XLogP

0.780

PSA

89.520

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Limmatvapirat C, Sirisopanaporn S, Kittakoop P.Antitubercular and antiplasmodial constituents of Abrus precatorius.Planta Med. 2004 Mar;70(3):276-8

2) Indian Medicinal Plants: An Illustrated Dictionary By C.P. Khare

Curator

Record - 4 of 38 [TOP]

Compound ID	1188
Compound Structure
Plant Source	Annona senegalensis Common Name:Wild Custard Apple, Wild Soursop
Source Family	Annonaceae
Origin	Nigeria
Plant Part Used
Extract	Methanol (71.7 %)
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Ibrahim, K., Oyewale, A.O., Amupitan, J.O., and Okogun, J.I., 2009, Antimycobacterial activity of some me-dicinal plants in Niger State, Nigeria. Afri. J. Infect. Dis., 3(2), 44-48
Curator

Record - 5 of 38 [TOP]

Compound ID	1191
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	78 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 6 of 38 [TOP]

Compound ID	1192
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Hexane
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	312.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 7 of 38 [TOP]

Compound ID	1193
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Ethyl acetate soluble
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	625 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 8 of 38 [TOP]

Compound ID	1194
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Methanol
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 9 of 38 [TOP]

Compound ID	1296
Compound Structure
Plant Source	Brucea antidysenterica Common Name:
Source Family	Simaroubaceae
Origin	Nigeria
Plant Part Used
Extract
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Ibrahim, K., Oyewale, A.O., Amupitan, J.O., and Okogun, J.I., 2009, Antimycobacterial activity of some me-dicinal plants in Niger State, Nigeria. Afri. J. Infect. Dis., 3(2), 44-48
Curator

Record - 10 of 38 [TOP]

Compound ID	1365
Compound Structure
Plant Source	Capparis brassii DC Common Name:
Source Family	Capparaceae
Origin	Nigeria
Plant Part Used	Root bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21
Curator

Record - 11 of 38 [TOP]

Compound ID	1524
Compound Structure
Plant Source	Combretum spp Common Name:Leadwood
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Stem bark, root bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, cough, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) http://www.bradturnsgreen.com/Wood%20Status%20List.pdf
Curator

Record - 12 of 38 [TOP]

Compound ID	1549
Compound Structure
Plant Source	Crateva adansonii Common Name:Caper Tree
Source Family	Capparaceae
Origin	Nigeria
Plant Part Used
Extract	Methanol (69 %)
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Ibrahim, K., Oyewale, A.O., Amupitan, J.O., and Okogun, J.I., 2009, Antimycobacterial activity of some me-dicinal plants in Niger State, Nigeria. Afri. J. Infect. Dis., 3(2), 44-48 2) www.africanethnomedicines.net
Curator

Record - 13 of 38 [TOP]

Compound ID	1600
Compound Structure
Plant Source	Detarium microcarpium Common Name:
Source Family	Caesalpiniaceae
Origin	Nigeria
Plant Part Used
Extract
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Ibrahim, K., Oyewale, A.O., Amupitan, J.O., and Okogun, J.I., 2009, Antimycobacterial activity of some me-dicinal plants in Niger State, Nigeria. Afri. J. Infect. Dis., 3(2), 44-48
Curator

Record - 14 of 38 [TOP]

Compound ID	1629
Compound Structure
Plant Source	Entada africana Guill. & Perr. Common Name:
Source Family	Mimosaceae
Origin	Nigeria
Plant Part Used	Stem bark, root bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	2500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, cough, whooping cough, dysentery, fever, wound
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) Mann A, Gbate M, Nda-Umar A. Medicinal and Economic Plants of Nupeland. Bida, Niger State, Nigeria: Jube-Evans Books and Publications; 2003. p. 276
Curator

Record - 15 of 38 [TOP]

Compound ID

1657

Compound Structure

Plant Source

Erythrina indica Common Name:

Source Family

Leguminosae

Origin

Ibadan, Nigeria

Plant Part Used

Root bark

Extract

Phenol

Target Bacteria

Mycobacterium smegmatis (ATCC 607)

Assay / Test Done

Agar Dilution - Streak Assay

Positive Control Used (conc.)

Streptomycin (1.7 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 400 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cajanin

PubChem ID

5281706

Ethnomedicinal Information

Trachoma, Elephantiasis, Microbial infections

PubMed ID [Source Literature]

10820816

Extract Preparation

Dried and ground root bark of Erythrina indica was successively extracted with a mixture of dichloro-methane-MeOH (1:1) and methanol. The dichloro-methane-MeOH (1:1) extract was concentrated to dryness

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

300.063

Molecular Formula

C₁₆H₁₂O₆

SMILES

O1c2c(c(=O)c(c3c(O)cc(O)cc3)c1)c(O)cc(OC)c2

XLogP

0.781

PSA

86.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Waffo AK, Azebaze GA, Nkengfack AE, Fomum ZT, Meyer M, Bodo B, van Heerden FR.Indicanines B and C, two isoflavonoid derivatives from the root bark of Erythrina indica.Phytochemistry. 2000 Apr;53(8):981-5

