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                  Page - 1 of 2                  Record - 1 of 44   [TOP]
Compound ID3960
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part Used
Extract
Target BacteriaMycobacterium fortuitum
Assay / Test Done
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified2 - (Methyldithio) Pyrimidine
PubChem IDNR
Ethnomedicinal Information
PubMed ID [Source Literature]19093848
Extract Preparation
Chemical Classification [Active Compound]Aromatic, Pyrimidine, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight157.997
Molecular FormulaC5H6N2S2
SMILESC1ccnc(n1)SSC
XLogP1.511
PSA76.380
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count2
No. of Rings1
No. of N2
No. of O0
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

Curator

                  Record - 2 of 44   [TOP]
Compound ID3975
Compound Structure
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Plant SourceAllium neapolitanum     Common Name:
Source FamilyAmaryllidaceae
OriginLincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium abcessus (ATCC 19977)
Assay / Test DoneColumbia Blood Agar
Positive Control Used (conc.)Ethambutol (128 µg/ml), Isoniazid (128 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml16 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCanthin-6-one
PubChem ID   97176
Ethnomedicinal Information
PubMed ID [Source Literature]17421058
Extract Preparation6.3 kg of macerated bulb material underwent cold extraction with hexane, chloroform and methanol (3 l)
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Carbazole, Quinoline, Amide
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight220.064
Molecular FormulaC14H8N2O
SMILESO=c1n2c3c(c4c2cccc4)ccnc3cc1
XLogP2.809
PSA34.890
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O1
No. of S0
Reference(s)1) O'Donnell G, Gibbons S.Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum.Phytother Res. 2007 Jul;21(7):653-7

Curator

                  Record - 3 of 44   [TOP]
Compound ID3974
Compound Structure
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Plant SourceAllium neapolitanum     Common Name:
Source FamilyAmaryllidaceae
OriginLincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium fortuitum (ATCC 6841)
Assay / Test DoneColumbia Blood Agar
Positive Control Used (conc.)Ethambutol (4 µg/ml), Isoniazid (0.25 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml16 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedCanthin-6-one
PubChem ID   97176
Ethnomedicinal Information
PubMed ID [Source Literature]17421058
Extract Preparation6.3 kg of macerated bulb material underwent cold extraction with hexane, chloroform and methanol (3 l)
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Carbazole, Quinoline, Amide
Media / Broth Used [Antimicrobial Assay/Test]
Cytotoxicity Assay [AID]
Molecular Weight220.064
Molecular FormulaC14H8N2O
SMILESO=c1n2c3c(c4c2cccc4)ccnc3cc1
XLogP2.809
PSA34.890
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O1
No. of S0
Reference(s)1) O'Donnell G, Gibbons S.Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum.Phytother Res. 2007 Jul;21(7):653-7

Curator

                  Record - 4 of 44   [TOP]
Compound ID3796
Compound Structure
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Plant SourceAllium neapolitanum     Common Name:NR
Source FamilyAmaryllidaceae
OriginLincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium phlei (ATCC 11758)
Assay / Test DoneColumbia Blood Agar
Positive Control Used (conc.)Ethambutol (0.5 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCanthin-6-one
PubChem ID   97176
Ethnomedicinal InformationNR
PubMed ID [Source Literature]17421058
Extract Preparation6.3 kg of macerated bulb material underwent cold extraction with hexane, chloroform and methanol (3 l)
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Carbazole, Quinoline, Amide
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight220.064
Molecular FormulaC14H8N2O
SMILESO=c1n2c3c(c4c2cccc4)ccnc3cc1
XLogP2.809
PSA34.890
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O1
No. of S0
Reference(s)1) O'Donnell G, Gibbons S.Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum.Phytother Res. 2007 Jul;21(7):653-7

