BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 3 Record - 1 of 65 [TOP]

Compound ID	1241
Compound Structure
Plant Source	Bauhinia microstachya var. massambabensis Common Name:Orchid Tree, Camel's Foot Tree, Mountain Ebony
Source Family	Fabaceae
Origin	USA
Plant Part Used	Leaf
Extract	Ethanol, hexane, dichloromethane, ethyl acetate, n - butanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Treatment of dolorous processes
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) LEITAO, Suzana G. et al. Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test. Rev. bras. farmacogn. [online]. 2006, vol.16, n.1, pp. 6-11 2) Meyre-Silva C, Yunes RA, Delle Monache F, Santos AR, Schmeling LO, Gadotti VM, Liz F, Cechinel-Filho V.Phytochemical and pharmacological analysis of Bauhinia microstachya (Raddi) Macbr. (Leguminosae).Z Naturforsch C. 2001 Nov-Dec;56(11-12):939-42
Curator

Record - 2 of 65 [TOP]

Compound ID	1242
Compound Structure
Plant Source	Bauhinia microstachya var. microstac hya Common Name:Orchid Tree, Camel's Foot Tree, Mountain Ebony
Source Family	Fabaceae
Origin	USA
Plant Part Used	Leaf
Extract	Ethanol, hexane, dichloromethane, ethyl acetate, n - butanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) LEITAO, Suzana G. et al. Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test. Rev. bras. farmacogn. [online]. 2006, vol.16, n.1, pp. 6-11
Curator

Record - 3 of 65 [TOP]

Compound ID

1280

Compound Structure

Plant Source

Borrichia frutescens L. Common Name:Sea Daisy

Source Family

Asteraceae (Compositae)

Origin

Southeastern USA

Plant Part Used

Flower, leaf, stem

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Fusidic acid (4 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(24R)-24,25-epoxycycloartan-3-one

PubChem ID

469544

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

8988597

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tetracyclic, Terpene, Triterpene, Cycloartane, Ketone, Epoxy

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against vero cells

Molecular Weight

440.365

Molecular Formula

C₃₀H₄₈O₂

SMILES

O=C1C([C@H]2[C@@]3([C@@]4(C3)[C@H]([C@]3([C@](CC4)([C@H](CC3)[C@@H](CC[C@H]3OC3(C)C)C)C)C)CC2)CC1)(C)C

XLogP

9.983

PSA

29.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cantrell CL, Lu T, Fronczek FR, Fischer NH, Adams LB, Franzblau SG.Antimycobacterial cycloartanes from Borrichia frutescens.J Nat Prod. 1996 Dec;59(12):1131-6

Curator

Record - 4 of 65 [TOP]

Compound ID

1281

Compound Structure

Plant Source

Borrichia frutescens L. Common Name:Sea Daisy

Source Family

Asteraceae (Compositae)

Origin

USA

Plant Part Used

Flower, leaf, stem

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Fusidic acid (4 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(3β, 24R) - 24, 25 - Epoxycycloartan - 3 - Ol

PubChem ID

469545

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

8988597

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tetracyclic, Terpene, Triterpene, Cycloartane, Epoxy, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against Vero cells

Molecular Weight

442.381

Molecular Formula

C₃₀H₅₀O₂

SMILES

O[C@H]1C([C@H]2[C@@]3([C@@]4(C3)[C@H]([C@]3([C@](CC4)([C@H](CC3)[C@@H](CC[C@H]3OC3(C)C)C)C)C)CC2)CC1)(C)C

XLogP

10.590

PSA

32.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cantrell CL, Lu T, Fronczek FR, Fischer NH, Adams LB, Franzblau SG.Antimycobacterial cycloartanes from Borrichia frutescens.J Nat Prod. 1996 Dec;59(12):1131-6

Curator

Record - 5 of 65 [TOP]

Compound ID

1282

Compound Structure

Plant Source

Borrichia frutescens L. Common Name:Sea Daisy

Source Family

Asteraceae (Compositae)

Origin

USA

Plant Part Used

Flower, leaf, stem

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Fusidic acid (4 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

64 - 128 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(23R)-3-Oxolanosta-8,24-dien-23-Ol

PubChem ID

469546

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

8988597

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tetracyclic, Steroid, Ketone, Prenylated

