BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 42 [TOP]

Compound ID	1082
Compound Structure
Plant Source	Agrophyron repens Linn. Beauv. Common Name:Couch Grass
Source Family	Gramineae
Origin	Worldwide
Plant Part Used	Rhizome
Extract	Methanol (6.83 %)
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antibiotic
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 2 of 42 [TOP]

Compound ID	1083
Compound Structure
Plant Source	Agrophyron repens Linn. Beauv. Common Name:Couch Grass
Source Family	Gramineae
Origin	Worldwide
Plant Part Used	Rhizome
Extract	Methanol (6.83 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Antibiotic
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 3 of 42 [TOP]

Compound ID	1093
Compound Structure
Plant Source	Allium cepa L. Common Name:Onion (English), Palaandu, Durgandh (Sanskrit)
Source Family	Amaryllidaceae
Origin	Malaysia, India
Plant Part Used	Rhizome
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Anonymous, 2010b. Herba dan tumbuhan ubatan, (Available at: http://pkukmweb.ukm.my/uahmad/tugasan/s2 99/a58713.htm)
Curator

Record - 4 of 42 [TOP]

Compound ID	1124
Compound Structure
Plant Source	Allium sativum L. Common Name:Garlic (English), Lashuna (Sanskrit)
Source Family	Amaryllidaceae
Origin	India, Africa, Malaysia
Plant Part Used	Rhizome
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, expectorant, cough, pulmonary phthisis, consumption, chronic diseases of lungs, whooping cough, laryngeal tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Zakaria, M., Mohd, M.A., 1994. Traditional Malay Medicinal Plants. Fajar Bakti Sdn Bhd, Kuala Lumpur, Malaysia
Curator

Record - 5 of 42 [TOP]

Compound ID

1474

Compound Structure

Plant Source

Clausena excavata Burm. f. Common Name:Clausena (English)

Source Family

Rutaceae

Origin

India

Plant Part Used

Rhizome

Extract

Chloroform

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Dentatin

PubChem ID

342801

Ethnomedicinal Information

Fever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold

PubMed ID [Source Literature]

12624822

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Coumarin, Benzopyran, Alkene, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against KB and BC - 1 cell lines

Molecular Weight

326.152

Molecular Formula

C₂₀H₂₂O₄

SMILES

O1c2c(C(C)(C)C=C)c3oc(=O)ccc3c(OC)c2C=CC1(C)C

XLogP

4.812

PSA

35.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Sunthitikawinsakul A, Kongkathip N, Kongkathip B, Phonnakhu S, Daly JW, Spande TF, Nimit Y, Rochanaruangrai S.Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities.Planta Med. 2003 Feb;69(2):155-7

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator

Record - 6 of 42 [TOP]

Compound ID

1475

Compound Structure

Plant Source

Clausena excavata Burm. f. Common Name:Clausena (English)

Source Family

Rutaceae

Origin

India

Plant Part Used

Rhizome

Extract

Chloroform

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Nor - Dentatin

PubChem ID

5495613

Ethnomedicinal Information

Fever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold

PubMed ID [Source Literature]

12624822

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Coumarin, Benzopyran, Alkene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against KB and BC - 1 cell lines

Molecular Weight

312.136

Molecular Formula

C₁₉H₂₀O₄

SMILES

O1c2c(C(C)(C)C=C)c3oc(=O)ccc3c(O)c2C=CC1(C)C

XLogP

4.293

PSA

46.530

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 7 of 42 [TOP]

Compound ID

1476

Compound Structure

Plant Source

Clausena excavata Burm. f. Common Name:Clausena (English)

Source Family

Rutaceae

Origin

India

Plant Part Used

Rhizome

Extract

Chloroform

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Clausenidin

PubChem ID

5315947

Ethnomedicinal Information

Fever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold

PubMed ID [Source Literature]

12624822

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Coumarin, Chromone, Alkene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against KB and BC - 1 cell lines

Molecular Weight

328.131

Molecular Formula

C₁₉H₂₀O₅

SMILES

O1C(CC(=O)c2c1c(C(C)(C)C=C)c1oc(=O)ccc1c2O)(C)C

XLogP

3.411

PSA

63.600

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 8 of 42 [TOP]

