BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 18 [TOP]

Compound ID

2385

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fresh root

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

PubChem ID

17758236

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

16462055

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Pentacyclic, Alkaloid, Thiophene, Benzopyran, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

485.202

Molecular Formula

C₃₀H₃₁NO₃S

SMILES

S1c(/C=C/2Oc3c(c4c2c2c(NC(C=C2C)(C)C)cc4)c(OC)c(O)cc3)c(/C(=C/CC)/C)cc1

XLogP

7.049

PSA

78.960

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

Record - 2 of 18 [TOP]

Compound ID

2386

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fresh root

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

N - [9 - (3, 4 - Methylenedioxyphenyl) - 2E, 4E, 8E - Nonatrienoyl] Pyrrolidine

PubChem ID

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

16462055

Extract Preparation

The fresh roots of Piper sarmentosum (481 g) were ground and extracted with 95 % EtOH at room temperature. After filtration and evaporation, the ethanolic extract was obtained as a brown viscous oil (19.4 g). The oil was partitioned between water (200 ml) and EtOAc (3 x 200 ml) and the water layer was further partitioned with n - BuOH (3 x 200 ml). Evaporation of the EtOAc-, n-BuOH- and water - soluble fractions gave a dark brown oil (6.3 g), a brown oil (1.8 g) and a light brown oil (10.5 g), respectively. The EtOAc - soluble fraction (6.3 g) was separated by flash column chromatography using silica gel

Chemical Classification [Active Compound]

Aromatic, Alkene, Phenylpropanoid, Pyrrolidine, Amide, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

325.168

Molecular Formula

C₂₀H₂₃NO₃

SMILES

C1c2c(ccc1/C=C/CC/C=C/C=C/C(=O)N1CCCC1)OCO2

XLogP

4.569

PSA

38.770

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

Record - 3 of 18 [TOP]

Compound ID

2387

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fresh root, fruit

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sarmentine

PubChem ID

6440616

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

16462055

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Alkene, Pyrrolidine, Amide, Alkaloid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

221.178

Molecular Formula

C₁₄H₂₃NO

SMILES

O=C(N1CCCC1)/C=C/C=C/CCCCC

XLogP

4.039

PSA

20.310

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

Record - 4 of 18 [TOP]

Compound ID

2388

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fresh Root

Extract

Ethanol

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Brachyamide B

PubChem ID

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Alkaloid, Pyrrolidine, Amide

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

327.183

Molecular Formula

C₂₀H₂₅NO₃

SMILES

C1N(CCC1)C(=O)/C=C/CCCC/C=C/c1cc2c(cc1)OCO2

XLogP

5.013

PSA

38.770

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

Record - 5 of 18 [TOP]

Compound ID

2389

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sarmentosine

PubChem ID

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Alkaloid, Pyrrolidine, Amide, Acid

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

N/A

Molecular Weight

299.152

Molecular Formula

C₁₈H₂₁NO₃

SMILES

C1c2c(ccc1/C=C/CC/C=C/C(=O)N1CCCC1)OCO2

XLogP

3.875

PSA

38.770

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

Record - 6 of 18 [TOP]

Compound ID

2390

Compound Structure

Plant Source

Piper sarmentosum Roxb. Common Name:Cha Plu

Source Family

Piperaceae

Origin

Probably Southeast Asia, Malaysia

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Pellitorine

PubChem ID

5318516

Ethnomedicinal Information

Cough, anti - tuberculosis and anti - plasmodial activities

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aliphatic, Alkene, Alkaloid, Amide

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

223.194

Molecular Formula

C₁₄H₂₅NO

SMILES

O=C(NCC(C)C)/C=C/C=C/CCCCC

XLogP

4.469

PSA

29.100

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

Record - 7 of 18 [TOP]

Compound ID

3723

Compound Structure

Plant Source

Piper sarmentosum Common Name:Cha Plu

Source Family

Piperaceae

Origin

Thailand

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1 - Allyl - 2 - Methoxy - 4, 5 - Methylenedioxybenzene

PubChem ID

95289

Ethnomedicinal Information

Antimycobacterial and antiplsmodial activity, antifungal

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkene, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

192.079

Molecular Formula

C₁₁H₁₂O₃

SMILES

O1c2c(OC1)cc(OC)c(c2)CC=C

XLogP

2.275

PSA

27.690

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

KeyaMukherjee, rachanake

Record - 8 of 18 [TOP]

