BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 32 [TOP]

Compound ID	1009
Compound Structure
Plant Source	Acacia kempeana F.Muell. Common Name:Witchetty Bush
Source Family	Mimosaceae
Origin	Australia
Plant Part Used	Bark, root bark, leaf
Extract	Ethanol
Target Bacteria	Mycobacterium fortuitum, Mycobacterium smegmatis
Assay / Test Done	Plate - Hole Diffusion Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	10 - 18 mm
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Chest infection, severe colds, general sickness
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Michelle Meilak and Enzo A. Palombo.Anti-Mycobacterial Activity of Extracts Derived from Australian Medicinal Plants.Research Journal of Microbiology 3 (7): 535-538, 2008
Curator

Record - 2 of 32 [TOP]

Compound ID	1191
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	78 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 3 of 32 [TOP]

Compound ID	1192
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Hexane
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	312.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 4 of 32 [TOP]

Compound ID	1193
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Ethyl acetate soluble
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	625 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 5 of 32 [TOP]

Compound ID	1194
Compound Structure
Plant Source	Anogeissus leiocarpus (DC.) Guill. & Perr. Common Name:African Birch
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Root bark, stem bark
Extract	Methanol
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, tuberculosis, worm killer, gonorrhoea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mann, A., Amupitan, J.O., Oyewale, A.O., Okogun, J.I., Ibrahim, K., Oladosu, P., Lawson, L., Olajide, I., and Nnamdi, A., 2008, Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotech., 7(11), 1630-1636 2) http://www.ajol.info/index.php/ajb/article/viewFile/58747/47072
Curator

Record - 6 of 32 [TOP]

Compound ID	1365
Compound Structure
Plant Source	Capparis brassii DC Common Name:
Source Family	Capparaceae
Origin	Nigeria
Plant Part Used	Root bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21
Curator

Record - 7 of 32 [TOP]

Compound ID	1524
Compound Structure
Plant Source	Combretum spp Common Name:Leadwood
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Stem bark, root bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, cough, tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) http://www.bradturnsgreen.com/Wood%20Status%20List.pdf
Curator

Record - 8 of 32 [TOP]

Compound ID	1629
Compound Structure
Plant Source	Entada africana Guill. & Perr. Common Name:
Source Family	Mimosaceae
Origin	Nigeria
Plant Part Used	Stem bark, root bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	2500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, cough, whooping cough, dysentery, fever, wound
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) Mann A, Gbate M, Nda-Umar A. Medicinal and Economic Plants of Nupeland. Bida, Niger State, Nigeria: Jube-Evans Books and Publications; 2003. p. 276
Curator

Record - 9 of 32 [TOP]

Compound ID	1653
Compound Structure
Plant Source	Erythrina variegata L. var. orientalis (L.) Merr.syn. Erythrina indica Lam. Common Name:Indian Coral Tree (English), Paaribhadra, Paaribhadraka, Paarijaataka, Mandaara (Sanskrit)
Source Family	Papilionaceae
Origin	India
Plant Part Used	Root bark
Extract	Phenol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Agar Dilution - Streak Assay
Positive Control Used (conc.)	Streptomycin (1.7 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	17.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough, microbial infections
PubMed ID [Source Literature]	10820816
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Waffo AK, Azebaze GA, Nkengfack AE, Fomum ZT, Meyer M, Bodo B, van Heerden FR.Indicanines B and C, two isoflavonoid derivatives from the root bark of Erythrina indica.Phytochemistry. 2000 Apr;53(8):981-5
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Record - 10 of 32 [TOP]

Compound ID

1656

Compound Structure

Plant Source

Erythrina variegata L. var. orientalis (L.) Merr.syn. Erythrina indica Lam. Common Name:Indian Coral Tree (English), Paaribhadra, Paaribhadraka, Paarijaataka, Mandaara (Sanskrit)

Source Family

Papilionaceae

Origin

India

Plant Part Used

Root bark

Extract

Phenol

Target Bacteria

Mycobacterium smegmatis (ATCC 607)

Assay / Test Done

Agar Dilution - Streak Assay

Positive Control Used (conc.)

