BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 5 Record - 1 of 101 [TOP]

Compound ID	1033
Compound Structure
Plant Source	Achillea millefolium L. Common Name:Yarrow (English), Brinjasipha (Sanskrit)
Source Family	Asteraceae (Compositae)
Origin	Mexico, India
Plant Part Used	Flower, leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	< 1:20 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Cough, tuberculosis, colds, flu, fever, astringent
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 2 of 101 [TOP]

Compound ID	1167
Compound Structure
Plant Source	Ambrosia peruviana Willd Common Name:
Source Family	Asteraceae (Compositae)
Origin	Peru
Plant Part Used	Leaf and flower
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	58 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 3 of 101 [TOP]

Compound ID

1280

Compound Structure

Plant Source

Borrichia frutescens L. Common Name:Sea Daisy

Source Family

Asteraceae (Compositae)

Origin

Southeastern USA

Plant Part Used

Flower, leaf, stem

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Fusidic acid (4 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(24R)-24,25-epoxycycloartan-3-one

PubChem ID

469544

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

8988597

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tetracyclic, Terpene, Triterpene, Cycloartane, Ketone, Epoxy

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against vero cells

Molecular Weight

440.365

Molecular Formula

C₃₀H₄₈O₂

SMILES

O=C1C([C@H]2[C@@]3([C@@]4(C3)[C@H]([C@]3([C@](CC4)([C@H](CC3)[C@@H](CC[C@H]3OC3(C)C)C)C)C)CC2)CC1)(C)C

XLogP

9.983

PSA

29.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cantrell CL, Lu T, Fronczek FR, Fischer NH, Adams LB, Franzblau SG.Antimycobacterial cycloartanes from Borrichia frutescens.J Nat Prod. 1996 Dec;59(12):1131-6

Curator

Record - 4 of 101 [TOP]

Compound ID

1281

Compound Structure

Plant Source

Borrichia frutescens L. Common Name:Sea Daisy

Source Family

Asteraceae (Compositae)

Origin

USA

Plant Part Used

Flower, leaf, stem

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Fusidic acid (4 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

8 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(3β, 24R) - 24, 25 - Epoxycycloartan - 3 - Ol

PubChem ID

469545

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

8988597

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tetracyclic, Terpene, Triterpene, Cycloartane, Epoxy, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against Vero cells

Molecular Weight

442.381

Molecular Formula

C₃₀H₅₀O₂

SMILES

O[C@H]1C([C@H]2[C@@]3([C@@]4(C3)[C@H]([C@]3([C@](CC4)([C@H](CC3)[C@@H](CC[C@H]3OC3(C)C)C)C)C)CC2)CC1)(C)C

XLogP

10.590

PSA

32.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cantrell CL, Lu T, Fronczek FR, Fischer NH, Adams LB, Franzblau SG.Antimycobacterial cycloartanes from Borrichia frutescens.J Nat Prod. 1996 Dec;59(12):1131-6

Curator

Record - 5 of 101 [TOP]

Compound ID

1282

Compound Structure

Plant Source

Borrichia frutescens L. Common Name:Sea Daisy

Source Family

Asteraceae (Compositae)

Origin

USA

Plant Part Used

Flower, leaf, stem

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Fusidic acid (4 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

64 - 128 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

(23R)-3-Oxolanosta-8,24-dien-23-Ol

PubChem ID

469546

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

8988597

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Tetracyclic, Steroid, Ketone, Prenylated

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against Vero cells

Molecular Weight

440.365

Molecular Formula

C₃₀H₄₈O₂

SMILES

O=C1C([C@H]2[C@@](C3=C([C@]4([C@@]([C@H](CC4)[C@@H](C[C@@H](O)C=C(C)C)C)(CC3)C)C)CC2)(CC1)C)(C)C

XLogP

7.784

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Cantrell CL, Lu T, Fronczek FR, Fischer NH, Adams LB, Franzblau SG.Antimycobacterial cycloartanes from Borrichia frutescens.J Nat Prod. 1996 Dec;59(12):1131-6

Curator

Record - 6 of 101 [TOP]

Compound ID	1283
Compound Structure
Plant Source	Borrichia frutescens L. Common Name:Sea Daisy
Source Family	Asteraceae (Compositae)
Origin	USA
Plant Part Used	Flower
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done
Positive Control Used (conc.)	Fusidic acid (4 µg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	8988597
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Cantrell CL, Lu T, Fronczek FR, Fischer NH, Adams LB, Franzblau SG.Antimycobacterial cycloartanes from Borrichia frutescens.J Nat Prod. 1996 Dec;59(12):1131-6
Curator