Compound ID	3724
Compound Structure	NR
Plant Source	Piper sarmentosum Common Name:Cha Plu
Source Family	Piperaceae
Origin	Thailand
Plant Part Used	Fresh root
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antimycobacterial and antiplasmodial activity, antifungal
PubMed ID [Source Literature]	16462055
Extract Preparation	The fresh roots of Piper sarmentosum (481 g) were ground and extracted with 95 % EtOH at room temperature. After filtration and evaporation, the ethanolic extract was obtained as a brown viscous oil (19.4 g). The oil was partitioned between water (200 ml) and EtOAc (3 x 200 ml) and the water layer was further partitioned with n - BuOH (3 x 200 ml). Evaporation of the EtOAc-, n-BuOH- and water - soluble fractions gave a dark brown oil (6.3 g), a brown oil (1.8 g) and a light brown oil (10.5 g), respectively. The EtOAc - soluble fraction (6.3 g) was separated by flash column chromatography using silica gel
Chemical Classification [Active Compound]	Aromatic, Alkene
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51
Curator	KeyaMukherjee, rachanake

Record - 9 of 18 [TOP]

Compound ID	3725
Compound Structure
Plant Source	Piper sarmentosum Common Name:Cha Plu
Source Family	Piperaceae
Origin	Thailand
Plant Part Used	Fresh root
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	25 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	16462055
Extract Preparation	The fresh roots of Piper sarmentosum (481 g) were ground and extracted with 95 % EtOH at room temperature. After filtration and evaporation, the ethanolic extract was obtained as a brown viscous oil (19.4 g). The oil was partitioned between water (200 ml) and EtOAc (3 x 200 ml) and the water layer was further partitioned with n - BuOH (3 x 200 ml). Evaporation of the EtOAc-, n-BuOH- and water - soluble fractions gave a dark brown oil (6.3 g), a brown oil (1.8 g) and a light brown oil (10.5 g), respectively. The EtOAc - soluble fraction (6.3 g) was separated by flash column chromatography using silica gel
Chemical Classification [Active Compound]	Aromatic, Alkene
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51
Curator	Gppreetha

Record - 10 of 18 [TOP]

Compound ID

3726

Compound Structure

Plant Source

Piper sarmentosum Common Name:Cha Plu

Source Family

Piperaceae

Origin

Thailand

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Horsfieldin

PubChem ID

Ethnomedicinal Information

Antimycobacterial and antiplasmodial activity, antifungal

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Pentacyclic, Lignan, Furanoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

356.126

Molecular Formula

C₂₀H₂₀O₆

SMILES

O1CC2C(C1c1cc(c(cc1)OC)O)CO[C@H]2c1ccc2OCOc2c1

XLogP

2.130

PSA

66.380

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

KeyaMukherjee, rachanake

Record - 11 of 18 [TOP]

Compound ID

3728

Compound Structure

Plant Source

Piper sarmentosum Common Name:Cha Plu

Source Family

Piperaceae

Origin

Thailand

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sarmentine

PubChem ID

6440616

Ethnomedicinal Information

Antimycobacterial and antiplasmodial activity, antifungal

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Alkene, Pyrrolidine, Amide, Alkaloid

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

221.178

Molecular Formula

C₁₄H₂₃NO

SMILES

O=C(N1CCCC1)/C=C/C=C/CCCCC

XLogP

4.039

PSA

20.310

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

KeyaMukherjee, rachanake

Record - 12 of 18 [TOP]

Compound ID

3729

Compound Structure

Plant Source

Piper sarmentosum Common Name:Cha Plu

Source Family

Piperaceae

Origin

Thailand

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

N - (3 - Phenylpropanoyl) Pyrrole

PubChem ID

11074385

Ethnomedicinal Information

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Phenylpropanoid, Pyrrol, Amide

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

199.100

Molecular Formula

C₁₃H₁₃NO

SMILES

O=C(n1cccc1)CCc1ccccc1

XLogP

4.579

PSA

22.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

KeyaMukherjee, gppreetha

Record - 13 of 18 [TOP]

Compound ID

3734

Compound Structure

Plant Source

Piper sarmentosum Common Name:Cha Plu

Source Family

Piperaceae

Origin

Thailand

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Guineensine

PubChem ID

6442405

Ethnomedicinal Information

Antimycobacterial and antiplasmodial activity, antifungal

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Amide, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

