BioPhytMol: A database of Phytomolecules against Mycobacteria

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Page - 1 of 1 Record - 1 of 10 [TOP]

Compound ID	1049
Compound Structure	N/A
Plant Source	Acorus calamus L. var. americanus (Raf.) Common Name:Sweetflag
Source Family	Araceae
Origin	North America
Plant Part Used	Root
Extract
Target Bacteria
Assay / Test Done	Microplate Resazurin Assay (MRA)
Positive Control Used (conc.)	Rifampin (2 and 0.4 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Adjuvant, analgesic, antihelmintic, antihemorrhagic, anti-inflammatory, antipyretic, antirheumatic, cold, cough, dermatological, emetic, gastrointestinal, gynaecological, child birth, hallucinogen, panacea, tonic, pediatric, pulmonary, stimulant, venereal infection
PubMed ID [Source Literature]	20657619
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Duncan Webster, Timothy D.G. Lee, Jill MoWebster D, Lee TD, Moore J, Manning T, Kunimoto D, LeBlanc D, Johnson JA, Gray CA.Antimycobacterial screening of traditional medicinal plants using the microplate resazurin assay.Can J Microbiol. 2010 Jun;56(6):487-94
Curator

Record - 2 of 10 [TOP]

Compound ID	1604
Compound Structure
Plant Source	Dieffenbachia maculata (Lodd G. Don) Common Name:Dumb Cane
Source Family	Araceae
Origin	Puerto Rico
Plant Part Used	Leaf
Extract	Ethanol (95 %)
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Middlebrook 7H9 Broth using BACTEC 460 System
Positive Control Used (conc.)	Rifampin
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	11746852
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG.Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities.Phytother Res. 2001 Nov;15(7):638-42 2) http://www.gardenstew.com/about2492.html
Curator

Record - 3 of 10 [TOP]

Compound ID	1615
Compound Structure
Plant Source	Dracontium loretense Krause Common Name:
Source Family	Araceae
Origin	Peru
Plant Part Used	Corm
Extract	Dichloromethane
Target Bacteria	Mycobacterium tuberculosis (ATCC 27294)
Assay / Test Done	BACTEC 460 (Becton Dickinson Diagnostic Instrument Systems, Sparks MD) Radiometric Assay
Positive Control Used (conc.)	Rifampin (2 µg/ml), Ethambutol (7.5 µg/ml)
Inhibition [%]	< 50 %
Activity [MIC] µg/ml	50 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Tuberculosis
PubMed ID [Source Literature]	13678239
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Graham JG, Pendland SL, Prause JL, Danzinger LH, Schunke Vigo J, Cabieses F, Farnsworth NR.Antimycobacterial evaluation of Peruvian plants.Phytomedicine. 2003;10(6-7):528-35
Curator

Record - 4 of 10 [TOP]

Compound ID	2396
Compound Structure
Plant Source	Pistia stratiotes L. Common Name:Water Lettuce (English)
Source Family	Araceae
Origin	Malaysia
Plant Part Used	Whole plant
Extract	Methanol
Target Bacteria	Mycobacterium tuberculosis H37Rv
Assay / Test Done	Colorimetric Tetrazolium Microplate Assay (TEMA)
Positive Control Used (conc.)	Isoniazid (0.078 µg/ml)
Inhibition [%]
Activity [MIC] µg/ml	1600 µg/ml
Activity (In terms of dilution)
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Coughing of blood
PubMed ID [Source Literature]
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Chooi, O.H., 2006. Tanaman Hiasan, Khasiat Makanan dan Ubatan. Utusan Publications and Distributors Sdn Bhd, Kuala Lumpur, Malaysia
Curator

Record - 5 of 10 [TOP]

Compound ID	3121
Compound Structure	NR
Plant Source	Acorus calamus L. Common Name:Calamus (English), Vacha (Sanskrit)
Source Family	Araceae
Origin	India
Plant Part Used	Rhizome
Extract	Essential oil
Target Bacteria	Mycobacterium tuberculosis H37Rv (human)
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	10 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Leprocy, bronchitis, pain in chest, asthma, cough, sore throat
PubMed ID [Source Literature]	17276637
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator	Najiya-beegum

Record - 6 of 10 [TOP]

