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                  Page - 1 of 1                  Record - 1 of 5   [TOP]
Compound ID2298
Compound Structure
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Plant SourcePedilanthus tithymaloides     Common Name:Devil's Backbone, Zigzag Plant, Jacob's Ladder
Source FamilyEuphorbiaceae
OriginThailand, Tropical America
Plant Part UsedMilky juice or latex
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.1 µg/ml), Kanamycin (2.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml12.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1α, 13β, 14α - trihydroxy - 3β, 7β - dibenzoyloxy - 9β, 15β - diacetoxyjatropha - 5, 11 E - diene
PubChem ID   23642402
Ethnomedicinal InformationAnti - inflammatory, antioxidant, anti - malaria
PubMed ID [Source Literature]17844996
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Diterpene, Jatrophane, Benzoyl, Acetyl
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight678.304
Molecular FormulaC38H46O11
SMILESO([C@@]12[C@H]([C@@H](OC(=O)c3ccccc3)[C@H]([C@@H]1O)C)/C=C([C@H](OC(=O)c1ccccc1)C[C@H](OC(=O)C)C(/C=C/[C@](O)([C@H]2O)C)(C)C)/C)C(=O)C
XLogP6.947
PSA165.890
H-bond Donor3
H-bond Acceptor11
No. of Rotatable Bond Count10
No. of Rings4
No. of N0
No. of O11
No. of S0
Reference(s)1) Mongkolvisut W, Sutthivaiyakit S.Antimalarial and antituberculous poly-O-acylated jatrophane diterpenoids from Pedilanthus tithymaloides.J Nat Prod. 2007 Sep;70(9):1434-8

2) http://www.flowersofIndia.net/catalog/slides/Devil%27s%20Backbone.html

Curator

                  Record - 2 of 5   [TOP]
Compound ID2299
Compound Structure
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Plant SourcePedilanthus tithymaloides     Common Name:Devil's Backbone, Zigzag Plant, Jacob's Ladder
Source FamilyEuphorbiaceae
OriginThailand, Tropical America
Plant Part UsedMilky juice or latex
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.1 µg/ml), Kanamycin (2.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1α, 7β, 13β, 14α - tetrahydroxy - 3β - benzoyloxy - 9β, 15β - diacetoxyjatropha - 5,11 E - diene
PubChem ID   23642403
Ethnomedicinal InformationAnti - inflammatory, antioxidant, anti - malaria
PubMed ID [Source Literature]17844996
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Diterpene, Jatrophane, Benzoyl, Acetyl, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight574.278
Molecular FormulaC31H42O10
SMILESO([C@@]12[C@H]([C@@H](OC(=O)c3ccccc3)[C@H]([C@@H]1O)C)/C=C([C@H](O)C[C@H](OC(=O)C)C(/C=C/[C@](O)([C@H]2O)C)(C)C)/C)C(=O)C
XLogP3.461
PSA159.820
H-bond Donor4
H-bond Acceptor10
No. of Rotatable Bond Count7
No. of Rings3
No. of N0
No. of O10
No. of S0
Reference(s)1) Mongkolvisut W, Sutthivaiyakit S.Antimalarial and antituberculous poly-O-acylated jatrophane diterpenoids from Pedilanthus tithymaloides.J Nat Prod. 2007 Sep;70(9):1434-8

2) http://www.flowersofIndia.net/catalog/slides/Devil%27s%20Backbone.html

Curator

                  Record - 3 of 5   [TOP]
Compound ID2300
Compound Structure
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Plant SourcePedilanthus tithymaloides     Common Name:Devil's Backbone, Zigzag Plant, Jacob's Ladder
Source FamilyEuphorbiaceae
OriginThailand, Tropical America
Plant Part UsedMilky juice or latex
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.1 µg/ml), Kanamycin (2.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1α, 8β, 9β, 14α, 15β - pentaacetoxy - 3β - benzoyloxy - 7 - oxojatropha - 5, 12 - diene
PubChem ID   23642498
Ethnomedicinal InformationAnti - inflammatory, antioxidant, anti - malaria
PubMed ID [Source Literature]17844996
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Diterpene, Jatrophane, Ketone, Benzoyl, Acetyl
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight698.294
Molecular FormulaC37H46O13
SMILESO([C@@]12[C@H]([C@@H](OC(=O)c3ccccc3)[C@H]([C@@H]1OC(=O)C)C)/C=C(C(=O)[C@H](OC(=O)C)[C@H](OC(=O)C)C(C/C=C(/[C@H]2OC(=O)C)C)(C)C)/C)C(=O)C
XLogP5.514
PSA174.870
H-bond Donor0
H-bond Acceptor13
No. of Rotatable Bond Count13
No. of Rings3
No. of N0
No. of O13
No. of S0
Reference(s)1) Mongkolvisut W, Sutthivaiyakit S.Antimalarial and antituberculous poly-O-acylated jatrophane diterpenoids from Pedilanthus tithymaloides.J Nat Prod. 2007 Sep;70(9):1434-8

