BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 19 Record - 1 of 460 [TOP]

Compound ID	1007
Compound Structure
Plant Source	Abuta grandifolia (Mart.) Sandwith Common Name:
Source Family	Menispermaceae
Origin	Peru
Plant Part Used	Root, stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 2 of 460 [TOP]

Compound ID	1009
Compound Structure
Plant Source	Acacia kempeana F.Muell. Common Name:Witchetty Bush
Source Family	Mimosaceae
Origin	Australia
Plant Part Used	Bark, root bark, leaf
Extract	Ethanol
Target Bacteria	Mycobacterium fortuitum, Mycobacterium smegmatis
Assay / Test Done	Plate - Hole Diffusion Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	10 - 18 mm
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Chest infection, severe colds, general sickness
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Michelle Meilak and Enzo A. Palombo.Anti-Mycobacterial Activity of Extracts Derived from Australian Medicinal Plants.Research Journal of Microbiology 3 (7): 535-538, 2008
Curator

Record - 3 of 460 [TOP]

Compound ID	1019
Compound Structure
Plant Source	Acacia sieberiana DC. var. woodii (Burtt Davy) Keay & Brenan Common Name:Paperbark Thorn
Source Family	Fabaceae
Origin	Africa
Plant Part Used	Root
Extract	Dichloromethane
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	6250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Fever, infectious diseases, inflammation and pain in the back
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251
Curator

Record - 4 of 460 [TOP]

Compound ID	1020
Compound Structure
Plant Source	Acacia sieberiana DC. var. woodii (Burtt Davy) Keay & Brenan Common Name:Paperbark Thorn
Source Family	Fabaceae
Origin	Africa
Plant Part Used	Root
Extract	Ethyl acetate
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	3120 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Fever, infectious diseases, inflammation and pain in the back
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251
Curator

Record - 5 of 460 [TOP]

Compound ID	1021
Compound Structure
Plant Source	Acacia sieberiana DC. var. woodii (Burtt Davy) Keay & Brenan Common Name:Paperbark Thorn
Source Family	Fabaceae
Origin	Africa
Plant Part Used	Root
Extract	Ethanol
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	780 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Fever, infectious diseases, inflammation and pain in the back
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251
Curator

Record - 6 of 460 [TOP]

Compound ID	1049
Compound Structure	N/A
Plant Source	Acorus calamus L. var. americanus (Raf.) Common Name:Sweetflag
Source Family	Araceae
Origin	North America
Plant Part Used	Root
Extract
Target Bacteria
Assay / Test Done	Microplate Resazurin Assay (MRA)
Positive Control Used (conc.)	Rifampin (2 and 0.4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Adjuvant, analgesic, antihelmintic, antihemorrhagic, anti-inflammatory, antipyretic, antirheumatic, cold, cough, dermatological, emetic, gastrointestinal, gynaecological, child birth, hallucinogen, panacea, tonic, pediatric, pulmonary, stimulant, venereal infection
PubMed ID [Source Literature]	20657619
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Duncan Webster, Timothy D.G. Lee, Jill MoWebster D, Lee TD, Moore J, Manning T, Kunimoto D, LeBlanc D, Johnson JA, Gray CA.Antimycobacterial screening of traditional medicinal plants using the microplate resazurin assay.Can J Microbiol. 2010 Jun;56(6):487-94
Curator

Record - 7 of 460 [TOP]

Compound ID	1087
Compound Structure
Plant Source	Albizia adianthifolia (Schumach.)W. F.Wight Common Name:Flat Crown, Rough - Bark Flat Crown, West African Albizia
Source Family	Fabaceae
Origin	Africa
Plant Part Used	Root
Extract	Ethanol
Target Bacteria	Mycobacterium aurum A+
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ciprofloxacin (1.8 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	6250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Fever, headaches, stomach problems, internal parasites and dysentery
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) I.M.S. Eldeen, J. Van Staden.Antimycobacterial activity of some trees used in South African traditional medicine.South African Journal of Botany, Volume 73, Issue 2, April 2007, Pages 248–251 2) http://www.worldagroforestry.org/sea/Products/AFDbases/af/asp/SpeciesInfo.asp?SpID=1760
Curator

Record - 8 of 460 [TOP]

Compound ID	1181
Compound Structure
Plant Source	Andira sp. (fruit), Bauhinia sp. Common Name:
Source Family	Fabaceae
Origin	Peru
Plant Part Used	Bark, root, stem
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 9 of 460 [TOP]

Compound ID	1191
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	78 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 10 of 460 [TOP]

Compound ID	1192
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Hexane
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	312.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 11 of 460 [TOP]

