BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 16 [TOP]

Compound ID	1172
Compound Structure
Plant Source	Anacardium Humile Common Name:Monkey Nut
Source Family	Anacardiaceae
Origin	Brazil
Plant Part Used	Leaf
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.015 - 0.05 µg/ml)
Inhibition [%]	90 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Effective for the ailment medicated
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pavan FR, Sato DN, Higuchi CT, Santos ACB, Vilegas W, Leite CQE 2009. In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants. Rev Bras Farmacogn 19: 204-206 2) http://www.ars-grin.gov/cgi-bin/duke/ethnobot.pl
Curator

Record - 2 of 16 [TOP]

Compound ID	1173
Compound Structure
Plant Source	Anacardium Humile Common Name:Monkey Nut
Source Family	Anacardiaceae
Origin	Brazil
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.015 - 0.05 µg/ml)
Inhibition [%]	90 %
Activity [MIC] µg/ml	500 µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Effective for the ailment medicated
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pavan FR, Sato DN, Higuchi CT, Santos ACB, Vilegas W, Leite CQE 2009. In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants. Rev Bras Farmacogn 19: 204-206
Curator

Record - 3 of 16 [TOP]

Compound ID	1174
Compound Structure
Plant Source	Anacardium occidentale L. Common Name:Cashew nut (English)
Source Family	Anacardiaceae
Origin	Malaysia
Plant Part Used	Fruit
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Mohamed, N., Sulaiman, S.F., Mohamad, S., Zakaria, Z., Wahab, H.A., 2005. Khasiat Ulam-ulaman. Penerbit Universiti Sains Malaysia, Penang, Malaysia
Curator

Record - 4 of 16 [TOP]

Compound ID	2135
Compound Structure
Plant Source	Mangifera indica L. Common Name:Mango (English), Aamra, Amb, Rasaal, Sahakaar, Pikavallabha, Madhudoot, Atisaurabha, Maakanda (Sanskrit)
Source Family	Anacardiaceae
Origin	India
Plant Part Used	Leaf
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Asthma, bronchitis, bronchitis, cough, throat troubles, asthma
PubMed ID [Source Literature]	10925394
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Wright CW.A review of antimycobacterial natural products.Phytother Res. 2000 Aug;14(5):303-22
Curator

Record - 5 of 16 [TOP]

Compound ID	2136
Compound Structure
Plant Source	Mangifera indica L. Common Name:Mango (English), Aamra, Amb, Rasaal, Sahakaar, Pikavallabha, Madhudoot, Atisaurabha, Maakanda (Sanskrit)
Source Family	Anacardiaceae
Origin	India
Plant Part Used	Leaf
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium smegmatis
Assay / Test Done	Disk Diffusion Assay
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml	1000 µg/disc
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)	12 mm
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, cough, throat troubles, asthma
PubMed ID [Source Literature]	10925394
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Newton SM, Lau C, Wright CW.A review of antimycobacterial natural products.Phytother Res. 2000 Aug;14(5):303-22
Curator

Record - 6 of 16 [TOP]

Compound ID	2137
Compound Structure
Plant Source	Mangifera speciosa Common Name:
Source Family	Anacardiaceae
Origin	Brazil
Plant Part Used	Leaf
Extract	Chloroform
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.015 - 0.05 µg/ml)
Inhibition [%]	90 %
Activity [MIC] µg/ml	4000 µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pavan FR, Sato DN, Higuchi CT, Santos ACB, Vilegas W, Leite CQE 2009. In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants. Rev Bras Farmacogn 19: 204-206
Curator

Record - 7 of 16 [TOP]

Compound ID	2138
Compound Structure
Plant Source	Mangifera speciosa Common Name:
Source Family	Anacardiaceae
Origin	Brazil
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv (ATCC 27 294)
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Isoniazid (0.015 - 0.05 µg/ml)
Inhibition [%]	90 %
Activity [MIC] µg/ml	2000 µg/ml
Activity (In terms of dilution)	1:25 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Pavan FR, Sato DN, Higuchi CT, Santos ACB, Vilegas W, Leite CQE 2009. In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants. Rev Bras Farmacogn 19: 204-206
Curator

