BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 21 [TOP]

Compound ID	1461
Compound Structure
Plant Source	Citrus aurantifolia Common Name:Lime, Common Lime, Sour Lime
Source Family	Rutaceae
Origin	Mexico
Plant Part Used	Peel
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis H37Rv (Sensitive)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory diseases, antiseptic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75 2) http://www.flowersofIndia.net/catalog/slides/Lime.html
Curator

Record - 2 of 21 [TOP]

Compound ID	1462
Compound Structure
Plant Source	Citrus aurantifolia Common Name:Lime, Common Lime, Sour Lime
Source Family	Rutaceae
Origin	Mexico
Plant Part Used	Peel
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis H37Rv (Rifampin resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory diseases, antiseptic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75 2) http://www.flowersofIndia.net/catalog/slides/Lime.html
Curator

Record - 3 of 21 [TOP]

Compound ID	1463
Compound Structure
Plant Source	Citrus aurantifolia Common Name:Lime, Common Lime, Sour Lime
Source Family	Rutaceae
Origin	Mexico
Plant Part Used	Peel
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis (Isoniazid resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory diseases, antiseptic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75 2) http://www.flowersofIndia.net/catalog/slides/Lime.html
Curator

Record - 4 of 21 [TOP]

Compound ID	1464
Compound Structure
Plant Source	Citrus aurantifolia Common Name:Lime, Common Lime, Sour Lime
Source Family	Rutaceae
Origin	Mexico
Plant Part Used	Peel
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis (Streptomycin resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory diseases, antiseptic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75 2) http://www.flowersofIndia.net/catalog/slides/Lime.html
Curator

Record - 5 of 21 [TOP]

Compound ID	1465
Compound Structure
Plant Source	Citrus aurantifolia Common Name:Lime, Common Lime, Sour Lime
Source Family	Rutaceae
Origin	Mexico
Plant Part Used	Peel
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis (Ethambutol resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory diseases, antiseptic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75 2) http://www.flowersofIndia.net/catalog/slides/Lime.html
Curator

Record - 6 of 21 [TOP]

Compound ID	1466
Compound Structure
Plant Source	Citrus aurantifolia Common Name:Lime, Common Lime, Sour Lime
Source Family	Rutaceae
Origin	Mexico
Plant Part Used	Peel
Extract	Chloroform, methanol, water
Target Bacteria	Mycobacterium tuberculosis H37Rv (Sensitive)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory diseases, antiseptic
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75 2) http://www.flowersofIndia.net/catalog/slides/Lime.html
Curator

Record - 7 of 21 [TOP]

Compound ID	1468
Compound Structure
Plant Source	Citrus sinensis Common Name:Sweet Orange, Navel Orange, Blood Orange
Source Family	Rutaceae
Origin	Mexico
Plant Part Used	Peel
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis H37Rv (Sensitive)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory diseases, antiseptic, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 8 of 21 [TOP]

Compound ID	1469
Compound Structure
Plant Source	Citrus sinensis Common Name:Sweet Orange, Navel Orange, Blood Orange
Source Family	Rutaceae
Origin	Mexico
Plant Part Used	Peel
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis H37Rv (Rifampin resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory diseases, antiseptic, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 9 of 21 [TOP]

Compound ID	1470
Compound Structure
Plant Source	Citrus sinensis Common Name:Sweet Orange, Navel Orange, Blood Orange
Source Family	Rutaceae
Origin	Mexico
Plant Part Used	Peel
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis (Isoniazid resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory diseases, antiseptic, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 10 of 21 [TOP]

Compound ID	1471
Compound Structure
Plant Source	Citrus sinensis Common Name:Sweet Orange, Navel Orange, Blood Orange
Source Family	Rutaceae
Origin	Mexico
Plant Part Used	Peel
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis (Streptomycin resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory diseases, antiseptic, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 11 of 21 [TOP]

Compound ID	1472
Compound Structure
Plant Source	Citrus sinensis Common Name:Sweet Orange, Navel Orange, Blood Orange
Source Family	Rutaceae
Origin	Mexico
Plant Part Used	Peel
Extract	Hexane
Target Bacteria	Mycobacterium tuberculosis (Ethambutol resistant)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory diseases, antiseptic, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 12 of 21 [TOP]

Compound ID	1473
Compound Structure
Plant Source	Citrus sinensis Common Name:Sweet Orange, Navel Orange, Blood Orange
Source Family	Rutaceae
Origin	Mexico
Plant Part Used	Peel
Extract	Chloroform, methanol, water
Target Bacteria	Mycobacterium tuberculosis H37Rv (Sensitive)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Streptomycin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (0.50 µg/ml), Rifampin (2.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Respiratory diseases, antiseptic, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) María del Rayo Camacho-Corona, Juan Manuel de Jesús Favela-Hernández, Omar González-Santiago, Elvira Garza-González, Gloria María Molina-Salinas, Salvador Said-Fernández, Guillermo Delgado, Julieta Luna-Herrerae.Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis.J. Mex. Chem. Soc. 2009, 53(2), 71-75
Curator

