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                  Page - 1 of 1                  Record - 1 of 3   [TOP]
Compound ID2646
Compound Structure
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Plant SourceStrobilanthes cusia     Common Name:
Source FamilyAcanthaceae
OriginChina, Taiwan
Plant Part Used
Extract
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneBACTEC Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml1 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedTryptanthrin
PubChem ID   73549
Ethnomedicinal InformationHas folkloric reputation for the topical treatment of athletes foot
PubMed ID [Source Literature]9828037
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Quinazolinone, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight248.059
Molecular FormulaC15H8N2O2
SMILESO=C1c2n(c3c1cccc3)c(=O)c1c(n2)cccc1
XLogP3.519
PSA46.500
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O2
No. of S0
Reference(s)1) Mitscher LA, Baker W.Tuberculosis: a search for novel therapy starting with natural products.Med Res Rev. 1998 Nov;18(6):363-74

2) L. A. Mitscher and W. R. Baker.A search for novel chemotherapy against tuberculosis amongst natural products.Pure Appl. Chem., 1998, Vol. 70, No. 2, pp. 365-371

Curator

                  Record - 2 of 3   [TOP]
Compound ID2647
Compound Structure
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Plant SourceStrobilanthes cusia     Common Name:
Source FamilyAcanthaceae
OriginChina, Taiwan
Plant Part Used
Extract
Target BacteriaMycobacterium smegmatis
Assay / Test DoneAgar - Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedTryptanthrin
PubChem ID   73549
Ethnomedicinal InformationHas folkloric reputation for the topical treatment of athletes foot
PubMed ID [Source Literature]9828037
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Quinazolinone, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight248.059
Molecular FormulaC15H8N2O2
SMILESO=C1c2n(c3c1cccc3)c(=O)c1c(n2)cccc1
XLogP3.519
PSA46.500
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O2
No. of S0
Reference(s)1) Mitscher LA, Baker W.Tuberculosis: a search for novel therapy starting with natural products.Med Res Rev. 1998 Nov;18(6):363-74

2) L. A. Mitscher and W. R. Baker.A search for novel chemotherapy against tuberculosis amongst natural products.Pure Appl. Chem., 1998, Vol. 70, No. 2, pp. 365-371

Curator

                  Record - 3 of 3   [TOP]
Compound ID2648
Compound Structure
DOWNLOAD:
Plant SourceStrobilanthes cusia     Common Name:
Source FamilyAcanthaceae
OriginChina, Taiwan
Plant Part Used
Extract
Target BacteriaMycobacterium avium complex
Assay / Test DoneBACTEC Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedTryptanthrin
PubChem ID   73549
Ethnomedicinal InformationHas folkloric reputation for the topical treatment of athletes foot
PubMed ID [Source Literature]9828037
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Quinazolinone, Alkaloid
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight248.059
Molecular FormulaC15H8N2O2
SMILESO=C1c2n(c3c1cccc3)c(=O)c1c(n2)cccc1
XLogP3.519
PSA46.500
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O2
No. of S0
Reference(s)1) Mitscher LA, Baker W.Tuberculosis: a search for novel therapy starting with natural products.Med Res Rev. 1998 Nov;18(6):363-74

2) L. A. Mitscher and W. R. Baker.A search for novel chemotherapy against tuberculosis amongst natural products.Pure Appl. Chem., 1998, Vol. 70, No. 2, pp. 365-371

Curator


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