383.246

Molecular Formula

C₂₄H₃₃NO₃

SMILES

O1c2cc(/C=C/CCCCCC/C=C/C=C/C(=O)NCC(C)C)ccc2OC1

XLogP

7.275

PSA

47.560

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

KeyaMukherjee, rachanake

Record - 14 of 18 [TOP]

Compound ID

3736

Compound Structure

Plant Source

Piper sarmentosum Common Name:Cha Plu

Source Family

Piperaceae

Origin

Thailand

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Brachystamide B

PubChem ID

10047263

Ethnomedicinal Information

Antimycobacterial and antiplasmodial activity, antifungal

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Alkaloid, Amide, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

411.277

Molecular Formula

C₂₆H₃₇NO₃

SMILES

O1c2cc(/C=C/CCCCCCCC/C=C/C=C/C(=O)NCC(C)C)ccc2OC1

XLogP

8.413

PSA

47.560

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

KeyaMukherjee, rachanake

Record - 15 of 18 [TOP]

Compound ID

3738

Compound Structure

Plant Source

Piper sarmentosum Common Name:Cha Plu

Source Family

Piperaceae

Origin

Thailand

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sarmentamide A

PubChem ID

11528614

Ethnomedicinal Information

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Phenylpropanoid, Pyrrolidone, Amide

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

215.095

Molecular Formula

C₁₃H₁₃NO₂

SMILES

O=C(N1CC=CC1=O)CCc1ccccc1

XLogP

3.518

PSA

37.380

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

Gppreetha

Record - 16 of 18 [TOP]

Compound ID

3739

Compound Structure

Plant Source

Piper sarmentosum Common Name:Cha Plu

Source Family

Piperaceae

Origin

Thailand

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sarmentamide B

PubChem ID

Ethnomedicinal Information

Antimycobacterial and antiplasmodial activity, antifungal

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Phenylpropanoid, Pyrrolidine, Amide, O-Acetyl

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

285.136

Molecular Formula

C₁₇H₁₉NO₃

SMILES

O=C(/C=C/c1ccccc1)N1C[C@@H]([C@H](C1)C(=O)C)C(=O)C

XLogP

2.976

PSA

54.450

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

KeyaMukherjee, rachanake

Record - 17 of 18 [TOP]

Compound ID

3740

Compound Structure

Plant Source

Piper sarmentosum Common Name:Cha Plu

Source Family

Piperaceae

Origin

Thailand

Plant Part Used

Fresh root

Extract

Ethanol (95 %)

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sarmentamide C

PubChem ID

11514809

Ethnomedicinal Information

Antimycobacterial and antiplasmodial activity, antifungal

PubMed ID [Source Literature]

16462055

Extract Preparation

Chemical Classification [Active Compound]

Aromatic, Alkene, Phenylpropanoid, Pyrrolidine, Amide, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

291.147

Molecular Formula

C₁₆H₂₁NO₄

SMILES

O=C(N1CCCC1)/C=C/c1c(OC)cc(OC)c(OC)c1

XLogP

1.744

PSA

48.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51

Curator

KeyaMukherjee, rachanake

Record - 18 of 18 [TOP]

Compound ID	3741
Compound Structure	NR
Plant Source	Piper sarmentosum Common Name:Cha Plu
Source Family	Piperaceae
Origin	Thailand
Plant Part Used	Fresh root
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.04 - 0.09 µg/ml) and Kanamycin sulphate (2.0 - 5.0 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Antimycobacterial and antiplasmodial activity, antifungal
PubMed ID [Source Literature]	16462055
Extract Preparation	The fresh roots of Piper sarmentosum (481 g) were ground and extracted with 95 % EtOH at room temperature. After filtration and evaporation, the ethanolic extract was obtained as a brown viscous oil (19.4 g). The oil was partitioned between water (200 ml) and EtOAc (3 x 200 ml) and the water layer was further partitioned with n - BuOH (3 x 200 ml). Evaporation of the EtOAc-, n-BuOH- and water - soluble fractions gave a dark brown oil (6.3 g), a brown oil (1.8 g) and a light brown oil (10.5 g), respectively. The EtOAc - soluble fraction (6.3 g) was separated by flash column chromatography using silica gel
Chemical Classification [Active Compound]	Aromatic, Alkene
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Tuntiwachwuttikul P, Phansa P, Pootaeng-On Y, Taylor WC.Chemical constituents of the roots of Piper sarmentosum.Chem Pharm Bull (Tokyo). 2006 Feb;54(2):149-51
Curator	KeyaMukherjee, rachanake

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