Record - 8 of 16 [TOP]

Compound ID	2495
Compound Structure
Plant Source	Rhus rogersii Schönland Common Name:
Source Family	Anacardiaceae
Origin	Africa
Plant Part Used	Bark
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (2.00 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 9 of 16 [TOP]

Compound ID	2496
Compound Structure
Plant Source	Rhus rogersii Schönland Common Name:
Source Family	Anacardiaceae
Origin	Africa
Plant Part Used	Bark
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis 2 (Clinical isolates resistant to Streptomycin, Rifampin, Ethambutol, Isoniazid)
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (100 µg/ml), Isoniazid (4.6 µg/ml), Ethambutol (12 µg/ml), Streptomycin (120 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 10 of 16 [TOP]

Compound ID	2571
Compound Structure
Plant Source	Schinus molle L. Common Name:Pepper Tree, California Pepper Tree, Chilean Pepper Tree, Mastic Tree, Molle
Source Family	Anacardiaceae
Origin	Turkey
Plant Part Used	Fruit, leaf
Extract	Ethanol (70 %)
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Microplate Alamar Blue Assay (MABA)
Positive Control Used (conc.)	Rifampin (0.0047 – 0.0095 µg/ml), Isoniazid (0.05 – 0.1 µg/ml), Kanamycin (2.5 – 5.0 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	200 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Bronchitis, constipation, coughs, excessive mucous, edema, eye diseases, gingivitis, gout, hypertension, menstrual disorders, rheumatism, sores, swelling, urinary insufficiency, urogenital inflammation, venereal disease, viruses and to stimulate digestion
PubMed ID [Source Literature]	15507348
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Tosun F, Kizilay CA, Sener B, Vural M, Palittapongarnpim P.Antimycobacterial screening of some Turkish plants.J Ethnopharmacol. 2004 Dec;95(2-3):273-5 2) http://www.worldagroforestry.org/treedb2/AFTPDFS/Schinus_molle.pdf 3) http://rainforest-database.com/plants/peppertree.htm
Curator

Record - 11 of 16 [TOP]

Compound ID	2576
Compound Structure
Plant Source	Sclerocarya birrea (A Rich) Hochst Common Name:Marula Tree
Source Family	Anacardiaceae
Origin	Africa
Plant Part Used	Bark
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis H37Ra
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (0.06 µg/ml), Isoniazid (0.06 µg/ml), Ethambutol (2.00 µg/ml), Streptomycin (0.50 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used for diarrhoea, dysentery, stomach problems, fever, cough, malaria, tonic and diabetes
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 12 of 16 [TOP]

Compound ID	2577
Compound Structure
Plant Source	Sclerocarya birrea (A Rich) Hochst Common Name:Marula Tree
Source Family	Anacardiaceae
Origin	Africa
Plant Part Used	Bark
Extract	Acetone
Target Bacteria	Mycobacterium tuberculosis 2 (Clinical isolates resistant to Streptomycin, Rifampin, Ethambutol, Isoniazid)
Assay / Test Done	Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Rifampin (100 µg/ml), Isoniazid (4.6 µg/ml), Ethambutol (12 µg/ml), Streptomycin (120 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	> 100 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Used for diarrhoea, dysentery, stomach problems, fever, cough, malaria, tonic and diabetes
PubMed ID [Source Literature]	20447452
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Green E, Samie A, Obi CL, Bessong PO, Ndip RN.Inhibitory properties of selected South African medicinal plants against Mycobacterium tuberculosis.J Ethnopharmacol. 2010 Jul 6;130(1):151-7
Curator

Record - 13 of 16 [TOP]

Compound ID	2626
Compound Structure
Plant Source	Spondias mombin L. Common Name:
Source Family	Anacardiaceae
Origin	Peru
Plant Part Used	Bark
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) radiometric assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 14 of 16 [TOP]

