BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 2 Record - 1 of 36 [TOP]

Compound ID	1088
Compound Structure
Plant Source	Albizia julibrissin Durazz. Common Name:Mimosa, Silk Tree (English)
Source Family	Fabaceae
Origin	India
Plant Part Used	Seed
Extract	Chloroform, methanol
Target Bacteria	Mycobacterium leprae
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, leprosy, tuberculous glands
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 2 of 36 [TOP]

Compound ID	1183
Compound Structure
Plant Source	Angelica archangelica L Common Name:Chandaa, Chandaamshuka, Kathachoraa (Sanskrit)
Source Family	Apiaceae (Umbelliferae)
Origin	India
Plant Part Used	Seed
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium smegmatis, Mycobacterium phlei
Assay / Test Done	Agar - Well Diffusion Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	13 - 18 mm
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchial cold, expectorant
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 3 of 36 [TOP]

Compound ID	1201
Compound Structure
Plant Source	Apium graveolens L. Common Name:Celery (English), Ajmodaa, Ajmoda, Ajmodikaa, Dipyaka (Sanskrit)
Source Family	Apiaceae (Umbelliferae)
Origin	India, Malaysia, Worldwide
Plant Part Used	Seed
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)	1:40 dilutions
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, chest pain, cough, anthelmintic, antifungal, fever, urinary calculi, obesity, musculoskeletal disorder, dropsy, chronic diarrhoea
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) http://parisaramahiti.kar.nic.in/Medicinal_plants_new/med%20plants/p18.html
Curator

Record - 4 of 36 [TOP]

Compound ID	1202
Compound Structure
Plant Source	Apium graveolens L. Common Name:Celery (English), Ajmodaa, Ajmoda, Ajmodikaa, Dipyaka (Sanskrit)
Source Family	Apiaceae (Umbelliferae)
Origin	India, Malaysia, Worldwide
Plant Part Used	Seed
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)	1:40 dilutions
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, chest pain, cough, anthelmintic, antifungal, fever, urinary calculi, obesity, musculoskeletal disorder, dropsy, chronic diarrhoea
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) http://parisaramahiti.kar.nic.in/Medicinal_plants_new/med%20plants/p18.html
Curator

Record - 5 of 36 [TOP]

Compound ID	1238
Compound Structure
Plant Source	Batis maritima L. Common Name:Turtleweed
Source Family	Bataceae
Origin	Puerto Rico
Plant Part Used	Seed
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Middlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)	Rifampin
Inhibition [%]	14 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	11746852
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42 2) http://plants.usda.gov/java/profile?symbol=BAMA5
Curator

Record - 6 of 36 [TOP]

Compound ID	1246
Compound Structure
Plant Source	Bauhinia variegata L. Common Name:Mountain Ebony, Buddhist Bauhinia (English), Kaanchanaara, Kanchanak (Sanskrit)
Source Family	Caesalpiniaceae
Origin	India
Plant Part Used	Seed
Extract	Protein fraction
Target Bacteria	Mycobacterium rhodochrous
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, tuberculous glands, bronchitis, consumption, cough, asthma
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 7 of 36 [TOP]

Compound ID	1290
Compound Structure
Plant Source	Brassica rapa L. emend. Metzger Common Name:Field Mustard, Turnip Rape (English), Sarshapa, Siddhaartha (Sanskrit)
Source Family	Brassicaceae
Origin	India
Plant Part Used	Seed
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Frisbey, A., Roberts, J.M., Jennings, J.C., Gottshall, R.Y., Lucas, E.H., 1953. The occurrence of antibacterial substances in seed plants with special reference to Mycobacterium tuberculosis. Michigan State University Agricultural Applied Science Quaternary Bulletin 35, 392–404 2) Anonymous, 1986. The Useful Plants of India. Council of Scientific and Industrial Research, New Delhi, India
Curator

Record - 8 of 36 [TOP]

