BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 30 [TOP]

Compound ID	1082
Compound Structure
Plant Source	Agrophyron repens Linn. Beauv. Common Name:Couch Grass
Source Family	Gramineae
Origin	Worldwide
Plant Part Used	Rhizome
Extract	Methanol (6.83 %)
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antibiotic
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 2 of 30 [TOP]

Compound ID	1083
Compound Structure
Plant Source	Agrophyron repens Linn. Beauv. Common Name:Couch Grass
Source Family	Gramineae
Origin	Worldwide
Plant Part Used	Rhizome
Extract	Methanol (6.83 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antibiotic
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 3 of 30 [TOP]

Compound ID	1201
Compound Structure
Plant Source	Apium graveolens L. Common Name:Celery (English), Ajmodaa, Ajmoda, Ajmodikaa, Dipyaka (Sanskrit)
Source Family	Apiaceae (Umbelliferae)
Origin	India, Malaysia, Worldwide
Plant Part Used	Seed
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)	1:40 dilutions
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, chest pain, cough, anthelmintic, antifungal, fever, urinary calculi, obesity, musculoskeletal disorder, dropsy, chronic diarrhoea
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) http://parisaramahiti.kar.nic.in/Medicinal_plants_new/med%20plants/p18.html
Curator

Record - 4 of 30 [TOP]

Compound ID	1202
Compound Structure
Plant Source	Apium graveolens L. Common Name:Celery (English), Ajmodaa, Ajmoda, Ajmodikaa, Dipyaka (Sanskrit)
Source Family	Apiaceae (Umbelliferae)
Origin	India, Malaysia, Worldwide
Plant Part Used	Seed
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)	1:40 dilutions
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, chest pain, cough, anthelmintic, antifungal, fever, urinary calculi, obesity, musculoskeletal disorder, dropsy, chronic diarrhoea
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) http://parisaramahiti.kar.nic.in/Medicinal_plants_new/med%20plants/p18.html
Curator

Record - 5 of 30 [TOP]

Compound ID	1203
Compound Structure
Plant Source	Apium graveolens L. Common Name:Celery (English), Ajmodaa, Ajmoda, Ajmodikaa, Dipyaka (Sanskrit)
Source Family	Apiaceae (Umbelliferae)
Origin	India, Malaysia, Worldwide
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, chest pain, cough, anthelmintic, antifungal, fever, urinary calculi, obesity, musculoskeletal disorder, dropsy, chronic diarrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Chooi, O.H., 2003. Sayuran, Khasiat Makanan dan Ubatan. Utusan Publications and Distributors Sdn Bhd, Kuala Lumpur, Malaysia 2) http://parisaramahiti.kar.nic.in/Medicinal_plants_new/med%20plants/p18.html
Curator

Record - 6 of 30 [TOP]

Compound ID

1440

Compound Structure

Plant Source

Chromolaena odorata Common Name:Siam Weed, Christmas Bush, Common Floss Flower

Source Family

Asteraceae (Compositae)

Origin

Neotropics, Worldwide

Plant Part Used

Flower

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin sulphate (2.50 µg/ml), Isoniazid (0.06 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Isosakuranetin

PubChem ID

160481

Ethnomedicinal Information

Treat skin wounds

PubMed ID [Source Literature]

15202555, 10811796

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.084

Molecular Formula

C₁₆H₁₄O₅

SMILES

O1[C@@H](CC(=O)c2c1cc(O)cc2O)c1ccc(OC)cc1

XLogP

1.416

PSA

75.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Suksamrarn, A., Chotipong, A., Suavansri, T., Boongird, S., Timsuksai, P., Vimuttipong, S., et al. (2004). Antimycobacterial activity and cytotoxicity of flavonoids from the flowers of Chromolaena odorata. Arch Pharm Res 27, 507u511

2) Schmidt GJ, Schilling EE.Phylogeny and biogeography of Eupatorium (Asteraceae: Eupatorieae) based on nuclear ITS sequence data.Am J Bot. 2000 May;87(5):716-26

Curator

Record - 7 of 30 [TOP]

Compound ID

1441

Compound Structure

Plant Source

Chromolaena odorata Common Name:Siam Weed, Christmas Bush, Common Floss Flower

Source Family

Asteraceae (Compositae)

Origin

Neotropics, Worldwide

Plant Part Used

Flower

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin sulphate (2.50 µg/ml), Isoniazid (0.06 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

4` - Hydroxy - 5, 6, 7 - Trimethoxyflavanone

PubChem ID

244387

Ethnomedicinal Information

Treats skin wounds

PubMed ID [Source Literature]

15202555, 10811796

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

330.110

Molecular Formula

C₁₈H₁₈O₆

SMILES

O1C(CC(=O)c2c1cc(OC)c(OC)c2OC)c1ccc(O)cc1

XLogP

1.491

PSA

74.220

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 8 of 30 [TOP]

Compound ID

1442

Compound Structure

Plant Source

Chromolaena odorata Common Name:Siam Weed, Christmas Bush, Common Floss Flower

Source Family

Asteraceae (Compositae)

Origin

Neotropics, Worldwide

Plant Part Used

Flower

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin sulphate (2.50 µg/ml), Isoniazid (0.06 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Acacetin

PubChem ID

5280442

Ethnomedicinal Information

Treats skin wounds

PubMed ID [Source Literature]

15202555, 10811796

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

284.068

Molecular Formula

C₁₆H₁₂O₅

SMILES

O1c2c(c(=O)cc1c1ccc(OC)cc1)c(O)cc(O)c2

XLogP

1.645

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 9 of 30 [TOP]

Compound ID

1443

Compound Structure

Plant Source

Chromolaena odorata Common Name:Siam Weed, Christmas Bush, Common Floss Flower

Source Family

Asteraceae (Compositae)