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against Vero cells

Molecular Weight

440.365

Molecular Formula

C₃₀H₄₈O₂

SMILES

O=C1C([C@H]2[C@@](C3=C([C@]4([C@@]([C@H](CC4)[C@@H](C[C@@H](O)C=C(C)C)C)(CC3)C)C)CC2)(CC1)C)(C)C

XLogP

7.784

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cantrell CL, Lu T, Fronczek FR, Fischer NH, Adams LB, Franzblau SG.Antimycobacterial cycloartanes from Borrichia frutescens.J Nat Prod. 1996 Dec;59(12):1131-6

Curator

Record - 6 of 65 [TOP]

Compound ID	1283
Compound Structure
Plant Source	Borrichia frutescens L. Common Name:Sea Daisy
Source Family	Asteraceae (Compositae)
Origin	USA
Plant Part Used	Flower
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)	Fusidic acid (4 µg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	8988597
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Cantrell CL, Lu T, Fronczek FR, Fischer NH, Adams LB, Franzblau SG.Antimycobacterial cycloartanes from Borrichia frutescens.J Nat Prod. 1996 Dec;59(12):1131-6
Curator

Record - 7 of 65 [TOP]

Compound ID	1284
Compound Structure
Plant Source	Borrichia frutescens L. Common Name:Sea Daisy
Source Family	Asteraceae (Compositae)
Origin	USA
Plant Part Used	Flower
Extract	Dichloromethane
Target Bacteria	Mycobacterium avium
Assay / Test Done
Positive Control Used (conc.)	Rifampin, Clarithromycin
Inhibition [%]	99 %
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	23195767
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) C.L. Cantrell, N.H. Fischer, L. Urbatsch, M.S. McGuire, S.G. Franzblau.Antimycobacterial crude plant extracts from South, Central, and North America.Phytomedicine, Volume 5, Issue 2, April 1998, Pages 137–145
Curator

Record - 8 of 65 [TOP]

Compound ID	1486
Compound Structure
Plant Source	Clematis virginiana Common Name:
Source Family	Ranunculaceae
Origin	USA
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	100 %
Activity [MIC] µg/ml	1:640 dilution
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Fitzpatrick, F.K.Plant substances achieve against mycobacterium tuberculoses.Antibiotics and Chemotherapy, Vol 4, Pages 528-536
Curator

Record - 9 of 65 [TOP]

Compound ID	1641
Compound Structure
Plant Source	Erigeron strigosus Muhl Common Name:Daisy Fleabane, Prairie Fleabane, Rough Fleabane
Source Family	Asteraceae (Compositae)
Origin	USA
Plant Part Used	Root
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done
Positive Control Used (conc.)	Rifampin, Clarithromycin
Inhibition [%]	100 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	23195767
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) C.L. Cantrell, N.H. Fischer, L. Urbatsch, M.S. McGuire, S.G. Franzblau.Antimycobacterial crude plant extracts from South, Central, and North America.Phytomedicine, Volume 5, Issue 2, April 1998, Pages 137–145
Curator

Record - 10 of 65 [TOP]

Compound ID	1722
Compound Structure
Plant Source	Euthamia leptocephala Greene Common Name:Bushy Goldentop
Source Family	Asteraceae (Compositae)
Origin	USA
Plant Part Used	Aerial
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	100 %
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	23195767
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) C.L. Cantrell, N.H. Fischer, L. Urbatsch, M.S. McGuire, S.G. Franzblau.Antimycobacterial crude plant extracts from South, Central, and North America.Phytomedicine, Volume 5, Issue 2, April 1998, Pages 137–145
Curator

Record - 11 of 65 [TOP]

Compound ID

1838

Compound Structure

Plant Source

Haplopappus sonoriensis Common Name:

Source Family

Asteraceae (Compositae)

Origin

USA

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

33 %

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

5 - Hydroxy - 3, 7, 4` - Trimethoxyflavone

PubChem ID

5468749

Ethnomedicinal Information

To treat coughs

PubMed ID [Source Literature]

12727485

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against human colorectal cancer cells, HCT-116 (ATCC CCL-247)

Molecular Weight

328.095

Molecular Formula

C₁₈H₁₆O₆

SMILES

O1c2c(c(=O)c(OC)c1c1ccc(OC)cc1)c(O)cc(OC)c2

XLogP

2.540

PSA

64.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Murillo JI, Encarnación-Dimayuga R, Malmstrøm J, Christophersen C, Franzblau SG. Antimycobacterial flavones from Haplopappus sonorensis.Fitoterapia Volume 74, Issue 3, April 2003, Pages 226-230