Compound ID	1390
Compound Structure
Plant Source	Casuarina equisetifolia J.R. & G.Forst Common Name:Beach Sheoak
Source Family	Casuarinaceae
Origin	Puerto Rico
Plant Part Used	Seed, leaf, stem
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Middlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)	Rifampin
Inhibition [%]	63, 57 and 34 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Astringent properties, diarrhea, dysentery, toothache
PubMed ID [Source Literature]	11746852
Extract Preparation	The plants were dried, at a temperature not exceeding 30°C, in an air - circulating oven. The material was powdered and extracted with 95 % ethanol. The organic solvent was removed by distillation under reduced pressure
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42 2) http://plants.usda.gov/java/profile?symbol=CAEQ
Curator

Record - 9 of 36 [TOP]

Compound ID	1392
Compound Structure
Plant Source	Casuarina equisetifolia L. Common Name:Casuarina, She Oak (English), Jhaau (Sanskrit)
Source Family	Casuarinaceae
Origin	India
Plant Part Used	Seed
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Radiorespirometric Bioassay
Positive Control Used (conc.)	Rifampin (1 µg/ml)
Inhibition [%]	63 %
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diarrhoea, dysentery, stomach ache, folklore medicine of Puerto Rico
PubMed ID [Source Literature]	11746852
Extract Preparation	The plants were dried, at a temperature not exceeding 30°C, in an air - circulating oven. The material was powdered and extracted with 95 % ethanol. The organic solvent was removed by distillation under reduced pressure
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42 2) Sudhanshu Kumar Jain.Dictionary of Indian Folk Medicine and Ethnobotany:A Reference Manual of Man-Plant Relationships, Ethnic Groups & Ethnobotanists in India.Deep Publications, 1991 - 311 pages
Curator

Record - 10 of 36 [TOP]

Compound ID	1723
Compound Structure
Plant Source	Exocarpus bidwilli Common Name:
Source Family	Santalaceae
Origin	New Zealand
Plant Part Used	Leaf, seed
Extract
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	96 well - plate format assay for bacteriostatic activity, two - fold serial dilution to measure any background optical density or fluorescence associated with the extract
Positive Control Used (conc.)	Rifampin (100 µM), Streptomycin (100 µM)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	20537175
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Earl EA, Altaf M, Murikoli RV, Swift S, O Toole R.Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC Complement Altern Med. 2010 Jun 10;10:25
Curator

Record - 11 of 36 [TOP]

Compound ID	1763
Compound Structure
Plant Source	Foeniculum vulgare Mill. Common Name:Fennel
Source Family	Apiaceae (Umbelliferae)
Origin	India, Pakistan, Mediterranean region, Mexico, Africa
Plant Part Used	Seed
Extract	Methanol (13.26 %)
Target Bacteria	Mycobacterium aurum
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diseases of the chest, cough, fever, respiratory diseases, digestion, over - weight, boosting metabolism as well as for stomach cramps
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) http://www.ageless.co.za/fennel.htm
Curator

Record - 12 of 36 [TOP]

Compound ID	1764
Compound Structure
Plant Source	Foeniculum vulgare Mill. Common Name:Fennel
Source Family	Apiaceae (Umbelliferae)
Origin	India, Pakistan, Mediterranean region, Mexico,Africa
Plant Part Used	Seed
Extract	Methanol (13.26 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Broth Microdilution Method (BMM)
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Diseases of the chest, cough, fever, respiratory diseases,digestion, over - weight, boosting metabolism as well as for stomach cramps
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) http://www.ageless.co.za/fennel.htm
Curator

Record - 13 of 36 [TOP]

Compound ID	1935
Compound Structure
Plant Source	Ipomoea muricatum Don syn. Calonyction muricatum Don Common Name:
Source Family	Convolvulaceae
Origin	India
Plant Part Used	Seed
Extract	Alkaloid fraction of chloroform extract
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cathartic, purgative
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

Record - 14 of 36 [TOP]

Compound ID	2183
Compound Structure
Plant Source	Miconia racemosa (Aubl.) DC. Common Name:Camasey Felpa
Source Family	Melastomataceae
Origin	Puerto Rico
Plant Part Used	Seed
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Middlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)	Rifampin
Inhibition [%]	41 %
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	11746852
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42 2) http://plants.usda.gov/java/profile?symbol=MIRA2
Curator