Record - 7 of 101 [TOP]

Compound ID	1284
Compound Structure
Plant Source	Borrichia frutescens L. Common Name:Sea Daisy
Source Family	Asteraceae (Compositae)
Origin	USA
Plant Part Used	Flower
Extract	Dichloromethane
Target Bacteria	Mycobacterium avium
Assay / Test Done
Positive Control Used (conc.)	Rifampin, Clarithromycin
Inhibition [%]	99 %
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	23195767
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) C.L. Cantrell, N.H. Fischer, L. Urbatsch, M.S. McGuire, S.G. Franzblau.Antimycobacterial crude plant extracts from South, Central, and North America.Phytomedicine, Volume 5, Issue 2, April 1998, Pages 137–145
Curator

Record - 8 of 101 [TOP]

Compound ID	1288
Compound Structure
Plant Source	Brassica nigra (L.) Koch. Common Name:Black Mustard (English), Banarasi Raai, Raajika (Sanskrit)
Source Family	Brassicaceae
Origin	India
Plant Part Used	Flower, leaf
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	< 1:40 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, cough, sore throat
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 9 of 101 [TOP]

Compound ID	1435
Compound Structure
Plant Source	Chenopodium ambrosioides L. Common Name:Indian Wormseed, Sweet Pigweed, Mexican Tea (English), Sugandh - Vaastuuka, Kshetra - Vaastuuka (Sanskrit)
Source Family	Chenopodiaceae
Origin	India, Africa
Plant Part Used	Flower, fruit
Extract	Essential oil
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, pulmonary complaints, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Opdyke, D.L.J., 1976. Fragrance raw materials monographs. Chenopodium oil.Food Chemistry and Toxicology 14, 713–715. 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 10 of 101 [TOP]

Compound ID

1440

Compound Structure

Plant Source

Chromolaena odorata Common Name:Siam Weed, Christmas Bush, Common Floss Flower

Source Family

Asteraceae (Compositae)

Origin

Neotropics, Worldwide

Plant Part Used

Flower

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin sulphate (2.50 µg/ml), Isoniazid (0.06 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Isosakuranetin

PubChem ID

160481

Ethnomedicinal Information

Treat skin wounds

PubMed ID [Source Literature]

15202555, 10811796

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.084

Molecular Formula

C₁₆H₁₄O₅

SMILES

O1[C@@H](CC(=O)c2c1cc(O)cc2O)c1ccc(OC)cc1

XLogP

1.416

PSA

75.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Suksamrarn, A., Chotipong, A., Suavansri, T., Boongird, S., Timsuksai, P., Vimuttipong, S., et al. (2004). Antimycobacterial activity and cytotoxicity of flavonoids from the flowers of Chromolaena odorata. Arch Pharm Res 27, 507u511

2) Schmidt GJ, Schilling EE.Phylogeny and biogeography of Eupatorium (Asteraceae: Eupatorieae) based on nuclear ITS sequence data.Am J Bot. 2000 May;87(5):716-26

Curator

Record - 11 of 101 [TOP]

Compound ID

1441

Compound Structure

Plant Source

Chromolaena odorata Common Name:Siam Weed, Christmas Bush, Common Floss Flower

Source Family

Asteraceae (Compositae)

Origin

Neotropics, Worldwide

Plant Part Used

Flower

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin sulphate (2.50 µg/ml), Isoniazid (0.06 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

4` - Hydroxy - 5, 6, 7 - Trimethoxyflavanone

PubChem ID

244387

Ethnomedicinal Information

Treats skin wounds

PubMed ID [Source Literature]

15202555, 10811796

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

330.110

Molecular Formula

C₁₈H₁₈O₆

SMILES

O1C(CC(=O)c2c1cc(OC)c(OC)c2OC)c1ccc(O)cc1

XLogP

1.491

PSA

74.220

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 12 of 101 [TOP]

Compound ID

1442

Compound Structure

Plant Source

Chromolaena odorata Common Name:Siam Weed, Christmas Bush, Common Floss Flower

Source Family

Asteraceae (Compositae)

Origin

Neotropics, Worldwide

Plant Part Used

Flower

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin sulphate (2.50 µg/ml), Isoniazid (0.06 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Acacetin

PubChem ID

5280442

Ethnomedicinal Information

Treats skin wounds

PubMed ID [Source Literature]