Streptomycin (1.7 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 450 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

5,4'-Di-O-Methylalpinumisoflavone

PubChem ID

10384155

Ethnomedicinal Information

Cough, microbial infections

PubMed ID [Source Literature]

10820816

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Flavonoid, Benzopyran, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

364.131

Molecular Formula

C₂₂H₂₀O₅

SMILES

O1C(C=Cc2c1cc1occ(c(=O)c1c2OC)c1ccc(OC)cc1)(C)C

XLogP

3.663

PSA

44.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Waffo AK, Azebaze GA, Nkengfack AE, Fomum ZT, Meyer M, Bodo B, van Heerden FR.Indicanines B and C, two isoflavonoid derivatives from the root bark of Erythrina indica.Phytochemistry. 2000 Apr;53(8):981-5

Curator

Record - 11 of 32 [TOP]

Compound ID

1657

Compound Structure

Plant Source

Erythrina indica Common Name:

Source Family

Leguminosae

Origin

Ibadan, Nigeria

Plant Part Used

Root bark

Extract

Phenol

Target Bacteria

Mycobacterium smegmatis (ATCC 607)

Assay / Test Done

Agar Dilution - Streak Assay

Positive Control Used (conc.)

Streptomycin (1.7 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 400 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Cajanin

PubChem ID

5281706

Ethnomedicinal Information

Trachoma, Elephantiasis, Microbial infections

PubMed ID [Source Literature]

10820816

Extract Preparation

Dried and ground root bark of Erythrina indica was successively extracted with a mixture of dichloro-methane-MeOH (1:1) and methanol. The dichloro-methane-MeOH (1:1) extract was concentrated to dryness

Chemical Classification [Active Compound]

Aromatic, Tricyclic, Flavonoid, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

300.063

Molecular Formula

C₁₆H₁₂O₆

SMILES

O1c2c(c(=O)c(c3c(O)cc(O)cc3)c1)c(O)cc(OC)c2

XLogP

0.781

PSA

86.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 12 of 32 [TOP]

Compound ID	1881
Compound Structure
Plant Source	Hymenocardia acida Tul. Common Name:Large Red - Hear
Source Family	Euphorbiaceae
Origin	Nigeria
Plant Part Used	Root bark
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 2500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Hemoptysis,tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) http://www.zimbabweflora.co.zw/speciesdata/species.php?species_id=134510
Curator

Record - 13 of 32 [TOP]

Compound ID	2703
Compound Structure
Plant Source	Terminalia avicennioides Guill. & Perr. Common Name:
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Mistletoes, root bark, fruit
Extract	Crude methanol
Target Bacteria	Mycobacterium tuberculosis clinical isolate
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Ethambutol (2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	78 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, hemoptysis, tuberculosis, sore throat, diarrhea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) Mann A, Gbate M, Nda-Umar A. Medicinal and Economic Plants of Nupeland. Bida, Niger State, Nigeria: Jube-Evans Books and Publications; 2003. p. 276
Curator

Record - 14 of 32 [TOP]

Compound ID	2704
Compound Structure
Plant Source	Terminalia avicennioides Guill. & Perr. Common Name:
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Mistletoes, root bark, fruit
Extract	Hexane
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, hemoptysis, tuberculosis, sore throat, diarrhea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) Mann A, Gbate M, Nda-Umar A. Medicinal and Economic Plants of Nupeland. Bida, Niger State, Nigeria: Jube-Evans Books and Publications; 2003. p. 276
Curator

Record - 15 of 32 [TOP]

Compound ID	2705
Compound Structure
Plant Source	Terminalia avicennioides Guill. & Perr. Common Name:
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Mistletoes, root bark, fruit
Extract	Ethyl acetate soluble
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	625 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, hemoptysis, tuberculosis, sore throat, diarrhea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) Mann A, Gbate M, Nda-Umar A. Medicinal and Economic Plants of Nupeland. Bida, Niger State, Nigeria: Jube-Evans Books and Publications; 2003. p. 276
Curator

Record - 16 of 32 [TOP]