Origin

Neotropics, Worldwide

Plant Part Used

Flower

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin sulphate (2.50 µg/ml), Isoniazid (0.06 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Luteolin

PubChem ID

5280445

Ethnomedicinal Information

Treats skin wounds

PubMed ID [Source Literature]

15202555, 10811796

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.048

Molecular Formula

C₁₅H₁₀O₆

SMILES

O1c2c(c(=O)cc1c1cc(O)c(O)cc1)c(O)cc(O)c2

XLogP

0.592

PSA

97.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 10 of 30 [TOP]

Compound ID	1854
Compound Structure
Plant Source	Helianthus annus Linn. Common Name:Sunflower
Source Family	Asteraceae (Compositae)
Origin	Worldwide, India
Plant Part Used	Petal
Extract	Methanol (42.56 %)
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Treatment of coughs and colds. Seeds have expectorant properties and have been used in bronchial, laryngeal and pulmonary affections and in whooping cough.
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 11 of 30 [TOP]

Compound ID	1855
Compound Structure
Plant Source	Helianthus annus Linn. Common Name:Sunflower
Source Family	Asteraceae (Compositae)
Origin	Worldwide, India
Plant Part Used	Petal
Extract	Methanol (42.56 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Treatment of coughs and colds. Seeds have expectorant properties and have been used in bronchial, laryngeal and pulmonary affections and in whooping cough.
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 12 of 30 [TOP]

Compound ID	1944
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Berry
Extract	Methanol (21.82 %)
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 13 of 30 [TOP]

Compound ID	1945
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Berry
Extract	Methanol (21.82 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 14 of 30 [TOP]

Compound ID	1946
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Leaf
Extract	Hexane, methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (Isoniazid and Ethambutol resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]	13680821
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Jimenez-Arellanes A, Meckes M, Ramirez R, Torres J, Luna-Herrera J.Activity against multidrug-resistant Mycobacterium tuberculosis in Mexican plants used to treat respiratory diseases.Phytother Res. 2003 Sep;17(8):903-8 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 15 of 30 [TOP]

Compound ID	1947
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Leaf
Extract	Hexane, methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (Rifampin resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Jimenez-Arellanes A, Meckes M, Ramirez R, Torres J, Luna-Herrera J.Activity against multidrug-resistant Mycobacterium tuberculosis in Mexican plants used to treat respiratory diseases.Phytother Res. 2003 Sep;17(8):903-8 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 16 of 30 [TOP]

Compound ID	1948
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:40 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 17 of 30 [TOP]

Compound ID	1949
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Mother tinture
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:40 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]	2118130
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Grange JM, Davey RW.Detection of antituberculous activity in plant extracts.J Appl Bacteriol. 1990 Jun;68(6):587-91 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 18 of 30 [TOP]

Compound ID	1950
Compound Structure
Plant Source	Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)
Source Family	Cupressaceae
Origin	Worldwide, Mexico, India, British Columbia, particularly in Europe
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid (10 µl of mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	50 µg extract/Disc
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antiseptic properties. In France berries used in treatment of scrofula and chest complaints
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83 2) http://plants.usda.gov/java/profile?symbol=JUCO6
Curator

Record - 19 of 30 [TOP]

Compound ID

1951

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Low Oxygen Recovery Assay (LORA)

Positive Control Used (conc.)

Inhibition [%]

97.7 %

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Longifolene

PubChem ID

289151

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Terpene, Sesquiterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against mammalian Vero cells (ATCC CCL-81)

Molecular Weight

204.188

Molecular Formula

C₁₅H₂₄

SMILES

C12C3C(C(=C)C1CC3)(CCCC2(C)C)C

XLogP

6.444

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Gordien AY, Gray AI, Franzblau SG, Seidel V.Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae).J Ethnopharmacol. 2009 Dec 10;126(3):500-5

2) http://plants.usda.gov/java/profile?symbol=JUCO6

Curator

Record - 20 of 30 [TOP]

Compound ID

1952

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

21.1 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Totarol

PubChem ID

92783

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3([C@H](C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 21 of 30 [TOP]

Compound ID

1953

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Non-replicating Mycobacterium tuberculosis H37Rv

Assay / Test Done

Low Oxygen Recovery Assay (LORA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

23.3 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Totarol

PubChem ID

92783

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3([C@H](C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 22 of 30 [TOP]

Compound ID

1954

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis (Isoniazid - resistant variant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

11 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Totarol

PubChem ID

92783

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3([C@H](C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 23 of 30 [TOP]

Compound ID

1955

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis (Streptomycin - resistant variant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

23.9 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Totarol

PubChem ID

92783

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3([C@H](C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 24 of 30 [TOP]

Compound ID

1956

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis (Moxifloxacin - resistant variant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

17.2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Totarol

PubChem ID

92783

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3([C@H](C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 25 of 30 [TOP]

Compound ID

1957

Compound Structure

Plant Source

Juniperus communis Linn. Common Name:Common Juniper (English), Hapushaa, Havushaa, Haauber, Matsyagandha (Sanskrit)

Source Family

Cupressaceae

Origin

Worldwide, Mexico, India, British Columbia, particularly in Europe

Plant Part Used

Root

Extract

Target Bacteria

Mycobacterium tuberculosis (Rifampin resistant variant)

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

5.8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Totarol

PubChem ID

92783

Ethnomedicinal Information

Antiseptic properties. In France berries used in treatment of scrofula and chest complaints

PubMed ID [Source Literature]

19755141

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tricyclic, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.230

Molecular Formula

C₂₀H₃₀O

SMILES

Oc1c(c2c([C@@]3([C@H](C(CCC3)(C)C)CC2)C)cc1)C(C)C

XLogP

8.211

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

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