15202555, 10811796

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

284.068

Molecular Formula

C₁₆H₁₂O₅

SMILES

O1c2c(c(=O)cc1c1ccc(OC)cc1)c(O)cc(O)c2

XLogP

1.645

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 13 of 101 [TOP]

Compound ID

1443

Compound Structure

Plant Source

Chromolaena odorata Common Name:Siam Weed, Christmas Bush, Common Floss Flower

Source Family

Asteraceae (Compositae)

Origin

Neotropics, Worldwide

Plant Part Used

Flower

Extract

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Kanamycin sulphate (2.50 µg/ml), Isoniazid (0.06 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Luteolin

PubChem ID

5280445

Ethnomedicinal Information

Treats skin wounds

PubMed ID [Source Literature]

15202555, 10811796

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

286.048

Molecular Formula

C₁₅H₁₀O₆

SMILES

O1c2c(c(=O)cc1c1cc(O)c(O)cc1)c(O)cc(O)c2

XLogP

0.592

PSA

97.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 14 of 101 [TOP]

Compound ID	1487
Compound Structure
Plant Source	Clerodendrum indicum (L.) Kuntze Common Name:Tuber Flower, Turk's Turban, Skyrocket (English), Bhargi (Sanskrit)
Source Family	Verbenaceae
Origin	Malaysia
Plant Part Used	Flower, stem
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1600 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Chooi, O.H., 2006. Tanaman Hiasan, Khasiat Makanan dan Ubatan. Utusan Publications and Distributors Sdn Bhd, Kuala Lumpur, Malaysia
Curator

Record - 15 of 101 [TOP]

Compound ID	1535
Compound Structure
Plant Source	Cordia boissieri Common Name:Anacahuita, Mexican Olive, Texas Olive, Texas Wild Olive, White Geiger
Source Family	Boraginaceae
Origin	Mexico
Plant Part Used	Flower
Extract	Hexane, methanol
Target Bacteria
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, used to alleviate rheumatism and pulmonary illness
PubMed ID [Source Literature]	13680821
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Jimenez-Arellanes A, Meckes M, Ramirez R, Torres J, Luna-Herrera J. Activity against multidrug-resistant Mycobacterium tuberculosis in Mexican plants used to treat respiratory diseases. Phytother Res. 2003 Sep;17(8):903-8 2) Lara, Teresa Rojas; Robert E. Paull (2008). Jules Janick; Robert E. Paull. ed. The Encyclopedia of Fruit & Nuts. CABI. p. 187 3) "Cordia boissieri". Germplasm Resources Information Network. United States Department of Agriculture. 2005-11-08. Retrieved 2009-12-09.
Curator

Record - 16 of 101 [TOP]

Compound ID	1544
Compound Structure
Plant Source	Costus speciosus (J. Koenig) Sm. Common Name:Crepe Ginger (English), Kushtha (Sanskrit)
Source Family	Costaceae
Origin	Malaysia
Plant Part Used	Stem, flower
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	800 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Chooi, O.H., 2004. Tumbuhan Liar, Khasiat Ubatan dan Kegunaan Lain. Utusan Publications and Distributors Sdn Bhd, Kuala Lumpur, Malaysia 2) http://www.flowersofIndia.net/catalog/slides/Crepe%20Ginger.html
Curator

Record - 17 of 101 [TOP]

Compound ID	1852
Compound Structure
Plant Source	Hebe stricta Common Name:Koromiko
Source Family	Plantaginaceae
Origin	New Zealand
Plant Part Used	Flower, leaf
Extract
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	96 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Skin problems, ulcers, diarrhoea, dysentery, kidney and bladder complaints
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 18 of 101 [TOP]

Compound ID	1874
Compound Structure
Plant Source	Humulus lupulus L. Common Name:Hops (English)
Source Family	Cannabaceae
Origin	India, USA
Plant Part Used	Flower
Extract	Water, ethanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stomach ache, diuretic, antiseptic, indigestion, tonic, sedative, nervous conditions, bacteriostatic, random screening
PubMed ID [Source Literature]	16695763
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gottshall RY, Lucas EH, Lickfeldt A, Roberts JM.The occurrence of antibacterial substances active against Mycobacterium tuberculosis in seed plants.J Clin Invest. 1949 Sep;28(5 Pt 1):920-3 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 19 of 101 [TOP]