Compound ID	2706
Compound Structure
Plant Source	Terminalia avicennioides Guill. & Perr. Common Name:
Source Family	Combretaceae
Origin	Nigeria
Plant Part Used	Mistletoes, root bark, fruit
Extract	Methanol
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Rifampin (0.03 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 1250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, cough, hemoptysis, tuberculosis, sore throat, diarrhea
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) A Mann, J O Amupitan, A O Oyewale, J I Okogun, K Ibrahim.An ethnobotanical survey of indigenous flora for treating tuberculosis and other respiratory diseases in Niger State, Nigeria.JOPAT Vol. 12 2007: pp. 1-21 2) Mann A, Gbate M, Nda-Umar A. Medicinal and Economic Plants of Nupeland. Bida, Niger State, Nigeria: Jube-Evans Books and Publications; 2003. p. 276
Curator

Record - 17 of 32 [TOP]

Compound ID	2780
Compound Structure
Plant Source	Vernonia amygdalinaDel Common Name:Bitter Leaf
Source Family	Asteraceae (Compositae)
Origin	Kenya
Plant Part Used	Root bark
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2, 1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Gastrointestinal problems, tuberculosis, asthma
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 18 of 32 [TOP]

Compound ID	2781
Compound Structure
Plant Source	Vernonia amygdalinaDel Common Name:Bitter Leaf
Source Family	Asteraceae (Compositae)
Origin	Kenya
Plant Part Used	Root bark
Extract	Methanol
Target Bacteria	Mycobacterium kansasii
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2, 1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	0.5, 1, 2 mg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Gastrointestinal problems, tuberculosis, asthma
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 19 of 32 [TOP]

Compound ID	2782
Compound Structure
Plant Source	Vernonia amygdalinaDel Common Name:Bitter Leaf
Source Family	Asteraceae (Compositae)
Origin	Kenya
Plant Part Used	Root bark
Extract	Methanol
Target Bacteria	Mycobacterium fortuitum
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2, 1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	0.5, 1,2 mg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Gastrointestinal problems, tuberculosis, asthma
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 20 of 32 [TOP]

Compound ID	2783
Compound Structure
Plant Source	Vernonia amygdalinaDel Common Name:Bitter Leaf
Source Family	Asteraceae (Compositae)
Origin	Kenya
Plant Part Used	Root bark
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	BACTEC MGIT™ 960 System
Positive Control Used (conc.)	Isoniazid (2, 1 and 0.5 mg/ml)
Inhibition [%]	100 %
Activity [MIC] µg/ml	0.5, 1, 2 mg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Gastrointestinal problems, tuberculosis, asthma
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mariita, Richard M.; Okemo, Paul O.; Orodho, John A.; Kirimuhuzya, Claude; Otieno, Joseph N.; Magadula, J. Joseph.Efficacy of 13 medicinal plants used by indigenous communities around Lake Victoria, Kenya, against tuberculosis, diarrhoea aausing bacteria and candida albicans.Pharmacy & Technology IJPT, Sep-2010, Vol. 2, Issue No.3, 771-791
Curator

Record - 21 of 32 [TOP]

Compound ID	2802
Compound Structure
Plant Source	Warbugia salutaris (Bertol. f.) Chiov Common Name:Pepper - Bark Tree
Source Family	Canellaceae
Origin	Africa
Plant Part Used	Bark or root bark
Extract	Dichloromethane bark extract
Target Bacteria	Mycobacterium tuberculosis, Mycobacterium bovis BCG
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Colds, sinuses, influenza and other chest complaints, antiparasitic powder applied to sores, fever, respiratory ailments
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Clarkson C, Madikane EV, Hansen SH, Smith PJ, Jaroszewski JW.HPLC-SPE-NMR characterization of sesquiterpenes in an antimycobacterial fraction from Warburgia salutaris.Planta Med. 2007 Jun;73(6):578-84 2) http://www.plantzAfrica.com/plantwxyz/warburg.htm
Curator

Record - 22 of 32 [TOP]

Compound ID

3113

Compound Structure

Plant Source

Erythrina indica Common Name:Indian Coral Tree (English), Paaribhadra, Paaribhadraka, Paarijaataka, Mandaara (Sanskrit)

Source Family

Leguminosae

Origin

Ibadan, Nigeria

Plant Part Used

Root bark

Extract

Phenol

Target Bacteria

Mycobacterium smegmatis (ATCC 607)

Assay / Test Done

Agar Dilution - Streak Assay

Positive Control Used (conc.)

