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                  Page - 1 of 1                  Record - 1 of 9   [TOP]
Compound ID1378
Compound Structure
Plant SourceCarpobrotus edulis L.     Common Name:Sour Fig, Cape Fig, Hottentot Fig
Source FamilyAizoaceae
OriginAfrica
Plant Part UsedLeaf
ExtractWater
Target BacteriaMycobacterium aurum
Assay / Test DoneMicrodilution Bioassays
Positive Control Used (conc.)Streptomycin (0.750 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml4690 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationDiarrhoea, tuberculosis, burn wounds (applied externally), sores on the oral mucosa, thrush and ulcers
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) L. V. Buwa and A. J. Afolayan.Antimicrobial activity of some medicinal plants used for the treatment of tuberculosis in the Eastern Cape Province, South Africa.African Journal of Biotechnology Vol. 8 (23), pp. 6683-6687

2) http://www.plantzAfrica.com/medmonographs/carpobrotedu.pdf

Curator

                  Record - 2 of 9   [TOP]
Compound ID1379
Compound Structure
Plant SourceCarpobrotus edulis L.     Common Name:Sour Fig, Cape Fig, Hottentot Fig
Source FamilyAizoaceae
OriginAfrica
Plant Part UsedLeaf
ExtractEthanol
Target BacteriaMycobacterium aurum
Assay / Test DoneMicrodilution Bioassays
Positive Control Used (conc.)Streptomycin (0.750 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml3125 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationDiarrhoea, tuberculosis, burn wounds (applied externally), sores on the oral mucosa, thrush and ulcers
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) L. V. Buwa and A. J. Afolayan.Antimicrobial activity of some medicinal plants used for the treatment of tuberculosis in the Eastern Cape Province, South Africa.African Journal of Biotechnology Vol. 8 (23), pp. 6683-6687

2) http://www.plantzAfrica.com/medmonographs/carpobrotedu.pdf

Curator

                  Record - 3 of 9   [TOP]
Compound ID1380
Compound Structure
Plant SourceCarpobrotus edulis L.     Common Name:Sour Fig, Cape Fig, Hottentot Fig
Source FamilyAizoaceae
OriginAfrica
Plant Part UsedLeaf
ExtractDichloromethane
Target BacteriaMycobacterium aurum
Assay / Test DoneMicrodilution Bioassays
Positive Control Used (conc.)Streptomycin (0.750 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml6250 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationDiarrhoea and to treat tuberculosis and applied externally to burn wounds, sores or to the oral mucosa to treat thrush and ulcers
PubMed ID [Source Literature]
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) L. V. Buwa and A. J. Afolayan.Antimicrobial activity of some medicinal plants used for the treatment of tuberculosis in the Eastern Cape Province, South Africa.African Journal of Biotechnology Vol. 8 (23), pp. 6683-6687

2) http://www.plantzAfrica.com/medmonographs/carpobrotedu.pdf

Curator

                  Record - 4 of 9   [TOP]
Compound ID1381
Compound Structure
Plant SourceCarpobrotus mellei     Common Name:
Source FamilyAizoaceae
OriginAfrica
Plant Part UsedLeaf juice
ExtractEthyl acetate
Target BacteriaMycobacterium smegmatis
Assay / Test DoneDisc Diffusion and Bioautography
Positive Control Used (conc.)Ciprofloxacin (40 µg/Disc)
Inhibition [%]
Activity [MIC] µg/ml15000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis, infections
PubMed ID [Source Literature]12834010
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Springfield EP, Amabeoku G, Weitz F, Mabusela W, Johnson Q. An assessment of two Carpobrotus species extracts as potential antimicrobial agents. Phytomedicine. 2003;10(5):434-9

Curator

                  Record - 5 of 9   [TOP]
Compound ID1382
Compound Structure
Plant SourceCarpobrotus mellei     Common Name:
Source FamilyAizoaceae
OriginAfrica
Plant Part UsedLeaf juice
ExtractWater
Target BacteriaMycobacterium smegmatis
Assay / Test DoneDisc Diffusion and Bioautography
Positive Control Used (conc.)Ciprofloxacin (40 µg/Disc)
Inhibition [%]
Activity [MIC] µg/ml30000 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationTuberculosis, infections
PubMed ID [Source Literature]12834010
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Springfield EP, Amabeoku G, Weitz F, Mabusela W, Johnson Q. An assessment of two Carpobrotus species extracts as potential antimicrobial agents. Phytomedicine. 2003;10(5):434-9

