BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 7 [TOP]

Compound ID	1100
Compound Structure
Plant Source	Allium sativum L. Common Name:Garlic (English), Lashuna (Sanskrit)
Source Family	Amaryllidaceae
Origin	India, Africa, Malaysia
Plant Part Used	Tuber
Extract	Water, methanol
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (2.00 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, expectorant, cough, pulmonary phthisis, consumption, chronic diseases of lungs, whooping cough, laryngeal tuberculosis
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 2 of 7 [TOP]

Compound ID	1101
Compound Structure
Plant Source	Allium sativum L. Common Name:Garlic (English), Lashuna (Sanskrit)
Source Family	Amaryllidaceae
Origin	India, Africa, Malaysia
Plant Part Used	Tuber
Extract	Water, methanol
Target Bacteria	Mycobacterium tuberculosis 2 (Clinical isolates resistant to Streptomycin, Rifampin, Ethambutol, Isoniazid)
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (100 µg/ml), Isoniazid (4.6 µg/ml), Ethambutol (12 µg/ml), Streptomycin (120 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, asthma, expectorant, cough, pulmonary phthisis, consumption, chronic diseases of lungs, whooping cough, laryngeal tuberculosis
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 3 of 7 [TOP]

Compound ID	2304
Compound Structure
Plant Source	Pelargonium grossularioides Common Name:Gooseberry Leaved Pelargonium
Source Family	Geraniaceae
Origin	Africa
Plant Part Used	Tuber
Extract
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, coughs
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) G. Scott, E.P. Springfield and N. Coldrey.A Pharmacognostical Study of 26 South African Plant Species Used as Traditional Medicines.Pharmaceutical Biology, 2004, Vol. 42, No. 3 , Pages 186-213 2) http://www.plantzAfrica.com/plantnop/pelarggross.htm
Curator

Record - 4 of 7 [TOP]

Compound ID	2305
Compound Structure
Plant Source	Pelargonium reniforme Common Name:
Source Family	Geraniaceae
Origin	Africa
Plant Part Used	Tuber
Extract	N - hexane
Target Bacteria	Mycobacterium aurum, Mycobacterium smegmatis, Mycobacterium fortuitum, Mycobacterium abscessus, Mycobacterium phlei
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, coughs
PubMed ID [Source Literature]	15194133
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Seidel V, Taylor PW. In vitro activity of extracts and constituents of Pelagonium against rapidly growing mycobacteria. Int J Antimicrob Agents. 2004, Jun;23(6):613-9
Curator

Record - 5 of 7 [TOP]

Compound ID

2306

Compound Structure

Plant Source

Pelargonium reniforme Common Name:

Source Family

Geraniaceae

Origin

Africa

Plant Part Used

Tuber

Extract

N - hexane

Target Bacteria

Mycobacterium aurum

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

2 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Linoleic Acid

PubChem ID

5280450

Ethnomedicinal Information

Tuberculosis, coughs

PubMed ID [Source Literature]

15194133

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aliphatic, Alkene, Fatty acid

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

280.240

Molecular Formula

C₁₈H₃₂O₂

SMILES

OC(=O)CCCCCCC/C=CC/C=CCCCCC

XLogP

7.865

PSA

37.300

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Seidel V, Taylor PW. In vitro activity of extracts and constituents of Pelagonium against rapidly growing mycobacteria. Int J Antimicrob Agents. 2004, Jun;23(6):613-9

Curator

Record - 6 of 7 [TOP]

Compound ID	2307
Compound Structure
Plant Source	Pelargonium sidoides Common Name:African Geranium
Source Family	Geraniaceae
Origin	Africa
Plant Part Used	Tuber
Extract	Unsaturated fatty acids
Target Bacteria	Mycobacterium aurum, Mycobacterium smegmatis, Mycobacterium fortuitum, Mycobacterium abscessus, Mycobacterium phlei
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, coughs
PubMed ID [Source Literature]	15194133
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Seidel V, Taylor PW. In vitro activity of extracts and constituents of Pelagonium against rapidly growing mycobacteria. Int J Antimicrob Agents. 2004, Jun;23(6):613-9
Curator

Record - 7 of 7 [TOP]

Compound ID	2310
Compound Structure
Plant Source	Pentanisia prunelloides Walp Common Name:Wild Verbena, Broad - Leaved Pentanisia
Source Family	Rubiaceae
Origin	Africa
Plant Part Used	Fleshy, tuberous root
Extract
Target Bacteria
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis, chest pain
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Watt, John Mitchell, and Maria Gerdina Breyer-Brandwijk. 1962. The medicinal and poisonous plants of southern and eastern Africa; being an account of their medicinal and other uses, chemical composition, pharmacological effects and toxicology in man and animal. Edinburgh: Livingstone (2nd Edition) 2) http://www.plantzAfrica.com/plantnop/pentanprunel.htm
Curator

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