Compound ID	3122
Compound Structure	NR
Plant Source	Acorus calamus L. Common Name:Calamus (English), Vacha (Sanskrit)
Source Family	Araceae
Origin	India
Plant Part Used	Rhizome
Extract	Essential oil
Target Bacteria	Mycobacterium tuberculosis B19 - 3 (bovine)
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	10 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Leprocy, bronchitis, pain in chest, asthma, cough, sore throat
PubMed ID [Source Literature]	17276637
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator	Najiya-beegum, vikramjitmandal

Record - 7 of 10 [TOP]

Compound ID	3123
Compound Structure	NR
Plant Source	Acorus calamus L. Common Name:Calamus (English), Vacha (Sanskrit)
Source Family	Araceae
Origin	India
Plant Part Used	Rhizome
Extract	Essential oil
Target Bacteria	Mycobacterium tuberculosis B19 - 1 (avian)
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	10 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Leprocy, bronchitis, pain in chest, asthma, cough, sore throat
PubMed ID [Source Literature]	17276637
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator	Najiya-beegum, vikramjitmandal

Record - 8 of 10 [TOP]

Compound ID	3124
Compound Structure	NR
Plant Source	Acorus calamus L. Common Name:Calamus (English), Vacha (Sanskrit)
Source Family	Araceae
Origin	India
Plant Part Used	Rhizome
Extract	Essential oil
Target Bacteria	Mycobacterium tuberculosis H52RS (Streptomycin resistant)
Assay / Test Done	Broth Dilution Assay
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	12.5 µg/ml
Activity (In terms of dilution)	NR
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	N/A
PubChem ID	NR
Ethnomedicinal Information	Leprocy, bronchitis, pain in chest, asthma, cough, sore throat
PubMed ID [Source Literature]	17276637
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator	Najiya-beegum, vikramjitmandal

Record - 9 of 10 [TOP]

Compound ID	3177
Compound Structure	NR
Plant Source	Ammorphophallus campanulatus Blume ex Decne Common Name:NR
Source Family	Araceae
Origin	India
Plant Part Used	Stem
Extract	Ether
Target Bacteria	Mycobacterium tuberculosis B19 - 3 (bovine)
Assay / Test Done	Tube Dilution Test
Positive Control Used (conc.)	NR
Inhibition [%]	NR
Activity [MIC] µg/ml	NR
Activity (In terms of dilution)	3.51 dilution
Activity (Zone of inhibition in mm)	NR
Active Compound Identified	NR
PubChem ID	NR
Ethnomedicinal Information	Leprosy, asthma, bronchitis, respiratory disease, various fever, pulmonary disorders, cough, cold
PubMed ID [Source Literature]
Extract Preparation	NR
Chemical Classification [Active Compound]	NR
Media / Broth Used [Antimicrobial Assay/Test]	NR
Cytotoxicity Assay [AID]	NR
Reference(s)	1) Gupta, K.C., Viswananthan, R. (1956). Antitubercular substances from plants: A preliminary study. Antibiot. Chemother., 6, 194-195
Curator	Najiya-beegum, vikramjitmandal

Record - 10 of 10 [TOP]

Compound ID	1170
Compound Structure
Plant Source	Amorphophallus campanulatus Blume ex Decne Common Name:Arsaghna, Balukand (Sanskrit)
Source Family	Araceae
Origin	India
Plant Part Used	Stem
Extract	Ether
Target Bacteria	Mycobacterium tuberculosis B19 - 3 (bovine)
Assay / Test Done
Positive Control Used (conc.)
Inhibition [%]
Activity [MIC] µg/ml
Activity (In terms of dilution)	1:5000 dilution
Activity (Zone of inhibition in mm)
Active Compound Identified
PubChem ID	NR
Ethnomedicinal Information	Leprosy, asthma, bronchitis respiratory disease, various fever, pulmonary disorders
PubMed ID [Source Literature]	17276637
Extract Preparation	N/A
Chemical Classification [Active Compound]	N/A
Media / Broth Used [Antimicrobial Assay/Test]	N/A
Cytotoxicity Assay [AID]	N/A
Reference(s)	1) Gautam R, Saklani A, Jachak SM.Indian medicinal plants as a source of antimycobacterial agents.J Ethnopharmacol. 2007 Mar 21;110(2):200-34
Curator

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