Record - 13 of 21 [TOP]

Compound ID	2475
Compound Structure
Plant Source	Pyrus malus L. Common Name:Cultivated Apple (English), Sinchitikaa (Sanskrit)
Source Family	Rosaceae
Origin	India
Plant Part Used	Leaf, peel
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	< 1:20 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Intermittent, remittent and bilious fevers, inflammed eyes, anthelmintic, refrigerant, hypnotic
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 14. Lalit Mohan Basu, Allahabad, India
Curator

Record - 14 of 21 [TOP]

Compound ID

3959

Compound Structure

Plant Source

Swinglea glutinosa Common Name:Tabog, Glutinous Swinglea

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

α - Terpineol

PubChem ID

17100

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

Chemical Classification [Active Compound]

Alicyclic, Terpene, Monoterpene, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

154.136

Molecular Formula

C₁₀H₁₈O

SMILES

OC(C1CCC(=CC1)C)(C)C

XLogP

2.369

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

Record - 15 of 21 [TOP]

Compound ID

2658

Compound Structure

Plant Source

Swinglea glutinosa Common Name:

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

β - Pinene

PubChem ID

14896

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Monoterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

136.125

Molecular Formula

C₁₀H₁₆

SMILES

C1(C2CC1C(=C)CC2)(C)C

XLogP

4.222

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

Record - 16 of 21 [TOP]

Compound ID

2659

Compound Structure

Plant Source

Swinglea glutinosa Common Name:

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

α - Pinene (12 %)

PubChem ID

6654

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Monoterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

136.125

Molecular Formula

C₁₀H₁₆

SMILES

C1(C2CC1C(=CC2)C)(C)C

XLogP

4.177

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

Record - 17 of 21 [TOP]

Compound ID

2660

Compound Structure

Plant Source

Swinglea glutinosa Common Name:

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Sabinene

PubChem ID

18818

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Monoterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

136.125

Molecular Formula

C₁₀H₁₆

SMILES

C12(C(C1)C(=C)CC2)C(C)C

XLogP

4.222

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

Record - 18 of 21 [TOP]

Compound ID

2661

Compound Structure

Plant Source

Swinglea glutinosa Common Name:

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Bicyclosesquiphellandrene

PubChem ID

521496

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Sesquiterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

204.188

Molecular Formula

C₁₅H₂₄

SMILES

C12C(CCC(C1=CC(=C)CC2)C(C)C)C

XLogP

6.239

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

Record - 19 of 21 [TOP]

Compound ID

2662

Compound Structure

Plant Source

Swinglea glutinosa Common Name:

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Limonene (4.4 %)

PubChem ID

22311

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Terpene, Monoterpene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

136.125

Molecular Formula

C₁₀H₁₆

SMILES

C1(CCC(=CC1)C)C(=C)C

XLogP

3.729

PSA

0.000

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

Record - 20 of 21 [TOP]

Compound ID

2663

Compound Structure

Plant Source

Swinglea glutinosa Common Name:

Source Family

Rutaceae

Origin

Colombia

Plant Part Used

Fruit peel

Extract

Essential oil (0.7 %)

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Macrodilution method in glass tubes

Positive Control Used (conc.)

Rifampin (0.50 µg/ml), Isoniazid (0.03 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 ± 36 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

1, 8 - Cineol

PubChem ID

2758

Ethnomedicinal Information

Skin affliction, tuberculosis

PubMed ID [Source Literature]

19753839

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Bicyclic, Terpene, Monoterpene, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

154.136

Molecular Formula

C₁₀H₁₈O

SMILES

O1C2(CCC(C1(C)C)CC2)C

XLogP

2.595

PSA

9.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60

Curator

Record - 21 of 21 [TOP]

Compound ID	2861
Compound Structure	N/A
Plant Source	Swinglea glutinosa Common Name:Tabog, Glutinous Swinglea
Source Family	Rutaceae
Origin	Colombia
Plant Part Used	Fruit peel
Extract	Fruit peel (0.7 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Macrodilution Method, following the protocol described by Abate et al. (1998)
Positive Control Used (conc.)	Isoniazid (0.19 ± 0.07 µg/ml), Rifampin (0.3 ± 0.21 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	100 ± 36 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	Mixture of Essential oils (Mixture)
PubChem ID	NR
Ethnomedicinal Information	NR
PubMed ID [Source Literature]	19753839
Extract Preparation	Microwave - Assisted Hydrodistillation (30 min, 250 ml water), using a Clevenger - type distillation apparatus and a Dean - Stark distillation trap in a domestic microwave oven (Kendo, MO-124, 2.5 GHz, 800 W) (9). Sodium sulfate was added as a drying agent to the decanted essential oil
Chemical Classification [Active Compound]	Mixture
Media / Broth Used [Antimicrobial Assay/Test]	Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Bueno-Sánchez JG, Martínez-Morales JR, Stashenko EE, Ribón W.Anti-tubercular activity of eleven aromatic and medicinal plants occurring in Colombia.Biomedica. 2009 Mar;29(1):51-60
Curator	Vikramjitmandal, reshmi

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