Curator

Record - 16 of 38 [TOP]

Compound ID	1732
Compound Structure
Plant Source	Faba spp Common Name:
Source Family	Fabaceae
Origin	Nigeria
Plant Part Used
Extract	Hexane (43.6 %)
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Ibrahim, K., Oyewale, A.O., Amupitan, J.O., and Okogun, J.I., 2009, Antimycobacterial activity of some me-dicinal plants in Niger State, Nigeria. Afri. J. Infect. Dis., 3(2), 44-48
Curator

Record - 17 of 38 [TOP]

Compound ID	1881
Compound Structure
Plant Source	Hymenocardia acida Tul. Common Name:Large Red - Hear
Source Family	Euphorbiaceae
Origin	Nigeria
Plant Part Used	Root bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 2500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Hemoptysis,tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) http://www.zimbabweflora.co.zw/speciesdata/species.php?species_id=134510
Curator

Record - 18 of 38 [TOP]

Compound ID	1981
Compound Structure
Plant Source	Laggera aurita (Linn f.) DC. Common Name:
Source Family	Asteraceae (Compositae)
Origin	Nigeria
Plant Part Used	Aerial
Extract	Crude methanol
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.02 µ/ml)
Inhibition [%]
Activity [MIC] µg/ml	625 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) O. Henry Egharevba1*, Peters Oladosu2, E. Samuel Okhale1, Iliya Ibrahim1, Kunle O. Folashade1, K. Simeon Okwute3 and I. Joseph Okogun1 Preliminary anti-tuberculosis screening of two Nigerian Laggera species (Laggera pterodonta and Laggera aurita) Journal of Medicinal Plants Research Vol. 4(12), pp. 1235-1237, 18 June, 2010
Curator

Record - 19 of 38 [TOP]

Compound ID	1982
Compound Structure
Plant Source	Laggera pterodonta (DC.) Sch. Bip. Common Name:
Source Family	Asteraceae (Compositae)
Origin	Nigeria
Plant Part Used	Aerial
Extract	Crude methanol
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Isoniazid (0.02 µ/ml)
Inhibition [%]
Activity [MIC] µg/ml	625 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Treatment of inflammation & swelling, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) O. Henry Egharevba1*, Peters Oladosu2, E. Samuel Okhale1, Iliya Ibrahim1, Kunle O. Folashade1, K. Simeon Okwute3 and I. Joseph Okogun1 Preliminary anti-tuberculosis screening of two Nigerian Laggera species (Laggera pterodonta and Laggera aurita) Journal of Medicinal Plants Research Vol. 4(12), pp. 1235-1237, 18 June, 2010 2) http://nopr.niscair.res.in/bitstream/123456789/9339/1/IJTK%203%281%29%2080-85.pdf
Curator

Record - 20 of 38 [TOP]

Compound ID	2243
Compound Structure
Plant Source	Neocarya macrophylla Common Name:Gingerbread Plum, Neou Oil Tree
Source Family	Chrysobalanaceae
Origin	Nigeria
Plant Part Used
Extract
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Ibrahim, K., Oyewale, A.O., Amupitan, J.O., and Okogun, J.I., 2009, Antimycobacterial activity of some me-dicinal plants in Niger State, Nigeria. Afri. J. Infect. Dis., 3(2), 44-48
Curator

Record - 21 of 38 [TOP]

Compound ID	2257
Compound Structure
Plant Source	Ocimum gratissimum L. Common Name:African Basil
Source Family	Labiatae
Origin	Nigeria, Kenya
Plant Part Used
Extract	Hexane (24.1 %)
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Ear problems, chest pains
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Ibrahim, K., Oyewale, A.O., Amupitan, J.O., and Okogun, J.I., 2009, Antimycobacterial activity of some me-dicinal plants in Niger State, Nigeria. Afri. J. Infect. Dis., 3(2), 44-48
Curator

Record - 22 of 38 [TOP]

Compound ID	2258
Compound Structure
Plant Source	Ocimum gratissimum L. Common Name:African Basil
Source Family	Labiatae
Origin	Nigeria, Kenya
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2,1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Ear problems, chest pains
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 23 of 38 [TOP]

Compound ID	2259
Compound Structure
Plant Source	Ocimum gratissimum L. Common Name:African Basil
Source Family	Labiatae
Origin	Nigeria, Kenya
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium kansasii
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2,1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Ear problems, chest pains
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 24 of 38 [TOP]

Compound ID	2260
Compound Structure
Plant Source	Ocimum gratissimum L. Common Name:African Basil
Source Family	Labiatae
Origin	Nigeria, Kenya
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium fortuitum
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2,1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Ear problems, chest pains
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 25 of 38 [TOP]

Compound ID	2261
Compound Structure
Plant Source	Ocimum gratissimum L. Common Name:African Basil
Source Family	Labiatae
Origin	Nigeria, Kenya
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2,1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Ear problems, chest pains
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

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