BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 38 [TOP]

Compound ID

3960

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Extract

Target Bacteria

Mycobacterium fortuitum

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - (Methyldithio) Pyrimidine

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Pyrimidine, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

157.997

Molecular Formula

C₅H₆N₂S₂

SMILES

C1ccnc(n1)SSC

XLogP

1.511

PSA

76.380

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

Curator

Record - 2 of 38 [TOP]

Compound ID

3902

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Chloroform

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Ethambutol, Isoniazid

Inhibition [%]

90 %

Activity [MIC] µg/ml

0.01 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - (Methyldithio) Pyridine - N - Oxide

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

172.997

Molecular Formula

C₆H₇NOS₂

SMILES

C1cc[n+](c(c1)SSC)[O-]

XLogP

1.646

PSA

77.540

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 3 of 38 [TOP]

Compound ID

3903

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Chloroform

Target Bacteria

Mycobacterium fortuitum

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - (Methyldithio) Pyridine - N - Oxide

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

172.997

Molecular Formula

C₆H₇NOS₂

SMILES

C1cc[n+](c(c1)SSC)[O-]

XLogP

1.646

PSA

77.540

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 4 of 38 [TOP]

Compound ID

3904

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Chloroform

Target Bacteria

Mycobacterium smegmatis

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (32 µg/ml), Isoniazid (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - (Methyldithio) Pyridine - N - Oxide

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

172.997

Molecular Formula

C₆H₇NOS₂

SMILES

C1cc[n+](c(c1)SSC)[O-]

XLogP

1.646

PSA

77.540

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 5 of 38 [TOP]

Compound ID

3905

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Chloroform

Target Bacteria

Mycobacterium smegmatis (mc² 2700)

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - (Methyldithio) Pyridine - N - Oxide

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

172.997

Molecular Formula

C₆H₇NOS₂

SMILES

C1cc[n+](c(c1)SSC)[O-]

XLogP

1.646

PSA

77.540

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 6 of 38 [TOP]

Compound ID

3906

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Chloroform

Target Bacteria

Mycobacterium phlei

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - (Methyldithio) Pyridine - N - Oxide

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

172.997

Molecular Formula

C₆H₇NOS₂

SMILES

C1cc[n+](c(c1)SSC)[O-]

XLogP

1.646

PSA

77.540

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 7 of 38 [TOP]

Compound ID

3907

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Chloroform

Target Bacteria

Mycobacterium bovis (BCG - Bacillus Calmette Guerin)

Assay / Test Done

Positive Control Used (conc.)

Ethambutol, Isoniazid

Inhibition [%]

90 %

Activity [MIC] µg/ml

0.01 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - (Methyldithio) Pyridine - N - Oxide

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

172.997

Molecular Formula

C₆H₇NOS₂

SMILES

C1cc[n+](c(c1)SSC)[O-]

XLogP

1.646

PSA

77.540

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 8 of 38 [TOP]

Compound ID

3908

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Chloroform

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27 294)

Assay / Test Done

Positive Control Used (conc.)

Ethambutol, Isoniazid

Inhibition [%]

100 %

Activity [MIC] µg/ml

0.01 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide

PubChem ID

45267926

Ethnomedicinal Information

Promotion of wound healing

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Dithiol, Pyridine-N-Oxide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

218.985

Molecular Formula

C₇H₉NOS₃

SMILES

S(SCSC)c1[n+]([O-])cccc1

XLogP

2.259

PSA

102.840

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 9 of 38 [TOP]

Compound ID

3909

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Chloroform

Target Bacteria

Mycobacterium fortuitum

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide

PubChem ID

45267926

Ethnomedicinal Information

Promotion of wound healing

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Dithiol, Pyridine-N-Oxide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

218.985

Molecular Formula

C₇H₉NOS₃

SMILES

S(SCSC)c1[n+]([O-])cccc1

XLogP

2.259

PSA

102.840

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 10 of 38 [TOP]

Compound ID

3910

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Chloroform

Target Bacteria

Mycobacterium smegmatis

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (32 µg/ml), Isoniazid (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide

PubChem ID

45267926

Ethnomedicinal Information

Promotion of wound healing

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Dithiol, Pyridine-N-Oxide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

218.985

Molecular Formula

C₇H₉NOS₃

SMILES

S(SCSC)c1[n+]([O-])cccc1

XLogP

2.259

PSA

102.840

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 11 of 38 [TOP]

Compound ID

3911

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Chloroform

Target Bacteria

Mycobacterium smegmatis (mc² 2700)

Assay / Test Done

Positive Control Used (conc.)

Not Tested

Inhibition [%]

Activity [MIC] µg/ml

4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide

PubChem ID

45267926

Ethnomedicinal Information

Promotion of wound healing

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Dithiol, Pyridine-N-Oxide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

218.985

Molecular Formula

C₇H₉NOS₃

SMILES

S(SCSC)c1[n+]([O-])cccc1

XLogP

2.259

PSA

102.840

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 12 of 38 [TOP]

Compound ID

3912

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Chloroform

Target Bacteria

Mycobacterium phlei

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide

PubChem ID

45267926

Ethnomedicinal Information

Promotion of wound healing

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Dithiol, Pyridine-N-Oxide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

218.985

Molecular Formula

C₇H₉NOS₃

SMILES

S(SCSC)c1[n+]([O-])cccc1

XLogP

2.259

PSA

102.840

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 13 of 38 [TOP]

Compound ID

3913

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Chloroform

Target Bacteria

Mycobacterium bovis (BCG - Bacillus Calmette Guerin)

Assay / Test Done

Positive Control Used (conc.)