Curator

Record - 12 of 65 [TOP]

Compound ID

1840

Compound Structure

Plant Source

Haplopappus sonoriensis Common Name:

Source Family

Asteraceae (Compositae)

Origin

USA

Plant Part Used

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

48 %

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Kumatakenin

PubChem ID

5318869

Ethnomedicinal Information

Antiulcer, antiviral

PubMed ID [Source Literature]

12727485

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against human colorectal cancer cells, HCT-116 (ATCC CCL-247)

Molecular Weight

314.079

Molecular Formula

C₁₇H₁₄O₆

SMILES

O1c2c(c(=O)c(OC)c1c1ccc(O)cc1)c(O)cc(OC)c2

XLogP

2.021

PSA

75.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Murillo JI, Encarnación-Dimayuga R, Malmstrøm J, Christophersen C, Franzblau SG. Antimycobacterial flavones from Haplopappus sonorensis.Fitoterapia Volume 74, Issue 3, April 2003, Pages 226-230

Curator

Record - 13 of 65 [TOP]

Compound ID	1862
Compound Structure
Plant Source	Hennecartia omphalandra Common Name:
Source Family	Monimiaceae
Origin	USA
Plant Part Used	Fruit, leaf
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294 H37Rv)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) LEITAO, Suzana G. et al. Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test. Rev. bras. farmacogn. [online]. 2006, vol.16, n.1, pp. 6-11
Curator

Record - 14 of 65 [TOP]

Compound ID	1874
Compound Structure
Plant Source	Humulus lupulus L. Common Name:Hops (English)
Source Family	Cannabaceae
Origin	India, USA
Plant Part Used	Flower
Extract	Water, ethanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stomach ache, diuretic, antiseptic, indigestion, tonic, sedative, nervous conditions, bacteriostatic, random screening
PubMed ID [Source Literature]	16695763
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gottshall RY, Lucas EH, Lickfeldt A, Roberts JM.The occurrence of antibacterial substances active against Mycobacterium tuberculosis in seed plants.J Clin Invest. 1949 Sep;28(5 Pt 1):920-3 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 15 of 65 [TOP]

Compound ID	1875
Compound Structure
Plant Source	Humulus lupulus L. Common Name:Hops (English)
Source Family	Cannabaceae
Origin	India, USA
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stomach ache, diuretic, antiseptic, indigestion, tonic, sedative, nervous conditions, bacteriostatic, random screening
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91
Curator

Record - 16 of 65 [TOP]

Compound ID	1918
Compound Structure
Plant Source	Inula helenium L. Common Name:Scabwort, Horse Heal, Wild Sunflower
Source Family	Asteraceae (Compositae)
Origin	Europe and temperate Asia, USA, China
Plant Part Used	Root
Extract	Dichloromethane, hexane
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)	Rifampin, Clarithromycin
Inhibition [%]	100 %
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used for stomach ulcers and chronic cough, respiratory tract infections, digestive support
PubMed ID [Source Literature]	23195767
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) C.L. Cantrell, N.H. Fischer, L. Urbatsch, M.S. McGuire, S.G. Franzblau.Antimycobacterial crude plant extracts from South, Central, and North America.Phytomedicine, Volume 5, Issue 2, April 1998, Pages 137–145
Curator

Record - 17 of 65 [TOP]

Compound ID	1919
Compound Structure
Plant Source	Inula helenium L. Common Name:Scabwort, Horse Heal, Wild Sunflower
Source Family	Asteraceae (Compositae)
Origin	Europe and Temperate Asia, USA, China
Plant Part Used	Root
Extract	Methanol (12.26 %)
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used for stomach ulcers and chronic cough, respiratory tract infections, digestive support
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 18 of 65 [TOP]

Compound ID	1920
Compound Structure
Plant Source	Inula helenium L. Common Name:Scabwort, Horse Heal, Wild Sunflower
Source Family	Asteraceae (Compositae)
Origin	Europe and Temperate Asia, USA, China
Plant Part Used	Root
Extract	Methanol (12.26 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used for stomach ulcers and chronic cough, respiratory tract infections, digestive support
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 19 of 65 [TOP]

Compound ID

1929

Compound Structure

Plant Source

Inula racemosa Hook. f. syn. Inula helenium L. Common Name:Elecampane (English), Pushkaramula, Pushkara, Paushkara, Padmapatra, Kaashmira, Kushtha - bheda (Sanskrit)