Compound ID

1477

Compound Structure

Plant Source

Clausena excavata Burm. f. Common Name:Clausena (English)

Source Family

Rutaceae

Origin

India

Plant Part Used

Rhizome

Extract

Chloroform

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

3 - Formylcarbazole

PubChem ID

20746

Ethnomedicinal Information

Fever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold

PubMed ID [Source Literature]

12624822

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Carbazole, Alkaloid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

181.089

Molecular Formula

C₁₃H₁₁N

SMILES

[nH]1c2c(c3c1cccc3)cc(cc2)C

XLogP

4.401

PSA

15.790

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 9 of 42 [TOP]

Compound ID

1478

Compound Structure

Plant Source

Clausena excavata Burm. f. Common Name:Clausena (English)

Source Family

Rutaceae

Origin

India

Plant Part Used

Rhizome

Extract

Chloroform

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

200 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Mukonal

PubChem ID

504068

Ethnomedicinal Information

Fever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold

PubMed ID [Source Literature]

12624822

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Alkaloid, Aldehyde, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

211.063

Molecular Formula

C₁₃H₉NO₂

SMILES

Oc1cc2[nH]c3c(c2cc1C=O)cccc3

XLogP

2.984

PSA

53.090

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 10 of 42 [TOP]

Compound ID

1479

Compound Structure

Plant Source

Clausena excavata Burm. f. Common Name:Clausena (English)

Source Family

Rutaceae

Origin

India

Plant Part Used

Rhizome

Extract

Hexane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

3 - Methoxycarbonylcarbazole

PubChem ID

Ethnomedicinal Information

Fever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold

PubMed ID [Source Literature]

12624822

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Alkaloid, Carbazole, Ester

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

225.079

Molecular Formula

C₁₄H₁₁NO₂

SMILES

[nH]1c2c(c3c1ccc(c3)C(=O)OC)cccc2

XLogP

3.425

PSA

42.090

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 11 of 42 [TOP]

Compound ID

1480

Compound Structure

Plant Source

Clausena excavata Burm. f. Common Name:Clausena (English)

Source Family

Rutaceae

Origin

India

Plant Part Used

Rhizome

Extract

Hexane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 – 0.090 µg/ml), Kanamycin sulphate (2 – 5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

2 - Hydroxy - 3 - Formyl - 7 - Methoxycarbazole

PubChem ID

189687

Ethnomedicinal Information

Fever, indigestion, malaria, colic, muscular pain, diuretic and as tonic; the allied species C. wampi Blanco for bronchitis, in Thai folk medicine for cold

PubMed ID [Source Literature]

12624822

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Alkaloid, Carbazole, Aldehyde, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

241.074

Molecular Formula

C₁₄H₁₁NO₃

SMILES

O(c1cc2[nH]c3c(c2cc1)cc(c(O)c3)C=O)C

XLogP

2.329

PSA

62.320

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 12 of 42 [TOP]

Compound ID	1543
Compound Structure
Plant Source	Costus sp. Common Name:
Source Family	Zingiberaceae
Origin	Peru
Plant Part Used	Rhizome
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 13 of 42 [TOP]

Compound ID	1583
Compound Structure
Plant Source	Cymbopogon citratus (DC. ex Nees) Stapf Common Name:Lemon Grass, Oil grass, West Indian Lemon Grass (English), Bhustrina (Sanskrit)
Source Family	Gramineae
Origin	Malaysia
Plant Part Used	Stem, rhizome
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Chin, W.Y., 2002. A Guide to Medicinal Plants. Singapore Science Centre, Singapore 2) http://www.flowersofIndia.net/catalog/slides/Lemon%20Grass.html
Curator

Record - 14 of 42 [TOP]

Compound ID

1738

Compound Structure

Plant Source

Ferula communis Common Name:Giant Fennel

Source Family

Apiaceae (Umbelliferae)

Origin

Saudi Arabia

Plant Part Used

Rhizome

Extract

Target Bacteria

Mycobacterium intracellulare

Assay / Test Done

Positive Control Used (conc.)