CuratorNajiya-beegum, vikramjitmandal

                  Record - 5 of 44   [TOP]
Compound ID3797
Compound Structure
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Plant SourceAllium neapolitanum     Common Name:NR
Source FamilyAmaryllidaceae
OriginLincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium smegmatis (mc2 2700)
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (0.25 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified8 - Hydroxy Canthin - 6 - One
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]17421058
Extract Preparation6.3 kg of macerated bulb material underwent cold extraction with hexane, chloroform and methanol (3 l)
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Carbazole, Quinoline, Amide, Phenol
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight235.063
Molecular FormulaC15H9NO2
SMILESC1ccc(c2c1c1c3n2c(=O)ccc3ccc1)O
XLogP2.854
PSA42.230
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count0
No. of Rings4
No. of N1
No. of O2
No. of S0
Reference(s)1) O'Donnell G, Gibbons S.Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum.Phytother Res. 2007 Jul;21(7):653-7

CuratorNajiya-beegum, vikramjitmandal

                  Record - 6 of 44   [TOP]
Compound ID3799
Compound Structure
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Plant SourceAllium neapolitanum     Common Name:NR
Source FamilyAmaryllidaceae
OriginLincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium smegmatis (ATCC 14468)
Assay / Test DoneColumbia Blood Agar
Positive Control Used (conc.)Ethambutol (0.25 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCanthin-6-one
PubChem ID   97176
Ethnomedicinal InformationNR
PubMed ID [Source Literature]17421058
Extract Preparation6.3 kg of macerated bulb material underwent cold extraction with hexane, chloroform and methanol (3 l)
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Carbazole, Quinoline, Amide
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight220.064
Molecular FormulaC14H8N2O
SMILESO=c1n2c3c(c4c2cccc4)ccnc3cc1
XLogP2.809
PSA34.890
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O1
No. of S0
Reference(s)1) O'Donnell G, Gibbons S.Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum.Phytother Res. 2007 Jul;21(7):653-7

CuratorNajiya-beegum, vikramjitmandal

                  Record - 7 of 44   [TOP]
Compound ID3800
Compound Structure
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Plant SourceAllium neapolitanum     Common Name:NR
Source FamilyAmaryllidaceae
OriginLincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium smegmatis (mc2 2700)
Assay / Test DoneColumbia Blood Agar
Positive Control Used (conc.)Ethambutol (0.25 µg/ml), Isoniazid (2 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedCanthin-6-one
PubChem ID   97176
Ethnomedicinal InformationNR
PubMed ID [Source Literature]17421058
Extract Preparation6.3 kg of macerated bulb material underwent cold extraction with hexane, chloroform and methanol (3 l)
Chemical Classification [Active Compound]Aromatic, Tetracyclic, Alkaloid, Carbazole, Quinoline, Amide
Media / Broth Used [Antimicrobial Assay/Test]NR
Cytotoxicity Assay [AID]NR
Molecular Weight220.064
Molecular FormulaC14H8N2O
SMILESO=c1n2c3c(c4c2cccc4)ccnc3cc1
XLogP2.809
PSA34.890
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count0
No. of Rings4
No. of N2
No. of O1
No. of S0
Reference(s)1) O'Donnell G, Gibbons S.Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum.Phytother Res. 2007 Jul;21(7):653-7