Curator

                  Record - 6 of 9   [TOP]
Compound ID1781
Compound Structure
Plant SourceGalenia africana L.     Common Name:Yellow Bush
Source FamilyAizoaceae
OriginAfrica
Plant Part UsedLeaf
ExtractEthanol
Target BacteriaMycobacterium smegmatis
Assay / Test DoneRapid Radiometric Method using BACTEC - 460 System
Positive Control Used (conc.)Ciprofloxacin (0.156 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml780 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationChest pains, tuberculosis, asthma
PubMed ID [Source Literature]18412151
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Mativandlela SP, Meyer JJ, Hussein AA, Houghton PJ, Hamilton CJ, Lall N.Activity against Mycobacterium smegmatis and M. tuberculosis by extract of South African medicinal plants.Phytother Res. 2008 Jun;22(6):841-5

Curator

                  Record - 7 of 9   [TOP]
Compound ID1782
Compound Structure
Plant SourceGalenia africana L.     Common Name:Yellow bush
Source FamilyAizoaceae
OriginAfrica
Plant Part UsedLeaf
ExtractEthanol
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRapid Radiometric Method using BACTEC - 460 System
Positive Control Used (conc.)Ciprofloxacin (0.156 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml1200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem IDNR
Ethnomedicinal InformationChest pains, tuberculosis, asthma
PubMed ID [Source Literature]18412151
Extract PreparationN/A
Chemical Classification [Active Compound]N/A
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Reference(s)1) Mativandlela SP, Meyer JJ, Hussein AA, Houghton PJ, Hamilton CJ, Lall N.Activity against Mycobacterium smegmatis and M. tuberculosis by extract of South African medicinal plants.Phytother Res. 2008 Jun;22(6):841-5

Curator

                  Record - 8 of 9   [TOP]
Compound ID1783
Compound Structure
DOWNLOAD:
Plant SourceGalenia africana L.     Common Name:Yellow Bush
Source FamilyAizoaceae
OriginAfrica
Plant Part UsedLeaf
ExtractHexane:Ethyl acetate
Target BacteriaMycobacterium smegmatis
Assay / Test DoneRapid Radiometric Method using BACTEC - 460 System
Positive Control Used (conc.)Ciprofloxacin (0.156 mg/ml)
Inhibition [%]
Activity [MIC] µg/ml31.2 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5, 7, 2` - Trihydroxyflavone
PubChem ID   5322064
Ethnomedicinal InformationChest pains, tuberculosis, asthma
PubMed ID [Source Literature]18412151
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight270.053
Molecular FormulaC15H10O5
SMILESO1c2c(c(=O)cc1c1c(O)cccc1)c(O)cc(O)c2
XLogP1.337
PSA77.760
H-bond Donor3
H-bond Acceptor4
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Mativandlela SP, Meyer JJ, Hussein AA, Houghton PJ, Hamilton CJ, Lall N.Activity against Mycobacterium smegmatis and M. tuberculosis by extract of South African medicinal plants.Phytother Res. 2008 Jun;22(6):841-5

Curator

                  Record - 9 of 9   [TOP]
Compound ID1784
Compound Structure
DOWNLOAD:
Plant SourceGalenia africana L.     Common Name:Yellow Bush
Source FamilyAizoaceae
OriginAfrica
Plant Part UsedLeaf
ExtractHexane:Ethyl acetate
Target BacteriaMycobacterium tuberculosis
Assay / Test DoneRapid Radiometric Method using BACTEC - 460 System
Positive Control Used (conc.)Isoniazid (0.2 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified5, 7, 2` - Trihydroxyflavone
PubChem ID   5322064
Ethnomedicinal InformationChest pains, tuberculosis, asthma
PubMed ID [Source Literature]18412151
Extract PreparationN/A
Chemical Classification [Active Compound]Aromatic, Tricyclic, Flavonoid, Phenol
Media / Broth Used [Antimicrobial Assay/Test]N/A
Cytotoxicity Assay [AID]N/A
Molecular Weight270.053
Molecular FormulaC15H10O5
SMILESO1c2c(c(=O)cc1c1c(O)cccc1)c(O)cc(O)c2
XLogP1.337
PSA77.760
H-bond Donor3
H-bond Acceptor4
No. of Rotatable Bond Count1
No. of Rings3
No. of N0
No. of O5
No. of S0
Reference(s)1) Mativandlela SP, Meyer JJ, Hussein AA, Houghton PJ, Hamilton CJ, Lall N.Activity against Mycobacterium smegmatis and M. tuberculosis by extract of South African medicinal plants.Phytother Res. 2008 Jun;22(6):841-5

Curator


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