Amikacin (0.25 µg/ml), Streptomycin (10 µg/ml), Isoniazid (10 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

1.25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Ferulenol

PubChem ID

54679300

Ethnomedicinal Information

Anti-mycobacterial

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Alkyl, Alkene, Coumarin, Prenylated, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

366.219

Molecular Formula

C₂₄H₃₀O₃

SMILES

O1c2c(c(O)c(C/C=C(/CC/C=C(/CCC=C(C)C)C)C)c1=O)cccc2

XLogP

8.182

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Mohammed A. Al-Yahya, Ilias Muhammad, Humayun H. Mirza, Farouk S. El-Feraly.Antibacterial constituents from the rhizomes of Ferula communis.Phytotherapy Research.12/1998;12(5):335-339

2) http://www.pfaf.org/user/Plant.aspx?LatinName=Ferula+communis

Curator

Record - 15 of 42 [TOP]

Compound ID

1739

Compound Structure

Plant Source

Ferula communis Common Name:Giant Fennel

Source Family

Apiaceae (Umbelliferae)

Origin

Saudi Arabia

Plant Part Used

Rhizome

Extract

Target Bacteria

Mycobacterium intracellulare

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Ferchromone

PubChem ID

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Terpene, Sesquiterpene, Chromone, Prenylated, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

384.230

Molecular Formula

C₂₄H₃₂O₄

SMILES

C1c2c(ccc1)OC1C(C2=O)CC([C@@](O1)(CC/C=C(/CCC=C(C)C)C)C)O

XLogP

5.430

PSA

55.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 16 of 42 [TOP]

Compound ID	2252
Compound Structure
Plant Source	Nuphar lutea L. Common Name:Yellow Water Lily, Yellow Pond Lily
Source Family	Nymphaceae
Origin	British Columbia
Plant Part Used	Rhizome
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid
Inhibition [%]
Activity [MIC] µg/ml	50 µg extract/Disc
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Food, healing wound or sores and treating infection
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83
Curator

Record - 17 of 42 [TOP]

Compound ID	2487
Compound Structure
Plant Source	Renealmia sp. Common Name:
Source Family	Zingiberaceae
Origin	Peru
Plant Part Used	Rhizome, leaf
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) radiometric assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 51 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 18 of 42 [TOP]

Compound ID	2759
Compound Structure
Plant Source	Tulbaghia alliacea L. Common Name:Wild Garlic, Woodland Garlic
Source Family	Amaryllidaceae
Origin	Africa
Plant Part Used	Rhizome
Extract	Acetone:water (4:1)
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Bioautography on TLC plates
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis symptoms
PubMed ID [Source Literature]	18384988
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Bamuamba K, Gammon DW, Meyers P, Dijoux-Franca MG, Scott G.Anti-mycobacterial activity of five plant species used as traditional medicines in the Western Cape Province (South Africa).J Ethnopharmacol. 2008 May 8;117(2):385-90
Curator

Record - 19 of 42 [TOP]

Compound ID	2831
Compound Structure
Plant Source	Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)
Source Family	Zingiberaceae
Origin	India, Malaysia
Plant Part Used	Rhizome
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium avium
Assay / Test Done	Radiorespirometric Bioassay
Positive Control Used (conc.)
Inhibition [%]	85 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) R.D. Hiserodt,S.G. Franzblau and R.T. Rosen.Isolation of 6-, 8-, and 10-Gingerol from Ginger Rhizome by HPLC and Preliminary Evaluation of Inhibition of Mycobacterium avium and Mycobacterium tuberculosis.J. Agric. Food Chem., 1998, 46 (7), pp 2504–2508 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India 3) Jain, S.K., Tarafder, C.R., 1970. Medicinal plant lore of the Santals. A revival of P.O. Boddings, work. Economic Botany 24, 241–278
Curator

Record - 20 of 42 [TOP]

Compound ID

2833

Compound Structure

Plant Source

Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)

Source Family

Zingiberaceae

Origin

India, Malaysia

Plant Part Used

Rhizome

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

10 - Gingerol

PubChem ID

168115

Ethnomedicinal Information

Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkyl, Ketone, Ether, Phenol, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