Compound ID	2627
Compound Structure
Plant Source	Spondias pinnata (L. f.) Kurz Common Name:Hogplum (English), Amrataka (Sanskrit)
Source Family	Anacardiaceae
Origin	Malaysia
Plant Part Used	Fruit
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Cough
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Rozi, F., 2010. Tips and Info about amra fruit, tamarind, rambutan, and more (Available at: http://baroji.blogspot.in/2010/01/tips-dan-info-tentang-buah-kedondong.html) 2) http://ayurvedicmedicinalplants.com/plants/206.html
Curator

Record - 15 of 16 [TOP]

Compound ID	3341
Compound Structure
Plant Source	Physalis angulata L. Common Name:NR
Source Family	Anacardiaceae
Origin	Spanish Mediterranean Area
Plant Part Used	Leaf
Extract	Methanol
Target Bacteria	Mycobacterium phlei (CECT 3009)
Assay / Test Done	NR
Positive Control Used (conc.)	Gentamicin (10 µg/ml)
Inhibition [%]	NR
Activity [MIC] µg/ml	1 x 10⁶ µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans
PubMed ID [Source Literature]	3325696
Extract Preparation
Chemical Classification [Active Compound]
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Ríos JL, Recio MC, Villar A.Antimicrobial activity of selected plants employed in the Spanish Mediterranean area.J Ethnopharmacol. 1987 Nov;21(2):139-52
Curator	Najiya Beegum

Record - 16 of 16 [TOP]

Compound ID

3861

Compound Structure

Plant Source

Rhus taitensis Guill. Common Name:Pumac

Source Family

Anacardiaceae

Origin

Papua New Guinea

Plant Part Used

Leaf, twig

Extract

Methanol

Target Bacteria

Mycobacterium tuberculosis H37Ra (ATCC 25177)

Assay / Test Done

MTT Assay

Positive Control Used (conc.)

Rifampin (0.0025 - 0.0079 µg/ml)

Inhibition [%]

Activity [MIC] µg/ml

10 µg/ml

Activity (In terms of dilution)

Activity (Zone of inhibition in mm)

Active Compound Identified

Tetrahydroxysqualene

PubChem ID

25058109

Ethnomedicinal Information

PubMed ID [Source Literature]

18710283

Extract Preparation

Air - dried leaves and twigs (108.6 g) of Rhus taitensis were ground and extracted with 250 ml MeOH (3 × 24 hours) at room temperature. The crude extract (1.7 g) was filtered and concentrated in vacuo. 5 grams of the crude extract were dissolved in MeOH and mixed with 5 g of HP20SS and dried. The mixture was then poured into a column and fractionated using 100 % water, 75 % H₂O / 25 % 2 - propanol, 50 % H₂O / 50 % 2 - propanol, 25 % H₂O / 75 % 2 - propanol, and 100 % MeOH to yield five fractions designated FW, F1, F2, F3, F4, respectively. The fractions were collected and the solvents evaporated using a centrifugal evaporator

Chemical Classification [Active Compound]

Aliphatic, Alkene, Terpene, Triterpene, Alcohol

Media / Broth Used [Antimicrobial Assay/Test]

ADC (Remel) supplemented 7H9 medium

Cytotoxicity Assay [AID]

Against Human T cells

Molecular Weight

474.371

Molecular Formula

C₃₀H₅₀O₄

SMILES

OCC(=CCC/C(=C/CC/C(=C/CC/C=C(/CC/C=C(/CCC=C(CO)CO)C)C)/C)/C)CO

XLogP

5.646

PSA

80.920

H-bond Donor

H-bond Acceptor

No. of Rotatable Bond Count

No. of Rings

No. of N

No. of O

No. of S

Reference(s)

1) Noro JC, Barrows LR, Gideon OG, Ireland CM, Koch M, Matainaho T, Piskaut P, Pond CD, Bugni TS.Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis.J Nat Prod. 2008 Sep;71(9):1623-4. Epub 2008 Aug 19

Curator

KeyaMukherjee, Farzana Shamsudeen, gppreetha

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