BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 9 [TOP]

Compound ID	1308
Compound Structure
Plant Source	Buxus papillosa C. K. syn. Buxus sempervirens L. Common Name:Himalayan Boxwood Tree (English)
Source Family	Buxaceae
Origin	India
Plant Part Used	Wood
Extract	Water
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:80 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Combs, pain, headache, stomatitis, febrifuge, syphilis, rheumatism, diaphoretic, random screening
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34 2) Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, vols. 14. Lalit Mohan Basu, Allahabad, India
Curator

Record - 2 of 9 [TOP]

Compound ID	2217
Compound Structure
Plant Source	Myoporum crassifolium Common Name:
Source Family	Myoporaceae
Origin	Caledonia
Plant Part Used	Wood
Extract	Hexane
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	96 - well Microplate Dilution Method
Positive Control Used (conc.)	Ethambutol (20 µg/ml), Pyrazynamide (2.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15588670
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Billo M, Cabalion P, Waikedre J, Fourneau C, Bouttier S, Hocquemiller R, Fournet A.Screening of some New Caledonian and Vanuatu medicinal plants for antimycobacterial activity.J Ethnopharmacol. 2005 Jan 4;96(1-2):195-200
Curator

Record - 3 of 9 [TOP]

Compound ID	2218
Compound Structure
Plant Source	Myoporum crassifolium Common Name:
Source Family	Myoporaceae
Origin	Caledonia
Plant Part Used	Wood
Extract	Essential oil
Target Bacteria	Mycobacterium bovis (BCG - Bacillus Calmette Guerin)
Assay / Test Done	96 - well Microplate Dilution Method
Positive Control Used (conc.)	Ethambutol (20 µg/ml), Pyrazynamide (2.5 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	15588670
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Billo M, Cabalion P, Waikedre J, Fourneau C, Bouttier S, Hocquemiller R, Fournet A.Screening of some New Caledonian and Vanuatu medicinal plants for antimycobacterial activity.J Ethnopharmacol. 2005 Jan 4;96(1-2):195-200
Curator

Record - 4 of 9 [TOP]

Compound ID	2694
Compound Structure
Plant Source	Taxus baccata L Common Name:European Yew (English), Thunera, Sthauneya, Sthauneyaka, Shukapushpa, Dhaatri - Patra, Vikarna (Sanskrit)
Source Family	Taxaceae
Origin	India
Plant Part Used	Wood
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin sulphate (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Expectorant
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) N. Erdemoglu, B. Sener and P. Palittapongarnpim.Antimycobacterial activity of Taxus baccata.Pharmaceutical Biology, 2003, Vol. 41, No. 8 , Pages 614-615
Curator

Record - 5 of 9 [TOP]

Compound ID

2824

Compound Structure

Plant Source

Zanthoxylum wutaiense Common Name:

Source Family

Rutaceae

Origin

China

Plant Part Used

Root, wood

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

35 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Methyl 7 - Methoxyanodendroate

PubChem ID

24970510

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

18564877

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Bicyclic, Furanoid, Ester, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

266.115

Molecular Formula

C₁₄H₁₈O₅

SMILES

O1[C@H](C(O)(C)C)Cc2c1c(OC)cc(c2)C(=O)OC

XLogP

1.508

PSA

64.990

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Huang HY, Ishikawa T, Peng CF, Tsai IL, Chen IS.Constituents of the root wood of Zanthoxylum wutaiense with antitubercular activity.J Nat Prod. 2008 Jul;71(7):1146-51

Curator

Record - 6 of 9 [TOP]

Compound ID

2825

Compound Structure

Plant Source

Zanthoxylum wutaiense Common Name:

Source Family

Rutaceae

Origin

China

Plant Part Used

Root, wood

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

35 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

7 - Methoxywutaifuranal

PubChem ID

24970511

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

18564877

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Alkyl, Alkene, Aldehyde, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

202.063

Molecular Formula

C₁₂H₁₀O₃

SMILES

O1c2c(cc(cc2OC)/C=C/C=O)cc1

XLogP

1.914

PSA

39.440

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Huang HY, Ishikawa T, Peng CF, Tsai IL, Chen IS.Constituents of the root wood of Zanthoxylum wutaiense with antitubercular activity.J Nat Prod. 2008 Jul;71(7):1146-51

Curator

Record - 7 of 9 [TOP]

Compound ID

2826

Compound Structure

Plant Source

Zanthoxylum wutaiense Common Name:

Source Family

Rutaceae

Origin

China

Plant Part Used

Root, wood

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

30 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Wutaiensal

PubChem ID

25015068

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

18564877

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Phenylpropanoid, Benzofuranoid, Aldehyde, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

262.121

Molecular Formula

C₁₅H₁₈O₄

SMILES

O1[C@H](C(O)(C)C)Cc2c1c(OC)cc(c2)/C=C/C=O

XLogP

1.873

PSA

55.760

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Huang HY, Ishikawa T, Peng CF, Tsai IL, Chen IS.Constituents of the root wood of Zanthoxylum wutaiense with antitubercular activity.J Nat Prod. 2008 Jul;71(7):1146-51

Curator

Record - 8 of 9 [TOP]

Compound ID

2827

Compound Structure

Plant Source

Zanthoxylum wutaiense Common Name:

Source Family

Rutaceae

Origin

China

Plant Part Used

Root, wood

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

30 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Dictamnine

PubChem ID

68085

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

18564877

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Quinoline, Furanoid, Alkaloid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

199.063

Molecular Formula

C₁₂H₉NO₂

SMILES

O1c2nc3c(c(OC)c2cc1)cccc3

XLogP

2.723

PSA

35.260

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Huang HY, Ishikawa T, Peng CF, Tsai IL, Chen IS.Constituents of the root wood of Zanthoxylum wutaiense with antitubercular activity.J Nat Prod. 2008 Jul;71(7):1146-51

Curator

Record - 9 of 9 [TOP]

Compound ID

2828

Compound Structure

Plant Source

Zanthoxylum wutaiense Common Name:

Source Family

Rutaceae

Origin

China

Plant Part Used

Root, wood

Extract

Target Bacteria

Mycobacterium tuberculosis H37Rv

Assay / Test Done

Positive Control Used (conc.)

Inhibition [%]

Activity [MIC] µg/ml

30 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

γ - Fagarine

PubChem ID

107936

Ethnomedicinal Information

Tuberculosis

PubMed ID [Source Literature]

18564877

Extract Preparation

N/A

Chemical Classification [Active Compound]

Aromatic, Quinoline, Furanoid, Alkaloid, Ether

Media / Broth Used [Antimicrobial Assay/Test]

N/A

Cytotoxicity Assay [AID]

N/A

Molecular Weight

229.074

Molecular Formula

C₁₃H₁₁NO₃

SMILES

O1c2nc3c(c(OC)c2cc1)cccc3OC

XLogP

2.068

PSA

44.490

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Huang HY, Ishikawa T, Peng CF, Tsai IL, Chen IS.Constituents of the root wood of Zanthoxylum wutaiense with antitubercular activity.J Nat Prod. 2008 Jul;71(7):1146-51

Curator

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