350.246

Molecular Formula

C₂₁H₃₄O₄

SMILES

O[C@@H](CCCCCCCCC)CC(=O)CCc1cc(OC)c(O)cc1

XLogP

5.163

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) R.D. Hiserodt,S.G. Franzblau and R.T. Rosen.Isolation of 6-, 8-, and 10-Gingerol from Ginger Rhizome by HPLC and Preliminary Evaluation of Inhibition of Mycobacterium avium and Mycobacterium tuberculosis.J. Agric. Food Chem., 1998, 46 (7), pp 2504–2508

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

3) Jain, S.K., Tarafder, C.R., 1970. Medicinal plant lore of the Santals. A revival of P.O. Boddings, work. Economic Botany 24, 241–278.

Curator

Record - 21 of 42 [TOP]

Compound ID

2834

Compound Structure

Plant Source

Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)

Source Family

Zingiberaceae

Origin

India, Malaysia

Plant Part Used

Rhizome

Extract

Dichloromethane

Target Bacteria

Mycobacterium avium

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

25 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

10 - Gingerol

PubChem ID

168115

Ethnomedicinal Information

Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkyl, Ketone, Ether, Phenol, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

350.246

Molecular Formula

C₂₁H₃₄O₄

SMILES

O[C@@H](CCCCCCCCC)CC(=O)CCc1cc(OC)c(O)cc1

XLogP

5.163

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 22 of 42 [TOP]

Compound ID

2835

Compound Structure

Plant Source

Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)

Source Family

Zingiberaceae

Origin

India, Malaysia

Plant Part Used

Rhizome

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

8 - Gingerol

PubChem ID

5275725

Ethnomedicinal Information

Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkyl, Ketone, Ether, Alcohol, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

322.214

Molecular Formula

C₁₉H₃₀O₄

SMILES

OC(CCCCCCC)CC(=O)CCc1cc(OC)c(O)cc1

XLogP

4.025

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 23 of 42 [TOP]

Compound ID

2836

Compound Structure

Plant Source

Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)

Source Family

Zingiberaceae

Origin

India, Malaysia

Plant Part Used

Rhizome

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis

Assay / Test Done

Radiorespirometric Bioassay

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

> 100 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

6 - Gingerol

PubChem ID

3473

Ethnomedicinal Information

Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis

PubMed ID [Source Literature]

Extract Preparation

N/A

Chemical Classification [Active Compound]

Alicyclic, Butenolide, Lactone, Alkene

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

294.183

Molecular Formula

C₁₇H₂₆O₄

SMILES

OC(CCCCC)CC(=O)CCc1cc(OC)c(O)cc1

XLogP

2.887

PSA

66.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 24 of 42 [TOP]

Compound ID	2837
Compound Structure
Plant Source	Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)
Source Family	Zingiberaceae
Origin	India, Malaysia
Plant Part Used	Rhizome
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1600 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis
PubMed ID [Source Literature]	21094237
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mohamad S, Zin NM, Wahab HA, Ibrahim P, Sulaiman SF, Zahariluddin AS, Noor SS.Antituberculosis potential of some ethnobotanically selected Malaysian plants.J Ethnopharmacol. 2011 Feb 16;133(3):1021-6
Curator

Record - 25 of 42 [TOP]

Compound ID	2838
Compound Structure
Plant Source	Zingiber officinale Rosc. Common Name:Ginger (English), Fresh Rhizome - Aardraka, Aadrikaa, Shrngibera (Sanskrit)
Source Family	Zingiberaceae
Origin	India, Malaysia
Plant Part Used	Rhizome
Extract	Methylene chloride
Target Bacteria
Assay / Test Done	BACTEC Assay
Positive Control Used (conc.)
Inhibition [%]	85 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Leprosy, expectorant, asthma, bronchitis, cough, phthisis, tuberculosis
PubMed ID [Source Literature]	21094237
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mohamad S, Zin NM, Wahab HA, Ibrahim P, Sulaiman SF, Zahariluddin AS, Noor SS.Antituberculosis potential of some ethnobotanically selected Malaysian plants.J Ethnopharmacol. 2011 Feb 16;133(3):1021-6
Curator

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