BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 46 [TOP]

Compound ID	1049
Compound Structure	N/A
Plant Source	Acorus calamus L. var. americanus (Raf.) Common Name:Sweetflag
Source Family	Araceae
Origin	North America
Plant Part Used	Root
Extract
Target Bacteria
Assay / Test Done	Microplate Resazurin Assay (MRA)
Positive Control Used (conc.)	Rifampin (2 and 0.4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Adjuvant, analgesic, antihelmintic, antihemorrhagic, anti-inflammatory, antipyretic, antirheumatic, cold, cough, dermatological, emetic, gastrointestinal, gynaecological, child birth, hallucinogen, panacea, tonic, pediatric, pulmonary, stimulant, venereal infection
PubMed ID [Source Literature]	20657619
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Duncan Webster, Timothy D.G. Lee, Jill MoWebster D, Lee TD, Moore J, Manning T, Kunimoto D, LeBlanc D, Johnson JA, Gray CA.Antimycobacterial screening of traditional medicinal plants using the microplate resazurin assay.Can J Microbiol. 2010 Jun;56(6):487-94
Curator

Record - 2 of 46 [TOP]

Compound ID	1278
Compound Structure
Plant Source	Borago officinalis Linn. Common Name:Borage
Source Family	Boraginaceae
Origin	Europe, North Africa, North America
Plant Part Used	Herb
Extract	Methanol (19.44 %)
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used in pulmonary diseases, consumption and to treat fever
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 3 of 46 [TOP]

Compound ID	1279
Compound Structure
Plant Source	Borago officinalis Linn. Common Name:Borage
Source Family	Boraginaceae
Origin	Europe, North Africa, North America
Plant Part Used	Herb
Extract	Methanol (19.44 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used in pulmonary diseases, consumption and to treat fever
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 4 of 46 [TOP]

Compound ID

1876

Compound Structure

Plant Source

Hydrastis canadensis Common Name:Goldenseal

Source Family

Ranunculaceae

Origin

North America

Plant Part Used

Root

Extract

Ethanol

Target Bacteria

Mycobacterium smegmatis (ATCC 607)

Assay / Test Done

Positive Control Used (conc.)

Streptomycin sulfate (1.56 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Berberine

PubChem ID

2353

Ethnomedicinal Information

Berberine has been demonstrated to reduce the infectivity of bacteria, fungi and protozoa in animals and humans by inhibiting the adherence of microorganisms to the host cells

PubMed ID [Source Literature]

9784149, 4906191

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

336.124

Molecular Formula

C₂₀H₁₈NO₄

SMILES

O1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1

XLogP

2.896

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gentry EJ, Jampani HB, Keshavarz-Shokri A, Morton MD, Velde DV, Telikepalli H, Mitscher LA, Shawar R, Humble D, Baker W.Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2.J Nat Prod. 1998 Oct;61(10):1187-93

2) Amin AH, Subbaiah TV, Abbasi KM.Berberine sulfate: antimicrobial activity, bioassay, and mode of action.Can J Microbiol. 1969 Sep;15(9):1067-76

Curator

Record - 5 of 46 [TOP]

Compound ID

1877

Compound Structure

Plant Source

Hydrastis canadensis Common Name:Goldenseal

Source Family

Ranunculaceae

Origin

North America

Plant Part Used

Root

Extract

Ethanol

Target Bacteria

Mycobacterium bovis (BCG - Bacillus Calmette Guerin)

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Berberine

PubChem ID

2353

Ethnomedicinal Information

Berberine has been demonstrated to reduce the infectivity of bacteria, fungi and protozoa in animals and humans by inhibiting the adherence of microorganisms to the host cells

PubMed ID [Source Literature]

9784149, 4906191

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

336.124

Molecular Formula

C₂₀H₁₈NO₄

SMILES

O1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1

XLogP

2.896

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 6 of 46 [TOP]

Compound ID

1878

Compound Structure

Plant Source

Hydrastis canadensis Common Name:Goldenseal

Source Family

Ranunculaceae

Origin

North America

Plant Part Used

Root

Extract

Ethanol

Target Bacteria

Mycobacterium avium complex

Assay / Test Done

Positive Control Used (conc.)

