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                  Page - 1 of 1                  Record - 1 of 3   [TOP]
Compound ID1493
Compound Structure
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Plant SourceClinacanthus siamensis Brem.     Common Name:Sophaghni, Vishaghni, Vishalata (Sanskrit)
Source FamilyAcanthaceae
OriginThailand
Plant Part UsedFresh leaf
ExtractEthanol
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.040 - 0.090 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound IdentifiedTrans - 3 - Methylthioacrylamide
PubChem ID   11819072
Ethnomedicinal InformationPoison bites, inflammation, traumatic edema and swelling due to poison stings.
PubMed ID [Source Literature]14646322
Extract PreparationN/A
Chemical Classification [Active Compound]Aliphatic, Alkene, Amide, Thioether
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight117.025
Molecular FormulaC4H7NOS
SMILESS(/C=C/C(=O)N)C
XLogP0.313
PSA68.390
H-bond Donor1
H-bond Acceptor3
No. of Rotatable Bond Count2
No. of Rings0
No. of N1
No. of O1
No. of S1
Reference(s)1) Tuntiwachwuttikul P, Pootaeng-on Y, Pansa P, Srisanpang T, Taylor WC.Sulfur-containing compounds from Clinacanthus siamensis.Chem Pharm Bull (Tokyo). 2003 Dec;51(12):1423-5

2) http://ayurvedicmedicinalplants.com/index.php?option=com_zoom&Itemid=26&page=view&catid=3&key=63&hit=1

Curator

                  Record - 2 of 3   [TOP]
Compound ID3373
Compound Structure
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Plant SourcePhysalis angulata L.     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedFresh leaf
Extract25 % NH4OH, 2 % HCl
Target BacteriaMycobacterium tuberculosis H37Rv
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)0.1 ml of aliquot from each of the 10 - fold dilutions
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedPilocarpin
PubChem IDNR
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Alkaloid, Lactone, Imidazole
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight208.121
Molecular FormulaC11H16N2O2
SMILESO1C(=O)C(C(C1)Cc1n(cnc1)C)CC
XLogP1.307
PSA44.120
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake

                  Record - 3 of 3   [TOP]
Compound ID3374
Compound Structure
DOWNLOAD:
Plant SourcePhysalis angulata L.     Common Name:NR
Source FamilyRutaceae
OriginGuadeloupe
Plant Part UsedFresh leaf
Extract25 % NH4OH, 2 % HCl
Target BacteriaMycobacterium avium 733
Assay / Test DoneNR
Positive Control Used (conc.)NR
Inhibition [%]NR
Activity [MIC] µg/mlBactec: > 100 µg/ml, 7H11 agar: > 200 µg/ml
Activity (In terms of dilution)0.1 ml of aliquot from each of the 10 - fold dilutions
Activity (Zone of inhibition in mm)NR
Active Compound IdentifiedPilocarpin
PubChem IDNR
Ethnomedicinal InformationAntimycobacterial
PubMed ID [Source Literature]9626931
Extract PreparationThe dried powdered material was moistened with 25 % NH4OH, and extracted by chloroform. The organic phase was treated with 2 % HCl, the acid layer was washed with petroleum ether, basified with 25 % NH4OH, and extracted with chloroform. The organic phase was washed with water, and dried over Na2SO4. The organic extracts were evaporated and subjected to chromatography on silica gel
Chemical Classification [Active Compound]Aromatic, Alkaloid, Lactone, Imidazole
Media / Broth Used [Antimicrobial Assay/Test]Fresh Loëwenstein - Jensen (LJ) slants, Middlebrook 7H11 agar medium
Cytotoxicity Assay [AID]NR
Molecular Weight208.121
Molecular FormulaC11H16N2O2
SMILESO1C(=O)C(C(C1)Cc1n(cnc1)C)CC
XLogP1.307
PSA44.120
H-bond Donor0
H-bond Acceptor3
No. of Rotatable Bond Count3
No. of Rings2
No. of N2
No. of O2
No. of S0
Reference(s)1) Rastogi N, Abaul J, Goh KS, Devallois A, Philogène E, Bourgeois P.Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.FEMS Immunol Med Microbiol. 1998 Apr;20(4):267-73

CuratorWvarsha, rachanake


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