BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 7 [TOP]

Compound ID	1785
Compound Structure
Plant Source	Galipea officinalis Common Name:Angustura Vera
Source Family	Rutaceae
Origin	South America
Plant Part Used	Bark
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:320 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used to treat diarrhoea and fevers
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91
Curator

Record - 2 of 7 [TOP]

Compound ID

1786

Compound Structure

Plant Source

Galipea officinalis Common Name:Angustura Vera

Source Family

Rutaceae

Origin

South America

Plant Part Used

Bark

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Isoniazid (0.12 µg/ml), Rifampin (0.001 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cusparine

PubChem ID

442893

Ethnomedicinal Information

Used to treat diarrhoea and fevers

PubMed ID [Source Literature]

10232071

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Alkaloid, Quinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

307.121

Molecular Formula

C₁₉H₁₇NO₃

SMILES

O1c2cc(CCc3nc4c(c(OC)c3)cccc4)ccc2OC1

XLogP

4.688

PSA

40.580

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Houghton PJ, Woldemariam TZ, Watanabe Y, Yates M.Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis.Planta Med. 1999 Apr;65(3):250-4

Curator

Record - 3 of 7 [TOP]

Compound ID

1787

Compound Structure

Plant Source

Galipea officinalis Common Name:Angustura Vera

Source Family

Rutaceae

Origin

South America

Plant Part Used

Bark

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Isoniazid (0.12 µg/ml), Rifampin (0.001 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Galipine

PubChem ID

68235

Ethnomedicinal Information

Used to treat diarrhoea and fevers

PubMed ID [Source Literature]

10232071

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Quinoline, Alkaloid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

323.152

Molecular Formula

C₂₀H₂₁NO₃

SMILES

O(c1c2c(nc(CCc3cc(OC)c(OC)cc3)c1)cccc2)C

XLogP

4.761

PSA

40.580

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Houghton PJ, Woldemariam TZ, Watanabe Y, Yates M.Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis.Planta Med. 1999 Apr;65(3):250-4

Curator

Record - 4 of 7 [TOP]

Compound ID

1788

Compound Structure

Plant Source

Galipea officinalis Common Name:Angustura Vera

Source Family

Rutaceae

Origin

South America

Plant Part Used

Bark

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Isoniazid (0.12 µg/ml), Rifampin (0.001 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

6.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

4 - Methoxy - 2 - N - Pentylquinoleine

PubChem ID

3009247

Ethnomedicinal Information

Used to treat diarrhoea and fevers

PubMed ID [Source Literature]

10232071

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Alkyl, Alkaloid, Quinoline, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

229.147

Molecular Formula

C₁₅H₁₉NO

SMILES

O(c1cc(nc2c1cccc2)CCCCC)C

XLogP

5.146

PSA

22.120

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Houghton PJ, Woldemariam TZ, Watanabe Y, Yates M.Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis.Planta Med. 1999 Apr;65(3):250-4

Curator

Record - 5 of 7 [TOP]

Compound ID

1789

Compound Structure

Plant Source

Galipea officinalis Common Name:Angustura Vera

Source Family

Rutaceae

Origin

South America

Plant Part Used

Bark

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Positive Control Used (conc.)

Isoniazid (0.12 µg/ml), Rifampin (0.001 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

N - Methyl - 2 - Quinolone

PubChem ID

11820

Ethnomedicinal Information

Used to treat diarrhoea and fevers

PubMed ID [Source Literature]

10232071

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Quinolone, Alkaloid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

159.068

Molecular Formula

C₁₀H₉NO

SMILES

O=c1n(c2c(cc1)cccc2)C

XLogP

2.261

PSA

17.070

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Houghton PJ, Woldemariam TZ, Watanabe Y, Yates M.Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis.Planta Med. 1999 Apr;65(3):250-4

Curator

Record - 6 of 7 [TOP]

Compound ID	2789
Compound Structure
Plant Source	Viola odorata Linn. Common Name:Sweet Violet (English)
Source Family	Violaceae
Origin	Europe including Britain, Northern Asia, North Tropical and South America, India
Plant Part Used	Leaf
Extract	Methanol (14.35 %)
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic, expectorant and used to treat cough, bronchitis, catarrh, flowers were used to treat consumption in the days of Charles II and were sold by all apothecaries
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 7 of 7 [TOP]

Compound ID	2790
Compound Structure
Plant Source	Viola odorata Linn. Common Name:Sweet Violet (English)
Source Family	Violaceae
Origin	Europe including Britain, Northern Asia, North Tropical and South America, India
Plant Part Used	Leaf
Extract	Methanol (14.35 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic, expectorant and used to treat cough, bronchitis, catarrh, the flowers were used to treat consumption in the days of Charles II and were sold by all apothecaries
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

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