BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 6 Record - 1 of 127 [TOP]

Compound ID	1001
Compound Structure
Plant Source	Abelmoschus esculentus (L.) Moench Common Name:Ladies Finger, Okra (English), Bhenda (Sanskrit)
Source Family	Malvaceae
Origin	Malaysia
Plant Part Used	Fruit
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Sore throat
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Chin, W.Y., 2002. A Guide to Medicinal Plants. Singapore Science Centre, Singapore 2) http://iu.ff.cuni.cz/pandanus/database/details.php?id=2530
Curator

Record - 2 of 127 [TOP]

Compound ID	1036
Compound Structure
Plant Source	Achyranthus aspera Linn. Common Name:Prickly Chaff Flower (English), Apaamaarga (Sanskrit)
Source Family	Amaranthaceae
Origin	India
Plant Part Used	Fruit, whole plant
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, bronchitis, expectorant, asthma, cough, pulmonary infections, skin diseases
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 3 of 127 [TOP]

Compound ID	1037
Compound Structure
Plant Source	Achyranthus aspera Linn. Common Name:Prickly Chaff Flower (English), Apaamaarga (Sanskrit)
Source Family	Amaranthaceae
Origin	India
Plant Part Used	Fruit, whole plant
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, bronchitis, expectorant, asthma, cough, pulmonary infections, skin diseases
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 4 of 127 [TOP]

Compound ID	1161
Compound Structure
Plant Source	Amborella trichopoda Baill. Common Name:
Source Family	Borellaceae
Origin	Caledonia
Plant Part Used	Fruit
Extract	Methanol
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	96 - well Microplate Dilution Method
Positive Control Used (conc.)	Ethambutol (20 µg/ml), Pyrazynamide (2.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1 - 2.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cystitis
PubMed ID [Source Literature]	15588670
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Billo M, Cabalion P, Waikedre J, Fourneau C, Bouttier S, Hocquemiller R, Fournet A.Screening of some New Caledonian and Vanuatu medicinal plants for antimycobacterial activity.J Ethnopharmacol. 2005 Jan 4;96(1-2):195-200
Curator

Record - 5 of 127 [TOP]

Compound ID	1174
Compound Structure
Plant Source	Anacardium occidentale L. Common Name:Cashew nut (English)
Source Family	Anacardiaceae
Origin	Malaysia
Plant Part Used	Fruit
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mohamed, N., Sulaiman, S.F., Mohamad, S., Zakaria, Z., Wahab, H.A., 2005. Khasiat Ulam-ulaman. Penerbit Universiti Sains Malaysia, Penang, Malaysia
Curator

Record - 6 of 127 [TOP]

Compound ID	1178
Compound Structure
Plant Source	Ananas comosus (L.) Merr. Common Name:Pineapple (English)
Source Family	Bromeliaceae
Origin	Malaysia
Plant Part Used	Fruit
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sore throat
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Ong, T., 2008. Rahsia Herba, 2nd ed. Alaf 21 Sdn Bhd, Shah Alam, Selangor, Malaysia
Curator

Record - 7 of 127 [TOP]

Compound ID	1206
Compound Structure
Plant Source	Areca catechu L. Common Name:Arecanut, Betel Nut (English), Puuga, Puugi, Kramuka, Ghontaa, Guwaak, Ghorant (Sanskrit)
Source Family	Arecaceae (Palmae)
Origin	India, Malaysia
Plant Part Used	Fruit
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, diuretic, digestive, small pox, dysentery, colic, cholera, leucorrhoea, random screening, cough and sore throat
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mohamad, S.R., Sintoh, M., 1999. Tinjauan kegunaan ubat-ubatan tradisional di Tamu terpilih di Sabah, Universiti Malaysia Sabah (Available at: http://rumahtani.multiply.com/journal/item/31/SENARAI TUMBUHAN UBATAN) 2) http://www.filipinoherbshealingwonders.filipinovegetarianrecipe.com/bunga.htm
Curator

Record - 8 of 127 [TOP]

Compound ID	1227
Compound Structure
Plant Source	Averrhoa bilimbi L. Common Name:Bilimbi, Cucumber - Tree (English)
Source Family	Oxalidaceae
Origin	Malaysia
Plant Part Used	Fruit, leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1600 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Whooping cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Chin, W.Y., 2002. A Guide to Medicinal Plants. Singapore Science Centre, Singapore 2) http://www.ars-grin.gov/cgi-bin/npgs/html/taxon.pl?6157
Curator

Record - 9 of 127 [TOP]

