BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 11 [TOP]

Compound ID	3294
Compound Structure
Plant Source	Euphorbia peplis L. Common Name:
Source Family	Euphorbiaceae
Origin	India, Northern Italy
Plant Part Used	Leaf, stem
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)	Ciprofloxacin (0.125 – 0.25 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	80 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]	14643323
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50
Curator	Vsheeba, vikramjitmandal

Record - 2 of 11 [TOP]

Compound ID	3295
Compound Structure
Plant Source	Euphorbia peplis L. Common Name:
Source Family	Euphorbiaceae
Origin	India, Northern Italy
Plant Part Used	Leaf, stem
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H331
Assay / Test Done
Positive Control Used (conc.)	Ciprofloxacin (0.125 – 0.25 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	40 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]	14643323
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50
Curator	Vsheeba, vikramjitmandal

Record - 3 of 11 [TOP]

Compound ID	3296
Compound Structure
Plant Source	Euphorbia peplis L. Common Name:
Source Family	Euphorbiaceae
Origin	India, Northern Italy
Plant Part Used	Leaf, stem
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H242
Assay / Test Done
Positive Control Used (conc.)	Ciprofloxacin (0.125 – 0.25 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	80 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]	14643323
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50
Curator	Vsheeba, vikramjitmandal

Record - 4 of 11 [TOP]

Compound ID	3297
Compound Structure
Plant Source	Euphorbia peplis L. Common Name:
Source Family	Euphorbiaceae
Origin	India, Northern Italy
Plant Part Used	Leaf, stem
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H172
Assay / Test Done
Positive Control Used (conc.)	Ciprofloxacin (0.125 – 0.25 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	80 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information
PubMed ID [Source Literature]	14643323
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Reference(s)	1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50
Curator	Vsheeba, vikramjitmandal

Record - 5 of 11 [TOP]

Compound ID

3298

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.125 – 0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 160 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4R, 8Z) - 2N - [(2R) - 2 - Hydroxytetracosenoil] - 8 (Z) - Octadecene - 1, 3, 4 - Triol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

843.680

Molecular Formula

C₄₈H₉₃NO₁₀

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)[C@@H](CCC/C=C/CCCCCCCCC)O)[C@H](O)CCCCCCCCCCCCCCCCCCCCCC

XLogP

14.906

PSA

189.170

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

Record - 6 of 11 [TOP]

Compound ID

3299

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

40 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4R, 8Z) - 2N - [(2R) - 2 - Hydroxyhexacosenoil] - 8 (Z) - Octadecene - 1, 3, 4 - Triol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

869.696

Molecular Formula

C₅₀H₉₅NO₁₀

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)[C@@H](CCC/C=C/CCCCCCCCC)O)[C@H](O)CCCCCCCCCCCCCC/C=C/CCCCCCCC

XLogP

15.528

PSA

189.170

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

Record - 7 of 11 [TOP]

Compound ID

3300

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H242

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.125 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 160 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4R, 8Z) - 2N - [(2R) - 2 - Hydroxytetracosanoil] - 8 (Z) - Octadecene - 1, 3, 4 - Triol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

843.680

Molecular Formula

C₄₈H₉₃NO₁₀

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)[C@@H](CCC/C=C/CCCCCCCCC)O)[C@H](O)CCCCCCCCCCCCCCCCCCCCCC

XLogP

14.906

PSA

189.170

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

Record - 8 of 11 [TOP]

Compound ID

3301

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H172

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 160 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4E, 8E) - 2N - [(2R) - 2 - Hydroxyhexadecanoylamino] - 4 (E), 8 (E) - Octadecadiene - 1, 3 - Diol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

713.544

Molecular Formula

C₄₀H₇₅NO₉

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)/C=C/CCC/C=C/CCCCCCCC)[C@H](O)CCCCCCCCCCCCCC

XLogP

11.345

PSA

168.940

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

Record - 9 of 11 [TOP]

Compound ID

3303

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H331

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.125 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

40 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4R, 8Z) - 2N - [(2R) - 2 - Hydroxyhexacosenoil] - 8 (Z) - Octadecene - 1, 3, 4 - Triol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

869.696

Molecular Formula

C₅₀H₉₅NO₁₀

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)[C@@H](CCC/C=C/CCCCCCCCC)O)[C@H](O)CCCCCCCCCCCCCC/C=C/CCCCCCCC

XLogP

15.528

PSA

189.170

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

Record - 10 of 11 [TOP]

Compound ID

3304

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H242

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.125 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

80 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4R, 8Z) - 2N - [(2R) - 2 - Hydroxyhexacosenoil] - 8 (Z) - Octadecene - 1, 3, 4 - Triol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

869.696

Molecular Formula

C₅₀H₉₅NO₁₀

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)[C@@H](CCC/C=C/CCCCCCCCC)O)[C@H](O)CCCCCCCCCCCCCC/C=C/CCCCCCCC

XLogP

15.528

PSA

189.170

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

Record - 11 of 11 [TOP]

Compound ID

3305

Compound Structure

Plant Source

Euphorbia peplis L. Common Name:

Source Family

Euphorbiaceae

Origin

India, Northern Italy

Plant Part Used

Leaf, stem

Extract

Target Bacteria

Mycobacterium tuberculosis H172

Assay / Test Done

Positive Control Used (conc.)

Ciprofloxacin (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

40 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - O - (β - D - Glucopyranosyl) - (2S, 3S, 4R, 8Z) - 2N - [(2R) - 2 - Hydroxyhexacosenoil] - 8 (Z) - Octadecene - 1, 3, 4 - Triol

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

14643323

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Cerebroside, Amide, Alcohol, Sugar

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

869.696

Molecular Formula

C₅₀H₉₅NO₁₀

SMILES

C(=O)(N[C@@H](CO[C@@H]1OC(C([C@H]([C@@H]1O)O)O)CO)[C@H](O)[C@@H](CCC/C=C/CCCCCCCCC)O)[C@H](O)CCCCCCCCCCCCCC/C=C/CCCCCCCC

XLogP

15.528

PSA

189.170

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cateni F, Zilic J, Falsone G, Scialino G, Banfi E.New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation.Bioorg Med Chem Lett. 2003 Dec 15;13(24):4345-50

Curator

Vsheeba, vikramjitmandal

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