Compound ID	1193
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Ethyl acetate soluble
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	625 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 12 of 460 [TOP]

Compound ID	1194
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Methanol
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 13 of 460 [TOP]

Compound ID

1218

Compound Structure

Plant Source

Artocarpus lakoocha Roxb.Artocarpus lacucha Buch.-Ham Common Name:Monkey Jack (English), Lakuch, Kshudra Panas, Granthiphala, Pitanaasha (Sanskrit)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 – 0.090 µg/ml) and Kanamycin sulphate (2 – 5 µg/ml))

Inhibition [%]

Activity [MIC] µg/ml

12.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Lakoochin A

PubChem ID

3012524

Ethnomedicinal Information

Leprosy, used as folkmedicine for other diseases

PubMed ID [Source Literature]

15043440

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Stilbene, Furanoid, Phenol, Prenylated, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against KB and BC - 1 cell lines

Molecular Weight

406.214

Molecular Formula

C₂₆H₃₀O₄

SMILES

O1c(c2c(CC=C(C)C)c(OC)cc(OC)c2CC=C(C)C)cc2c1cc(O)cc2

XLogP

5.873

PSA

51.830

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Puntumchai A, Kittakoop P, Rajviroongit S, Vimuttipong S, Likhitwitayawuid K, Thebtaranonth Y.Lakoochins A and B, new antimycobacterial stilbene derivatives from Artocarpus lakoocha.J Nat Prod. 2004 Mar;67(3):485-6

2) Pushpangadan P, Atal CK.Ethno-medico-botanical investigations in Kerala I. Some primitive tribals of western ghats and their herbal medicine.J Ethnopharmacol. 1984 Jun;11(1):59-77

Curator

Record - 14 of 460 [TOP]

Compound ID

1219

Compound Structure

Plant Source

Artocarpus lakoocha Roxb.Artocarpus lacucha Buch.-Ham Common Name:Monkey Jack (English), Lakuch, Kshudra Panas, Granthiphala, Pitanaasha (Sanskrit)

Source Family

Moraceae

Origin

India

Plant Part Used

Root

Extract

Dichloromethane

Target Bacteria

Mycobacterium tuberculosis H37Ra

Assay / Test Done

Microplate Alamar Blue Assay (MABA)

Positive Control Used (conc.)

Isoniazid (0.040 – 0.090 µg/ml) and Kanamycin sulphate (2 – 5 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

50 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Lakoochin B

PubChem ID

6479925

Ethnomedicinal Information

Leprosy, used as folkmedicine for other diseases

PubMed ID [Source Literature]

15043440

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Stilbene, Furanoid, Phenol, Prenylated

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

Against KB and BC - 1 cell lines

Molecular Weight

446.246

Molecular Formula

C₂₉H₃₄O₄

SMILES

O1c(c2c(C/C=C(/CCC=C(C)C)C)c(O)cc(O)c2CC=C(C)C)cc2c1cc(O)cc2

XLogP

6.657

PSA

73.830

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 15 of 460 [TOP]

Compound ID	1221
Compound Structure
Plant Source	Asclepias fruticosa L. (and Asclepias physocarpa (E. Mey.) Schltr.) Common Name:African Milkweed
Source Family	Asclepiadaceae
Origin	Africa
Plant Part Used	Root
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (2.00 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used for diarrhoea and stomach pain, facilitate child-birth, asthma, diabetes, tuberculosis, headache and emetic to strengthen the body
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 16 of 460 [TOP]

Compound ID	1222
Compound Structure
Plant Source	Asclepias fruticosa L. (and Asclepias physocarpa (E. Mey.) Schltr.) Common Name:African Milkweed
Source Family	Asclepiadaceae
Origin	Africa
Plant Part Used	Root
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis 2 (Clinical isolates resistant to Streptomycin, Rifampin, Ethambutol, Isoniazid)
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (100 µg/ml), Isoniazid (4.6 µg/ml), Ethambutol (12 µg/ml), Streptomycin (120 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used for diarrhoea and stomach pain, facilitate child-birth, asthma, diabetes, tuberculosis, headache and emetic to strengthen the body
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 17 of 460 [TOP]

Compound ID	1224
Compound Structure
Plant Source	Aspidosperma parvifolium A. DC. Common Name:
Source Family	Apocynaceae
Origin	Peru
Plant Part Used	Root
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	52 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 18 of 460 [TOP]