Source Family

Asteraceae (Compositae)

Origin

India, USA

Plant Part Used

Root

Extract

Hexane, dichloromethane, methanol

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Rifampin (0.25 - 0.125 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

32 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Isoalantolactone

PubChem ID

73285

Ethnomedicinal Information

Tuberculosis, lung disorders, cough, expectorant, random screening, bronchitis

PubMed ID [Source Literature]

10364842

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Sesquiterpene, Lactone

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

232.146

Molecular Formula

C₁₅H₂₀O₂

SMILES

O1[C@@H]2C[C@@]3([C@@H](C[C@@H]2C(=C)C1=O)C(=C)CCC3)C

XLogP

3.681

PSA

26.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cantrell CL, Abate L, Fronczek FR, Franzblau SG, Quijano L, Fischer NH.Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa.Planta Med. 1999 May;65(4):351-5

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator

Record - 20 of 65 [TOP]

Compound ID

1974

Compound Structure

Plant Source

Karwinskia humboldtiana Common Name:Wild Cherry

Source Family

Rhamnaceae

Origin

USA

Plant Part Used

Root

Extract

Dichloromethane, ethanol (95 %)

Target Bacteria

Mycobacterium smegmatis (ATCC 607)

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Karwinaphthol B

PubChem ID

442522

Ethnomedicinal Information

Seeds are poisonous but fruit pulp is edible. Used locally in Mexico to treat convulsions

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Isochroman, Benzopyran, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

288.136

Molecular Formula

C₁₇H₂₀O₄

SMILES

O1[C@@H](c2c(C[C@@H]1C)cc1c(c2O)c(OC)cc(OC)c1)C

XLogP

2.444

PSA

47.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Mitscher LA, Gollapudi SR, Oburn DS, Drake S. 1985. Antimicrobial agents from higher plants: Two dimethylbenzisochromans from Karawinskia humboldtiana. Phytochemistry 24: 1681±1683.

2) Usher G. 1974. A Dictionary of Plants Used by Man. Macmillan: New York; 82

Curator

Record - 21 of 65 [TOP]

Compound ID	2060
Compound Structure
Plant Source	Lippia alba forma intermedia Common Name:Wild Marjoram
Source Family	Verbenaceae
Origin	USA
Plant Part Used	Leaf
Extract	Ethanol, hexane, dichloromethane, ethyl acetate, n - butanol
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294 H37Rv)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) LEITAO, Suzana G. et al. Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test. Rev. bras. farmacogn. [online]. 2006, vol.16, n.1, pp. 6-11
Curator

Record - 22 of 65 [TOP]

Compound ID	2063
Compound Structure
Plant Source	Lippia integrifolia Common Name:
Source Family	Verbenaceae
Origin	USA
Plant Part Used	Aerial
Extract	Water infusion, methanol, dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294 H37Rv)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) LEITAO, Suzana G. et al. Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test. Rev. bras. farmacogn. [online]. 2006, vol.16, n.1, pp. 6-11
Curator

Record - 23 of 65 [TOP]

Compound ID	2066
Compound Structure
Plant Source	Lippia lacunosa Common Name:
Source Family	Verbenaceae
Origin	USA
Plant Part Used	Leaf
Extract	Hexane, dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294 H37Rv)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) LEITAO, Suzana G. et al. Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test. Rev. bras. farmacogn. [online]. 2006, vol.16, n.1, pp. 6-11
Curator

Record - 24 of 65 [TOP]

Compound ID	2078
Compound Structure
Plant Source	Lippia rotundifolia Common Name:
Source Family	Verbenaceae
Origin	USA
Plant Part Used	Leaf
Extract	Hexane, dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294 H37Rv)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) LEITAO, Suzana G. et al. Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test. Rev. bras. farmacogn. [online]. 2006, vol.16, n.1, pp. 6-11
Curator

Record - 25 of 65 [TOP]

Compound ID	2091
Compound Structure
Plant Source	Lupinus polyphyllus Common Name:
Source Family	Fabaceae
Origin	USA
Plant Part Used	Leaf, stem
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	1:80 dilution
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) E. H. Lucas, Ardeth Lickfeldt, R. Y. Gottshall and J. C. Jennings.The Occurrence of Antibacterial Substances in Seed Plants with Special Reference to Mycobacterium Tuberculosis.Bulletin of the Torrey Botanical Club, Vol. 78, No. 4 (Jul. - Aug., 1951), pp. 310-321
Curator

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