BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 7 [TOP]

Compound ID	2006
Compound Structure
Plant Source	Laurelia novae - zelandiae Common Name:Pukatea
Source Family	Atherospermataceae
Origin	New Zealand
Plant Part Used	Inner Bark
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	96 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]	90 %
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sores, ulcers, toothache and tuberculosis
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 2 of 7 [TOP]

Compound ID	2007
Compound Structure
Plant Source	Laurelia novae - zelandiae Common Name:Pukatea
Source Family	Atherospermataceae
Origin	New Zealand
Plant Part Used	Inner Bark
Extract	Methanol
Target Bacteria	Mycobacterium bovis
Assay / Test Done	97 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]	90 %
Activity [MIC] µg/ml	2500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sores, ulcers, toothache and tuberculosis
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 3 of 7 [TOP]

Compound ID	2008
Compound Structure
Plant Source	Laurelia novae - zelandiae Common Name:Pukatea
Source Family	Atherospermataceae
Origin	New Zealand
Plant Part Used	Inner Bark
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	98 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]	90 %
Activity [MIC] µg/ml	3750 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Sores, ulcers, toothache and tuberculosis
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 4 of 7 [TOP]

Compound ID

2274

Compound Structure

Plant Source

Oplopanax horridus Smith Miq. Common Name:Devil's Club

Source Family

Araliaceae

Origin

USA

Plant Part Used

Inner bark

Extract

Methanol, dichloromethane

Target Bacteria

Mycobacterium tuberculosis, Mycobacterium avium

Assay / Test Done

Disk Diffusion Assay

Positive Control Used (conc.)

Isoniazid (100 µg/disk)

Inhibition [%]

100 %

Activity [MIC] µg/ml

100 µg/disk

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Falcarindiol

PubChem ID

6436239

Ethnomedicinal Information

Diabetes, rheumatism, tuberculosis, colds, headaches and lung ailments

PubMed ID [Source Literature]

9392889

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Alkyne, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

260.178

Molecular Formula

C₁₇H₂₄O₂

SMILES

O[C@@H](/C=CCCCCCCC)C#CC#C[C@@H](O)C=C

XLogP

4.573

PSA

40.460

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Kobaisy M, Abramowski Z, Lermer L, Saxena G, Hancock RE, Towers GH, Doxsee D, Stokes RW.Antimycobacterial polyynes of Devils Club (Oplopanax horridus), a North American native medicinal plant.J Nat Prod. 1997 Nov;60(11):1210-3

2) Turner, N. J., L. C. Thompson, M. T. Thompson and A. Z. York. 1990. Thompson Ethnobotany: Knowledge and usage of plants by the Thompson Indians of British Columbia. Victoria: Royal British Columbia Museum, Memoir No. 3

Curator

Record - 5 of 7 [TOP]

Compound ID

2275

Compound Structure

Plant Source

Oplopanax horridus Smith Miq. Common Name:Devil's Club

Source Family

Araliaceae

Origin

USA

Plant Part Used

Inner bark

Extract

Methanol, dichloromethane

Target Bacteria

Mycobacterium tuberculosis, Mycobacterium avium

Assay / Test Done

Disk Diffusion Assay

Positive Control Used (conc.)

Inhibition [%]

100 %

Activity [MIC] µg/ml

20 µg/disk

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Falcarinol

PubChem ID

5469789

Ethnomedicinal Information

Diabetes, rheumatism, tuberculosis, colds, headaches and lung ailments

PubMed ID [Source Literature]

9392889

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Alkyne, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

244.183

Molecular Formula

C₁₇H₂₄O

SMILES

O[C@H](C#CC#CC/C=CCCCCCCC)C=C

XLogP

6.197

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Kobaisy M, Abramowski Z, Lermer L, Saxena G, Hancock RE, Towers GH, Doxsee D, Stokes RW.Antimycobacterial polyynes of Devils Club (Oplopanax horridus), a North American native medicinal plant.J Nat Prod. 1997 Nov;60(11):1210-3

2) Turner, N. J., L. C. Thompson, M. T. Thompson and A. Z. York. 1990. Thompson Ethnobotany: Knowledge and Usage of Plants by the Thompson Indians of British Columbia. Victoria, British Columbia, Royal British Columbia Museum

Curator

Record - 6 of 7 [TOP]

Compound ID

2276

Compound Structure

Plant Source

Oplopanax horridus Smith Miq. Common Name:Devil's Club

Source Family

Araliaceae

Origin

USA

Plant Part Used

Inner bark

Extract

Methanol, dichloromethane

Target Bacteria

Mycobacterium tuberculosis, Mycobacterium avium

Assay / Test Done

Disk Diffusion Assay

Positive Control Used (conc.)

Isoniazid

Inhibition [%]

Activity [MIC] µg/ml

10 µg/disk

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Oplopandiol

PubChem ID

6474833

Ethnomedicinal Information

Diabetes, rheumatism, tuberculosis, colds, headaches and lung ailments

PubMed ID [Source Literature]

9392889

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Alkyne, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

262.193

Molecular Formula

C₁₇H₂₆O₂

SMILES

O[C@@H](/C=CCCCCCCC)C#CC#C[C@@H](O)CC

XLogP

4.977

PSA

40.460

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Kobaisy M, Abramowski Z, Lermer L, Saxena G, Hancock RE, Towers GH, Doxsee D, Stokes RW.Antimycobacterial polyynes of Devils Club (Oplopanax horridus), a North American native medicinal plant.J Nat Prod. 1997 Nov;60(11):1210-3

2) Turner, N. J., L. C. Thompson, M. T. Thompson and A. Z. York. 1990. Thompson Ethnobotany: Knowledge and Usage of Plants by the Thompson Indians of British Columbia. Victoria, British Columbia, Royal British Columbia Museum

Curator

Record - 7 of 7 [TOP]

Compound ID	2277
Compound Structure
Plant Source	Oplopanax horridus Smith Miq. Common Name:Devil's Club
Source Family	Araliaceae
Origin	USA
Plant Part Used	Inner bark
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid
Inhibition [%]	100 %
Activity [MIC] µg/ml	10 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diabetes, rheumatism, tuberculosis, colds, headaches and lung ailments
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83 2) http://cms.herbalgram.org/herbalgram/issue62/article2697.html
Curator

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