Streptomycin sulfate (6.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Berberine

PubChem ID

2353

Ethnomedicinal Information

Berberine has been demonstrated to reduce the infectivity of bacteria, fungi and protozoa in animals and humans by inhibiting the adherence of microorganisms to the host cells

PubMed ID [Source Literature]

9784149, 4906191

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Isoquinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

336.124

Molecular Formula

C₂₀H₁₈NO₄

SMILES

O1c2cc3CC[n+]4c(c3cc2OC1)cc1c(c4)c(OC)c(OC)cc1

XLogP

2.896

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 7 of 46 [TOP]

Compound ID

1931

Compound Structure

Plant Source

Ipomoea leptophylla Common Name:Bush Morning Glory, Manroot

Source Family

Convolvulaceae

Origin

North America

Plant Part Used

Leaf

Extract

Soluble extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

BACTEC 460 radiometric system

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

NR (inactive)

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Operculinic acid

PubChem ID

44584575

Ethnomedicinal Information

Treatment for stomach troubles, tuberculosis

PubMed ID [Source Literature]

14640518

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Fatty acid, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

1018.520

Molecular Formula

C₄₆H₈₂O₂₄

SMILES

O([C@@H]1O[C@H]([C@H](O[C@@H]2O[C@H]([C@H](O)[C@@H](O)[C@H]2O)C)[C@@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO)C)[C@@H]1[C@@H](O)[C@@H](O)[C@@H](O[C@H]1C)O[C@@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]1O[C@H](CCCCCCCCCC(=O)O)CCCCC)C

XLogP

1.041

PSA

372.360

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Barnes CC, Smalley MK, Manfredi KP, Kindscher K, Loring H, Sheeley DM.Characterization of an anti-tuberculosis resin glycoside from the prairie medicinal plant Ipomoea leptophylla.J Nat Prod. 2003 Nov;66(11):1457-62

Curator

Record - 8 of 46 [TOP]

Compound ID

1932

Compound Structure

Plant Source

Ipomoea leptophylla Common Name:Bush Morning Glory, Manroot

Source Family

Convolvulaceae

Origin

North America

Plant Part Used

Leaf

Extract

Soluble extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

BACTEC 460 radiometric system

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Trans - Cinnamic Acid

PubChem ID

444539

Ethnomedicinal Information

Treatment for stomach troubles, tuberculosis

PubMed ID [Source Literature]

14640518

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkene, Acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

148.052

Molecular Formula

C₉H₈O₂

SMILES

OC(=O)/C=C/c1ccccc1

XLogP

3.904

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 9 of 46 [TOP]

Compound ID

1933

Compound Structure

Plant Source

Ipomoea leptophylla Common Name:Bush Morning Glory, Manroot

Source Family

Convolvulaceae

Origin

North America

Plant Part Used

Leaf

Extract

Soluble extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

BACTEC 460 radiometric system

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Propanoic acid

PubChem ID

1032

Ethnomedicinal Information

Treatment for stomach troubles, tuberculosis

PubMed ID [Source Literature]

14640518

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

74.037

Molecular Formula

C₃H₆O₂

SMILES

OC(=O)CC

XLogP

0.173

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 10 of 46 [TOP]

Compound ID

1934

Compound Structure

Plant Source

Ipomoea leptophylla Common Name:Bush Morning Glory, Manroot

Source Family

Convolvulaceae

Origin

North America

Plant Part Used

Leaf

Extract

Soluble extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

BACTEC 460 radiometric system

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Lauric acid

PubChem ID

3893

Ethnomedicinal Information

Treatment for stomach troubles, tuberculosis

PubMed ID [Source Literature]

14640518

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Fatty acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

200.178

Molecular Formula

C₁₂H₂₄O₂

SMILES

OC(=O)CCCCCCCCCCC

XLogP

5.294

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 11 of 46 [TOP]

Compound ID	2549
Compound Structure
Plant Source	Sanguinaria canadensis Linn. Common Name:Bloodroot
Source Family	Papaveraceae
Origin	North America
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	62.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 12 of 46 [TOP]

Compound ID	2550
Compound Structure
Plant Source	Sanguinaria canadensis Linn. Common Name:Bloodroot
Source Family	Papaveraceae
Origin	North America
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 13 of 46 [TOP]

Compound ID

2551

Compound Structure

Plant Source

Sanguinaria canadensis Linn. Common Name:Bloodroot

Source Family

Papaveraceae

Origin

North America

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium aurum

Assay / Test Done

Broth Microdilution Method (BMM)

Positive Control Used (conc.)

Streptomycin (1.14 ± 0.02 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

9.61 ± 4.52 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sanguinarine

PubChem ID

5154

Ethnomedicinal Information

Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

332.092

Molecular Formula

C₂₀H₁₄NO₄

SMILES

O1c2c3c(c4c([n+](c3)C)c3c(cc4)cc4OCOc4c3)ccc2OC1

XLogP

3.297

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67

Curator

Record - 14 of 46 [TOP]

Compound ID

2552

Compound Structure

Plant Source

Sanguinaria canadensis Linn. Common Name:Bloodroot

Source Family

Papaveraceae

Origin

North America

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium smegmatis

Assay / Test Done

Broth Microdilution Method (BMM)

Positive Control Used (conc.)