Compound ID	1233
Compound Structure
Plant Source	Balsamorhiza sagittata (Pursh) Nutt. Common Name:Arrowleaf Balsamroot
Source Family	Meliaceae
Origin	British Columbia
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Isoniazid
Inhibition [%]	100 %
Activity [MIC] µg/ml	50 µg extract/Disc
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Stomach pains, colds, whooping cough, tuberculosis, fevers and headache, to treat sore mouths and throats, toothaches, for body aches such as rheumatism, on wounds, blisters, bites, swellings and sores (root), for dysentery (seeds)
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A.R. McCutcheon, R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.Anti-Mycobacterial Screening of British Columbian Medicinal Plants.Pharmaceutical Biology, 1997, Vol. 35, No. 2 , Pages 77-83
Curator

Record - 19 of 460 [TOP]

Compound ID	1245
Compound Structure
Plant Source	Bauhinia vahlii Wt. & Arn. Common Name:
Source Family	Caesalpiniaceae
Origin	India
Plant Part Used	Root
Extract	Methanol
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	Chloramphenicol
Inhibition [%]
Activity [MIC] µg/ml	3000000 µg/ml of dried plant material
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Dysentery, stomach ache, tonic, aphrodisiac, cuts, wounds
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 20 of 460 [TOP]

Compound ID	1295
Compound Structure
Plant Source	Browneopsis ucayalina Huber Common Name:
Source Family	Fabaceae
Origin	Peru
Plant Part Used	Root
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 21 of 460 [TOP]

Compound ID	1298
Compound Structure
Plant Source	Brunfelsia grandiflora D. Don Common Name:
Source Family	Solanaceae
Origin	Peru
Plant Part Used	Leaf, root
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 22 of 460 [TOP]

Compound ID	1328
Compound Structure
Plant Source	Caesalpinia digyna Rottl. Common Name:Teri Pods (English), Vaakeri (Sanskrit)
Source Family	Caesalpiniaceae
Origin	India
Plant Part Used	Root
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Phthisis, glandular, intestinal and bone tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Patel, M.R., R.A. Bellare and C.V. Deliwala.Antitubercular action of Caesalpinia digyna Rottl. roots.IJEB 4, 4, 214-215 2) Anon., 1967. Antibacterial action of Vakeri root. Indian Journal of Pharmacy 29, 103–104.
Curator

Record - 23 of 460 [TOP]

Compound ID	1329
Compound Structure
Plant Source	Caesalpinia digyna Rottl. Common Name:Teri Pods (English), Vaakeri (Sanskrit)
Source Family	Caesalpiniaceae
Origin	India
Plant Part Used	Root
Extract	Ethanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Phthisis, glandular, intestinal and bone tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Patel, M.R., R.A. Bellare and C.V. Deliwala.Antitubercular action of Caesalpinia digyna Rottl. roots.IJEB 4, 4, 214-215 2) Anon., 1967. Antibacterial action of Vakeri root. Indian Journal of Pharmacy 29, 103–104.
Curator

Record - 24 of 460 [TOP]

Compound ID	1330
Compound Structure
Plant Source	Caesalpinia digyna Rottl. Common Name:Teri Pods (English), Vaakeri (Sanskrit)
Source Family	Caesalpiniaceae
Origin	India
Plant Part Used	Root
Extract	Water:Ethanol (80:20)
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)	1:80 dilution (It was 7 times more active than Ethanol extract and 5 times more active than aqueous extract)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Phthisis, glandular, intestinal and bone tuberculosis
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Patel, M.R., R.A. Bellare and C.V. Deliwala.Antitubercular action of Caesalpinia digyna Rottl. roots.IJEB 4, 4, 214-215 3) Anon., 1967. Antibacterial action of Vakeri root. Indian Journal of Pharmacy 29, 103–104.
Curator

Record - 25 of 460 [TOP]

Compound ID	1332
Compound Structure
Plant Source	Caesalpinia pulcherrima Common Name:Poinciana, Peacock Flower, Red Bird of Paradise
Source Family	Fabaceae
Origin	Native to Central America, grown widely in South and Southeast Asia
Plant Part Used	Root
Extract
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	6.25 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Fever, sores, cough, breathing difficulty and chest pain
PubMed ID [Source Literature]	14531033
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Promsawan N, Kittakoop P, Boonphong S, Nongkunsarn P.Antitubercular cassane furanoditerpenoids from the roots of Caesalpinia pulcherrima.Planta Med. 2003 Aug;69(8):776-7 2) "Taxon: Caesalpinia pulcherrima (L.) Sw.". Germplasm Resources Information Network. United States Department of Agriculture. 2004-03-26 3) S. Allen Counter (2006-07-24). "Amazon mystery: A medicine man understood the secrets of this plant long before we did. How?". The Boston Globe.
Curator

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