BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 5 [TOP]

Compound ID	1450
Compound Structure
Plant Source	Cinnamomum zeylandicum Breyn. Common Name:Cinnamon, Ceylon Cinnamon (English), Tvak, Daaruchini (Sanskrit)
Source Family	Lauraceae
Origin	Sri Lanka, Sumatra, Eastern Islands, Brazil, Mauritius, India, Jamaica
Plant Part Used	Bark
Extract	Methanol (9.41 %)
Target Bacteria	Mycobacterium avium
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic and used to treat gonorrhoea, asthma, diabetes, diseases of oral cavity, bronchitis, expectorant
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
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Record - 2 of 5 [TOP]

Compound ID	1451
Compound Structure
Plant Source	Cinnamomum zeylandicum Breyn. Common Name:Cinnamon, Ceylon Cinnamon (English),Tvak, Daaruchini (Sanskrit)
Source Family	Lauraceae
Origin	Sri Lanka, Sumatra, Eastern Islands, Brazil, Mauritius, India, Jamaica, Malaysia
Plant Part Used	Bark
Extract	Methanol (9.41 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic and used to treat gonorrhoea, asthma, diabetes, diseases of oral cavity, bronchitis, expectorant
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
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Record - 3 of 5 [TOP]

Compound ID	1452
Compound Structure
Plant Source	Cinnamomum zeylanicum Breyn. Common Name:Cinnamon, Ceylon Cinnamon (English),Tvak, Daaruchini (Sanskrit)
Source Family	Lauraceae
Origin	Sri Lanka, Sumatra, Eastern Islands, Brazil, Mauritius, India, Jamaica
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]	100 %
Activity [MIC] µg/ml	1:640 dilution
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic and used to treat gonorrhoea, asthma, diabetes, diseases of oral cavity, bronchitis, expectorant
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 14. Lalit Mohan Basu, Allahabad, India
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Record - 4 of 5 [TOP]

Compound ID	1453
Compound Structure
Plant Source	Cinnamomum zeylanicum Breyn. Common Name:Cinnamon, Ceylon Cinnamon (English),Tvak, Daaruchini (Sanskrit)
Source Family	Lauraceae
Origin	Sri Lanka, Sumatra, Eastern Islands, Brazil, Mauritius, India, Jamaica, Malaysia
Plant Part Used	Stem
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic and used to treat gonorrhoea, asthma, diabetes, diseases of oral cavity, bronchitis, expectorant
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Ong, T., 2008. Rahsia Herba, 2nd ed. Alaf 21 Sdn Bhd, Shah Alam, Selangor, Malaysia 2) http://parisaramahiti.kar.nic.in/Medicinal_plants_new/med%20plants/p52.html
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Record - 5 of 5 [TOP]

Compound ID

2578

Compound Structure

Plant Source

Scleropyrum pentandrum Common Name:

Source Family

Santalaceae

Origin

India, Malaysia, Philippines, Singapore, Sri Lanka

Plant Part Used

Twig

Extract

Hexane

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Rifampin (0.004 µg/ml), Isoniazid (0.06 µg/ml), Kanamycin sulphate (2.5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Scleropyric acid

PubChem ID

11594149

Ethnomedicinal Information

Malaria, tuberculosis

PubMed ID [Source Literature]

16204994

Extract Preparation

The pulverized, dry twigs (1.06 kg) were extracted successively with n - Hexane, CHCl₃ and MeOH in a soxhlet extraction apparatus to yield the hexane (7.12 g), CHCl₃ (3.50 g), and MeOH (12.42 g) extracts, respectively

Chemical Classification [Active Compound]

Aliphatic, Alkene, Alkyne, Fatty acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

264.209

Molecular Formula

C₁₇H₂₈O₂

SMILES

OC(=O)CCCCCCCCCCC#CCCC=C

XLogP

6.563

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Suksamrarn A, Buaprom M, Udtip S, Nuntawong N, Haritakun R, Kanokmedhakul S.Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum.Chem Pharm Bull (Tokyo). 2005 Oct;53(10):1327-9

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