Compound ID	1234
Compound Structure
Plant Source	Bambusa guada Common Name:Bamboo
Source Family	Gramineae
Origin	Mexico
Plant Part Used	Fruit
Extract	Hexane, methanol
Target Bacteria
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]	13680821
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Jimenez-Arellanes A, Meckes M, Ramirez R, Torres J, Luna-Herrera J. Activity against multidrug-resistant Mycobacterium tuberculosis in Mexican plants used to treat respiratory diseases. Phytother Res. 2003 Sep;17(8):903-8
Curator

Record - 10 of 127 [TOP]

Compound ID	1237
Compound Structure
Plant Source	Barringtonia racemosa Roxb. Common Name:Stream Barringtonia, Freshwater Mangrove, Indian Oak (English)
Source Family	Lecythidaceae
Origin	Malaysia
Plant Part Used	Fruit, leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sore throat, asthma, cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Chooi, O.H., 2004. Tumbuhan Liar, Khasiat Ubatan dan Kegunaan Lain. Utusan Publications and Distributors Sdn Bhd, Kuala Lumpur, Malaysia
Curator

Record - 11 of 127 [TOP]

Compound ID	1293
Compound Structure
Plant Source	Bromelia balansal Common Name:
Source Family	Bromeliaceae
Origin	Brazil
Plant Part Used	Fruit
Extract	Chloroform, methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.015 - 0.05 µg/ml)
Inhibition [%]	90 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pavan FR, Sato DN, Higuchi CT, Santos ACB, Vilegas W, Leite CQE 2009. In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants. Rev Bras Farmacogn 19: 204-206
Curator

Record - 12 of 127 [TOP]

Compound ID	1369
Compound Structure
Plant Source	Capsicum annum L. Common Name:Chilli, Red Chilli (English), Katuvira, Maricha (Sanskrit)
Source Family	Solanaceae
Origin	Malaysia
Plant Part Used	Fruit
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1600 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis and asthma
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Anonymous, 2010b. Herba dan tumbuhan ubatan (Available at: http://pkukmweb.ukm.my/uahmad/tugasan/s2 99/a58713.htm) 2) http://www.himalayahealthcare.com/herbfinder/h_capsicum.htm
Curator

Record - 13 of 127 [TOP]

Compound ID	1371
Compound Structure
Plant Source	Carica papaya L. Common Name:Papaya, Papaw (English), Erand Karkati, Papitaa, Chirbhita (Sanskrit)
Source Family	Caricaceae
Origin	India, Malaysia
Plant Part Used	Fruit
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant, Asthma
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Ong, T., 2008. Rahsia Herba, 2nd ed. Alaf 21 Sdn Bhd, Shah Alam, Selangor, Malaysia
Curator

Record - 14 of 127 [TOP]

Compound ID	1385
Compound Structure
Plant Source	Cassia fistula Common Name:Fistula, Laburnum, Purging Fistula, Golden Shower, Amaltas
Source Family	Fabaceae
Origin	Mexico
Plant Part Used	Fruit
Extract	Hexane, methanol
Target Bacteria
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, healing ulcers, useful against skin diseases, liver troubles, tuberculous glands, haematemesis, pruritus, leucoderm, diabetes, rheumatism
PubMed ID [Source Literature]	13680821
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Jimenez-Arellanes A, Meckes M, Ramirez R, Torres J, Luna-Herrera J. Activity against multidrug-resistant Mycobacterium tuberculosis in Mexican plants used to treat respiratory diseases. Phytother Res. 2003 Sep;17(8):903-8
Curator

Record - 15 of 127 [TOP]

Compound ID	1399
Compound Structure
Plant Source	Ceiba pentandra (L.) Gaertn. Common Name:Kapok tree, Silk Cotton Tree (English), Shweta Shalmali (Sanskrit)
Source Family	Bombacaceae
Origin	Malaysia
Plant Part Used	Fruit
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1600 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Chin, W.Y., 2002. A Guide to Medicinal Plants. Singapore Science Centre, Singapore 2) www.worldagroforestry.org/treedb2/AFTPDFS/Ceiba_pentandra.pdf
Curator

Record - 16 of 127 [TOP]

Compound ID	1435
Compound Structure
Plant Source	Chenopodium ambrosioides L. Common Name:Indian Wormseed, Sweet Pigweed, Mexican Tea (English), Sugandh - Vaastuuka, Kshetra - Vaastuuka (Sanskrit)
Source Family	Chenopodiaceae
Origin	India, Africa
Plant Part Used	Flower, fruit
Extract	Essential oil
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, pulmonary complaints, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Opdyke, D.L.J., 1976. Fragrance raw materials monographs. Chenopodium oil.Food Chemistry and Toxicology 14, 713–715. 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 17 of 127 [TOP]