Streptomycin (0.17 ± 0.04 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

41.18 ± 16.85 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sanguinarine

PubChem ID

5154

Ethnomedicinal Information

Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

332.092

Molecular Formula

C₂₀H₁₄NO₄

SMILES

O1c2c3c(c4c([n+](c3)C)c3c(cc4)cc4OCOc4c3)ccc2OC1

XLogP

3.297

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 15 of 46 [TOP]

Compound ID

2553

Compound Structure

Plant Source

Sanguinaria canadensis Linn. Common Name:Bloodroot

Source Family

Papaveraceae

Origin

North America

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium bovis (BCG - Bacillus Calmette Guerin)

Assay / Test Done

Broth Microdilution Method (BMM)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

24.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sanguinarine

PubChem ID

5154

Ethnomedicinal Information

Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Quinoline, Alkaloid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

332.092

Molecular Formula

C₂₀H₁₄NO₄

SMILES

O1c2c3c(c4c([n+](c3)C)c3c(cc4)cc4OCOc4c3)ccc2OC1

XLogP

3.297

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 16 of 46 [TOP]

Compound ID

2554

Compound Structure

Plant Source

Sanguinaria canadensis Linn. Common Name:Bloodroot

Source Family

Papaveraceae

Origin

North America

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium aurum

Assay / Test Done

Broth Microdilution Method (BMM)

Positive Control Used (conc.)

Streptomycin (1.14 ± 0.02 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

7.30 ± 1.91 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Chelerythrine

PubChem ID

2703

Ethnomedicinal Information

Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Quinoline,Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

348.124

Molecular Formula

C₂₁H₁₈NO₄

SMILES

O1c2cc3c4[n+](cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C

XLogP

3.370

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 17 of 46 [TOP]

Compound ID

2555

Compound Structure

Plant Source

Sanguinaria canadensis Linn. Common Name:Bloodroot

Source Family

Papaveraceae

Origin

North America

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium smegmatis

Assay / Test Done

Broth Microdilution Method (BMM)

Positive Control Used (conc.)

Streptomycin (0.17 ± 0.04 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

29.00 ± 17.60 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Chelerythrine

PubChem ID

2703

Ethnomedicinal Information

Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Quinoline,Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

348.124

Molecular Formula

C₂₁H₁₈NO₄

SMILES

O1c2cc3c4[n+](cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C

XLogP

3.370

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 18 of 46 [TOP]

Compound ID

2556

Compound Structure

Plant Source

Sanguinaria canadensis Linn. Common Name:Bloodroot

Source Family

Papaveraceae

Origin

North America

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium bovis (BCG - Bacillus Calmette Guerin)

Assay / Test Done

Broth Microdilution Method (BMM)

Positive Control Used (conc.)

Streptomycin (0.17 ± 0.04 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

14.3 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Chelerythrine

PubChem ID

2703

Ethnomedicinal Information

Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Alkaloid, Quinoline,Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

348.124

Molecular Formula

C₂₁H₁₈NO₄

SMILES

O1c2cc3c4[n+](cc5c(c4ccc3cc2OC1)ccc(OC)c5OC)C

XLogP

3.370

PSA

40.800

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 19 of 46 [TOP]

Compound ID	2557
Compound Structure
Plant Source	Sanguinaria canadensis Linn. Common Name:Bloodroot
Source Family	Papaveraceae
Origin	North America
Plant Part Used	Root
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, antimicrobial, antiviral, dentrifice, has anaesthetic properties, used to treat skin infections, pulmonary consumption, fever and epithelial tumours, cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gottshall RY, Lucas EH, Lickfeldt A, Roberts JM. 1949. The occurrence of antibacterial substances active against Mycobacterium tuberculosis in seed plants. J Clin Invest 28: 920±92
Curator

Record - 20 of 46 [TOP]

Compound ID

2614

Compound Structure

Plant Source

Solidago canadensis L. Common Name:Goldenrod, Woundwort

Source Family

Asteraceae (Compositae)

Origin

North America

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Rifampin (0.25 - 0.125 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(2Z)-8-dehydromatricaria ester

PubChem ID

Ethnomedicinal Information

Urinary and kidney infections and stones, catarrh. The plant has a cleansing action on the kidneys, and a reputation for clearing upper respiratory mucus

PubMed ID [Source Literature]

9810277

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Alkyne, Ester

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

174.068

Molecular Formula

C₁₁H₁₀O₂

SMILES

C(=O)(OC)/C=C/C#CC#C/C=C/C

XLogP

3.071

PSA

26.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Lu T, Cantrell CL, Robbs SL, Franzblau SG, Fischer NH.Antimycobacterial matricaria esters and lactones from Astereae species.Planta Med. 1998 Oct;64(7):665-7

2) http://www.anniesremedy.com/herb_detail365.php

Curator

Record - 21 of 46 [TOP]

Compound ID

2617

Compound Structure

Plant Source

Solidago rugosa Mill Common Name:Wrinkleleaf Goldenrod

Source Family

Asteraceae (Compositae)