2) http://www.flowersofIndia.net/catalog/slides/Devil%27s%20Backbone.html

Curator

                  Record - 4 of 5   [TOP]
Compound ID2301
Compound Structure
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Plant SourcePedilanthus tithymaloides     Common Name:Devil's Backbone, Zigzag Plant, Jacob's Ladder
Source FamilyEuphorbiaceae
OriginThailand,Tropical America
Plant Part UsedMilky juice or latex
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.1 µg/ml), Kanamycin (2.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified7, 8β, 9β, 14α, 15β - Pentaacetoxy - 3β - benzoyloxy - 1α, 5β - dihydroxyjatropha - 6 (7), 12 - diene
PubChem ID   23642499
Ethnomedicinal InformationAnti - inflammatory, antioxidant, anti - malaria
PubMed ID [Source Literature]17844996
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Diterpene, Jatrophane, Benzoyl, Acetyl, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight716.304
Molecular FormulaC37H48O14
SMILESO([C@@]12[C@H]([C@@H](OC(=O)c3ccccc3)[C@H]([C@@H]1O)C)[C@H](O)/C(=C(/OC(=O)C)[C@H](OC(=O)C)[C@H](OC(=O)C)C(C/C=C(/[C@H]2OC(=O)C)C)(C)C)/C)C(=O)C
XLogP4.498
PSA198.260
H-bond Donor2
H-bond Acceptor14
No. of Rotatable Bond Count13
No. of Rings3
No. of N0
No. of O14
No. of S0
Reference(s)1) Mongkolvisut W, Sutthivaiyakit S.Antimalarial and antituberculous poly-O-acylated jatrophane diterpenoids from Pedilanthus tithymaloides.J Nat Prod. 2007 Sep;70(9):1434-8

2) http://www.flowersofIndia.net/catalog/slides/Devil%27s%20Backbone.html

Curator

                  Record - 5 of 5   [TOP]
Compound ID2302
Compound Structure
DOWNLOAD:
Plant SourcePedilanthus tithymaloides     Common Name:Devil's Backbone, Zigzag Plant, Jacob's Ladder
Source FamilyEuphorbiaceae
OriginThailand,Tropical America
Plant Part UsedMilky juice or latex
ExtractDichloromethane
Target BacteriaMycobacterium tuberculosis H37Ra
Assay / Test DoneMicroplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)Isoniazid (0.1 µg/ml), Kanamycin (2.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified1α, 7, 8β, 9β, 14α, 15β - Hexaacetoxy - 3β - benzoyloxy - 5β - hydroxyjatropha - 6 (7), 12 - diene
PubChem ID   23642500
Ethnomedicinal InformationAnti - inflammatory, antioxidant, anti - malaria
PubMed ID [Source Literature]17844996
Extract PreparationN/A
Chemical Classification [Active Compound]Alicyclic, Bicyclic, Terpene, Diterpene, Jatrophane, Benzoyl, Acetyl, Alcohol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight758.315
Molecular FormulaC39H50O15
SMILESO([C@@]12[C@H]([C@@H](OC(=O)c3ccccc3)[C@H]([C@@H]1OC(=O)C)C)[C@H](O)/C(=C(/OC(=O)C)[C@H](OC(=O)C)[C@H](OC(=O)C)C(C/C=C(/[C@H]2OC(=O)C)C)(C)C)/C)C(=O)C
XLogP5.238
PSA204.330
H-bond Donor1
H-bond Acceptor15
No. of Rotatable Bond Count15
No. of Rings3
No. of N0
No. of O15
No. of S0
Reference(s)1) Mongkolvisut W, Sutthivaiyakit S.Antimalarial and antituberculous poly-O-acylated jatrophane diterpenoids from Pedilanthus tithymaloides.J Nat Prod. 2007 Sep;70(9):1434-8

2) http://www.flowersofIndia.net/catalog/slides/Devil%27s%20Backbone.html

Curator


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