Compound ID	1568
Compound Structure
Plant Source	Cucumis muricatus Wall. syn. Cucumis sativus L. Common Name:Cucumber (English), Trapusha, Trapushi, Tiktakarkatikaa (Sanskrit)
Source Family	Cucurbitaceae
Origin	India
Plant Part Used	Fruit
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	< 1:40 dilution
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Whooping cough
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Megoneisto, Rao, R.R., 1983. Ethnobotanical studies in Nagaland-4. Sixty two medicinal plants used by the Angami Nagas. Journal of Economic Taxonomy and Botany 4, 167–172.
Curator

Record - 18 of 127 [TOP]

Compound ID	1569
Compound Structure
Plant Source	Cucurbita maxima Duchesne Common Name:Red Gourd, Red Pumpkin (English), Peeta Kuushmaanda, Kuushmaandaka (Sanskrit)
Source Family	Cucurbitaceae
Origin	India
Plant Part Used	Fruit
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	< 1:20 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diuretic, cures kapha, tonic, migraine, inflammation, boils, neuralgia
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 19 of 127 [TOP]

Compound ID	1570
Compound Structure
Plant Source	Cucurbita pepo L. Common Name:Pumpkin, Marrow (English)
Source Family	Cucurbitaceae
Origin	India
Plant Part Used	Fruit
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium phlei
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, bronchitis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Frisbey, A., Roberts, J.M., Jennings, J.C., Gottshall, R.Y., Lucas, E.H., 1953. The occurrence of antibacterial substances in seed plants with special reference to Mycobacterium tuberculosis. Michigan State University Agricultural Applied Science Quaternary Bulletin 35, 392–404 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 20 of 127 [TOP]

Compound ID	1573
Compound Structure
Plant Source	Cupania sp. Common Name:
Source Family	Sapindaceae
Origin	Peru
Plant Part Used	Fruit, leaf, root
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 21 of 127 [TOP]

Compound ID	1591
Compound Structure
Plant Source	Datura innoxia Miller Common Name:Recurved Thorn Apple
Source Family	Solanaceae
Origin	Turkey
Plant Part Used	Aerial, fruit
Extract	Ethanol (70 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5 2) http://luirig.altervista.org/schedeit/ae/datura_innoxia.htm
Curator

Record - 22 of 127 [TOP]

Compound ID	1740
Compound Structure
Plant Source	Ficus carica L. Common Name:Fig, Cultivated Fig, Edible Fig, Wild Fig (English), Anjeer, Anjira, Kakodomar, Phalgu (Sanskrit)
Source Family	Moraceae
Origin	Malaysia
Plant Part Used	Fruit, leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1600 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]	21094237
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mohamad S, Zin NM, Wahab HA, Ibrahim P, Sulaiman SF, Zahariluddin AS, Noor SS.Antituberculosis potential of some ethnobotanically selected Malaysian plants.J Ethnopharmacol. 2011 Feb 16;133(3):1021-6
Curator

Record - 23 of 127 [TOP]

Compound ID	1771
Compound Structure
Plant Source	Foeniculum vulgare Mill. Common Name:Fennel
Source Family	Apiaceae (Umbelliferae)
Origin	India, Pakistan, Mediterranean region, Mexico, Africa
Plant Part Used	Fruit
Extract	Essential oil
Target Bacteria
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diseases of the chest, cough, fever, respiratory diseases, digestion, over - weight, boosting metabolism as well as for stomach cramps
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Bruneton, J. 1995. Pharmacognosy, phytochemistry, medicinal plants. Intercept Ltd., Andover, Hampshire, England 2) Grieve, M. 1967. A modern herbal. Hafner Publishing Co., New York, Dictionary of Natural Products (2003). CD-ROM. London: Chapman & Hall/CRC, http://plants.usda.gov/java/profile?symbol=FOVU 3) http://www.ageless.co.za/fennel.htm
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Record - 24 of 127 [TOP]

Compound ID	1862
Compound Structure
Plant Source	Hennecartia omphalandra Common Name:
Source Family	Monimiaceae
Origin	USA
Plant Part Used	Fruit, leaf
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294 H37Rv)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) LEITAO, Suzana G. et al. Screening of Central and South American plant extracts for antimycobacterial activity by the Alamar Blue test. Rev. bras. farmacogn. [online]. 2006, vol.16, n.1, pp. 6-11
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Record - 25 of 127 [TOP]

Compound ID	1917
Compound Structure
Plant Source	Inga sp Common Name:
Source Family	Fabaceae
Origin	Peru
Plant Part Used	Bark, fruit
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

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