Streptomycin (1.7 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

18.5 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Indicanine B

PubChem ID

Ethnomedicinal Information

Trachoma, Elephantiasis, Microbial infections

PubMed ID [Source Literature]

10820816

Extract Preparation

Dichloromethane - methanol (1:1)

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Flavonoid, Coumarin, Benzopyran, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

366.110

Molecular Formula

C₂₁H₁₈O₆

SMILES

O1C(C=Cc2c1cc1c(c2OC)c(c(c(=O)o1)c1ccc(cc1)O)O)(C)C

XLogP

4.028

PSA

75.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Waffo AK, Azebaze GA, Nkengfack A E, Fomum ZT, Meyer M, Bodo B, Heerden FR. Indicanines B and C, two isoflavonoids derivatives from the root bark of Erythrina indica. Phytochemistry. 2003;53:981–985. 2000.

Curator

KeyaMukherjee, vsheeba

Record - 23 of 32 [TOP]

Compound ID

3114

Compound Structure

Plant Source

Erythrina indica Common Name:NR

Source Family

Fabaceae

Origin

Ibadan, Nigeria

Plant Part Used

Root bark

Extract

Phenol

Target Bacteria

Mycobacterium smegmatis (ATCC 607)

Assay / Test Done

Agar Dilution - Streak Assay

Positive Control Used (conc.)

Streptomycin (1.7 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 150 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Indicanine C

PubChem ID

10736576

Ethnomedicinal Information

Trachoma, Elephantiasis, Microbial infections

PubMed ID [Source Literature]

10820816

Extract Preparation

Dichloromethane - methanol (1:1)

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Flavonoid, Benzopyran, Ether, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

350.115

Molecular Formula

C₂₁H₁₈O₅

SMILES

O1C(C=Cc2c1cc1occ(c(=O)c1c2OC)c1ccc(O)cc1)(C)C

XLogP

3.144

PSA

55.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, vsheeba

Record - 24 of 32 [TOP]

Compound ID

3115

Compound Structure

Plant Source

Erythrina indica Common Name:NR

Source Family

Fabaceae

Origin

Ibadan, Nigeria

Plant Part Used

Root bark

Extract

Target Bacteria

Mycobacterium smegmatis (ATCC 607)

Assay / Test Done

Agar Dilution - Streak Assay

Positive Control Used (conc.)

Streptomycin (1.7 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 450 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Dimethyl Alpinumisoflavone

PubChem ID

10384155

Ethnomedicinal Information

Trachoma, Elephantiasis, Microbial infections

PubMed ID [Source Literature]

10820816

Extract Preparation

Dichloromethane - methanol (1:1)

Chemical Classification [Active Compound]

Aromatic, Tetracyclic, Flavonoid, Benzopyran, Ether

Media / Broth Used [Antimicrobial Assay/Test]

Cytotoxicity Assay [AID]

Molecular Weight

364.131

Molecular Formula

C₂₂H₂₀O₅

SMILES

O1C(C=Cc2c1cc1occ(c(=O)c1c2OC)c1ccc(OC)cc1)(C)C

XLogP

3.663

PSA

44.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

KeyaMukherjee, vsheeba

Record - 25 of 32 [TOP]

Compound ID	3128
Compound Structure	N/A
Plant Source	Adansonia digitata L. Common Name:Gorakshi
Source Family	Bombacaceae
Origin	India
Plant Part Used	Root bark
Extract	Methanol
Target Bacteria	Mycobacterium phlei
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)	NR
Inhibition [%]	2 mg/disc
Activity [MIC] µg/ml	NR
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Bronchial asthma
PubMed ID [Source Literature]	21214438
Extract Preparation
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Anani K, Hudson JB, de Souza C, Akpagana K, Tower GH, Arnason JT, Gbeassor M.Investigation of medicinal plants of togo for antiviral and antimicrobial activities.Pharm Biol. 2000;38(1):40-5
Curator	Najiya-beegum, vikramjitmandal

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