CuratorNajiya-beegum, vikramjitmandal

                  Record - 8 of 44   [TOP]
Compound ID3902
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)Ethambutol, Isoniazid
Inhibition [%]90 %
Activity [MIC] µg/ml0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Pyridine - N - Oxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight172.997
Molecular FormulaC6H7NOS2
SMILESC1cc[n+](c(c1)SSC)[O-]
XLogP1.646
PSA77.540
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count2
No. of Rings1
No. of N1
No. of O1
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 9 of 44   [TOP]
Compound ID3903
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium fortuitum
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (0.25 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Pyridine - N - Oxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight172.997
Molecular FormulaC6H7NOS2
SMILESC1cc[n+](c(c1)SSC)[O-]
XLogP1.646
PSA77.540
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count2
No. of Rings1
No. of N1
No. of O1
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 10 of 44   [TOP]
Compound ID3904
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium smegmatis
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (32 µg/ml), Isoniazid (0.25 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Pyridine - N - Oxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight172.997
Molecular FormulaC6H7NOS2
SMILESC1cc[n+](c(c1)SSC)[O-]
XLogP1.646
PSA77.540
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count2
No. of Rings1
No. of N1
No. of O1
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 11 of 44   [TOP]
Compound ID3905
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium smegmatis (mc2 2700)
Assay / Test DoneNR
Positive Control Used (conc.)ND
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Pyridine - N - Oxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight172.997
Molecular FormulaC6H7NOS2
SMILESC1cc[n+](c(c1)SSC)[O-]
XLogP1.646
PSA77.540
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count2
No. of Rings1
No. of N1
No. of O1
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 12 of 44   [TOP]
Compound ID3906
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium phlei
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Pyridine - N - Oxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight172.997
Molecular FormulaC6H7NOS2
SMILESC1cc[n+](c(c1)SSC)[O-]
XLogP1.646
PSA77.540
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count2
No. of Rings1
No. of N1
No. of O1
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 13 of 44   [TOP]
Compound ID3907
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol, Isoniazid
Inhibition [%]90 %
Activity [MIC] µg/ml0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - (Methyldithio) Pyridine - N - Oxide
PubChem IDNR
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Pyridine-N-Oxide, Disulfide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight172.997
Molecular FormulaC6H7NOS2
SMILESC1cc[n+](c(c1)SSC)[O-]
XLogP1.646
PSA77.540
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count2
No. of Rings1
No. of N1
No. of O1
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 14 of 44   [TOP]
Compound ID3908
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol, Isoniazid
Inhibition [%]100 %
Activity [MIC] µg/ml0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide
PubChem ID   45267926
Ethnomedicinal InformationPromotion of wound healing
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Dithiol, Pyridine-N-Oxide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight218.985
Molecular FormulaC7H9NOS3
SMILESS(SCSC)c1[n+]([O-])cccc1
XLogP2.259
PSA102.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings1
No. of N1
No. of O1
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 15 of 44   [TOP]
Compound ID3909
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium fortuitum
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (0.25 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml8 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide
PubChem ID   45267926
Ethnomedicinal InformationPromotion of wound healing
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Dithiol, Pyridine-N-Oxide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight218.985
Molecular FormulaC7H9NOS3
SMILESS(SCSC)c1[n+]([O-])cccc1
XLogP2.259
PSA102.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings1
No. of N1
No. of O1
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 16 of 44   [TOP]
Compound ID3910
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium smegmatis
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (32 µg/ml), Isoniazid (0.25 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide
PubChem ID   45267926
Ethnomedicinal InformationPromotion of wound healing
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Dithiol, Pyridine-N-Oxide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight218.985
Molecular FormulaC7H9NOS3
SMILESS(SCSC)c1[n+]([O-])cccc1
XLogP2.259
PSA102.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings1
No. of N1
No. of O1
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 17 of 44   [TOP]
Compound ID3911
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium smegmatis (mc2 2700)
Assay / Test DoneNR
Positive Control Used (conc.)Not Tested
Inhibition [%]NR
Activity [MIC] µg/ml4 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide
PubChem ID   45267926
Ethnomedicinal InformationPromotion of wound healing
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Dithiol, Pyridine-N-Oxide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight218.985
Molecular FormulaC7H9NOS3
SMILESS(SCSC)c1[n+]([O-])cccc1
XLogP2.259
PSA102.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings1
No. of N1
No. of O1
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 18 of 44   [TOP]
Compound ID3912
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium phlei
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml2 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide
PubChem ID   45267926
Ethnomedicinal InformationPromotion of wound healing
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Dithiol, Pyridine-N-Oxide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight218.985
Molecular FormulaC7H9NOS3
SMILESS(SCSC)c1[n+]([O-])cccc1
XLogP2.259
PSA102.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings1
No. of N1
No. of O1
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 19 of 44   [TOP]
Compound ID3913
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractChloroform
Target BacteriaMycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol, Isoniazid
Inhibition [%]90 %
Activity [MIC] µg/ml0.01 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2 - [(Methylthiomethyl) Dithio] Pyridine - N - Oxide
PubChem ID   45267926
Ethnomedicinal InformationPromotion of wound healing
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Dithiol, Pyridine-N-Oxide
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight218.985
Molecular FormulaC7H9NOS3
SMILESS(SCSC)c1[n+]([O-])cccc1
XLogP2.259
PSA102.840
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count4
No. of Rings1
No. of N1
No. of O1
No. of S3
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 20 of 44   [TOP]
Compound ID3914
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test DoneNR
Positive Control Used (conc.)
Inhibition [%]NR
Activity [MIC] µg/mlNR
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)
PubChem ID   3109
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Disulfide, Dipyrithione
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight252.003
Molecular FormulaC10H8N2O2S2
SMILESS(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1
XLogP1.726
PSA104.480
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 21 of 44   [TOP]
Compound ID3915
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium fortuitum
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (0.25 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml16 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)
PubChem ID   3109
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Disulfide, Dipyrithione
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight252.003
Molecular FormulaC10H8N2O2S2
SMILESS(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1
XLogP1.726
PSA104.480
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 22 of 44   [TOP]
Compound ID3916
Compound Structure
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Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium smegmatis
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (32 µg/ml), Isoniazid (0.25 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml16 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)
PubChem ID   3109
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Disulfide, Dipyrithione
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight252.003
Molecular FormulaC10H8N2O2S2
SMILESS(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1
XLogP1.726
PSA104.480
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 23 of 44   [TOP]
Compound ID3917
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium smegmatis (mc2 2700)
Assay / Test DoneNR
Positive Control Used (conc.)Not Tested
Inhibition [%]NR
Activity [MIC] µg/mlNot tested
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)
PubChem ID   3109
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Disulfide, Dipyrithione
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight252.003
Molecular FormulaC10H8N2O2S2
SMILESS(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1
XLogP1.726
PSA104.480
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 24 of 44   [TOP]
Compound ID3918
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium phlei
Assay / Test DoneNR
Positive Control Used (conc.)Ethambutol (2 µg/ml), Isoniazid (128 µg/ml)
Inhibition [%]NR
Activity [MIC] µg/ml16 µg/ml
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)
PubChem ID   3109
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationA 4.43 kg quantity of macerated bulbs was extracted exhaustively with hexane, chloroform and methanol
Chemical Classification [Active Compound]Aromatic, Alkaloid, Disulfide, Dipyrithione
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight252.003
Molecular FormulaC10H8N2O2S2
SMILESS(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1
XLogP1.726
PSA104.480
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal

                  Record - 25 of 44   [TOP]
Compound ID3919
Compound Structure
DOWNLOAD:
Plant SourceAllium stipitatum Regel     Common Name:Ornamental Onion, Glory of Pamir
Source FamilyAmaryllidaceae
OriginSpalding, Lincolnshire, UK
Plant Part UsedBulb
ExtractNR
Target BacteriaMycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test DoneNR
Positive Control Used (conc.)
Inhibition [%]NR
Activity [MIC] µg/mlNR
Activity (In terms of dilution)NR
Activity (Zone of inhibition in mm)NR
Active Compound Identified2, 2' - Dithio - Bis - Pyridine - N - Oxide (Dipyrithione)
PubChem ID   3109
Ethnomedicinal InformationNR
PubMed ID [Source Literature]19093848
Extract PreparationNR
Chemical Classification [Active Compound]Aromatic, Alkaloid, Disulfide, Dipyrithione
Media / Broth Used [Antimicrobial Assay/Test]Columbia blood agar (Oxoid)
Cytotoxicity Assay [AID]Sulforhodamine B Short - Term Cytotoxicity Assay
Molecular Weight252.003
Molecular FormulaC10H8N2O2S2
SMILESS(Sc1[n+]([O-])cccc1)c1[n+]([O-])cccc1
XLogP1.726
PSA104.480
H-bond Donor0
H-bond Acceptor2
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S2
Reference(s)1) O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S.Bioactive pyridine-N-oxide disulfides from Allium stipitatum.J Nat Prod. 2009 Mar 27;72(3):360-5

CuratorVikramjitmandal


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