Record - 15 of 36 [TOP]

Compound ID	2249
Compound Structure
Plant Source	Nigella sativum L. Common Name:Black Cumin (English)
Source Family	Ranunculaceae
Origin	India
Plant Part Used	Seed
Extract	Methanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 vaule 0.17)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Fever
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 16 of 36 [TOP]

Compound ID	2250
Compound Structure
Plant Source	Nigella sativum L. Common Name:Black Cumin (English)
Source Family	Ranunculaceae
Origin	India
Plant Part Used	Seed
Extract	Methanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 vaule 1.14)
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Fever
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67
Curator

Record - 17 of 36 [TOP]

Compound ID	2255
Compound Structure
Plant Source	Ocimum basilicum L. Common Name:Sweet Basil, Basil Herb (English), Barbari, Tuvari, Tungi (Sanskrit)
Source Family	Lamiaceae
Origin	India, Malaysia
Plant Part Used	Seed
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	General infectious diseases, antiseptic, disinfectant, cough, expectorant
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Frisbey, A., Roberts, J.M., Jennings, J.C., Gottshall, R.Y., Lucas, E.H., 1953. The occurrence of antibacterial substances in seed plants with special reference to Mycobacterium tuberculosis. Michigan State University Agricultural Applied Science Quaternary Bulletin 35, 392–404
Curator

Record - 18 of 36 [TOP]

Compound ID	2435
Compound Structure
Plant Source	Potamogeton pectinatus L. Common Name:
Source Family	Potamogetonaceae
Origin	India
Plant Part Used	Aerial, seed
Extract	Ethanol (80 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Agar Dilution - Streak Assay
Positive Control Used (conc.)
Inhibition [%]	Partial
Activity [MIC] µg/ml	1000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cold, fever, blood diseases, used in herbal medicine for other diseases
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Al-Shamma A, Mitscher LA.Comprehensive survey of indigenous Iraqi plants for potential economic value. 1. Screening results of 327 species for alkaloids and antimicrobial agents.J Nat Prod. 1979 Nov-Dec;42(6):633-42 2) Sharma, S.K., 1998. Medicinal Plants Used in Ayurveda. National Academy of Ayurveda, Ministry of Health and Family Welfare, Govt. of India, New Delhi, India
Curator

Record - 19 of 36 [TOP]

Compound ID	2455
Compound Structure
Plant Source	Psoralea corylifoila L. Common Name:Babchi, Purple Fleabane (English), Somaraaji, Somavalli, Somavallik (Sanskrit)
Source Family	Fabaceae
Origin	India
Plant Part Used	Seed
Extract	Ethanol
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 = 1.14 µg/ml [0.78 µM])
Inhibition [%]
Activity [MIC] µg/ml	> 500 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, asthma, bronchitis, respiratory diseases, various fevers, pulmonary disorders
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 20 of 36 [TOP]

Compound ID	2456
Compound Structure
Plant Source	Psoralea corylifoila L. Common Name:Babchi, Purple Fleabane (English), Somaraaji, Somavalli, Somavallik (Sanskrit)
Source Family	Fabaceae
Origin	India
Plant Part Used	Seed
Extract	Ethanol
Target Bacteria	Mycobacterium avium
Assay / Test Done	Micro Broth Dilution Method
Positive Control Used (conc.)	Streptomycin (IC50 value 0.17)
Inhibition [%]
Activity [MIC] µg/ml	62.5 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, asthma, bronchitis, respiratory diseases, various fevers, pulmonary disorders
PubMed ID [Source Literature]	11744296
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India
Curator

Record - 21 of 36 [TOP]

Compound ID

2457

Compound Structure

Plant Source

Psoralea corylifoila L. Common Name:Babchi, Purple Fleabane (English), Somaraaji, Somavalli, Somavallik (Sanskrit)

Source Family

Fabaceae

Origin

India

Plant Part Used

Seed

Extract

Target Bacteria

Mycobacterium aurum

Assay / Test Done

Micro Broth Dilution Method

Positive Control Used (conc.)