Origin

North America

Plant Part Used

Root, Aerial

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

> 100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Kolavenol

PubChem ID

6442554

Ethnomedicinal Information

Anti - inflammatory, tuberculosis

PubMed ID [Source Literature]

7772306

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Diterpene, Alcohol, Alkene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

290.261

Molecular Formula

C₂₀H₃₄O

SMILES

OC/C=C(/CC[C@@]1([C@@H]2[C@@](CC[C@H]1C)(C(=CCC2)C)C)C)C

XLogP

7.061

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Lu T, Vargas D, Franzblau SG, Fischer NH. Diterpenes from Solidago rugosa.Phytochemistry.1995 Jan;38(2):451-6

Curator

Record - 22 of 46 [TOP]

Compound ID

2618

Compound Structure

Plant Source

Solidago rugosa Mill Common Name:Wrinkleleaf Goldenrod

Source Family

Asteraceae (Compositae)

Origin

North America

Plant Part Used

Root, Aerial

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

> 100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Hardwickiic acid

PubChem ID

479908

Ethnomedicinal Information

Anti - inflammatory, tuberculosis

PubMed ID [Source Literature]

7772306

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Diterpene, Terpene, Furanoid, Acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

302.188

Molecular Formula

C₁₉H₂₆O₃

SMILES

OC(=O)C1=CCC[C@@H]2[C@]([C@@H](CC[C@@H]12)C)(CCc1ccoc1)C

XLogP

5.727

PSA

50.440

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Lu T, Vargas D, Franzblau SG, Fischer NH. Diterpenes from Solidago rugosa.Phytochemistry.1995 Jan;38(2):451-6

Curator

Record - 23 of 46 [TOP]

Compound ID

2619

Compound Structure

Plant Source

Solidago rugosa Mill Common Name:Wrinkleleaf Goldenrod

Source Family

Asteraceae (Compositae)

Origin

North America

Plant Part Used

Root, Aerial

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

> 100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(+)-3β - Hydroxymanool

PubChem ID

479909

Ethnomedicinal Information

Anti - inflammatory, tuberculosis

PubMed ID [Source Literature]

7772306

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Diterpene, Alcohol, Alkene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

306.256

Molecular Formula

C₂₀H₃₄O₂

SMILES

O[C@@H]1C([C@H]2[C@@]([C@H](C(=C)CC2)CC[C@](O)(C)C=C)(CC1)C)(C)C

XLogP

4.737

PSA

40.460

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Lu T, Vargas D, Franzblau SG, Fischer NH. Diterpenes from Solidago rugosa.Phytochemistry.1995 Jan;38(2):451-6

Curator

Record - 24 of 46 [TOP]

Compound ID

2620

Compound Structure

Plant Source

Solidago rugosa Mill Common Name:Wrinkleleaf Goldenrod

Source Family

Asteraceae (Compositae)

Origin

North America

Plant Part Used

Root, Aerial

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

> 100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Monoacetate

PubChem ID

3035155

Ethnomedicinal Information

Anti - inflammatory, tuberculosis

PubMed ID [Source Literature]

7772306

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tetracyclic, Steroid, Lactone, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

806.445

Molecular Formula

C₄₃H₆₆O₁₄

SMILES

OC12[C@H]3[C@@H]([C@@]4([C@H](CC3)C[C@@H](O[C@H]3O[C@@H]([C@@H](O[C@H]5O[C@@H]([C@@H](OC(=O)C)[C@@H](O)C5)C)[C@@H](O[C@H]5O[C@@H]([C@@H](O)[C@@H](O)C5)C)C3)C)CC4)C)CC[C@@]1([C@H](CC2)C1=CC(=O)OC1)C

XLogP

4.155

PSA

188.900

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Lu T, Vargas D, Franzblau SG, Fischer NH. Diterpenes from Solidago rugosa.Phytochemistry.1995 Jan;38(2):451-6

Curator

Record - 25 of 46 [TOP]

Compound ID

2621

Compound Structure

Plant Source

Solidago rugosa Mill Common Name:Wrinkleleaf Goldenrod

Source Family

Asteraceae (Compositae)

Origin

North America

Plant Part Used

Root, Aerial

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

> 100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Entabietic acid

PubChem ID

479912

Ethnomedicinal Information

Anti - inflammatory, tuberculosis

PubMed ID [Source Literature]

7772306

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Diterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

272.250

Molecular Formula

C₂₀H₃₂

SMILES

[C@@]12([C@@H](C(CCC1)(C)C)CC=C1[C@H]2CCC(=C1)C(C)C)C

XLogP

8.607

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Lu T, Vargas D, Franzblau SG, Fischer NH. Diterpenes from Solidago rugosa.Phytochemistry.1995 Jan;38(2):451-6

Curator

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