Ethambutol, Isoniazid

Inhibition [%]

90 %

Activity [MIC] µg/ml

0.01 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide

PubChem ID

45267926

Ethnomedicinal Information

Promotion of wound healing

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Dithiol, Pyridine-N-Oxide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

218.985

Molecular Formula

C₇H₉NOS₃

SMILES

S(SCSC)c1[n+]([O-])cccc1

XLogP

2.259

PSA

102.840

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 14 of 38 [TOP]

Compound ID

3914

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv (ATCC 27 294)

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)

PubChem ID

3109

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Alkaloid, Disulfide, Dipyrithione

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

252.003

Molecular Formula

C₁₀H₈N₂O₂S₂

SMILES

S(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1

XLogP

1.726

PSA

104.480

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 15 of 38 [TOP]

Compound ID

3915

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Target Bacteria

Mycobacterium fortuitum

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

16 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)

PubChem ID

3109

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Alkaloid, Disulfide, Dipyrithione

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

252.003

Molecular Formula

C₁₀H₈N₂O₂S₂

SMILES

S(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1

XLogP

1.726

PSA

104.480

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 16 of 38 [TOP]

Compound ID

3916

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Target Bacteria

Mycobacterium smegmatis

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (32 µg/ml), Isoniazid (0.25 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

16 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)

PubChem ID

3109

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Alkaloid, Disulfide, Dipyrithione

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

252.003

Molecular Formula

C₁₀H₈N₂O₂S₂

SMILES

S(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1

XLogP

1.726

PSA

104.480

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 17 of 38 [TOP]

Compound ID

3917

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Target Bacteria

Mycobacterium smegmatis (mc² 2700)

Assay / Test Done

Positive Control Used (conc.)

Not Tested

Inhibition [%]

Activity [MIC] µg/ml

Not tested

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)

PubChem ID

3109

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Alkaloid, Disulfide, Dipyrithione

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

252.003

Molecular Formula

C₁₀H₈N₂O₂S₂

SMILES

S(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1

XLogP

1.726

PSA

104.480

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 18 of 38 [TOP]

Compound ID

3918

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Target Bacteria

Mycobacterium phlei

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

16 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)

PubChem ID

3109

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

A 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol

Chemical Classification [Active Compound]

Aromatic, Alkaloid, Disulfide, Dipyrithione

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

252.003

Molecular Formula

C₁₀H₈N₂O₂S₂

SMILES

S(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1

XLogP

1.726

PSA

104.480

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 19 of 38 [TOP]

Compound ID

3919

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Bulb

Extract

Target Bacteria

Mycobacterium bovis (BCG - Bacillus Calmette Guerin)

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)

PubChem ID

3109

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkaloid, Disulfide, Dipyrithione

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

252.003

Molecular Formula

C₁₀H₈N₂O₂S₂

SMILES

S(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1

XLogP

1.726

PSA

104.480

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 20 of 38 [TOP]

Compound ID

3920

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Extract

Target Bacteria

Mycobacterium fortuitum

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - (Methyldithio) Pyridine

PubChem ID

173923

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Pyridine, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

157.002

Molecular Formula

C₆H₇NS₂

SMILES

S(SC)c1ncccc1

XLogP

2.407

PSA

63.490

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 21 of 38 [TOP]

Compound ID

3921

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Extract

Target Bacteria

Mycobacterium smegmatis

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - (Methyldithio) Quinoline

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Quinoline, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

207.018

Molecular Formula

C₁₀H₉NS₂

SMILES

C1cccc2c1ccc(n2)SSC

XLogP

4.035

PSA

63.490

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 22 of 38 [TOP]

Compound ID

3922

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Extract

Target Bacteria

Mycobacterium smegmatis (mc² 2700)

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

Not tested

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - (Methyldithio) Pyridine

PubChem ID

173923

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Pyridine, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

157.002

Molecular Formula

C₆H₇NS₂

SMILES

S(SC)c1ncccc1

XLogP

2.407

PSA

63.490

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 23 of 38 [TOP]

Compound ID

3923

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Extract

Target Bacteria

Mycobacterium phlei

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

16 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - (Methyldithio) Pyridine

PubChem ID

173923

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Pyridine, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

157.002

Molecular Formula

C₆H₇NS₂

SMILES

S(SC)c1ncccc1

XLogP

2.407

PSA

63.490

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 24 of 38 [TOP]

Compound ID

3925

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Extract

Target Bacteria

Mycobacterium smegmatis

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - (Methyldithio) Pyridine

PubChem ID

173923

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Pyridine, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

157.002

Molecular Formula

C₆H₇NS₂

SMILES

S(SC)c1ncccc1

XLogP

2.407

PSA

63.490

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

Record - 25 of 38 [TOP]

Compound ID

3928

Compound Structure

Plant Source

Allium stipitatum Regel Common Name:Ornamental Onion, Glory of Pamir

Source Family

Amaryllidaceae

Origin

Spalding, Lincolnshire, UK

Plant Part Used

Extract

Target Bacteria

Mycobacterium fortuitum

Assay / Test Done

Positive Control Used (conc.)

Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - (Methyldithio) Quinoline

PubChem ID

Ethnomedicinal Information

PubMed ID [Source Literature]

19093848

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Quinoline, Disulfide

Media / Broth Used [Antimicrobial Assay/Test]

Columbia blood agar (Oxoid)

Cytotoxicity Assay [AID]

Sulforhodamine B Short - Term Cytotoxicity Assay

Molecular Weight

207.018

Molecular Formula

C₁₀H₉NS₂

SMILES

C1cccc2c1ccc(n2)SSC

XLogP

4.035

PSA

63.490

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Vikramjitmandal

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