Compound ID	2028
Compound Structure
Plant Source	Leptospermum scoparium Common Name:Manuka
Source Family	Myrtaceae
Origin	New Zealand
Plant Part Used	Flower
Extract
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	96 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Colds, pains, urinary troubles
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 20 of 101 [TOP]

Compound ID	2106
Compound Structure
Plant Source	Magnolia grandiflora L. Common Name:Bull Bay, Great Laurel Magnolia, Southern Magnolia (English), Him - Champaa (Sanskrit)
Source Family	Magnoliaceae
Origin	India, USA
Plant Part Used	Flower
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Radiorespirometric Bioassay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Clarithromycin (32 µg/ml)
Inhibition [%]	99 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stimulant, diaphoretic, tonic, malaria, rheumatism, random screening, Other u - methylene - g - lactone - bearing sesquiterpene lactones are moderately active against MT with MICs of 64,
PubMed ID [Source Literature]	23195767
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) C.L. Cantrell, N.H. Fischer, L. Urbatsch, M.S. McGuire, S.G. Franzblau.Antimycobacterial crude plant extracts from South, Central, and North America.Phytomedicine, Volume 5, Issue 2 , Pages 137-145, April 1998
Curator

Record - 21 of 101 [TOP]

Compound ID	2107
Compound Structure
Plant Source	Magnolia grandiflora L. Common Name:Bull Bay, Great Laurel Magnolia, Southern Magnolia (English), Him - Champaa (Sanskrit)
Source Family	Magnoliaceae
Origin	India, USA
Plant Part Used	Flower
Extract	Dichloromethane
Target Bacteria	Mycobacterium avium
Assay / Test Done	Radiorespirometric Bioassay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Clarithromycin (32 µg/ml)
Inhibition [%]	91 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stimulant, diaphoretic, tonic, malaria, rheumatism, random screening, Other u - methylene - g - lactone - bearing sesquiterpene lactones are moderately active against MT with MICs of 64,
PubMed ID [Source Literature]	23195767
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) C.L. Cantrell, N.H. Fischer, L. Urbatsch, M.S. McGuire, S.G. Franzblau.Antimycobacterial crude plant extracts from South, Central, and North America.Phytomedicine, Volume 5, Issue 2 , Pages 137-145, April 1998
Curator

Record - 22 of 101 [TOP]

Compound ID	2112
Compound Structure
Plant Source	Magnolia grandiflora L. Common Name:Bull Bay, Great Laurel Magnolia, Southern Magnolia (English), Him - Champaa (Sanskrit)
Source Family	Magnoliaceae
Origin	India, USA
Plant Part Used	Flower, fruit, leaf
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]	100 %
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stimulant, diaphoretic, tonic, malaria, rheumatism, random screening, Other u - methylene - g - lactone - bearing sesquiterpene lactones are moderately active against MT with MICs of 64,
PubMed ID [Source Literature]	23195767
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Fischer NH, Lu T, Cantrell CL, Castañeda-Acosta J, Quijano L, Franzblau SG.Antimycobacterial evaluation of germacranolides.Phytochemistry. 1998 Sep;49(2):559-64
Curator

Record - 23 of 101 [TOP]

Compound ID	2142
Compound Structure
Plant Source	Marrubium vulgare L. Common Name:Horehound (English)
Source Family	Lamiaceae
Origin	India
Plant Part Used	Flower
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, pulmonary troubles
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Anonymous, 1986. The Useful Plants of India. Council of Scientific and Industrial Research, New Delhi, India
Curator

Record - 24 of 101 [TOP]

Compound ID	2146
Compound Structure
Plant Source	Matricaria chamomilla L. Common Name:German Chamomile, Chamomile(English)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Flower
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Agar - Dilution Test
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gottshall RY, Lucas EH, Lickfeldt A, Roberts JM.The occurrence of antibacterial substances active against Mycobacterium tuberculosis in seed plants.J Clin Invest. 1949 Sep;28(5 Pt 1):920-3 2) Anonymous, 1986. The Useful Plants of India. Council of Scientific and Industrial Research, New Delhi, India
Curator

Record - 25 of 101 [TOP]

Compound ID	2147
Compound Structure
Plant Source	Matricaria chamomilla L. Common Name:German Chamomile, Chamomile (English)
Source Family	Asteraceae (Compositae)
Origin	India
Plant Part Used	Flower
Extract	Essential oil
Target Bacteria	Mycobacterium phlei
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Anonymous, 1986. The Useful Plants of India. Council of Scientific and Industrial Research, New Delhi, India
Curator

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