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                  Page - 1 of 1                  Record - 1 of 4   [TOP]
Compound ID2578
Compound Structure
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Plant SourceScleropyrum pentandrum     Common Name:
Source FamilySantalaceae
OriginIndia, Malaysia, Philippines, Singapore, Sri Lanka
Plant Part UsedTwig
ExtractHexane
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Rifampin (0.004 µg/ml), Isoniazid (0.06 µg/ml), Kanamycin sulphate (2.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedScleropyric acid
PubChem ID   11594149
Ethnomedicinal InformationMalaria, tuberculosis
PubMed ID [Source Literature]16204994
Extract PreparationThe pulverized, dry twigs (1.06 kg) were extracted successively with n - Hexane, CHCl3 and MeOH in a soxhlet extraction apparatus to yield the hexane (7.12 g), CHCl3 (3.50 g), and MeOH (12.42 g) extracts, respectively
Chemical Classification [Active Compound]Aliphatic, Alkene, Alkyne, Fatty acid
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight264.209
Molecular FormulaC17H28O2
SMILESOC(=O)CCCCCCCCCCC#CCCC=C
XLogP6.563
PSA37.300
H-bond Donor1
H-bond Acceptor2
No. of Rotatable Bond Count12
No. of Rings0
No. of N0
No. of O2
No. of S0
Reference(s)1) Suksamrarn A, Buaprom M, Udtip S, Nuntawong N, Haritakun R, Kanokmedhakul S.Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum.Chem Pharm Bull (Tokyo). 2005 Oct;53(10):1327-9

Curator

                  Record - 2 of 4   [TOP]
Compound ID3044
Compound Structure
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Plant SourceAlpinia purpurata (Vieill.) K. Schum     Common Name:Red Ginger
Source FamilyZingiberaceae
OriginPhilippines
Plant Part UsedLeaf
ExtractEthanol
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Rifampin (99% inhibition at 0.18 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml> 128 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedSitosteryl - 3 - O - 6 - Palmitoyl - β - D - glucoside
PubChem IDNR
Ethnomedicinal InformationAntiviral activity against HIV
PubMed ID [Source Literature]21120040
Extract PreparationAir dried leaves mixed with ethanol, hexane, dichloromethane and n - butanol
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Steroid, Triterpene, Sugar
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H11 agar
Cytotoxicity Assay [AID]Plant sterols, particularly U - Sitosterol and its glucosides, have been investigated as immune regulators of T - cell activity and as agents in maintaining the CD4+ count
Molecular Weight646.481
Molecular FormulaC39H66O7
SMILESC1C[C@@H](CC2=CCC3C([C@@]12C)CC[C@@]1([C@H](CCC31)[C@H](C)CC[C@@H](CC)C(C)C)C)OC1OC(C(C(C1O)O)O)COC(=O)CCC
XLogP11.620
PSA105.450
H-bond Donor3
H-bond Acceptor7
No. of Rotatable Bond Count13
No. of Rings5
No. of N0
No. of O7
No. of S0
Reference(s)1) Villaflores OB, Macabeo AP, Gehle D, Krohn K, Franzblau SG, Aguinaldo AM.Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis.Pharmacogn Mag. 2010 Oct;6(24):339-44

CuratorVikramjitmandal

                  Record - 3 of 4   [TOP]
Compound ID3045
Compound Structure
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Plant SourceAlpinia purpurata (Vieill.) K. Schum     Common Name:Red Ginger
Source FamilyZingiberaceae
OriginPhilippines
Plant Part UsedLeaf
ExtractEthanol
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Rifampin (99% inhibition at 0.18 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml> 128 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)NR
Active Compound Identifiedβ - Sitosteryl Galactoside
PubChem IDNR
Ethnomedicinal InformationAntiviral activity against HIV
PubMed ID [Source Literature]21120040
Extract PreparationAir dried leaves mixed with ethanol, hexane, dichloromethane and n - butanol
Chemical Classification [Active Compound]Alicyclic, Tetracyclic, Steroid, Sugar
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H11 agar
Cytotoxicity Assay [AID]Plant sterols, particularly U - Sitosterol and its glucosides, have been investigated as immune regulators of T - cell activity and as agents in maintaining the CD4+ count
Molecular Weight576.439
Molecular FormulaC35H60O6
SMILESC1C[C@@H](CC2=CCC3C([C@@]12C)CC[C@@]1([C@H](CCC31)[C@H](C)CC[C@@H](CC)C(C)C)C)OC1OC(C(C(C1O)O)O)CO
XLogP10.487
PSA99.380
H-bond Donor4
H-bond Acceptor6
No. of Rotatable Bond Count9
No. of Rings5
No. of N0
No. of O6
No. of S0
Reference(s)1) Villaflores OB, Macabeo AP, Gehle D, Krohn K, Franzblau SG, Aguinaldo AM.Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis.Pharmacogn Mag. 2010 Oct;6(24):339-44

CuratorVikramjitmandal

                  Record - 4 of 4   [TOP]
Compound ID3046
Compound Structure
DOWNLOAD:
Plant SourceAlpinia purpurata (Vieill.) K. Schum     Common Name:Red Ginger
Source FamilyZingiberaceae
OriginPhilippines
Plant Part UsedLeaf
ExtractEthanol
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Rifampin (99% inhibition at 0.18 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml> 128 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedKumatakenin
PubChem ID   5318869
Ethnomedicinal InformationAntiviral activity against HIV
PubMed ID [Source Literature]21120040
Extract PreparationAir dried leaves mixed with ethanol, hexane, dichloromethane and n-butanol
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Ether, Phenol
Media / Broth Used [Antimicrobial Assay/Test]Middlebrook 7H11 agar
Cytotoxicity Assay [AID]Plant sterols, particularly U - Sitosterol and its glucosides, have been investigated as immune regulators of T - cell activity and as agents in maintaining the CD4+ count
Molecular Weight314.079
Molecular FormulaC17H14O6
SMILESO1c2c(c(=O)c(OC)c1c1ccc(O)cc1)c(O)cc(OC)c2
XLogP2.021
PSA75.990
H-bond Donor2
H-bond Acceptor5
No. of Rotatable Bond Count3
No. of Rings3
No. of N0
No. of O6
No. of S0
Reference(s)1) Villaflores OB, Macabeo AP, Gehle D, Krohn K, Franzblau SG, Aguinaldo AM.Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis.Pharmacogn Mag. 2010 Oct;6(24):339-44

CuratorVikramjitmandal, farzana-shamsudeen-shamsudeen


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