Streptomycin (1.14 ± 0.02 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

15.79 ± 10.66 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Bakuchiol

PubChem ID

5468522

Ethnomedicinal Information

Leprosy, asthma, bronchitis, respiratory diseases, various fevers, pulmonary disorders

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

256.183

Molecular Formula

C₁₈H₂₄O

SMILES

Oc1ccc(/C=C/[C@](CCC=C(C)C)(C)C=C)cc1

XLogP

7.589

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Newton SM, Lau C, Gurcha SS, Besra GS, Wright CW.The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.J Ethnopharmacol. 2002 Jan;79(1):57-67

2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 1–4. Lalit Mohan Basu, Allahabad, India

Curator

Record - 22 of 36 [TOP]

Compound ID

2458

Compound Structure

Plant Source

Psoralea corylifoila L. Common Name:Babchi, Purple Fleabane (English), Somaraaji, Somavalli, Somavallik (Sanskrit)

Source Family

Fabaceae

Origin

India

Plant Part Used

Seed

Extract

Target Bacteria

Mycobacterium smegmatis

Assay / Test Done

Micro Broth Dilution Method

Positive Control Used (conc.)

Streptomycin (0.17 ± 0.04 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

> 500 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Bakuchiol

PubChem ID

5468522

Ethnomedicinal Information

Leprosy, asthma, bronchitis, respiratory diseases, various fevers, pulmonary disorders

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

256.183

Molecular Formula

C₁₈H₂₄O

SMILES

Oc1ccc(/C=C/[C@](CCC=C(C)C)(C)C=C)cc1

XLogP

7.589

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 23 of 36 [TOP]

Compound ID

2459

Compound Structure

Plant Source

Psoralea corylifoila L. Common Name:Babchi, Purple Fleabane (English), Somaraaji, Somavalli, Somavallik (Sanskrit)

Source Family

Fabaceae

Origin

India

Plant Part Used

Seed

Extract

Target Bacteria

Mycobacterium bovis

Assay / Test Done

Micro Broth Dilution Method

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

21.4 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Bakuchiol

PubChem ID

5468522

Ethnomedicinal Information

Leprosy, asthma, bronchitis, respiratory diseases, various fevers, pulmonary disorders

PubMed ID [Source Literature]

11744296

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Terpene, Meroterpene, Phenol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

256.183

Molecular Formula

C₁₈H₂₄O

SMILES

Oc1ccc(/C=C/[C@](CCC=C(C)C)(C)C=C)cc1

XLogP

7.589

PSA

20.230

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

Curator

Record - 24 of 36 [TOP]

Compound ID	2655
Compound Structure
Plant Source	Swietenia humilis Common Name:Pacific Mahogany, Dry Zone Mahogany
Source Family	Meliaceae
Origin	Mexico
Plant Part Used	Seed
Extract	Hexane, methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	> 200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Adelina Jimenez-Arellanes1, Mariana Meckes1, Raquel Ramirez1, Javier Torres2 and Julieta Luna-Herrera3 Activity against Multidrug-resistant Mycobacterium tuberculosis in Mexican Plants Used to Treat Respiratory Diseases PHYTOTHERAPY RESEARCH Phytother. 2) http://www.worldagroforestry.org/treedb2/AFTPDFS/Swietenia_humilis.pdf
Curator

Record - 25 of 36 [TOP]

Compound ID	2754
Compound Structure
Plant Source	Trigonella foenum-graecum L. Common Name:Fenugreek (English), Methikaa, Methi, Vastikaa, Selu, Methini, Dipani, Bahupatrikaa, Bodhaini, Gandhaphala (Sanskrit)
Source Family	Fabaceae
Origin	India
Plant Part Used	Seed
Extract	Protein fraction
Target Bacteria	Mycobacterium rhodochrous
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, bronchitis, cough
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

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